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Clin Sci (Lond) (2022) 136 (8): 639–642.
Published: 27 April 2022
... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . 25-hydroxyvitamin D adipose bile cholecalciferol metabolism This year is the 100th anniversary of the first use of the term vitamin D to describe a fat-soluble...
Clin Sci (Lond) (2008) 114 (9): 567–588.
Published: 02 April 2008
...Marcelo G. Roma; Fernando A. Crocenzi; Enrique A. Sánchez Pozzi The recent overwhelming advances in molecular and cell biology have added enormously to our understanding of the physiological processes involved in bile formation and, by extension, to our comprehension of the consequences...
Julia GORELIK, Sian E. HARDING, Andrew I. SHEVCHUK, Duleepa KORALAGE, Max LAB, Michael DE SWIET, Yuri KORCHEV, Catherine WILLIAMSON
Clin Sci (Lond) (2002) 103 (2): 191–200.
Published: 17 July 2002
...Julia GORELIK; Sian E. HARDING; Andrew I. SHEVCHUK; Duleepa KORALAGE; Max LAB; Michael DE SWIET; Yuri KORCHEV; Catherine WILLIAMSON Obstetric cholestasis is characterized by raised bile acids, and can be complicated by intrauterine death. We have shown that the bile acid taurocholate causes loss...
Clin Sci (Lond) (2002) 102 (6): 603–614.
Published: 30 April 2002
... in bile formation has been very limited. The hepatocyte couplet model offers a unique opportunity to study in vitro the intracellular processes involved: not only the physiology and pathophysiology of bile formation, but also the corresponding structural and molecular disturbances underlying different...
Clin Sci (Lond) (2001) 100 (4): 363–369.
Published: 26 February 2001
... rate abnormalities have been reported in obstetric cholestasis, we hypothesized that intra-uterine death is caused by impaired fetal cardiomyocyte function, resulting in fetal cardiac arrest. Obstetric cholestasis is associated with raised levels of maternal and fetal serum bile acids, and we propose...
Clin Sci (Lond) (1998) 95 (5): 637–644.
Published: 01 November 1998
... themselves, pass from the inflamed colon to the liver via an enterohepatic circulation. However, there are no data on biliary concentrations of neutrophil granule products in patients with active and inactive inflammatory bowel disease. 2. Gall bladder bile was obtained at laparotomy from 42 patients...
Clin Sci (Lond) (1995) 89 (2): 121–128.
Published: 01 August 1995
...Massimino Carrella; Annalisa Csillaghy; Renato de Mercato; Agesilao D'Arienzo 1. Chylomicron remnants, the intermediate intestinal lipoproteins carrying the bulk of dietary cholesterol, are actively taken up and degraded in the hepatocytes, releasing cholesterol which can be excreted in bile...
Yilmaz Cakaloglu, George Marinos, Joanne Marsden, Timothy J. Peters, Roger Williams, J. Michael Tredger
Clin Sci (Lond) (1993) 84 (6): 675–679.
Published: 01 June 1993
... (duodenum and proximal jejunum distal to the common bile duct); SII (distal jejunum); SIII (proximal ileum) and SIV (distal ileum). 2. Cyclosporin A concentrations in whole blood were assayed by an enzyme-mediated immunoassay for up to 4 h in samples drawn from the femoral vein and used to determine...
F. Perez-Barriocanal, J. G. Redondo-Torres, G. R. Villanueva, E. Arteche, M. M. Berenson, J. J. G. Marin
Clin Sci (Lond) (1989) 77 (5): 473–478.
Published: 01 November 1989
..., namely phospholipids, cholesterol and 5′-nucleotidase, into bile in anaesthetized rats receiving saline or taurocholate (0.5 μmol min −1 100 g −1 body weight) with or without protoporphyrin IX infusion (10 or 20 μg min −1 100 g −1 body weight). 2. Protoporphyrin IX induced an impairment of spontaneous...
Clin Sci (Lond) (1984) 66 (4): 487–491.
Published: 01 April 1984
...S. Erlinger; M. Dumont; I. Zouboulis-Vafiadis; G. De Couet 1. The biliary maximum secretory rate (SR max. ) of glycoursodeoxycholate in the bile fistula anaesthetized rat was about five times that of unconjugated ursodeoxycholate. 2. Likewise, the biliary SR max. of tauro-7-ketolithocholate...
