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Keywords: apoptosis
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Articles
Clin Sci (Lond) (2021) 135 (13): 1591–1608.
Published: 07 July 2021
... were utilized. Immunohistochemical staining, immunofluorescent staining, RT-polymerase chain reaction (PCR) and Western blotting were performed. We further generated cell models with NELL2 silenced or overexpressed. Subsequently, proliferation, cycle, and apoptosis of prostate cells were determined...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (4): 613–627.
Published: 18 February 2021
... extracellular matrix (ECM) synthesis and significantly inhibited HG-induced HaCaT cell damage. Further analysis indicated that BBR activated TrxR1, suppressed its downstream JNK signaling, thereby inhibiting oxidative stress and apoptosis, promoted cell proliferation, down-regulated matrix metalloproteinase...
Articles
Clin Sci (Lond) (2020) 134 (15): 2055–2073.
Published: 10 August 2020
... oxidative stress (8-iso-PGF2α)-activated cyclooxygenase-thromboxane A2 [COX-TXA 2 ] pathway, apoptosis, and tubular injury accompanied by a decrease in hyper-responsiveness to the vasoconstrictor 8-iso-PGF2α in perfused kidneys. In vitro experiments revealed that 8-iso-PGF2α induced oxidative stress...
Articles
Clin Sci (Lond) (2020) 134 (10): 1127–1141.
Published: 21 May 2020
... the effect of Hcy on melanocytic destruction and its involvement in the pathogenesis of vitiligo. Our results showed that Hcy level was significantly elevated in the serum of progressive vitiligo patients. Notably, Hcy induced cell apoptosis in melanocytes via activating reactive oxygen species (ROS...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (7): 695–710.
Published: 30 March 2020
... of NDP-MSH, because Adriamycin-inflicted cytopathic signs in primary podocytes prepared from WT mice were all mitigated by NDP-MSH, including apoptosis, loss of podocyte markers, de novo expression of the podocyte injury marker desmin, actin cytoskeleton derangement and podocyte hypermotility. Consistent...
Articles
Clin Sci (Lond) (2020) 134 (2): 155–167.
Published: 23 January 2020
... and suppressed apoptosis during the development and progression of the disease. Previous studies have shown that a novel tumor oncogene, spermatogenic basic helix-loop-helix transcription factor zip 1 (SPZ1), can promote proliferation. However, it is unclear whether SPZ1 plays a role in suppressing apoptosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (22): 2245–2264.
Published: 19 November 2019
.... We focus on processes triggering and exacerbating apoptotic signalling in the liver of NAFLD patients and their metabolic and pathological implications. Indeed, liver injury and inflammation are cardinal histopathological features of NASH, a duo in which derailment of apoptosis is of paramount...
Articles
Clin Sci (Lond) (2019) 133 (19): 2029–2044.
Published: 14 October 2019
...Ting Xie; Wing Yan So; Xing Yu Li; Po Sing Leung Fibroblast growth factor 21 (FGF21) is known as a potent metabolic regulator but its protective mechanisms against lipotoxicity-induced β-cell dysfunction and apoptosis remain elusive. Here, we aimed to examine the regulatory pathways whereby FGF21...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (13): 1523–1536.
Published: 15 July 2019
...Xiao Sun; Xiuli Feng; Dandan Zheng; Ang Li; Chunyan Li; Siying Li; Zhongxi Zhao Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). CS heightens inflammation, oxidative stress and apoptosis. Ergosterol is the main bioactive ingredient in Cordyceps sinensis ( C...
Articles
Clin Sci (Lond) (2019) 133 (13): 1439–1455.
Published: 15 July 2019
... ten (PTEN), has been implicated in smooth muscle cell (SMC) proliferation and apoptosis. PTENP1 is the pseudogene of PTEN. However, it is unclear whether and how PTENP1 functions in the proliferation and apoptosis of human aortic SMCs (HASMCs). Here, we hypothesised that PTENP1 inhibits HASMC...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (9): 1067–1084.
Published: 09 May 2019
... such as hydrogen peroxide (H 2 O 2 ). Mitochondrial protein 18 (Mtp18) is a novel mitochondrial inner membrane protein, shown to involve in the regulation of mitochondrial dynamics. Although Mtp18 is abundant in cardiac muscles, its role in cardiac apoptosis remains elusive. The present study aimed to detect...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (4): 551–564.
Published: 18 February 2019
...) neutrophilia and NE activity in mice. The reduction in BALF neutrophils in CS-exposed mice by matrine was not due to reductions in pro-neutrophil cytokines/chemokines, but rather matrine’s ability to cause apoptosis of neutrophils, which we demonstrated ex vivo . Thus, our data suggest that matrine has anti...
