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Keywords: animal modelClose
Clin Sci (Lond) (2016) 130 (3): 127–150.
Published: 17 December 2015
... to manage PAD which can be applied to patients unlikely to benefit from interventional approaches. Many of the therapeutic agents successful in inducing angiogenesis and arteriogenesis in pre-clinical animal models of PAD have failed to have efficacy in human randomized control trials. One possible reason...
Roumen Parapanov, Jérôme Lugrin, Nathalie Rosenblatt-Velin, François Feihl, Bernard Waeber, Giuseppina Milano, Catherine Vergely, Na Li, Pal Pacher, Lucas Liaudet
Clin Sci (Lond) (2015) 129 (2): 187–198.
Published: 30 April 2015
... ( Figure 3 D). animal model inflammation innate immunity myocardial infarction oxidative stress toll-like receptors • MI triggers an inflammatory response orchestrated by members of the TLRs. Detrimental roles have been reported for TLR2, TLR3 and TLR4 and thus pharmacological...
Amalia Forte, Barbara Rinaldi, Liberato Berrino, Francesco Rossi, Umberto Galderisi, Marilena Cipollaro
Clin Sci (Lond) (2014) 127 (11): 615–634.
Published: 25 July 2014
... of restenosis, which remains a clinically relevant problem. Biomedical research in pre-clinical animal models of (re)stenosis, despite its limitations, has contributed enormously to the identification of processes involved in restenosis progression, going well beyond the initial dogma of a primarily...
Najib T. Ayas, Allen A. J. Hirsch, Ismail Laher, T. Douglas Bradley, Atul Malhotra, Vsevolod Y. Polotsky, Esra Tasali
Clin Sci (Lond) (2014) 127 (4): 209–216.
Published: 10 April 2014
... and increased age, the strongest risk factor is obesity. The aim of the present review is to focus on three cutting-edge topics with respect to OSA. The section on animal models covers various strategies used to simulate the physiology or the effects of OSA in animals, and how these have helped to understand...
Jason P. Riley, Barbara Fuchs, Lisa Sjöberg, Gunnar P. Nilsson, Lars Karlsson, Sven-Erik Dahlén, Navin L. Rao, Mikael Adner
Clin Sci (Lond) (2013) 125 (11): 533–542.
Published: 25 July 2013
... of chronic airway inflammation in asthmatic patients [ 1 , 2 ], there is a great need to have an animal model where mast cell activation occurs and where the mediators of the mast cell-dependent response are the same as in humans. Such a model would be predictive for investigating mechanisms with relevance...
Alain Rudiger, Alex Dyson, Karen Felsmann, Jane E. Carré, Valerie Taylor, Sian Hughes, Innes Clatworthy, Alessandro Protti, Denis Pellerin, Jana Lemm, Ralf A. Claus, Michael Bauer, Mervyn Singer
Clin Sci (Lond) (2013) 124 (6): 391–401.
Published: 27 November 2012
.... The concentration of isoflurane was kept between 1.0 and 1.5%, so that the animals tolerated the study but could react to a leg pinch with a withdrawal response. animal model echocardiography faecal peritonitis gene transcript heart failure sepsis • Myocardial function is depressed in sepsis...
Includes: Supplementary data
Masanori Iwase, Miya Wada, Masanori Wakisaka, Hideyuki Yoshizumi, Mototaka Yoshinari, Masatoshi Fujishima
Clin Sci (Lond) (1995) 89 (3): 255–260.
Published: 01 September 1995
... pressure in adult offspring. We recently developed a new animal model of high-risk pregnancy complicated by hypertension and diabetes mellitus [lo]. Spontaneously hyperten- sive rats (SHRs), a genetic hypertensive model, were made diabetic by neonatal STZ treatment. In this model, moderately severe...