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Clin Sci (Lond) (2023) 137 (15): 1209.
Published: 16 August 2023
... Targeting immune mechanisms in T2 and non-T2 inflammation Target Approach Name Company Patients Status/clinical phase IgE IgE (Cε3 domain-site involved in binding to FcRI) humanized IgG1 MoAb omalizumab Novartis Asthma urticaria CRSwNP approved IgE (Cε3 domain) humanized MoAb...
Peter S. Cunningham, Callum Jackson, Amlan Chakraborty, Jafar Cain, Hannah J. Durrington, John F. Blaikley
Clin Sci (Lond) (2023) 137 (11): 895–912.
Published: 14 June 2023
... findings from these two approaches in the context of four common respiratory diseases (asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and respiratory infection). Potential methods used to identify and measure human circadian oscillations are also discussed as these will be useful...
Ilja Striz, Kornel Golebski, Zuzana Strizova, Stelios Loukides, Petros Bakakos, Nicola A. Hanania, Milos Jesenak, Zuzana Diamant
Clin Sci (Lond) (2023) 137 (9): 727–753.
Published: 18 May 2023
...Ilja Striz; Kornel Golebski; Zuzana Strizova; Stelios Loukides; Petros Bakakos; Nicola A. Hanania; Milos Jesenak; Zuzana Diamant Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) or without (CRSsNP) are chronic respiratory diseases. These two disorders often co-exist based on common...
Nikita Lad, Alice M. Murphy, Cristina Parenti, Carl P. Nelson, Neil C. Williams, Graham R. Sharpe, Philip G. McTernan
Clin Sci (Lond) (2021) 135 (24): 2729–2748.
Published: 17 December 2021
...Nikita Lad; Alice M. Murphy; Cristina Parenti; Carl P. Nelson; Neil C. Williams; Graham R. Sharpe; Philip G. McTernan Low-grade inflammation is often an underlying cause of several chronic diseases such as asthma, obesity, cardiovascular disease, and type 2 diabetes mellitus (T2DM). Defining...
Clin Sci (Lond) (2021) 135 (20): 2423–2428.
Published: 28 October 2021
... , 41 ]. © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 asthma interdisciplinary pathology personalized medicine translational science There have also been great strides in anatomical diagnostics. Non-invasive and minimally...
Lin Yuan, Xun Zhang, Ming Yang, Xizi Du, Leyuan Wang, Shuangyan Wu, Mengping Wu, Zhen Duan, Gelei Xiao, Yizhou Zou, Yang Xiang, Xiangping Qu, Huijun Liu, Ling Qin, Qingwu Qin, Xiaoqun Qin, Chi Liu
Clin Sci (Lond) (2020) 134 (13): 1735–1749.
Published: 10 July 2020
...Lin Yuan; Xun Zhang; Ming Yang; Xizi Du; Leyuan Wang; Shuangyan Wu; Mengping Wu; Zhen Duan; Gelei Xiao; Yizhou Zou; Yang Xiang; Xiangping Qu; Huijun Liu; Ling Qin; Qingwu Qin; Xiaoqun Qin; Chi Liu Airway epithelial cells (AECs) play a key role in asthma susceptibility and severity. Integrin β4...
Includes: Supplementary data
Mikael Adner, Brendan J. Canning, Herman Meurs, William Ford, Patricia Ramos Ramírez, Mariska P.M. van den Berg, Mark A. Birrell, Eva Stoffels, Lennart K.A. Lundblad, Gunnar P. Nilsson, Henric K. Olsson, Maria G. Belvisi, Sven-Erik Dahlén
Clin Sci (Lond) (2020) 134 (11): 1219–1242.
Published: 05 June 2020
...Mikael Adner; Brendan J. Canning; Herman Meurs; William Ford; Patricia Ramos Ramírez; Mariska P.M. van den Berg; Mark A. Birrell; Eva Stoffels; Lennart K.A. Lundblad; Gunnar P. Nilsson; Henric K. Olsson; Maria G. Belvisi; Sven-Erik Dahlén Research using animal models of asthma is currently...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (9): 1063–1079.
