... in phagocyte NADPH oxidase causes chronic granulomatous disease (CGD) in humans, a condition that can also be studied in CGD mice. Clinical observations in CGD patients suggest a higher susceptibility to autoimmune diseases, in particular lupus, idiopathic thrombocytopenic purpura and rheumatoid arthritis...

...Shu Zhu; Youcun Qian IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in host defence against bacterial and fungal infections, as well as in the pathogenesis of autoimmune diseases. The present review focuses on current knowledge of the regulation...

... idiopathic arthritis. IL-6 is also critically involved in experimentally induced autoimmune diseases. All clinical findings and animal models suggest that IL-6 plays a number of critical roles in the pathogenesis of autoimmune diseases. In the present review, we first summarize the IL-6/IL-6R system and IL-6...

... at the present address: Novartis Pharmaceuticals UK Limited, Horsham, West Sussex RH125 AB, U.K. (email charlie.weller@novartis.com ). 27 9 2010 17 11 2010 25 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 asthma atherosclerosis autoimmune disease host...

... to the intensive exploration of the role of this subset in disease resulting in a number of studies concluding that a quantitative or qualitative decline in T reg -cells is an important part of the breakdown in self-tolerance leading to the development of autoimmune diseases. Although T reg -cells have...

...Annamaria De Bellis; Giuseppe Ruocco; Marina Battaglia; Marisa Conte; Concetta Coronella; Gilda Tirelli; Antonio Bellastella; Elena Pane; Antonio Agostino Sinisi; Antonio Bizzarro; Giuseppe Bellastella LYH (lymphocytic hypophysitis) is an autoimmune disease of the pituitary gland which can present...