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Keywords: asthma
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Clin Sci (Lond) (2023) 137 (11): 895–912.
Published: 14 June 2023
... findings from these two approaches in the context of four common respiratory diseases (asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and respiratory infection). Potential methods used to identify and measure human circadian oscillations are also discussed as these will be useful...
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Clin Sci (Lond) (2021) 135 (24): 2729–2748.
Published: 17 December 2021
...Nikita Lad; Alice M. Murphy; Cristina Parenti; Carl P. Nelson; Neil C. Williams; Graham R. Sharpe; Philip G. McTernan Low-grade inflammation is often an underlying cause of several chronic diseases such as asthma, obesity, cardiovascular disease, and type 2 diabetes mellitus (T2DM). Defining...
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Clin Sci (Lond) (2021) 135 (20): 2423–2428.
Published: 28 October 2021
... of clinical science, as it morphs into translational medicine, is now creating unique possibilities where even the most intractable diseases are now open to being conquered. asthma interdisciplinary pathology personalized medicine translational science Having experienced the horrendous effects...
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Clin Sci (Lond) (2020) 134 (13): 1735–1749.
Published: 10 July 2020
...Lin Yuan; Xun Zhang; Ming Yang; Xizi Du; Leyuan Wang; Shuangyan Wu; Mengping Wu; Zhen Duan; Gelei Xiao; Yizhou Zou; Yang Xiang; Xiangping Qu; Huijun Liu; Ling Qin; Qingwu Qin; Xiaoqun Qin; Chi Liu Airway epithelial cells (AECs) play a key role in asthma susceptibility and severity. Integrin β4...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (11): 1219–1242.
Published: 05 June 2020
...Mikael Adner; Brendan J. Canning; Herman Meurs; William Ford; Patricia Ramos Ramírez; Mariska P.M. van den Berg; Mark A. Birrell; Eva Stoffels; Lennart K.A. Lundblad; Gunnar P. Nilsson; Henric K. Olsson; Maria G. Belvisi; Sven-Erik Dahlén Research using animal models of asthma is currently...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (9): 1063–1079.
Published: 05 May 2020
...Asoka Banno; Aravind T. Reddy; Sowmya P. Lakshmi; Raju C. Reddy Asthma is a chronic disease of the airways that has long been viewed predominately as an inflammatory condition. Accordingly, current therapeutic interventions focus primarily on resolving inflammation. However, the mainstay of asthma...
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Clin Sci (Lond) (2018) 132 (3): 327–338.
Published: 02 February 2018
...Kimberley C.W. Wang; Timothy D. Le Cras; Alexander N. Larcombe; Graeme R. Zosky; John G. Elliot; Alan L. James; Peter B. Noble Airway remodelling and allergic inflammation are key features of airway hyperresponsiveness (AHR) in asthma; however, their interrelationships are unclear. The present...
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Clin Sci (Lond) (2018) 132 (2): 273–284.
Published: 25 January 2018
...Kimberley C.W. Wang; Alexander N. Larcombe; Luke J. Berry; Jude S. Morton; Sandra T. Davidge; Alan L. James; Peter B. Noble Epidemiological studies demonstrate an association between intrauterine growth restriction (IUGR) and asthma; however the underlying mechanism is unknown. We investigated...
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Clin Sci (Lond) (2017) 131 (14): 1723–1735.
Published: 30 June 2017
...Richard J. Russell; Christopher Brightling The pathogenesis of asthma is complex and multi-faceted. Asthma patients have a diverse range of underlying dominant disease processes and pathways despite apparent similarities in clinical expression. Here, we present the current understanding of asthma...
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Clin Sci (Lond) (2017) 131 (10): 1027–1043.
Published: 09 May 2017
... and causally linked to eosinophilic airway inflammation. These assumptions underpin guidelines for the management of asthma ( Figure 2 ), which recommend a step-wise increase in anti-inflammatory medications to achieve control of symptoms and optimal lung function [ 6 ]. Current guidelines for COPD also...
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Clin Sci (Lond) (2015) 128 (4): 235–256.
Published: 17 October 2014
... of the models currently used in the settings of asthma, idiopathic pulmonary fibrosis and COPD. The ultimate hope is that this will contribute to a more rational, efficient and sustainable development of a range of new treatments for respiratory diseases that continue to cause substantial morbidity...