Published: 05 May 2020
...Asoka Banno; Aravind T. Reddy; Sowmya P. Lakshmi; Raju C. Reddy Asthma is a chronic disease of the airways that has long been viewed predominately as an inflammatory condition. Accordingly, current therapeutic interventions focus primarily on resolving inflammation. However, the mainstay of asthma...
Kimberley C.W. Wang, Timothy D. Le Cras, Alexander N. Larcombe, Graeme R. Zosky, John G. Elliot, Alan L. James, Peter B. Noble
Clin Sci (Lond) (2018) 132 (3): 327–338.
Published: 02 February 2018
...Kimberley C.W. Wang; Timothy D. Le Cras; Alexander N. Larcombe; Graeme R. Zosky; John G. Elliot; Alan L. James; Peter B. Noble Airway remodelling and allergic inflammation are key features of airway hyperresponsiveness (AHR) in asthma; however, their interrelationships are unclear. The present...
Kimberley C.W. Wang, Alexander N. Larcombe, Luke J. Berry, Jude S. Morton, Sandra T. Davidge, Alan L. James, Peter B. Noble
Clin Sci (Lond) (2018) 132 (2): 273–284.
Published: 25 January 2018
...Kimberley C.W. Wang; Alexander N. Larcombe; Luke J. Berry; Jude S. Morton; Sandra T. Davidge; Alan L. James; Peter B. Noble Epidemiological studies demonstrate an association between intrauterine growth restriction (IUGR) and asthma; however the underlying mechanism is unknown. We investigated...
Penny A. Rudd, Belinda J. Thomas, Ali Zaid, Martin MacDonald, Keiko Kan-o, Michael S. Rolph, Anand R. Soorneedi, Philip G. Bardin, Suresh Mahalingam
Clin Sci (Lond) (2017) 131 (14): 1713–1721.
Published: 30 June 2017
..., second only to the closely related respiratory syncytial virus (RSV). Clinical evidence suggests that hMPV is associated with acute exacerbations of asthma in both children and adults, and may play a role in initiating asthma development in children. Animal models have demonstrated that airway...
Clin Sci (Lond) (2017) 131 (14): 1723–1735.
Published: 30 June 2017
...Richard J. Russell; Christopher Brightling The pathogenesis of asthma is complex and multi-faceted. Asthma patients have a diverse range of underlying dominant disease processes and pathways despite apparent similarities in clinical expression. Here, we present the current understanding of asthma...
Clin Sci (Lond) (2017) 131 (10): 1027–1043.
Published: 09 May 2017
... and causally linked to eosinophilic airway inflammation. These assumptions underpin guidelines for the management of asthma ( Figure 2 ), which recommend a step-wise increase in anti-inflammatory medications to achieve control of symptoms and optimal lung function [ 6 ]. Current guidelines for COPD also...
Simon G. Royce, Anna M. Tominaga, Matthew Shen, Krupesh P. Patel, Brooke M. Huuskes, Rebecca Lim, Sharon D. Ricardo, Chrishan S. Samuel
Clin Sci (Lond) (2016) 130 (23): 2151–2165.
Published: 20 October 2016
...Simon G. Royce; Anna M. Tominaga; Matthew Shen; Krupesh P. Patel; Brooke M. Huuskes; Rebecca Lim; Sharon D. Ricardo; Chrishan S. Samuel Current asthma therapies primarily target airway inflammation (AI) and suppress episodes of airway hyperresponsiveness (AHR) but fail to treat airway remodelling...
Clin Sci (Lond) (2015) 128 (4): 235–256.
Published: 17 October 2014
... of the models currently used in the settings of asthma, idiopathic pulmonary fibrosis and COPD. The ultimate hope is that this will contribute to a more rational, efficient and sustainable development of a range of new treatments for respiratory diseases that continue to cause substantial morbidity...
Clin Sci (Lond) (2014) 127 (11): 635–643.
