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Keywords: antioxidant
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Clin Sci (Lond) (2022) 136 (13): 1019–1023.
Published: 01 July 2022
... of synthesis of long chain highly unsaturated PUFAs. The authors interpreted their findings to indicate that a low hepatic content of n - 3 PUFAs has a causal role in NAFLD. The second paper reported lower hepatic antioxidant defences and increased markers of oxidative stress in NAFLD, consistent with a role...
Clin Sci (Lond) (2022) 136 (8): 537–555.
Published: 21 April 2022
...) exposure, worsens vascular function and if so, whether the antioxidant ebselen alleviates this vascular dysfunction. Male BALB/c mice were exposed to either room air or CS for 8 weeks followed by inoculation with IAV (Mem71, 1 × 10 4.5 pfu). Mice were treated with ebselen (10 mg/kg) or vehicle (5% w/v CM...
Clin Sci (Lond) (2015) 128 (3): 197–212.
Published: 03 October 2014
...Marie-Claude Denis; Yves Desjardins; Alexandra Furtos; Valérie Marcil; Stéphanie Dudonné; Alain Montoudis; Carole Garofalo; Edgard Delvin; André Marette; Emile Levy Cranberry fruit has been reported to have high antioxidant effectiveness that is potentially linked to its richness in diversified...
Includes: Supplementary data
Clin Sci (Lond) (2013) 124 (1): 1–15.
Published: 07 September 2012
... (nuclear factor κB) activation, inflammation, apoptosis or necrosis, low-to-moderate levels can enhance the antioxidant response, via Nrf2 (nuclear factor-erythroid 2-related factor 2) activation. However, a clear definition of these concentration thresholds remains to be established. Although a number...
Clin Sci (Lond) (2012) 123 (3): 173–192.
Published: 12 April 2012
... that scavenge ROS (reactive oxygen species) and antioxidants in the management of several diseases related to free radical damage. The majority of free radicals are generated by mitochondria as a consequence of the mitochondrial cycle, whereas free radical accumulation is limited by the action of a variety...
Clin Sci (Lond) (2012) 122 (6): 289–299.
Published: 22 November 2011
... cells and in blood vessels in muscle biopsies of patients. Antioxidant vitamins transiently restored FMD in patients [ΔAUC/τ (change in AUC/τ) for the brachial artery, +1.38±0.49%, P <0.05; ΔAUC/τ for the femoral artery, +0.98±0.24%, P <0.01] but had no effect on FMD in controls (brachial artery...
Includes: Supplementary data
Clin Sci (Lond) (2011) 121 (10): 427–436.
Published: 25 July 2011
... and anxiety disorders, we increased fetal glucocorticoid exposure by administering the 11β-HSD inhibitor CBX (carbenoxolone; 12 mg·kg −1 of body weight·day −1 ) during the final week of murine gestation. We hypothesized that maternal antioxidant (tempol throughout pregnancy) would block glucocorticoid...
Clin Sci (Lond) (2010) 118 (4): 303–311.
Published: 16 November 2009
... (total antioxidant capacity). These measures were assessed following 10 days of detraining in the HI group. The HI group had greater peak reactive hyperaemic FBF responses compared with the LO group, despite no difference in resting CD34 + cell number, CD34 + /VEGFR2 + cell number, CFU-EC colonies or CFU...
Clin Sci (Lond) (2009) 116 (8): 659–668.
Published: 16 March 2009
... of age. AmplexRed was used to measure H 2 O 2 production. Activities of the antioxidant enzymes Mn-SOD (manganese superoxide dismutase), GPx (glutathione peroxidase) and catalase were measured. Compared with controls, a significant increase in Complex I H 2 O 2 production was found in intact mitochondria...
Clin Sci (Lond) (2009) 116 (5): 433–441.
