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Keywords: angiotensin converting enzyme 2
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Articles
Clin Sci (Lond) (2022) 136 (5): 309–321.
Published: 02 March 2022
...-ND) . abdominal aortic aneurysm angiotensin converting enzyme 2 calcium chloride fevipiprant laropiprant prostaglandin D2 Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease, characterized by immune cell infiltration and proteolytic degradation of the vascular wall...
Includes: Supplementary data
Articles
In Collection
Coronavirus
Clin Sci (Lond) (2021) 135 (24): 2667–2689.
Published: 15 December 2021
... in the cytokine storm , and (4) production of pro-apoptotic factors causing EC death. Next, adopting a blocking strategy against the S protein receptors angiotensin-converting enzyme 2 (ACE2) and CD147, we discovered that the S protein stimulates the phosphorylation/activation of the extracellular signal...
Articles
In Collection
Coronavirus
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
... cells and cytotrophoblasts (CTBs), as shown in Figure 2 B [ 20–22 ]. These changes in ACE2 distribution suggest that the placental susceptibility to SARS-CoV-2 and the disease manifestation may vary throughout gestation. angiotensin converting enzyme 2 cardiovascular disease COVID-19 placental...
Articles
Clin Sci (Lond) (2021) 135 (7): 911–924.
Published: 12 April 2021
...). Correspondence: Tanja Zeller ( t.zeller@uke.de ) or Robert Lukowski ( robert.lukowski@uni-tuebingen.de ) © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 angiotensin converting enzyme 2 Blood pressure hypertension immunsystem renin-angiotensin...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (6): 775–791.
Published: 17 March 2021
... therefore hypothesized that another metabolic pathway of brain angiotensin II, such as the conversion of angiotensin II into angiotensin 1-7 (Ang 1-7) by angiotensin-converting enzyme 2 (ACE2) might be activated following brain APA inhibition. We found that the intracerebroventricular (icv) administration...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (5): 683–686.
Published: 02 March 2021
... ( cferrari@wakehealth.edu ) 28 01 2021 12 02 2021 16 02 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 adipocytes angiotensin converting enzyme 2 heart failure vascular endothelial growth factor This work...
Articles
Clin Sci (Lond) (2021) 135 (2): 387–407.
Published: 29 January 2021
... and mRNA Human [ 40 ] Lungs ACE2 protein Rat [ 41 ] Vasa Vasorum ACE2 protein Human [ 42 ] Eye Mas1 protein and mRNA Mouse [ 43 ] Lungs Mas1 mRNA and protein Human [ 44 ] Brain Mas1 mRNA Rat [ 45 ] Abbreviations: ACE-2, angiotensin-converting enzyme 2; Mas1, Mas1...
Articles
Clin Sci (Lond) (2021) 135 (2): 367–385.
Published: 27 January 2021
.../progenitor cells have the potential of revascularization; however, diabetes attenuates vasoreparative functions. Angiotensin-converting enzyme 2 (ACE2) is the vasoprotective enzyme of renin–angiotensin system in contrast with the canonical angiotensin-converting enzyme (ACE). The present study tested...
Articles
Clin Sci (Lond) (2020) 134 (23): 3229–3232.
Published: 11 December 2020
...Michael Bader; Anthony J. Turner; Natalia Alenina This Editorial, written by Guest Editors Professor Michael Bader, Professor Anthony J. Turner and Dr Natalia Alenina, proudly introduces the Clinical Science -themed collection on angiotensin-converting enzyme 2 (ACE2), a multifunctional protein...
Articles
Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Published: 07 December 2020
...Fiona J. Warner; Harinda Rajapaksha; Nicholas Shackel; Chandana B. Herath Twenty years ago, the discovery of angiotensin-converting enzyme 2 (ACE2) was an important breakthrough dramatically enhancing our understanding of the renin–angiotensin system (RAS). The classical RAS is driven by its key...
Articles
Clin Sci (Lond) (2020) 134 (23): 3063–3078.
Published: 02 December 2020
...Thiago Verano-Braga; Ana Luiza Valle Martins; Daisy Motta-Santos; Maria José Campagnole-Santos; Robson Augusto Souza Santos In 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin...
Articles
Clin Sci (Lond) (2020) 134 (22): 3047–3062.
Published: 24 November 2020
...Koichi Yamamoto; Hikari Takeshita; Hiromi Rakugi Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin–angiotensin system (RAS), ACE2 cleaves angiotensin II (Ang II) into angiotensin 1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (22): 2987–3006.
Published: 19 November 2020
...). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . angiotensin converting enzyme 2 AT2 receptor COVID-19 inflammation The discovery in 2003...
Articles
Clin Sci (Lond) (2020) 134 (21): 2851–2871.
Published: 04 November 2020
... inhibitor angiotensin converting enzyme 2 COVID-19 metalloproteases Regulatory peptides control various physiological processes ranging from fertilisation and development to immunity and nervous system function. Active peptides are formed from precursors and are degraded by peptidases after...
Articles
Clin Sci (Lond) (2020) 134 (21): 2823–2833.
Published: 03 November 2020
... of inflammatory bowel disease (IBD). amino acid transporters angiotensin converting enzyme 2 kidney tubule small intestine ACE2 is expressed in a wide variety of human tissues with highest levels found in small intestine, kidney proximal tubule, testes, and the gallbladder [ 1 , 2 ]. The small...
Articles
Clin Sci (Lond) (2020) 134 (21): 2791–2805.
Published: 02 November 2020
... ]. Correspondence: Daniel Batlle ( d-batlle@northwestern.edu ) 04 09 2020 14 10 2020 16 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 angiotensin converting enzyme 2 COVID-19 renin-angiotensin system SARS-CoV-2...
Articles
Clin Sci (Lond) (2020) 134 (18): 2489–2501.
Published: 29 September 2020
... Press Limited on behalf of the Biochemical Society 2020 angiotensin converting enzyme 2 coronavirus COVID-19 metalloproteases renin-angiotensin system SARS The generation of Ace2 knockout mice strengthened the importance of ACE2 in cardiac function [ 53 ]. The Ace2 knockout mice...
Articles
Clin Sci (Lond) (2020) 134 (17): 2319–2336.
Published: 09 September 2020
...) by promoting angiotensin converting enzyme 2 ( ACE2 ) transcription leading to increased ACE2 protein and activity while also antagonizing the effects of angiotensin II (Ang II). Apelin modulation of the RAS by increasing ACE2 action is limited due to its rapid degradation by proteases, including ACE2...
Articles
In Collection
Coronavirus
Clin Sci (Lond) (2020) 134 (5): 543–545.
Published: 13 March 2020
..., 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought...
Articles
Clin Sci (Lond) (2019) 133 (18): 2005–2018.
Published: 24 September 2019
... 13 09 2019 Angiotensin 1-7 Angiotensin Converting Enzyme 2 Mas receptor Muscle weakness osteoporosis CNF is a hallmark of muscle regeneration but is also associated with muscle aging [ 15 , 18 ]. We previously found that CNFs increased in 25-month-old ACE2KO mice compared...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (1): 55–74.
Published: 08 January 2019
... ( mchappel@wakehealth.edu ) 03 08 2018 20 11 2018 03 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 angiotensin converting enzyme 2 angiotensin-(1-7) ACE fetal programming In parallel with the development...
Includes: Supplementary data