Published: 29 July 2014
...William J. Anderson; Philip M. Short; Peter A. Williamson; Arvind Manoharan; Brian J. Lipworth The murine asthma model shows that switching off airway β 2 receptors with an inverse agonist may confer anti-inflammatory effects as well as corticosteroid-sparing activity. We have assessed for any...
Clin Sci (Lond) (2014) 126 (11): 805–818.
Published: 21 February 2014
... of chronic allergic asthma in mice. Animals sensitized to OVA (ovalbumin) received controlled low-level challenge with aerosolized antigen for 4 weeks, followed by a single moderate-level challenge to simulate an allergen-induced exacerbation of asthmatic inflammation. Induction of an exacerbation...
Includes: Supplementary data
Deborah L. Clarke, Nicola H. E. Davis, Jayesh B. Majithiya, Sian C. Piper, Arthur Lewis, Matthew A. Sleeman, Dominic J. Corkill, Richard D. May
Clin Sci (Lond) (2014) 126 (8): 567–580.
Published: 08 December 2013
...Deborah L. Clarke; Nicola H. E. Davis; Jayesh B. Majithiya; Sian C. Piper; Arthur Lewis; Matthew A. Sleeman; Dominic J. Corkill; Richard D. May Viral respiratory tract infections are known triggers of asthma exacerbations in both adults and children. The current standard of care, inhaled CS...
William J. Anderson, Philip M. Short, Peter A. Williamson, Ashley E. Morrison, Colin Palmer, Roger Tavendale, Brian J. Lipworth
Clin Sci (Lond) (2014) 126 (1): 75–83.
Published: 09 September 2013
... be detrimental in asthma. The isomeric formulation of salbutamol and the B2ADR (β 2 adrenoceptor) 16 genotype may also influence this phenomenon. We performed a randomized, double-blind, placebo-controlled, triple crossover, proof of concept trial comparing 2 weeks of regular therapy with inhaled racemic...
Hiroki Mori, Nicole S. Parker, Deborah Rodrigues, Kathryn Hulland, Deborah Chappell, Jennifer S. Hincks, Helen Bright, Steven M. Evans, David J. Lamb
Clin Sci (Lond) (2013) 125 (12): 565–574.
Published: 02 August 2013
...Hiroki Mori; Nicole S. Parker; Deborah Rodrigues; Kathryn Hulland; Deborah Chappell; Jennifer S. Hincks; Helen Bright; Steven M. Evans; David J. Lamb A significant number of clinical asthma exacerbations are triggered by viral infection. We aimed to characterize the effect of virus infection...
Kumar Changani, Catherine Pereira, Simon Young, Robert Shaw, Simon P. Campbell, Kashmira Pindoria, Steve Jordan, Katherine Wiley, Sarah Bolton, Tony Nials, Michael Haase, Mike Pedrick, Richard Knowles
Clin Sci (Lond) (2013) 125 (12): 555–564.
Published: 02 August 2013
...-dimensional images were low-pass filtered (Gaussian) and the lungs were selected using a computer-assisted volume segmentation from −1000 to −250 HU, which was visually inspected and altered as necessary to ensure inclusion of all lung areas and exclusion of any non-lung areas. asthma computed...
Includes: Supplementary data
Jason P. Riley, Barbara Fuchs, Lisa Sjöberg, Gunnar P. Nilsson, Lars Karlsson, Sven-Erik Dahlén, Navin L. Rao, Mikael Adner
Clin Sci (Lond) (2013) 125 (11): 533–542.
Published: 25 July 2013
...Jason P. Riley; Barbara Fuchs; Lisa Sjöberg; Gunnar P. Nilsson; Lars Karlsson; Sven-Erik Dahlén; Navin L. Rao; Mikael Adner One feature of allergic asthma, the EAR (early allergic reaction), is not present in the commonly used mouse models. We therefore investigated the mediators involved in EAR...
Clin Sci (Lond) (2013) 124 (8): 517–519.
