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Keywords: animal model
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Clin Sci (Lond) (2016) 130 (3): 127–150.
Published: 17 December 2015
... to manage PAD which can be applied to patients unlikely to benefit from interventional approaches. Many of the therapeutic agents successful in inducing angiogenesis and arteriogenesis in pre-clinical animal models of PAD have failed to have efficacy in human randomized control trials. One possible reason...
Clin Sci (Lond) (2014) 127 (11): 615–634.
Published: 25 July 2014
... of restenosis, which remains a clinically relevant problem. Biomedical research in pre-clinical animal models of (re)stenosis, despite its limitations, has contributed enormously to the identification of processes involved in restenosis progression, going well beyond the initial dogma of a primarily...
Clin Sci (Lond) (2014) 127 (4): 209–216.
Published: 10 April 2014
... and increased age, the strongest risk factor is obesity. The aim of the present review is to focus on three cutting-edge topics with respect to OSA. The section on animal models covers various strategies used to simulate the physiology or the effects of OSA in animals, and how these have helped to understand...
Clin Sci (Lond) (2013) 125 (11): 533–542.
Published: 25 July 2013
... of chronic airway inflammation in asthmatic patients [ 1 , 2 ], there is a great need to have an animal model where mast cell activation occurs and where the mediators of the mast cell-dependent response are the same as in humans. Such a model would be predictive for investigating mechanisms with relevance...
Clin Sci (Lond) (2013) 124 (6): 391–401.
Published: 27 November 2012
.... The concentration of isoflurane was kept between 1.0 and 1.5%, so that the animals tolerated the study but could react to a leg pinch with a withdrawal response. animal model echocardiography faecal peritonitis gene transcript heart failure sepsis • Myocardial function is depressed in sepsis...
Includes: Supplementary data