Articles
Clin Sci (Lond) (2018) 132 (20): 2189–2205.
Published: 19 October 2018
..., and LC 17a/b ) expression was determined via competitive reverse transcriptase PCR. SM myosin heavy chain (MHC), non-muscle (NM) MHC isoforms (NMMHC-A and NMMHC-B), and proteins related to cell apoptosis were further analyzed via Western blotting. Masson’s trichrome staining was applied to tissue...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
... oxidative stress are both critical for ensuing diabetic tubular cell injury and apoptosis; whether these two processes are interlinked remains unclear. In the present study, we observed changes in mitochondrial morphology and expression of associated proteins in tubules of patients with DN. We demonstrated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (9): 985–1001.
Published: 23 May 2018
...), inflammatory markers (tumor necrosis factor α (TNF-α), INFγ, IL-17, IL-10, inducible nitric oxide synthase (iNOS)), colon damage, apoptosis (cleaved caspase 3), nuclear factor κB (NFκB) and STAT-3 activation, and bacterial translocation were measured. Compared with mice treated with DSS, mice also treated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (4): 449–459.
Published: 22 February 2018
... apoptosis observed in the wild-type (WT) rat. We then investigated the role of Crp3 in early integrin-mediated signaling apoptosis in isolated jugular SMC. Interestingly, under basal conditions, ceramide treatment failed to induce apoptosis in both WT and Crp3-KO SMC. Under stretch, Crp3 expression...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (13): 1419–1428.
Published: 23 June 2017
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 apoptosis biological antioxidant potential Hypertension lipid peroxidation oxidative stress Several experimental and clinical data prove that hypertension and oxidative stress are closely related [ 7...
Articles
Clin Sci (Lond) (2017) 131 (8): 759–773.
Published: 06 April 2017
...Dongcheng Feng; Jihong Yao; Guangzhi Wang; Zhenlu Li; Guo Zu; Yang Li; Fuwen Luo; Shili Ning; Wasim Qasim; Zhao Chen; Xiaofeng Tian Intestinal epithelial oxidative stress and apoptosis constitute key pathogenic mechanisms underlying intestinal ischemia/reperfusion (I/R) injury. We previously...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (23): 2121–2138.
Published: 20 October 2016
...Guillermo Mazzolini; Jan-Peter Sowa; Ali Canbay The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately balanced combination thereof...
Articles
Clin Sci (Lond) (2016) 130 (18): 1641–1653.
Published: 08 August 2016
... on myocardial I/R injury and autophagy. C57BL/6 mice underwent left coronary artery (LCA) occlusion and cultured neonatal rat cardiomyocytes (NRCs) subjected to hypoxia were treated with vehicle or PD during reperfusion or re-oxygenation. We noted that PD enhanced autophagy and decreased apoptosis during I/R...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (8): 587–599.
Published: 08 March 2016
...-A or captopril. We further demonstrated elevated renal parenchymal apoptosis in TBI rats, which was mitigated by EET-A or captopril. Additional studies revealed that captopril or EET-A mitigated renal apoptosis by acting on the p53/Fas/FasL (Fas ligand) apoptotic pathway. The present study demonstrates a novel...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (4): 289–299.
Published: 14 January 2016
... activates differential robust fibrotic, apoptotic and inflammatory responses via ERK1/2 in cardiomyocytes and cardiac fibroblasts inducing DCM and CHF. Blocking the ERK1/2 pathway prevented progression of FasL-induced DCM and CHF by reducing fibrosis, inflammation and apoptosis in the myocardium...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (4): 273–287.
Published: 14 January 2016
.... In vitro , stimulation of the alveolar epithelial type II (ATII)-like LA4 cell line with L -carnitine diminished apoptosis induced by both PPE and H 2 O 2 . Moreover, PPE-treated mice demonstrated impaired lung function compared with PBS-treated controls (lung compliance; 0.067±0.008 ml/cmH 2 0 compared...
Articles
Clin Sci (Lond) (2016) 130 (3): 167–181.
Published: 17 December 2015
... into the cytosol to activate, along with Apaf-1 (apoptotic protease-activating factor 1), caspase 9 that, in turn, activates effector caspase 3, caspase 6, and caspase 7, suggesting the execution of the intrinsic apoptotic pathway. Whereas active caspase 3 underwent nuclear translocation, AIF (apoptosis-inducing...
Articles
Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
... apoptosis induced by a range of common stressors. Glucocorticoids, which are ubiquitously elevated for a prolonged period postoperatively, generated increased levels of mitochondrial reactive oxygen species, activated caspase-1 and mature interleukin (IL)-1β in human lymphocytes, suggesting inflammasome...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (12): 923–936.