Published: 08 January 2013
...Ian Sayers Asthma is heterogeneous with respect to clinical presentation, underlying disease mechanisms and response to existing drugs making tailored therapy desirable. Pharmacogenetics, the study of the influence of genetic polymorphisms on drug efficacy and/or adverse effects, is relatively...
Brian J. Lipworth, Kaninika Basu, Helen P. Donald, Roger Tavendale, Donald F. Macgregor, Simon A. Ogston, Colin N. A. Palmer, Somnath Mukhopadhyay
Clin Sci (Lond) (2013) 124 (8): 521–528.
Published: 08 January 2013
...). We therefore evaluated using montelukast as an alternative to salmeterol as tailored second-line asthma controller therapy in children expressing this susceptible genotype. A total of 62 persistent asthmatic children with the homozygous Arg 16 genotype were randomized to receive salmeterol (50 μg...
Clin Sci (Lond) (2013) 124 (1): 41–51.
Published: 07 September 2012
...Simon G. Royce; Amelia Sedjahtera; Chrishan S. Samuel; Mimi L. K. Tang Although CSs (corticosteroids) demonstrate potent effects in the control of airway inflammation in asthma, many patients continue to experience symptoms and AHR (airway hyper-responsiveness) despite optimal treatment...
Clin Sci (Lond) (2011) 120 (11): 473–484.
Published: 15 February 2011
... compilation © 2011 Biochemical Society 2011 asthma atherosclerosis autoimmune disease host defence mast cell activation mast cell progenitor Paul Ehrlich first described MCs (mast cells) or ‘mastzellen’ in 1878 based on their unique staining characteristics and their large granule content...
Clin Sci (Lond) (2010) 118 (2): 115–120.
Published: 15 January 2010
...Brian J. LIPWORTH; Peter A. WILLIAMSON Asthma was originally thought to be associated with an intrinsic defect in β 2 ADR ( β 2 -adrenoceptor) function, tipping the balance towards parasympathetic bronchoconstriction. Hence β -blocking drugs (such as β 2 ADR antagonists and inverse agonists) may...
Stephen T. Holgate, Hasan S. Arshad, Graham C. Roberts, Peter H. Howarth, Philipp Thurner, Donna E. Davies
Clin Sci (Lond) (2010) 118 (7): 439–450.
Published: 23 December 2009
...Stephen T. Holgate; Hasan S. Arshad; Graham C. Roberts; Peter H. Howarth; Philipp Thurner; Donna E. Davies Asthma is an inflammatory disorder of the conducting airways that has strong association with allergic sensitization. The disease is characterized by a polarized Th-2 (T-helper-2)-type T-cell...
Clin Sci (Lond) (2006) 110 (2): 175–191.
Published: 17 January 2006
... disease states, including Alzheimer's disease, depression, pain and asthma. In addition, the role of BDNF (brain-derived neurotrophic factor) in synaptic plasticity and memory formation is discussed. Unlike the other neurotrophins, BDNF is secreted in an activity-dependent manner that allows the highly...
Clin Sci (Lond) (2006) 110 (2): 265.
Published: 17 January 2006
...Colleen T. Bruce; Paul S. Thomas The Biochemical Society 2006 asthma cytokine etanercept inflammation tumour necrosis factor-α (TNF-α) Correspondence: Dr Paul S. Thomas (email email@example.com ). 21 9 2005 14 10 2005 14 10 2005 We read the review...
Clin Sci (Lond) (2005) 109 (2): 135–142.
Published: 25 July 2005
... and have proved to be safe and effective in the treatment of patients with RA, Crohn's disease and psoriasis refractory to conventional treatments. Biological therapies blocking TNF-α are likely to constitute a considerable advance in the management of those difficult cases of asthma that are particularly...
Clin Sci (Lond) (2005) 108 (6): 463–477.
Published: 24 May 2005
..., whereas the importance of structural changes to the phenomenon of airways hyperresponsiveness may be dependent on the specific clinical phenotype of asthma evaluated. Reduced compliance of the airway wall secondary to enhanced matrix deposition may protect against airway narrowing. Conversely, in severe...
