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Keywords: animal modelClose
Clin Sci (Lond) (2016) 130 (3): 127–150.
Published: 17 December 2015
... to manage PAD which can be applied to patients unlikely to benefit from interventional approaches. Many of the therapeutic agents successful in inducing angiogenesis and arteriogenesis in pre-clinical animal models of PAD have failed to have efficacy in human randomized control trials. One possible reason...
Roumen Parapanov, Jérôme Lugrin, Nathalie Rosenblatt-Velin, François Feihl, Bernard Waeber, Giuseppina Milano, Catherine Vergely, Na Li, Pal Pacher, Lucas Liaudet
Clin Sci (Lond) (2015) 129 (2): 187–198.
Published: 30 April 2015
...-reperfusion, by enhancing cardiac oxidative stress and p38 activation. TLR5 may thus convey cardioprotective signals during myocardial infarction (MI). animal model inflammation innate immunity myocardial infarction oxidative stress toll-like receptors • MI triggers an inflammatory...
Amalia Forte, Barbara Rinaldi, Liberato Berrino, Francesco Rossi, Umberto Galderisi, Marilena Cipollaro
Clin Sci (Lond) (2014) 127 (11): 615–634.
Published: 25 July 2014
... of restenosis, which remains a clinically relevant problem. Biomedical research in pre-clinical animal models of (re)stenosis, despite its limitations, has contributed enormously to the identification of processes involved in restenosis progression, going well beyond the initial dogma of a primarily...
Najib T. Ayas, Allen A. J. Hirsch, Ismail Laher, T. Douglas Bradley, Atul Malhotra, Vsevolod Y. Polotsky, Esra Tasali
Clin Sci (Lond) (2014) 127 (4): 209–216.
Published: 10 April 2014
... and increased age, the strongest risk factor is obesity. The aim of the present review is to focus on three cutting-edge topics with respect to OSA. The section on animal models covers various strategies used to simulate the physiology or the effects of OSA in animals, and how these have helped to understand...
Jason P. Riley, Barbara Fuchs, Lisa Sjöberg, Gunnar P. Nilsson, Lars Karlsson, Sven-Erik Dahlén, Navin L. Rao, Mikael Adner
Clin Sci (Lond) (2013) 125 (11): 533–542.
Published: 25 July 2013
... management. Correspondence: Associate Professor Mikael Adner (email email@example.com ). 22 2 2013 13 6 2013 25 6 2013 25 6 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 airway hyper-responsiveness (AHR) animal model asthma combination...
Alain Rudiger, Alex Dyson, Karen Felsmann, Jane E. Carré, Valerie Taylor, Sian Hughes, Innes Clatworthy, Alessandro Protti, Denis Pellerin, Jana Lemm, Ralf A. Claus, Michael Bauer, Mervyn Singer
Clin Sci (Lond) (2013) 124 (6): 391–401.
Published: 27 November 2012
... animal model echocardiography faecal peritonitis gene transcript heart failure sepsis • Myocardial function is depressed in sepsis and is an important prognosticator in patients. • Using a long-term fluid-resuscitated rat model of faecal peritonitis, we demonstrate that significant...
Includes: Supplementary data
Masanori Iwase, Miya Wada, Masanori Wakisaka, Hideyuki Yoshizumi, Mototaka Yoshinari, Masatoshi Fujishima
Clin Sci (Lond) (1995) 89 (3): 255–260.
Published: 01 September 1995
.... This suggests the importance of the metabolic environment during fetal growth for the development of hypertension. 4 4 1995 25 4 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 animal model growth retardation insulin resistance non-insulin-dependent diabetes...