Published: 27 March 2015
... decreased MI-induced infarct size, concomitant with an improved cardiac function, leading to an increase in the survival rate. The myocardial apoptosis in the border zone was dramatically reduced by Vinexin-β deficiency, resulting from the altered expression of apoptotic factors. Furthermore, Vinexin-β...
Articles
Clin Sci (Lond) (2015) 128 (10): 665–678.
Published: 20 February 2015
..., but it remains inconclusive whether this gene promotes or inhibits cell apoptosis. In the present study, we attempted to investigate the role of Ankrd1 on AngII (angiotensin II)- or pressure-overload-induced cardiomyocyte apoptosis. In the failing hearts of mice with pressure overload, the protein expression...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (9): 567–578.
Published: 11 February 2015
... in various human and mouse non-tumour cells. We investigated the intracellular distribution of AT 2 receptors including their presence in mitochondria and their role in the induction of apoptosis and cell death in cultured human uterine leiomyosarcoma (SK-UT-1) cells and control human uterine smooth muscle...
Articles
Clin Sci (Lond) (2015) 128 (9): 579–592.
Published: 11 February 2015
... processes involved in neointima formation. apoptosis chlorinated lipids oxidized phospholipids proliferation restenosis vascular smooth muscle • Abnormal VSMC proliferation and migration contribute to restenosis in patients following revascularization techniques such as balloon...
Articles
Clin Sci (Lond) (2015) 128 (9): 527–535.
Published: 27 January 2015
... also has pro-apoptotic, mitogenic and pro-fibrogenic effects, all of which potentially promote active remodelling and expansion of the mesangium. Although mitochondrial dysfunction seems to mediate the aldosterone-induced mesangial apoptosis, the ROS dependent epithelial growth factor receptor (EGFR...
Articles
Clin Sci (Lond) (2015) 128 (5): 321–323.
Published: 13 November 2014
... an important therapeutic potential of the H 2 S pathway in diabetic cardiomyopathy. Correspondence : Professor Gavin Y. Oudit (email gavin.oudit@ualberta.ca ). 20 10 2014 21 10 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 apoptosis diabetic...
Articles
Clin Sci (Lond) (2015) 128 (5): 325–335.
Published: 13 November 2014
... S. The echocardiographical and histopathological data indicated that H 2 S improved left ventricular function and prevented cardiac hypertrophy and myocardial fibrosis in diabetic rats. H 2 S was also found to attenuate hyperglycaemia-induced inflammation, oxidative stress and apoptosis...
Articles
Clin Sci (Lond) (2014) 127 (12): 665–677.
Published: 08 August 2014
... with an up-regulation of nuclear factor κB (NF-κB) and increased apoptosis. Heart tissue also exhibited an enhanced expression of pro-inflammatory cytokines. Selective NOD1 activation with C 12 -γ- D -glutamyl- m -diaminopimelic acid (iEDAP) resulted in an increased NF-κB activation and apoptosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (8): 519–526.
Published: 30 June 2014
... unclear. A possible role of myocardial apoptosis in the pathogenesis has not been previously examined. We hypothesized that dysregulation of apoptotic signalling participates in cardiac dysfunction in the cirrhotic heart. Therefore, we evaluated apoptotic pathways in the hearts of mice with chronic BDL...
Articles
Clin Sci (Lond) (2014) 127 (7): 507–518.
Published: 25 June 2014
... tunicamycin, or conversely with the ER protectant tauroursodeoxycholic acid (TUDCA), on the metabolic and hepatic features. foz/foz mice are obese, glucose intolerant and develop NASH characterized by steatosis, inflammation, ballooned hepatocytes and apoptosis from 6 weeks of HFD feeding...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (7): 435–448.
Published: 17 June 2014
... subjected to transverse aortic constriction (TAC) or sham surgery. The influences of H2R activation or inactivation on mitochondrial function, apoptosis and fibrosis were evaluated in cultured neonatal rat cardiomyocytes and fibroblasts as well as in murine hearts. After 4 weeks, H2R-knockout mice had...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (6): 405–413.
Published: 29 May 2014
... by inducing the PHR (portal hypertensive response) via B 2 R, whereas DABK (des-Arg 9 -BK), a B 1 R agonist, does not elicit the response. During IRI (ischaemia/reperfusion injury), important changes occur in the microcirculation, and cell death by necrosis and apoptosis is involved in poor graft function...
Articles
Clin Sci (Lond) (2013) 124 (7): 467–478.
Published: 07 December 2012
.... Persaud (email shanta.persaud@kcl.ac.uk ). 17 8 2012 15 10 2012 19 10 2012 19 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 apoptosis cannabinoid receptor gene expression insulin secretion mouse islet • The ECS has physiological...
