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Keywords: angiotensinogen
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Clin Sci (Lond) (2021) 135 (14): 1727–1731.
Published: 22 July 2021
..., although renin’s substrate, angiotensinogen, appears to be synthesized locally in the brain, brain angiotensin (Ang) II disappeared after selective silencing of hepatic angiotensinogen. This implies that brain Ang generation depends on hepatic angiotensinogen after all. Rodrigues et al. ( Clin Sci (Lond...
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Clin Sci (Lond) (2021) 135 (2): 259–274.
Published: 22 January 2021
... to mediate deoxycorticosterone acetate (DOCA)-salt hypertension, an animal model for human primary hyperaldosteronism. Here, we determined whether brainstem angiotensin II is generated from locally synthesized angiotensinogen and mediates DOCA-salt hypertension. To this end, chronic DOCA-salt-hypertensive...
Includes: Supplementary data
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Clin Sci (Lond) (2000) 98 (1): 57–64.
Published: 22 November 1999
... whether changes in hepatic and plasma angiotensinogen levels and hepatic angiotensin-converting enzyme (ACE) activity might explain the decrease in ANG II synthesis. Male Sprague–Dawley rats, equilibrated on a low-sodium diet, were anaesthetized and received a sodium load of 1.5 mmol/kg (using 3× normal...
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Clin Sci (Lond) (1982) 63 (s8): 149s–152s.
Published: 01 October 1982
...Nidia Basso; Diana Grispon; Patricia Ruiz; Alberto C. Taquini 1. The distribution of angiotensinogen and endogenous renin-like activity were analysed in different areas of the central nervous system in normal and DOC-salt-treated hypertensive rats. 2. Angiotensinogen concentration and renin-like...
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Clin Sci (Lond) (1982) 62 (4): 355–360.
Published: 01 April 1982
...J. Bouhnik; E. Clauser; J. Gardes; P. Corvol; J. Menard 1. Antibodies were raised in rabbits against pure rat angiotensinogen. The antisera obtained were highly specific for rat angiotensinogen and did not bind hog, dog, rabbit, monkey or human angiotensinogen. They did not cross-react...
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Clin Sci Mol Med (1976) 51 (s3): 155s–157s.
Published: 01 December 1976
...E. Hackenthal; R. Hackenthal; K. G. Hofbauer 1. The possible inhibitory effect of des-angiotensin I substrate on the renin-substrate reaction was studied. For this purpose rat angiotensinogen was purified 50-fold from plasma of nephrectomized rats. Des-angiotensin substrate was prepared from...