Published: 02 February 2009
...D. Walter Wray; Abhimanyu Uberoi; Lesley Lawrenson; Damian M. Bailey; Russell S. Richardson Both antioxidant supplementation and exercise training have been identified as interventions which may reduce oxidative stress and thus improve cardiovascular health, but the interaction...
Clin Sci (Lond) (2009) 116 (2): 87–98.
Published: 15 December 2008
... levels and CHD (coronary heart disease) risk. The cardioprotective effects of HDLs have been attributed to several mechanisms, including their involvement in the reverse cholesterol transport pathway. HDLs also have antioxidant, anti-inflammatory and antithrombotic properties and promote endothelial...
Clin Sci (Lond) (2009) 116 (1): 41–43.
Published: 28 November 2008
...Adam Mullan; Naveed Sattar The oxidation hypothesis for CHD (coronary heart disease) is attractive; however, the almost universal failure of antioxidant vitamin supplementation as a CVD (cardiovascular disease) risk modifier challenges the oxidation hypothesis, at least as a concept that easily...
Clin Sci (Lond) (2009) 116 (1): 53–60.
Published: 28 November 2008
...Mark Woodward; Kevin D. Croft; Trevor A. Mori; Henrietta Headlam; Xiao Suo Wang; Cacang Suarna; Mark J. Raftery; Stephen W. MacMahon; Roland Stocker The role of oxidative damage in the aetiology of coronary disease remains controversial, as clinical trials investigating the effect of antioxidants...
Clin Sci (Lond) (2009) 116 (1): 71–79.
Published: 28 November 2008
...Ying-Ying Yang; Yi-Tsau Huang; Kuei-Chuan Lee; Fa-Yauh Lee; Tzung-Yan Lee; Ming-Chih Hou; Han-Chieh Lin; Shou-Dong Lee Liver cirrhosis is characterized by increased IHR (intrahepatic resistance) and lipid peroxidation, and decreased antioxidative defence. The present study investigates the effects...
Clin Sci (Lond) (2008) 114 (8): 553–560.
Published: 13 March 2008
... preconditioning. The extent and source of oxidative stress and its effect on antioxidant status in the human liver during intermittent ischaemia and reperfusion remains ill-defined. Therefore the aim of the present study was to investigate the occurrence of oxidative stress in humans undergoing liver resection...
Clin Sci (Lond) (2008) 114 (4): 265–273.
Published: 15 January 2008
... of endothelial regeneration and neointimal growth. Moreover, evidence suggests antioxidants improve re-endothelialization and inhibit ISR. By promoting, rather than blocking, the healing process, antioxidant and other therapies may offer an alternative or additional approach over the antiproliferative approaches...
Clin Sci (Lond) (2008) 114 (3): 251–256.
Published: 08 January 2008
...Patrice Faure; Nicolas Wiernsperger; Camille Polge; Alain Favier; Serge Halimi Free radical production is increased during diabetes. Serum albumin is a major antioxidant agent, and structural modification of albumin induced by glucose or free radicals impairs its antioxidant properties. Therefore...
Clin Sci (Lond) (2007) 113 (12): 459–466.
Published: 14 November 2007
..., which suggests that mitochondria are involved in increased cell death induced by severe hypobaric hypoxia in mice skeletal muscle. apoptotic signalling antioxidant high altitude membrane integrity mitochondrial dysfunction vitamin E (α-tocopherol) The depressurization period to reach...
Clin Sci (Lond) (2007) 112 (12): 599–606.
Published: 14 May 2007
.... Plasma MDA (malondialdehyde) and TAC (total antioxidative capacity) status, erythrocyte GSH content and SOD (superoxide dismutase) activity were determined. A comet assay was employed to evaluate DNA damage. Compared with subjects with NGT, patients with IGR had reduced erythrocyte SOD activity. Patients...
Clin Sci (Lond) (2007) 112 (11): 543–555.
Published: 01 May 2007
... of anti-inflammatory cytokines, whereas chronic exercise reduces basal levels of pro-inflammatory cytokines. Exercise training also induces the expression of antioxidant and anti-inflammatory mediators in the vascular wall that may directly inhibit the development of atherosclerosis. Limited studies...