Articles
Clin Sci (Lond) (2013) 124 (1): 1–15.
Published: 07 September 2012
... (nuclear factor κB) activation, inflammation, apoptosis or necrosis, low-to-moderate levels can enhance the antioxidant response, via Nrf2 (nuclear factor-erythroid 2-related factor 2) activation. However, a clear definition of these concentration thresholds remains to be established. Although a number...
Articles
Clin Sci (Lond) (2012) 123 (9): 545–546.
Published: 13 July 2012
...Regje M. E. Blümer; Gregory R. Steinberg TRAIL [TNF (tumour necrosis factor)-related apoptosis-inducing ligand] is in clinical trials for the treatment of cancer. In the present issue of Clinical Science , Bernardi and co-workers report that the administration of TRAIL in mice fed on a high-fat...
Articles
Clin Sci (Lond) (2012) 123 (9): 547–555.
Published: 13 July 2012
...Stella Bernardi; Giorgio Zauli; Christos Tikellis; Riccardo Candido; Bruno Fabris; Paola Secchiero; Mark E. Cooper; Merlin C. Thomas TRAIL [TNF (tumour necrosis factor)-related apoptosis-inducing ligand] has recently been shown to ameliorate the natural history of DM (diabetes mellitus). It has...
Articles
Clin Sci (Lond) (2012) 123 (7): 417–427.
Published: 07 June 2012
.... The role of magnesium in cancer is also critically examined with regard to mitochondrial function, apoptosis and resistance to treatment. Finally, we bring together the latest experimental evidence indicating that alteration in the expression and/or activity of magnesium channels is a frequent finding...
Articles
Clin Sci (Lond) (2011) 121 (8): 315–329.
Published: 24 June 2011
... Kenneth R. Boheler (email bohelerk@grc.nia.nih.gov ). 9 3 2011 28 4 2011 16 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging apoptosis cardiomyocyte cardiovascular disease The molecular basis responsible for the transition from...
Articles
Clin Sci (Lond) (2011) 120 (1): 37–49.
Published: 17 September 2010
... administration and exercise caused increased cardiac mitochondrial SOD activity. Exercise ameliorated liver mitochondrial complex activities. No alterations were observed in the measured MPTP and apoptosis-related proteins in heart and liver mitochondria. The results demonstrate that acute exercise protects...
Articles
Clin Sci (Lond) (2010) 118 (7): 473–485.
Published: 12 January 2010
... expression of DNA damage markers and of DNA repair genes, together with the assessment of proliferation and apoptosis indexes. The expression of the oxidative DNA damage marker 7,8-dihydro-8-oxo-2′-deoxyguanosine was increased at 3 and 7 days after arteriotomy, with immunostaining distributed in the injured...
Articles
Clin Sci (Lond) (2010) 118 (3): 173–181.
Published: 26 October 2009
...Marc Germain; Ruth S. Slack BCL-2 homologues are major regulators of apoptosis and, as such, play an active role in the survival of adult neurons following injury. In recent years, these proteins have also been associated with the regulation of autophagy, a catabolic process involved...
Articles
Clin Sci (Lond) (2010) 118 (1): 19–29.
Published: 28 September 2009
... for treatment targeting ER stress. Correspondence: Dr Toru Hosoi (email toruh@hiroshima-u.ac.jp ) or Professor Koichiro Ozawa (email ozawak@hiroshima-u.ac.jp ). 19 12 2008 9 4 2009 8 5 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 apoptosis cancer...
Articles
Clin Sci (Lond) (2009) 116 (12): 861–870.
Published: 14 May 2009
...Christian Körner; Benjamin Krämer; Daniela Schulte; Martin Coenen; Stefan Mauss; Gerd Fätkenheuer; Johannes Oldenburg; Jacob Nattermann; Jürgen K. Rockstroh; Ulrich Spengler Apoptosis importantly contributes to loss of CD4 + T-cells in HIV infection, and modification of their apoptosis may explain...
Articles
Clin Sci (Lond) (2008) 115 (11): 343–351.
Published: 03 November 2008
... and IL-10 was enhanced, but TNF-α (tumour necrosis factor-α), IFN-γ (interferon-γ) and IL-6 was reduced. Quorum-sensing signal molecules induced apoptosis in dendritic cells and CD4 + cells, but not CD8 + cells. Dendritic cells from patients with sepsis were depleted and ex vivo showed defective...
Articles
Clin Sci (Lond) (2008) 114 (1): 27–35.
Published: 30 November 2007
... require an entire volume. To provide a general view of the importance of Mg in cellular pathophysiology, we will review and discuss Mg-related cell functions that are shared by most tissues, namely proliferation, metabolism and apoptosis. Several important aspects of Mg biochemistry and physiology...