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Clin Sci (Lond) (2014) 126 (11): 805–818.
Published: 21 February 2014
... of chronic allergic asthma in mice. Animals sensitized to OVA (ovalbumin) received controlled low-level challenge with aerosolized antigen for 4 weeks, followed by a single moderate-level challenge to simulate an allergen-induced exacerbation of asthmatic inflammation. Induction of an exacerbation...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 126 (8): 567–580.
Published: 08 December 2013
...Deborah L. Clarke; Nicola H. E. Davis; Jayesh B. Majithiya; Sian C. Piper; Arthur Lewis; Matthew A. Sleeman; Dominic J. Corkill; Richard D. May Viral respiratory tract infections are known triggers of asthma exacerbations in both adults and children. The current standard of care, inhaled CS...
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Clin Sci (Lond) (2013) 124 (8): 517–519.
Published: 08 January 2013
...Ian Sayers Asthma is heterogeneous with respect to clinical presentation, underlying disease mechanisms and response to existing drugs making tailored therapy desirable. Pharmacogenetics, the study of the influence of genetic polymorphisms on drug efficacy and/or adverse effects, is relatively...
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Clin Sci (Lond) (2013) 124 (8): 521–528.
Published: 08 January 2013
...). We therefore evaluated using montelukast as an alternative to salmeterol as tailored second-line asthma controller therapy in children expressing this susceptible genotype. A total of 62 persistent asthmatic children with the homozygous Arg 16 genotype were randomized to receive salmeterol (50 μg...
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Clin Sci (Lond) (2011) 120 (11): 473–484.
Published: 15 February 2011
... compilation © 2011 Biochemical Society 2011 asthma atherosclerosis autoimmune disease host defence mast cell activation mast cell progenitor Paul Ehrlich first described MCs (mast cells) or ‘mastzellen’ in 1878 based on their unique staining characteristics and their large granule content...
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Clin Sci (Lond) (2010) 118 (2): 115–120.
Published: 15 January 2010
...Brian J. LIPWORTH; Peter A. WILLIAMSON Asthma was originally thought to be associated with an intrinsic defect in β 2 ADR ( β 2 -adrenoceptor) function, tipping the balance towards parasympathetic bronchoconstriction. Hence β -blocking drugs (such as β 2 ADR antagonists and inverse agonists) may...
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Clin Sci (Lond) (2010) 118 (7): 439–450.
Published: 23 December 2009
...Stephen T. Holgate; Hasan S. Arshad; Graham C. Roberts; Peter H. Howarth; Philipp Thurner; Donna E. Davies Asthma is an inflammatory disorder of the conducting airways that has strong association with allergic sensitization. The disease is characterized by a polarized Th-2 (T-helper-2)-type T-cell...
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Clin Sci (Lond) (2006) 110 (2): 175–191.
Published: 17 January 2006
... disease states, including Alzheimer's disease, depression, pain and asthma. In addition, the role of BDNF (brain-derived neurotrophic factor) in synaptic plasticity and memory formation is discussed. Unlike the other neurotrophins, BDNF is secreted in an activity-dependent manner that allows the highly...
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Clin Sci (Lond) (2006) 110 (2): 265.
Published: 17 January 2006
...Colleen T. Bruce; Paul S. Thomas The Biochemical Society 2006 asthma cytokine etanercept inflammation tumour necrosis factor-α (TNF-α) Correspondence: Dr Paul S. Thomas (email paul.thomas@unsw.edu.au ). 21 9 2005 14 10 2005 14 10 2005 We read the review...
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Clin Sci (Lond) (2005) 109 (2): 135–142.
Published: 25 July 2005
... and have proved to be safe and effective in the treatment of patients with RA, Crohn's disease and psoriasis refractory to conventional treatments. Biological therapies blocking TNF-α are likely to constitute a considerable advance in the management of those difficult cases of asthma that are particularly...
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Clin Sci (Lond) (2005) 108 (6): 463–477.
Published: 24 May 2005
..., whereas the importance of structural changes to the phenomenon of airways hyperresponsiveness may be dependent on the specific clinical phenotype of asthma evaluated. Reduced compliance of the airway wall secondary to enhanced matrix deposition may protect against airway narrowing. Conversely, in severe...
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Clin Sci (Lond) (2003) 105 (2): 181–185.
