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Keywords: apoptosis
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Clin Sci (Lond) (2023) 137 (15): 1195–1208.
Published: 10 August 2023
...Qiaoli Tang; Wanting Shi; Ming Liu; Liqin Tang; Wei Ren; Shaolin Shi MPV17 is a mitochondrial inner membrane protein, and its deficiency can cause mitochondrial DNA (mtDNA) depletion, increase reactive oxygen species (ROS), and promote apoptosis in several cell types, suggesting that MPV17 plays...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (6): 453–468.
Published: 21 March 2023
...Jinshan Xing; Gan Qiao; Xin Luo; Shuang Liu; Shaokun Chen; Geng Ye; Chunxiang Zhang; Jingyan Yi Polycystic ovary syndrome (PCOS), a common reproductive endocrine disorder in women of reproductive age, causes anovulatory infertility. Increased apoptosis of granulosa cells has been identified as one...
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Clin Sci (Lond) (2021) 135 (4): 613–627.
Published: 18 February 2021
... extracellular matrix (ECM) synthesis and significantly inhibited HG-induced HaCaT cell damage. Further analysis indicated that BBR activated TrxR1, suppressed its downstream JNK signaling, thereby inhibiting oxidative stress and apoptosis, promoted cell proliferation, down-regulated matrix metalloproteinase...
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Clin Sci (Lond) (2020) 134 (10): 1127–1141.
Published: 21 May 2020
... the effect of Hcy on melanocytic destruction and its involvement in the pathogenesis of vitiligo. Our results showed that Hcy level was significantly elevated in the serum of progressive vitiligo patients. Notably, Hcy induced cell apoptosis in melanocytes via activating reactive oxygen species (ROS...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (2): 155–167.
Published: 23 January 2020
... and suppressed apoptosis during the development and progression of the disease. Previous studies have shown that a novel tumor oncogene, spermatogenic basic helix-loop-helix transcription factor zip 1 (SPZ1), can promote proliferation. However, it is unclear whether SPZ1 plays a role in suppressing apoptosis...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (22): 2245–2264.
Published: 19 November 2019
.... We focus on processes triggering and exacerbating apoptotic signalling in the liver of NAFLD patients and their metabolic and pathological implications. Indeed, liver injury and inflammation are cardinal histopathological features of NASH, a duo in which derailment of apoptosis is of paramount...
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Clin Sci (Lond) (2019) 133 (19): 2029–2044.
Published: 14 October 2019
...Ting Xie; Wing Yan So; Xing Yu Li; Po Sing Leung Fibroblast growth factor 21 (FGF21) is known as a potent metabolic regulator but its protective mechanisms against lipotoxicity-induced β-cell dysfunction and apoptosis remain elusive. Here, we aimed to examine the regulatory pathways whereby FGF21...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (13): 1439–1455.
Published: 15 July 2019
... ten (PTEN), has been implicated in smooth muscle cell (SMC) proliferation and apoptosis. PTENP1 is the pseudogene of PTEN. However, it is unclear whether and how PTENP1 functions in the proliferation and apoptosis of human aortic SMCs (HASMCs). Here, we hypothesised that PTENP1 inhibits HASMC...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (9): 1067–1084.
Published: 09 May 2019
... such as hydrogen peroxide (H 2 O 2 ). Mitochondrial protein 18 (Mtp18) is a novel mitochondrial inner membrane protein, shown to involve in the regulation of mitochondrial dynamics. Although Mtp18 is abundant in cardiac muscles, its role in cardiac apoptosis remains elusive. The present study aimed to detect...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (4): 551–564.
Published: 18 February 2019
...) neutrophilia and NE activity in mice. The reduction in BALF neutrophils in CS-exposed mice by matrine was not due to reductions in pro-neutrophil cytokines/chemokines, but rather matrine’s ability to cause apoptosis of neutrophils, which we demonstrated ex vivo . Thus, our data suggest that matrine has anti...
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Clin Sci (Lond) (2018) 132 (20): 2189–2205.
Published: 19 October 2018
..., and LC 17a/b ) expression was determined via competitive reverse transcriptase PCR. SM myosin heavy chain (MHC), non-muscle (NM) MHC isoforms (NMMHC-A and NMMHC-B), and proteins related to cell apoptosis were further analyzed via Western blotting. Masson’s trichrome staining was applied to tissue...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
... oxidative stress are both critical for ensuing diabetic tubular cell injury and apoptosis; whether these two processes are interlinked remains unclear. In the present study, we observed changes in mitochondrial morphology and expression of associated proteins in tubules of patients with DN. We demonstrated...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (9): 985–1001.
