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Clin Sci (Lond) (2021) 135 (14): 1727–1731.
Published: 22 July 2021
..., although renin’s substrate, angiotensinogen, appears to be synthesized locally in the brain, brain angiotensin (Ang) II disappeared after selective silencing of hepatic angiotensinogen. This implies that brain Ang generation depends on hepatic angiotensinogen after all. Rodrigues et al. ( Clin Sci (Lond...
Clin Sci (Lond) (2021) 135 (7): 885–886.
Published: 09 April 2021
...Estrellita Uijl; A.H. Jan Danser We thank Dr. Ferrario and colleagues for their interest in our work. They suggest that we cannot conclude that liver-targeted angiotensinogen (AGT) small interfering (si)RNA lowers brainstem angiotensin (Ang) II levels, and that brain-derived AGT likely...
Clin Sci (Lond) (2021) 135 (7): 907–910.
Published: 09 April 2021
... angiotensinogen blood brain barrier hypertension neural Dear Editor We read with great interest the article by Uijl et al. [ 1 ] who reported that liver-directed small interfering RNA (siRNA) targeted to angiotensinogen (AGT) does not reverse the hypertension induced in male Sprague–Dawley rats...
Estrellita Uijl, Liwei Ren, Katrina M. Mirabito Colafella, Richard van Veghel, Ingrid M. Garrelds, Oliver Domenig, Marko Poglitsch, Ivan Zlatev, Jae B. Kim, Stephen Huang, Lauren Melton, Ewout J. Hoorn, Don Foster, A.H. Jan Danser
Clin Sci (Lond) (2021) 135 (2): 259–274.
Published: 22 January 2021
... to mediate deoxycorticosterone acetate (DOCA)-salt hypertension, an animal model for human primary hyperaldosteronism. Here, we determined whether brainstem angiotensin II is generated from locally synthesized angiotensinogen and mediates DOCA-salt hypertension. To this end, chronic DOCA-salt-hypertensive...
Includes: Supplementary data
Erwan BOZEC, Céline FASSOT, Anne-Isabelle TROPEANO, Pierre BOUTOUYRIE, Xavier JEUNEMAITRE, Patrick LACOLLEY, Hubert DABIRE, Stéphane LAURENT
Clin Sci (Lond) (2003) 105 (5): 637–644.
Published: 01 November 2003
...Erwan BOZEC; Céline FASSOT; Anne-Isabelle TROPEANO; Pierre BOUTOUYRIE; Xavier JEUNEMAITRE; Patrick LACOLLEY; Hubert DABIRE; Stéphane LAURENT The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease. Carotid intima-media thickness (IMT) is an early marker...
Clin Sci (Lond) (2002) 103 (1): 101–106.
Published: 20 June 2002
... angioplasty. Five hundred and eleven patients after first successful angioplasty were characterized with respect to the angiotensinogen M235T, angiotensin-converting enzyme insertion/deletion and angiotensin II type 1 receptor A1166C gene polymorphisms. In 164 of these patients repeated angioplasty...
Clin Sci (Lond) (2000) 99 (1): 19–25.
Published: 06 June 2000
..., genetic factors may be involved. In the present study, we investigated the associations between the angiotensinogen T174M and M235T, the angiotensin I-converting enzyme (ACE) I/D and the angiotensin II type 1 receptor A1166C gene polymorphisms and restenosis in 511 patients who had undergone successful...
Clin Sci (Lond) (2000) 98 (1): 57–64.
Published: 22 November 1999
... whether changes in hepatic and plasma angiotensinogen levels and hepatic angiotensin-converting enzyme (ACE) activity might explain the decrease in ANG II synthesis. Male Sprague–Dawley rats, equilibrated on a low-sodium diet, were anaesthetized and received a sodium load of 1.5 mmol/kg (using 3× normal...
Clin Sci (Lond) (1988) 75 (4): 411–414.
Published: 01 October 1988
... 1970 The Biochemical Society and the Medical Research Society 1970 acute-phase protein angiotensin-converting enzyme angiotensinogen continuous ambulatory peritoneal dialysis peritonitis renin substrate Clinical Science (1988) 75,411-414 41 1 Increased levels of immunoreactive plasma...
Clin Sci (Lond) (1982) 63 (s8): 149s–152s.
Published: 01 October 1982
...Nidia Basso; Diana Grispon; Patricia Ruiz; Alberto C. Taquini 1. The distribution of angiotensinogen and endogenous renin-like activity were analysed in different areas of the central nervous system in normal and DOC-salt-treated hypertensive rats. 2. Angiotensinogen concentration and renin-like...
Clin Sci (Lond) (1982) 62 (4): 355–360.
Published: 01 April 1982
...J. Bouhnik; E. Clauser; J. Gardes; P. Corvol; J. Menard 1. Antibodies were raised in rabbits against pure rat angiotensinogen. The antisera obtained were highly specific for rat angiotensinogen and did not bind hog, dog, rabbit, monkey or human angiotensinogen. They did not cross-react...
Clin Sci Mol Med (1976) 51 (s3): 155s–157s.
Published: 01 December 1976
...E. Hackenthal; R. Hackenthal; K. G. Hofbauer 1. The possible inhibitory effect of des-angiotensin I substrate on the renin-substrate reaction was studied. For this purpose rat angiotensinogen was purified 50-fold from plasma of nephrectomized rats. Des-angiotensin substrate was prepared from...