Aydanur EKICI, Sevda YILMAZ, Mehmet EKICI, Füsun KALPAKLIOĞLU, Yasemin KARADENIZ, Mesut ARSLAN, Ahmet ITEGINLI, Turkan KARA, Ercan KURTIPEK
Clin Sci (Lond) (2003) 105 (2): 181–185.
Published: 01 August 2003
... are different. We investigated the perception of bronchoconstriction in subjects with bronchiectasis, asthma and chronic bronchitis and possible contributing factors. Forty-seven non-smoking subjects with bronchiectasis, 50 subjects with asthma and 31 with chronic bronchitis were challenged with histamine...
Clin Sci (Lond) (2002) 103 (2): 201–211.
Published: 17 July 2002
...A.J. WARDLAW; C.E. BRIGHTLING; R. GREEN; G. WOLTMANN; P. BRADDING; I.D. PAVORD Asthma is a condition characterized by variable airflow obstruction, airway hyper-responsiveness (AHR) and airway inflammation which is usually, but not invariably, eosinophilic. Current thoughts on the pathogenesis...
Scott G. RAMSAY, Christopher J. KENYON, Niall WHYTE, Ian C. MCKAY, Neil C. THOMSON, George B. M. LINDOP
Clin Sci (Lond) (2000) 98 (1): 1–7.
Published: 19 November 1999
...Scott G. RAMSAY; Christopher J. KENYON; Niall WHYTE; Ian C. MCKAY; Neil C. THOMSON; George B. M. LINDOP Airway remodelling occurs in chronic asthma. Angiotensin II promotes growth in cardiovascular remodelling. Since the renin–angiotensin system is activated in acute severe asthma, we hypothesized...
Clin Sci (Lond) (1999) 96 (3): 253–259.
Published: 01 March 1999
...-eight patients with stable mild to moderate asthma and receiving inhaled corticosteroids were randomized in a parallel group, double-blind, double-dummy fashion to receive 2 weeks of treatment with either formoterol (12 μ g once daily, 6 μ g twice daily or 24 μ g twice daily) or terbutaline (500 μ g...
Clin Sci (Lond) (1998) 95 (5): 611–619.
Published: 01 November 1998
...Suree SOMPRADEEKUL; Rana HEJAL; Melissa McLANE; K. A. LENNER; J. A. NELSON; E. R. McFADDEN, Jr. 1. The thermal precipitants of asthma (exercise and hyperventilation) appear to have a unique pathogenesis that does not alter bronchial responsiveness. In the present work, we tested whether hyperpnoea...
Clin Sci (Lond) (1998) 95 (4): 513–517.
Published: 01 October 1998
... was suppressed by inhaled corticosteroid therapy. 2. Ten normotensive patients with mild–moderate asthma, mean age 24.0 (S.D. 9.8) years and mean arterial pressure 90.7 (9.8) mmHg, were studied in a double-blind, randomized crossover design comparing placebo with fluticasone propionate, 1000 ; μ g administered...
Clin Sci (Lond) (1998) 95 (2): 143–149.
Published: 01 August 1998
... or several direct interactions between tobacco smoke compounds and albuterol. Correspondence : Professor B. Bruguerolle. 4 12 1997 18 2 1998 26 3 1998 © 1988 The Biochemical Society and the Medical Research Society 1988 albuterol asthma bronchial reactivity carbachol...
Ligia J. DOMINGUEZ, Mario BARBAGALLO, Gabriele Di LORENZO, Agata DRAGO, Santi SCOLA, Giuseppina MORICI, Calogero CARUSO
Clin Sci (Lond) (1998) 95 (2): 137–142.
Published: 01 August 1998
...Ligia J. DOMINGUEZ; Mario BARBAGALLO; Gabriele Di LORENZO; Agata DRAGO; Santi SCOLA; Giuseppina MORICI; Calogero CARUSO 1. Increased bronchial smooth muscle contractility with consequent bronchial hyperreactivity are characteristic physiopathological events of asthma. Since magnesium intervenes...