Published: 23 May 2018
...), inflammatory markers (tumor necrosis factor α (TNF-α), INFγ, IL-17, IL-10, inducible nitric oxide synthase (iNOS)), colon damage, apoptosis (cleaved caspase 3), nuclear factor κB (NFκB) and STAT-3 activation, and bacterial translocation were measured. Compared with mice treated with DSS, mice also treated...
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Clin Sci (Lond) (2017) 131 (13): 1419–1428.
Published: 23 June 2017
... in vascular oxidative stress plays a key role in the pathophysiological consequences of hypertension, including kidney disease [ 6 ]. Recent evidence states that oxidative stress is a crucial molecular mechanism involved in the pathogenesis of hypertensive renal damage [ 14 ] and that apoptosis occurs...
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Clin Sci (Lond) (2016) 130 (23): 2121–2138.
Published: 20 October 2016
...Guillermo Mazzolini; Jan-Peter Sowa; Ali Canbay The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately balanced combination thereof...
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Clin Sci (Lond) (2016) 130 (18): 1641–1653.
Published: 08 August 2016
... on myocardial I/R injury and autophagy. C57BL/6 mice underwent left coronary artery (LCA) occlusion and cultured neonatal rat cardiomyocytes (NRCs) subjected to hypoxia were treated with vehicle or PD during reperfusion or re-oxygenation. We noted that PD enhanced autophagy and decreased apoptosis during I/R...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (8): 587–599.
Published: 08 March 2016
...-A or captopril. We further demonstrated elevated renal parenchymal apoptosis in TBI rats, which was mitigated by EET-A or captopril. Additional studies revealed that captopril or EET-A mitigated renal apoptosis by acting on the p53/Fas/FasL (Fas ligand) apoptotic pathway. The present study demonstrates a novel...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (4): 289–299.
Published: 14 January 2016
... activates differential robust fibrotic, apoptotic and inflammatory responses via ERK1/2 in cardiomyocytes and cardiac fibroblasts inducing DCM and CHF. Blocking the ERK1/2 pathway prevented progression of FasL-induced DCM and CHF by reducing fibrosis, inflammation and apoptosis in the myocardium...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (4): 273–287.
Published: 14 January 2016
.... In vitro , stimulation of the alveolar epithelial type II (ATII)-like LA4 cell line with L -carnitine diminished apoptosis induced by both PPE and H 2 O 2 . Moreover, PPE-treated mice demonstrated impaired lung function compared with PBS-treated controls (lung compliance; 0.067±0.008 ml/cmH 2 0 compared...
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Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
... apoptosis induced by a range of common stressors. Glucocorticoids, which are ubiquitously elevated for a prolonged period postoperatively, generated increased levels of mitochondrial reactive oxygen species, activated caspase-1 and mature interleukin (IL)-1β in human lymphocytes, suggesting inflammasome...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 128 (12): 923–936.
Published: 27 March 2015
... decreased MI-induced infarct size, concomitant with an improved cardiac function, leading to an increase in the survival rate. The myocardial apoptosis in the border zone was dramatically reduced by Vinexin-β deficiency, resulting from the altered expression of apoptotic factors. Furthermore, Vinexin-β...
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Clin Sci (Lond) (2015) 128 (9): 567–578.
Published: 11 February 2015
... in various human and mouse non-tumour cells. We investigated the intracellular distribution of AT 2 receptors including their presence in mitochondria and their role in the induction of apoptosis and cell death in cultured human uterine leiomyosarcoma (SK-UT-1) cells and control human uterine smooth muscle...
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Clin Sci (Lond) (2015) 128 (9): 579–592.
Published: 11 February 2015
... with neointima formation [ 7 ]. However, what remains to be determined is the role that modified lipids present in the vessel wall play in mediating the enhanced neointima formation in hyperlipidaemic mice. apoptosis chlorinated lipids oxidized phospholipids proliferation restenosis vascular smooth...
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Clin Sci (Lond) (2015) 128 (9): 527–535.