Published: 01 August 2003
... are different. We investigated the perception of bronchoconstriction in subjects with bronchiectasis, asthma and chronic bronchitis and possible contributing factors. Forty-seven non-smoking subjects with bronchiectasis, 50 subjects with asthma and 31 with chronic bronchitis were challenged with histamine...
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Clin Sci (Lond) (2002) 103 (2): 201–211.
Published: 17 July 2002
...A.J. WARDLAW; C.E. BRIGHTLING; R. GREEN; G. WOLTMANN; P. BRADDING; I.D. PAVORD Asthma is a condition characterized by variable airflow obstruction, airway hyper-responsiveness (AHR) and airway inflammation which is usually, but not invariably, eosinophilic. Current thoughts on the pathogenesis...
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Clin Sci (Lond) (2000) 98 (1): 1–7.
Published: 19 November 1999
...Scott G. RAMSAY; Christopher J. KENYON; Niall WHYTE; Ian C. MCKAY; Neil C. THOMSON; George B. M. LINDOP Airway remodelling occurs in chronic asthma. Angiotensin II promotes growth in cardiovascular remodelling. Since the renin–angiotensin system is activated in acute severe asthma, we hypothesized...
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Clin Sci (Lond) (1999) 96 (3): 253–259.
Published: 01 March 1999
...-eight patients with stable mild to moderate asthma and receiving inhaled corticosteroids were randomized in a parallel group, double-blind, double-dummy fashion to receive 2 weeks of treatment with either formoterol (12 μ g once daily, 6 μ g twice daily or 24 μ g twice daily) or terbutaline (500 μ g...
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Clin Sci (Lond) (1998) 95 (5): 611–619.
Published: 01 November 1998
...Suree SOMPRADEEKUL; Rana HEJAL; Melissa McLANE; K. A. LENNER; J. A. NELSON; E. R. McFADDEN, Jr. 1. The thermal precipitants of asthma (exercise and hyperventilation) appear to have a unique pathogenesis that does not alter bronchial responsiveness. In the present work, we tested whether hyperpnoea...
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Clin Sci (Lond) (1998) 95 (4): 513–517.
Published: 01 October 1998
... was suppressed by inhaled corticosteroid therapy. 2. Ten normotensive patients with mild–moderate asthma, mean age 24.0 (S.D. 9.8) years and mean arterial pressure 90.7 (9.8) mmHg, were studied in a double-blind, randomized crossover design comparing placebo with fluticasone propionate, 1000 ; μ g administered...
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Clin Sci (Lond) (1998) 94 (6): 557–572.
Published: 01 June 1998
...Peter J. Barnes 1. Glucocorticoids are widely used for the suppression of inflammation in chronic inflammatory diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease and autoimmune diseases, all of which are associated with increased expression of inflammatory genes...
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Clin Sci (Lond) (1998) 94 (5): 525–529.
Published: 01 May 1998
... the exposed skin respectively. It is now known that skin chilling does not amplify the effects of breathing cold air, but it is not established if this lack of interaction is unique, or applies to other forms of airway constrictors. 2. To provide data on this issue, 10 subjects with atopic asthma underwent...
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Clin Sci (Lond) (1995) 89 (6): 619–624.
Published: 01 December 1995
... levels and hospital admissions for asthma. 17 8 1995 23 8 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 asthma bronchial hyper-reactivity inflammation neutrophils ozone respiratory system sputum Clinical Science (1995) 89, 61%24 (Printed...
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Clin Sci (Lond) (1994) 86 (6): 647–652.
Published: 01 June 1994
...Alan J. Knox © 1994 The Biochemical Society and the Medical Research Society 1994 airway smooth muscle asthma Clinical Science (1994) 86, 64Y-652 (Printed in Great Britain) Editorial Review MY Airway remodelling in asthma: role of airway smooth muscle Alan J. KNOX Respiratory Medicine...
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Clin Sci (Lond) (1993) 85 (3): 367–371.
Published: 01 September 1993
...J. P. Jamison; R. K. McKinley 1. The aim of this study was to determine the validity of various numerical indices of peak flow variability as tests for asthma. 2. Normal ( n = 24) and asthmatic ( n = 123) subjects aged 10-70 years were recruited from the community. Asthma was diagnosed by full...
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