... and lengthening of the QT interval. There is an increased susceptibility to arrhythmias during pregnancy and the postpartum period. Some changes in the ECG are clearly the result of changes in ion channel expression and behaviour, but little is known about the ionic basis for this electrical remodelling. Most...

... in cardiovascular disease. The function, regulation and clinical significance of cardiovascular K 2P channels are summarized in the present review, and therapeutic options are emphasized. © 2016 Authors; published by Portland Press Limited 2016 Key words: anti-arrhythmic therapy, arrhythmia, atrial...

...). Arrhythmic scores during programmed stimulation in DOCA-salt rats were significantly higher than those in the control rats. Triple therapy, despite being effective on BP (blood pressure), offered neither attenuated cardiomyocyte hypertrophy nor anti-arrhythmia. The effects of DOCA-salt treatment on NGF...

... of 240 beats/min) and 24 h later, when the dogs were subjected to a 25 min occlusion and reperfusion of the LAD (left anterior descending coronary artery). Compared with the SP (sham-paced) controls ( n =20), in dogs paced 24 h previously ( n =16) there were reductions in arrhythmia severity [e.g. number...

... efficiency, CSR and a higher incidence of arrhythmias, and probably plays a central pathophysiological role in patients with HF. arrhythmia chemoreflex Cheyne–Stokes respiration heart failure natriuretic peptide noradrenaline Despite the advances in the treatment of chronic HF (heart failure...

... indicated that QT lengthening and cardiac arrhythmia in the two present patients were due to inhibition of I Kr (rapidly activating delayed rectifier K + current) by probucol, in addition to the significant suppression of HERG current in HERG channels with the M124T mutation. Correspondence: Dr Kenshi...

... that the increased big-ET level observed 1h after the last induction and shock therapy of ventricular fibrillation might have a pathophysiological role in the increased incidence of post-operative spontaneous ventricular arrhythmias. The Seventh International Conference on Endothelin was held at the University...

... with ischaemic heart disease ( n = 80), cardiac arrhythmia ( n = 60), diabetes mellitus ( n = 36), essential hypertension ( n = 194) and hypercholesterolaemia ( n = 60). The same measurements were made in healthy controls (30 men and 26 women; mean age 58±11 years). The serum ionized Mg concentration...

...Patrick DAVEY In certain disease states prolongation of the QT interval has been shown to be arrhythmogenic. Whether QTc interval changes with position and thus whether certain positions are more arrhythmogenic than others is not known for different diseases that predispose to arrhythmias...

...Abdulhalim S. SERAFI; Stephen J. EVANS; John V. JONES 1. This study examined the effect of an acute injection of contrast medium on generation of arrhythmias in diseased hearts in man. 2. Subjects were 100 patients in sinus rhythm undergoing cardiac catheterization in whom good quality...

... to be arrhythmogenic, it is hoped that compounds such as EMD 57033 may increase cardiac output without exacerbating arrhythmias in patients with cardiac failure. This is the first study to examine whether EMD 57033 influences the susceptibility of the heart to ventricular arrhythmias. 2. We used the isolated working...

...A. D. Struthers; C. Quigley; M. J. Brown 1. The game of squash has recently been associated with a high incidence of ventricular arrhythmias and sudden death. To investigate this further, plasma catecholamines and potassium (K + ) were monitored during a game of squash in six normal volunteers. 2...

... < 0.0025). 6. Thus atrial fibrillation may reduce coronary blood flow and induce myocardial ischaemia in the presence of coronary stenosis in excess of atrial tachycardia. 6 4 1987 11 5 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 arrhythmia atrial...