Published: 27 January 2015
... also has pro-apoptotic, mitogenic and pro-fibrogenic effects, all of which potentially promote active remodelling and expansion of the mesangium. Although mitochondrial dysfunction seems to mediate the aldosterone-induced mesangial apoptosis, the ROS dependent epithelial growth factor receptor (EGFR...
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Clin Sci (Lond) (2015) 128 (5): 321–323.
Published: 13 November 2014
... an important therapeutic potential of the H 2 S pathway in diabetic cardiomyopathy. Correspondence : Professor Gavin Y. Oudit (email gavin.oudit@ualberta.ca ). 20 10 2014 21 10 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 apoptosis diabetic...
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Clin Sci (Lond) (2015) 128 (5): 325–335.
Published: 13 November 2014
... S. The echocardiographical and histopathological data indicated that H 2 S improved left ventricular function and prevented cardiac hypertrophy and myocardial fibrosis in diabetic rats. H 2 S was also found to attenuate hyperglycaemia-induced inflammation, oxidative stress and apoptosis...
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Clin Sci (Lond) (2014) 127 (12): 665–677.
Published: 08 August 2014
... with an up-regulation of nuclear factor κB (NF-κB) and increased apoptosis. Heart tissue also exhibited an enhanced expression of pro-inflammatory cytokines. Selective NOD1 activation with C 12 -γ- D -glutamyl- m -diaminopimelic acid (iEDAP) resulted in an increased NF-κB activation and apoptosis...
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Clin Sci (Lond) (2014) 127 (8): 519–526.
Published: 30 June 2014
... unclear. A possible role of myocardial apoptosis in the pathogenesis has not been previously examined. We hypothesized that dysregulation of apoptotic signalling participates in cardiac dysfunction in the cirrhotic heart. Therefore, we evaluated apoptotic pathways in the hearts of mice with chronic BDL...
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Clin Sci (Lond) (2014) 127 (6): 405–413.
Published: 29 May 2014
... by inducing the PHR (portal hypertensive response) via B 2 R, whereas DABK (des-Arg 9 -BK), a B 1 R agonist, does not elicit the response. During IRI (ischaemia/reperfusion injury), important changes occur in the microcirculation, and cell death by necrosis and apoptosis is involved in poor graft function...
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Clin Sci (Lond) (2013) 124 (7): 467–478.
Published: 07 December 2012
... Invitrogen. Real-time PCR master mix and plates were purchased from Roche Diagnostics. Apoptosis anti-active caspase 3/7 glo kits were obtained from Promega. Islets were isolated from male ICR mice, under local animal care and ethical use protocols. Pancreata were digested by collagenase (1 mg/ml...
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Clin Sci (Lond) (2012) 123 (9): 545–546.
Published: 13 July 2012
...Regje M. E. Blümer; Gregory R. Steinberg TRAIL [TNF (tumour necrosis factor)-related apoptosis-inducing ligand] is in clinical trials for the treatment of cancer. In the present issue of Clinical Science , Bernardi and co-workers report that the administration of TRAIL in mice fed on a high-fat...
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Clin Sci (Lond) (2012) 123 (7): 417–427.
Published: 07 June 2012
.... The role of magnesium in cancer is also critically examined with regard to mitochondrial function, apoptosis and resistance to treatment. Finally, we bring together the latest experimental evidence indicating that alteration in the expression and/or activity of magnesium channels is a frequent finding...
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Clin Sci (Lond) (2011) 121 (8): 315–329.
Published: 24 June 2011
... ). 9 3 2011 28 4 2011 16 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging apoptosis cardiomyocyte cardiovascular disease Aging is often thought of as a progressive disorder that decreases an organism's ability to maintain ‘normostasis...
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Clin Sci (Lond) (2010) 118 (7): 473–485.
Published: 12 January 2010
... expression of DNA damage markers and of DNA repair genes, together with the assessment of proliferation and apoptosis indexes. The expression of the oxidative DNA damage marker 7,8-dihydro-8-oxo-2′-deoxyguanosine was increased at 3 and 7 days after arteriotomy, with immunostaining distributed in the injured...
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Clin Sci (Lond) (2010) 118 (3): 173–181.
Published: 26 October 2009
...Marc Germain; Ruth S. Slack BCL-2 homologues are major regulators of apoptosis and, as such, play an active role in the survival of adult neurons following injury. In recent years, these proteins have also been associated with the regulation of autophagy, a catabolic process involved...