Clin Sci (Lond) (1979) 56 (6): 533–538.
Published: 01 June 1979
...S. P. Lee; T. H. Lim; A. J. Scott 1. The soluble glycoproteins of human bile, gall-bladder mucosa and gall stones have been extracted and hydrolysed, and the monosaccharides analysed by gas-liquid chromatography. 2. Human biliary glycoproteins contained 55–75% of carbohydrate, the major...
Clin Sci Mol Med (1978) 55 (4): 399–406.
Published: 01 October 1978
...R. J. Vonk; E. Scholtens; J. H. Strubbe 1. In unanaesthetized, freely moving rats, which displayed a circadian rhythm in bile flow, hepatic transport of dibromosulphthalein was investigated at midnight when bile flow was high and at noon when bile flow was lower. The influence of pentobarbital...
Clin Sci Mol Med (1978) 55 (3): 253–259.
Published: 01 September 1978
...R. J. Vonk; A. B. D. van Doorn; J. H. Strubbe 1. In freely moving, unanaesthetized rats bile flow was measured continuously over the whole day-night cycle. Bile composition was analysed and the influence of food intake on bile flow was investigated. 2. In both sexes a distinct circadian variation...
Clin Sci Mol Med (1978) 55 (1): 63–71.
Published: 01 July 1978
... patients. 2. In the bile-containing duodenal aspirates of Gilbert's patients the average proportion of bilirubin found as bilirubin diglucuronide was 68% (normal 88%) and of bilirubin monoglucuronide, 23% (normal 7%). Both differences were significant at the P < 0.001 level. In the Gilbert's patients...
Clin Sci Mol Med (1977) 53 (4): 373–377.
Published: 01 October 1977
... in serum, urine and bile. 2. The chromatography data indicated an excretion of 25-hydroxycholecalciferol both in bile and urine and, in urine, also of 1,25-dihydroxycholecalciferol. In bile, fractions of labelled substances were also obtained which, according to their elution positions, might represent...
Clin Sci Mol Med (1975) 49 (3): 237–245.
Published: 01 September 1975
...-chromatography studies. 3. The nature of the copper complexes formed by secretions obtained from patients with Wilson's disease was similar to that of complexes formed by secretions of normal subjects. 4. Bile contained a copper-binding fraction of high molecular weight which was more concentrated in gall...
Clin Sci Mol Med (1975) 49 (3): 253–256.
Published: 01 September 1975
...S. Erlinger; Dominique Bienfait; Renee Poupon; Micheline Dumont; M. Duval 1. The influence of lysine acetylsalicylate on bile flow, erythritol clearance and bile salt, phospholipid and cholesterol secretion in bile was studied in unanaesthetized dogs fitted with a Thomas duodenal cannula. 2. Lysine...
Clin Sci Mol Med (1974) 46 (6): 729–741.
Published: 01 June 1974
...A. Lavoie; B. A. Cooper 1. [ 3 H]Folic acid infused intravenously into patients with biliary fistulae appeared promptly in bile, coincident with 131 I-labelled Rose Bengal injected simultaneously. The radioactivity was distributed among several fractions of biological folates present in bile...
Clin Sci Mol Med (1974) 46 (4): 433–448.
Published: 01 April 1974
...-HCC. 4. Treatment with phenobarbitone enhanced the excretion of metabolites of radioactive vitamin D 3 in bile. These metabolites were largely water-soluble conjugates of peaks IV, V and VI, which included glucuronides. Peak IV in bile was not identical with 25-HCC. 5. Prolonged treatment...
Clin Sci Mol Med (1973) 44 (1): 9–15.
Published: 01 January 1973
...J. L. Gollan; D. J. Deller 1. Gall-bladder bile was obtained at cholecystectomy from seven patients who had been given [ 64 Cu]cupric acetate intravenously. 2. Studies using dialysis and Sephadex gel filtration indicated that most of the 64 Cu in the bile was in a heat-stable complex of molecular...
Clin Sci (1972) 43 (3): 413–431.
Published: 01 September 1972
.... 4. Metabolically produced 25-hydroxycholecalciferol is also taken up from the blood into many tissues, probably by protein-binding. 5. Vitamin D is excreted in bile principally as more polar metabolites. Smaller amounts of cholecalciferol and 25-hydroxycholecalciferol are also excreted...