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Keywords: angiotensin-(1–7)
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Clin Sci (Lond) (2021) 135 (23): 2619–2623.
Published: 08 December 2021
... Limited on behalf of the Biochemical Society 2021 Angiotensin-(1-7) Cardiovascular System Renin-Angiotensin System Sympathetic Nervous System Transgenic Rat Vasopressin The renin–angiotensin system (RAS) regulates hydromineral balance, cardiovascular, renal, neuronal, and other organ...
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Clin Sci (Lond) (2020) 134 (23): 3063–3078.
Published: 02 December 2020
... angiotensin converting enzyme 2 angiotensin-(1-7) Covid-19 Renin-angiotensin system The renin–angiotensin system (RAS) is composed by a number of different enzymes and effector peptides that are involved in the dynamic control of many body functions. Many components of the RAS have opposing actions...
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Clin Sci (Lond) (2020) 134 (19): 2645–2664.
Published: 16 October 2020
... composed of ACE2/angiotensin-(1-7)/mas receptor [ACE2/Ang-(1-7)/mas-R] [ 32 ] may facilitate the induction of an inappropriate ACE2 response in the presence of a harmful stimuli. Unfortunately, a direct examination of this hypothesis awaits investigation. ACE2 is a zinc metallopeptidase residing...
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Clin Sci (Lond) (2020) 134 (19): 2581–2595.
Published: 14 October 2020
.... ACE2 functions as a carboxymonopeptidase hydrolyzing the cleavage of a single C-terminal residue from Angiotensin-II (Ang-II), the key peptide hormone of RAS, to form Angiotensin-(1-7) (Ang-(1-7)), which binds to the G-protein–coupled Mas receptor and activates signaling pathways that counteract...
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Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
... ) 28 02 2018 19 04 2018 23 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 Alzheimer’s disease angiotensin-(1-7) cognitive impairment hypertension Mas receptor stroke The RAS is of profound physiological...
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Clin Sci (Lond) (2015) 128 (10): 649–663.
Published: 20 February 2015
...Yixuan Shi; Chao-Sheng Lo; Ranjit Padda; Shaaban Abdo; Isabelle Chenier; Janos G. Filep; Julie R. Ingelfinger; Shao-Ling Zhang; John S.D. Chan We investigated the relationship between Ang-(1–7) [angiotensin-(17)] action, sHTN (systolic hypertension), oxidative stress, kidney injury, ACE2...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 127 (5): 295–306.
Published: 07 May 2014
...), and the depressor arm represented by Ang-(1–7) [angiotensin-(17)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1–7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1–7...
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Clin Sci (Lond) (2014) 127 (4): 251–264.
Published: 16 April 2014
.... In the present study, we investigated whether Ang-(1–7) [angiotensin-(17)], through the Mas-1 receptor, can counteract the signalling induced by AngII in mouse skeletal muscle and cause a decrease in the expression and further activity of TGF-β1 in skeletal muscle cells. Our results show that Ang-(1–7...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 126 (10): 695–706.
Published: 27 January 2014
.... The RAAS consists of an excitatory arm involving AngII (angiotensin II), ACE (angiotensin-converting enzyme) and the AT 1 R (AngII type 1 receptor). The RAAS also consists of a protective arm consisting of Ang-(1–7) [angiotensin-(17)], the AT 2 R (AngII type 2 receptor), ACE2 and the Mas receptor...
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Clin Sci (Lond) (2014) 126 (9): 613–630.
Published: 14 January 2014
... drugs that block the RAS (renin–angiotensin system) may also act to prevent diabetes. Despite its long history, new components within the RAS continue to be discovered. Among them, Ang-(1–7) [angiotensin-(17)] has gained special attention as a counter-regulatory hormone opposing many of the AngII...
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Clin Sci (Lond) (2014) 126 (7): 507–516.
Published: 11 December 2013
...) [angiotensin-(17)]. Enhanced ACE2 expression may be protective in diabetes, cardiovascular disease and cancer. However, relatively little is known about the specific physiological factors regulating ACE2 expression. In the present paper, we show, by Western blotting and qPCR (quantitative real-time PCR...
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Clin Sci (Lond) (2014) 126 (7): 471–482.
Published: 06 December 2013
... shown clinical benefits. ACE2, the recently discovered homologue of ACE, is a monocarboxypeptidase which converts AngII into Ang-(1–7) [angiotensin-(17)] which, by virtue of its actions on the MasR (Mas receptor), opposes the effects of AngII. In animal models of diabetes, an early increase in ACE2...
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Clin Sci (Lond) (2014) 126 (7): 461–469.
Published: 06 December 2013
...Carlos Maria Ferrario; Sarfaraz Ahmad; Sayaka Nagata; Stephen W. Simington; Jasmina Varagic; Neal Kon; Louis Joseph Dell’Italia Lessons learned from the characterization of the biological roles of Ang-(1–7) [angiotensin-(17)] in opposing the vasoconstrictor, proliferative and prothrombotic actions...
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Clin Sci (Lond) (2013) 124 (7): 443–456.
Published: 07 December 2012
... of the actions of the RAS. However, over the past 10 years, several studies have presented evidence for the existence of a new arm of the RAS, namely the ACE (angiotensin-converting enzyme) 2/Ang-(1–7) [angiotensin-(17)]/Mas axis. Ang-(1–7) can be produced from AngI or AngII via endo- or carboxy-peptidases...
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Clin Sci (Lond) (2011) 121 (7): 297–303.
Published: 07 June 2011
...-(1–7) [angiotensin-(17)]. Of note, although AngIV and Ang-(1–7) exhibited only modest affinity at AT 2 R compared with AngII, these two angiotensin peptides, together with AngIII, had substantial AT 2 R selectivity over AT 1 R. Collectively, our results suggest that shorter angiotensin peptides can...
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Clin Sci (Lond) (2010) 118 (4): 269–279.
Published: 16 November 2009
.... angiotensin-(17) kidney mas receptor renal injury renin–angiotensin system (RAS) Alterations within the RAS (renin–angiotensin system) are pivotal for the development and progression of renal disease [ 1 , 2 ]. ACE2 (angiotensin-converting enzyme 2) [ 3 – 5 ] is a recently discovered...
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