Clin Sci (Lond) (2006) 110 (1): 133–141.
Published: 12 December 2005
... species. There is also evidence of exercise-induced muscle damage, possibly caused by the increase in free radical generation. The Biochemical Society 2006 antioxidant electron spin resonance (ESR) exercise free radical hypoxia oxidative stress Total CK (creatine kinase...
Clin Sci (Lond) (2004) 107 (6): 589–600.
Published: 24 November 2004
.... Sixteen mountaineers (11 males/five females) were matched for physical fitness and caloric intake and assigned in a double-blind manner to either antioxidant ( n =8) or placebo ( n =8) supplementation, which was enforced for 7 days at sea level and during an 11-day ascent to 4780 m. Enteral prophylaxis...
Clin Sci (Lond) (2004) 107 (6): 625–629.
Published: 24 November 2004
... demonstrated NEFA-induced endothelial dysfunction of large conduit arteries, reversible by the antioxidant ascorbic acid. We therefore investigated the effect of NEFAs on carbachol-induced endothelium-dependent vasodilation of rat resistance arteries in vitro using the technique of wire myography. In addition...
Clin Sci (Lond) (2004) 106 (1): 107–109.
Published: 01 January 2004
... intrinsic antioxidant, during exhaustive exercise, we performed a randomized, blinded, placebo-controlled study on eight male well-trained athletes. subjects were randomly allocated to either a group given 1000 mg of ascorbate daily ( n =4) or a placebo group ( n =4). Fasting serum lipids and urate...
Clin Sci (Lond) (2003) 105 (4): 425–430.
Published: 01 October 2003
...W. S. WARING; A. CONVERY; V. MISHRA; A. SHENKIN; D. J. WEBB; S. R. J. MAXWELL Uric acid (UA) possesses free-radical-scavenging properties, and systemic administration is known to increase serum antioxidant capacity. However, it is not known whether this protects against oxidative stress...
Clin Sci (Lond) (2003) 105 (2): 173–180.
Published: 01 August 2003
..., lipid peroxidation, cellular fibronectin and ferric reducing ability of plasma (FRAP; i.e. antioxidant capacity). After methionine loading, whole-blood levels of free and oxidized cysteine and homocysteine were increased in both groups. Furthermore, the total plasma levels of homocysteine were higher...
Clin Sci (Lond) (1998) 95 (4): 459–465.
Published: 01 October 1998
... concerning the therapeutic benefit of the former which is an expensive form of treatment. 2. Albumin has several biological functions, in particular as a ligand binder. It also acts as an extracellular transition metal ion-binding and radical-scavenging antioxidant. These functions are influenced...
Clin Sci (Lond) (1993) 84 (4): 407–412.
Published: 01 April 1993
...Nicholas J. Miller; Catherine Rice-Evans; Michael J. Davies; Vimala Gopinathan; Anthony Milner 1. A new method has been developed for measuring the total antioxidant capacity of body fluids and drug solutions, based on the absorbance of the ABTS*+ radical cation. 2. An automated method for use...
Clin Sci (Lond) (1991) 81 (3): 413–417.
Published: 01 September 1991
...John M. C. Gutteridge 1. The copper-containing protein caeruloplasmin has several oxidase activities. 2. Its ability to catalyse the oxidation of ferrous ions to the ferric state (ferroxidase activity) makes it an important antioxidant in vivo . 3. Recent reports have suggested that oral...
Clin Sci (Lond) (1991) 81 (1): 31–36.
Published: 01 July 1991
... the efficacy of the antioxidant and free-radical scavenger N -acetylcysteine in improving the survival of ischaemic rabbit epigastric skin flaps was tested. 2. At the time of reperfusion flaps were given: (1) balanced salt solution by intravenous whole-body administration, (2) N -acetylcysteine (200 mg/kg...