... AT 2 R agonist, on the prevention of endothelial dysfunction, extracellular matrix (ECM) remodeling and arterial stiffness associated with diet-induced obesity (DIO). Five-week-old male C57BL/6J mice were fed a standard (Chow) or high-fat diet (HF) for 6 weeks. Half of the animals of each group were...

... aging via lifestyle and pharmacological strategies that improve mitochondrial health. We will also identify promising areas and important considerations (‘research gaps’) for future investigation. arterial stiffness endothelial function mitophagy oxidative stress reactive oxygen species...

... factors are associated with reduced NO levels. Overactivity of renal sympathetic nerves, chronic overactivation of the renin–angiotensin system and inflammation can reduce NO levels which can drive arterial stiffness. Arterial stiffness is identified as a unique feature in resistant hypertension...

...Gang Li; Zhe Cao; Xiao-wei Wu; Hui-kun Wu; Yi Ma; Bin Wu; Wei-qing Wang; Jian Cheng; Zi-hua Zhou; Yuan-chao Tu Arterial stiffness is an independent indicator of cardiovascular risk. Autoantibodies (AAs) against angiotensin AT 1 receptor (AT 1 -AAs) and α 1 -adrenergic receptor (α 1 -AAs...

... and associated cardiac output, the structure, mechanics, and function of the arteries are altered. Specifically, in healthy pregnancy there is a remodeling of arteries (increased angiogenesis and vasodilation), a generalized reduction in arterial stiffness (increased compliance), and an enhanced endothelial...

... factors for cognitive decline is the key to reducing dementia risk. Arterial stiffness is one such potential risk factor. It is independently associated with cardiovascular outcome in dialysis patients. Importantly, the recent demonstration of an independent association between arterial stiffness...

... in hemodialysis patients is common and associated with adverse outcomes. So far, the underlying pathogenesis remains unclear. Therefore, we examined the potential relationship between cognitive impairment and three different categories of risk factors with particular focus on arterial stiffness measured by pulse...

...%. Immediately after the exercise test blood pressures were recorded at the arm with the highest pressure at rest and at both ankles. ABI-ex (ABI after exercise) was calculated for both legs. The lowest ABI-ex value was used in the analysis. arterial stiffness cardiovascular disease gender specific...

... details the mechanisms involved in arterial calcification and arterial remodelling associated with CKD, and provides the clinical consequences of large and small artery stiffness and remodelling in CKD patients. Correspondence: Dr Marie Briet (email mariebriet1@free.fr ). 10 2 2012 30 3...

... produced VC inhibitors. VC determines increased arterial stiffness, left ventricular hypertrophy, a decrease in coronary artery perfusion, myocardial ischaemia and increased cardiovascular morbidity and mortality. Although current therapeutic strategies focus on the correction of phosphate, calcium...

...Yasmin; Kevin M. O'shaughnessy Cardiovascular disease is the leading cause of death worldwide and premature arterial stiffening is a key contributor to this risk. A large body of evidence now points to arterial stiffness as an independent predictor of cardiovascular events. Stiffness can...

... ). 2 8 2007 1 11 2007 21 11 2007 21 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 arterial stiffness augmentation index cardiovascular risk chronic fatigue syndrome inflammation pulse wave analysis CFS (chronic fatigue syndrome...

...Richard J. Woodman Increased arterial stiffness is influenced by both functional and structural properties of the vessel wall, including changes in content of smooth muscle, elastin and collagen, reduced endothelial production of NO and increased release of endothelin-1 or AngII (angiotensin II...

... infusion, arterial stiffness indices [SI (stiffness index) and RI (reflection index)] and haemodynamic parameters were measured. There was a significantly higher RI response to AngII ( P =0.0004 for both 8 and 16 ng/min doses) and to PD123319 ( P =0.004 and P =0.03 for 10 and 20 μg/min doses respectively...

... ‘arterial stiffness’ denotes alterations in the mechanical properties of arteries, and much effort has focused on how best to measure this. Pulse pressure, pulse wave velocity, pulse waveform analysis, localized assessment of blood vessel mechanics and other methods have all been used. We review...

... (time delay) between the SBP and DBP peak of the FAP waveform ( Figure 1 ). Correspondence: Dr Jan Simek (email jan_simek@hotmail.com ). 18 10 2004 4 1 2005 1 3 2005 1 3 2005 The Biochemical Society 2005 arterial stiffness Finapres neurally mediated syncope...

... to impaired central processing of baroreceptor information following stroke or reduced baroreceptor activity due to increased large artery stiffness. We evaluated the relationship between large (aortic) artery stiffness and cardiac BRS during the acute phase of ischaemic stroke and in comparison with a group...

...M. Tessa SAVAGE; Charles J. FERRO; Sarah J. PINDER; Charles R.V. TOMSON Arterial stiffness potently predicts mortality in dialysis patients. Pulse-wave analysis permits the non-invasive assessment of indices of arterial stiffness and the central pressure waveform by applanation tonometry. The aim...

... These authors contributed equally to this study. 5 10 2001 4 1 2002 14 3 2002 The Biochemical Society and the Medical Research Society © 2002 2002 arterial stiffness carotid artery elastin hypertension Williams syndrome 21Clinical Science (2002) 103, 21 28 (Printed in Great...

... blood pressure >140/90mmHg and <190/120mmHg (mean of two consecutive auscultatory office measurements after 5min of rest)]. We measured (1) three potential determinants reflecting different aspects of central artery stiffness [the overall systemic arterial compliance, the aortic augmentation index...

... ). The Biochemical Society and the Medical Research Society © 2002 2002 arterial compliance arterial impedance arterial stiffness pulse contour analysis pulse-wave velocity. 51Clinical Science (2002) 102, 51 67 (Printed in Great Britain) + R E V I E W Evaluation of mechanical arterial properties...

... to precede systolic dysfunction in our hypertensive subjects. 16 5 1994 1 8 1994 5 8 1994 © 1994 The Biochemical Society and the Medical Research Society 1994 arterial stiffness essential hypertension haemodynamic arterial load isovolumic relaxation period pulse wave...

... Society and the Medical Research Society 1976 arterial distensibility arterial stiffness hypertension systolic blood pressure Clinical Science and Molecular Medicine (1976) 51, 3579-360s. Relationship of age and blood pressure to baroreflex sensitivity and arterial compliance in man 0. S...