Clin Sci (Lond) (1998) 94 (6): 557–572.
Published: 01 June 1998
...Peter J. Barnes 1. Glucocorticoids are widely used for the suppression of inflammation in chronic inflammatory diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease and autoimmune diseases, all of which are associated with increased expression of inflammatory genes...
Clin Sci (Lond) (1998) 94 (5): 525–529.
Published: 01 May 1998
... the exposed skin respectively. It is now known that skin chilling does not amplify the effects of breathing cold air, but it is not established if this lack of interaction is unique, or applies to other forms of airway constrictors. 2. To provide data on this issue, 10 subjects with atopic asthma underwent...
Clin Sci (Lond) (1996) 90 (3): 227–234.
Published: 01 March 1996
...C. M. B. Higgs; G. Laszlo 1. Perception of asthma by patients can be assessed from the relationship between symptom scores and peak expiratory flows. This study was designed to investigate the possibility that medication can affect perception of the sensation of asthma independently of changes...
T. J. N. Hiltermann, J. Stolk, P. S. Hiemstra, P. H. B. Fokkens, P. J. A. Rombout, J. K. Sont, P. J. Sterk, J. H. Dijkman
Clin Sci (Lond) (1995) 89 (6): 619–624.
Published: 01 December 1995
... levels and hospital admissions for asthma. 17 8 1995 23 8 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 asthma bronchial hyper-reactivity inflammation neutrophils ozone respiratory system sputum Clinical Science (1995) 89, 61%24 (Printed...
Clin Sci (Lond) (1995) 88 (4): 439–446.
Published: 01 April 1995
... adrenaline asthma bronchoconstriction neuropeptide Y noradrenaline sympathetic nervous system Clinical Science (1995) I, 439446 (Printed in Great Britain) 439 Sympathoadrenal responses to bronchoconstriction in asthma: an invasive and kinetic study of plasma catecholamines Kjell LARSSON, Per CARLENS...
Clin Sci (Lond) (1994) 86 (6): 647–652.
Published: 01 June 1994
...Alan J. Knox © 1994 The Biochemical Society and the Medical Research Society 1994 airway smooth muscle asthma Clinical Science (1994) 86, 64Y-652 (Printed in Great Britain) Editorial Review MY Airway remodelling in asthma: role of airway smooth muscle Alan J. KNOX Respiratory Medicine...
Clin Sci (Lond) (1994) 86 (1): 59–65.
Published: 01 January 1994
...G. E. Packe; W. Freeman; Ruth M. Cayton 1. The rates of change in mean peak expiratory flow and in diurnal variation in peak flow were compared in 14 patients recovering from acute severe asthma. 2. Peak expiratory flow was measured on hospital admission, and at 6-hourly intervals for the next 3...
Clin Sci (Lond) (1993) 85 (4): 455–463.
Published: 01 October 1993
...Neil L. A. Misso; Robyn L. Gillon; Marcia L. Taylor; Geoffrey A. Stewart; Philip J. Thompson 1. Platelet-activating factor is a putative mediator of inflammation in asthma and the enzyme acetyl-CoA:lyso-platelet-activating factor acetyltransferase appears to be important in regulating platelet...
Clin Sci (Lond) (1993) 85 (3): 367–371.
Published: 01 September 1993
...J. P. Jamison; R. K. McKinley 1. The aim of this study was to determine the validity of various numerical indices of peak flow variability as tests for asthma. 2. Normal ( n = 24) and asthmatic ( n = 123) subjects aged 10-70 years were recruited from the community. Asthma was diagnosed by full...
Clin Sci (Lond) (1993) 85 (2): 237–244.
Published: 01 August 1993
...Signy Reynisdottir; Hans Wahrenberg; Gunnar Bylin; Peter Arner 1. Adrenoceptor subtype function was studied in isolated adipocytes obtained by subcutaneous fat biopsies from nine patients with mild asthma. The biopsies were taken before and after 7 days treatment with 25 mg of prednisolone given...