..., although renin’s substrate, angiotensinogen, appears to be synthesized locally in the brain, brain angiotensin (Ang) II disappeared after selective silencing of hepatic angiotensinogen. This implies that brain Ang generation depends on hepatic angiotensinogen after all. Rodrigues et al. ( Clin Sci (Lond...

... 8. Mullick A.E. , Yeh S.T. , Graham M.J. et al . ( 2017 ) Blood pressure lowering and safety improvements with liver angiotensinogen inhibition in models of hypertension and kidney injury . Hypertension 70 , 566 – 576 10.1161/HYPERTENSIONAHA.117.09755 28716988 9...

...Carlos M. Ferrario; Leanne Groban; Hao Wang; Sarfaraz Ahmad We read with great interest the article by Uijl et al. [ 1 ] who reported that liver-directed small interfering RNA (siRNA) targeted to angiotensinogen (AGT) does not reverse the hypertension induced in male Sprague–Dawley rats...

... to mediate deoxycorticosterone acetate (DOCA)-salt hypertension, an animal model for human primary hyperaldosteronism. Here, we determined whether brainstem angiotensin II is generated from locally synthesized angiotensinogen and mediates DOCA-salt hypertension. To this end, chronic DOCA-salt-hypertensive...

...Erwan BOZEC; Céline FASSOT; Anne-Isabelle TROPEANO; Pierre BOUTOUYRIE; Xavier JEUNEMAITRE; Patrick LACOLLEY; Hubert DABIRE; Stéphane LAURENT The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease. Carotid intima-media thickness (IMT) is an early marker...

... angioplasty. Five hundred and eleven patients after first successful angioplasty were characterized with respect to the angiotensinogen M235T, angiotensin-converting enzyme insertion/deletion and angiotensin II type 1 receptor A1166C gene polymorphisms. In 164 of these patients repeated angioplasty...

..., genetic factors may be involved. In the present study, we investigated the associations between the angiotensinogen T174M and M235T, the angiotensin I-converting enzyme (ACE) I/D and the angiotensin II type 1 receptor A1166C gene polymorphisms and restenosis in 511 patients who had undergone successful...

... whether changes in hepatic and plasma angiotensinogen levels and hepatic angiotensin-converting enzyme (ACE) activity might explain the decrease in ANG II synthesis. Male Sprague–Dawley rats, equilibrated on a low-sodium diet, were anaesthetized and received a sodium load of 1.5 mmol/kg (using 3× normal...

.... 26 2 1988 21 3 1988 © 1970 The Biochemical Society and the Medical Research Society 1970 acute-phase protein angiotensin-converting enzyme angiotensinogen continuous ambulatory peritoneal dialysis peritonitis renin substrate Clinical Science (1988) 75,411-414 41 1 Increased...

...Nidia Basso; Diana Grispon; Patricia Ruiz; Alberto C. Taquini 1. The distribution of angiotensinogen and endogenous renin-like activity were analysed in different areas of the central nervous system in normal and DOC-salt-treated hypertensive rats. 2. Angiotensinogen concentration and renin-like...

...J. Bouhnik; E. Clauser; J. Gardes; P. Corvol; J. Menard 1. Antibodies were raised in rabbits against pure rat angiotensinogen. The antisera obtained were highly specific for rat angiotensinogen and did not bind hog, dog, rabbit, monkey or human angiotensinogen. They did not cross-react...

...E. Hackenthal; R. Hackenthal; K. G. Hofbauer 1. The possible inhibitory effect of des-angiotensin I substrate on the renin-substrate reaction was studied. For this purpose rat angiotensinogen was purified 50-fold from plasma of nephrectomized rats. Des-angiotensin substrate was prepared from...