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Keywords: autoimmune disease
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Articles
Clin Sci (Lond) (2015) 128 (10): 635–648.
Published: 20 February 2015
... in phagocyte NADPH oxidase causes chronic granulomatous disease (CGD) in humans, a condition that can also be studied in CGD mice. Clinical observations in CGD patients suggest a higher susceptibility to autoimmune diseases, in particular lupus, idiopathic thrombocytopenic purpura and rheumatoid arthritis...
Articles
Clin Sci (Lond) (2012) 122 (11): 487–511.
Published: 10 February 2012
...Shu Zhu; Youcun Qian IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in host defence against bacterial and fungal infections, as well as in the pathogenesis of autoimmune diseases. The present review focuses on current knowledge of the regulation...
Articles
Clin Sci (Lond) (2012) 122 (4): 143–159.
Published: 14 October 2011
... idiopathic arthritis. IL-6 is also critically involved in experimentally induced autoimmune diseases. All clinical findings and animal models suggest that IL-6 plays a number of critical roles in the pathogenesis of autoimmune diseases. In the present review, we first summarize the IL-6/IL-6R system and IL-6...
Articles
Clin Sci (Lond) (2011) 120 (11): 473–484.
Published: 15 February 2011
... compilation © 2011 Biochemical Society 2011 asthma atherosclerosis autoimmune disease host defence mast cell activation mast cell progenitor Paul Ehrlich first described MCs (mast cells) or ‘mastzellen’ in 1878 based on their unique staining characteristics and their large granule content...
Articles
Clin Sci (Lond) (2009) 116 (8): 639–649.
Published: 16 March 2009
... to the intensive exploration of the role of this subset in disease resulting in a number of studies concluding that a quantitative or qualitative decline in T reg -cells is an important part of the breakdown in self-tolerance leading to the development of autoimmune diseases. Although T reg -cells have...
Articles
Clin Sci (Lond) (2008) 114 (6): 413–421.
Published: 12 February 2008
...Annamaria De Bellis; Giuseppe Ruocco; Marina Battaglia; Marisa Conte; Concetta Coronella; Gilda Tirelli; Antonio Bellastella; Elena Pane; Antonio Agostino Sinisi; Antonio Bizzarro; Giuseppe Bellastella LYH (lymphocytic hypophysitis) is an autoimmune disease of the pituitary gland which can present...