...T. Ogihara; T. Hata; Anna Maruyama; H. Mikami; M. Nakamaru; T. Mandai; Y. Kumahara 1. To characterize the renin-angiotensin-aldosterone system in elderly hypertensive patients, an angiotensin II antagonist, [Sar 1 ,Ile 8 ]angiotensin II, was infused into individuals 60 years old and older...

... treatment. © 1978 The Biochemical Society and the Medical Research Society 1978 angiotensin II angiotensin II antagonist hypertension renin saralasin Clinical Science and Molecular Medicine (1978) 55,319s-321s Renin-angiotensin system in mild essential hypertension. The functional...

... angiotensin II antagonist hypertension nephrectomy renin Clinical Science and Molecular Medicine (1978) J4,633-637 Effect of administration of Sar1-Ala8-angiotensin II during the development and maintenance of renal hypertension in the rat M. FERNANDES, R. FIORENTINI, G. ONESTI, G. BELLINI*, A. B. GOULD...

.... Saralasin has a protective effect against glycerol-induced acute renal failure only when volume is replaced concomitantly. 16 6 1977 13 12 1977 © 1978 The Biochemical Society and the Medical Research Society 1978 angiotensin II antagonist glycerol-induced acute renal failure renin...

...N. C. Trippodo; J. E. Hall; T. E. Lohmeier; A. C. Guyton 1. The intrarenal role of angiotensin II in controlling sodium excretion was examined in anaesthetized, dehydrated dogs by infusing the angiotensin II antagonist Sar 1 -Ile 8 -angiotensin II directly into the renal artery. Comparisons were...

... of the specific competitive angiotensin II antagonist Sar 1 -Ala 8 -angiotensin II (P113). 2. The P113-induced fall of the blood pressure did correlate with the log PRA ( r = 0·888, P < 0001). This correlation was found irrespective of different types of hypertension and treatment schedules. 3. During volume...

...H. Thurston; J. D. Swales 1. Infusion of angiotensin II antagonist failed to restore the blood pressure of short-term Goldblatt 2-kidney hypertensive rats to normal levels before and after sodium restriction. 2. The blood pressure of both normal and sodium-restricted Goldblatt 2-hypertensive rats...

... ‘natural’ substrate and is subsequently converted into angiotensin II. © 1975 The Biochemical Society and the Medical Research Society 1975 angiotensin II antagonist converting enzyme inhibitor isolated rat kidney plasma renin substrate renal haemodynamics tetradecapeptide renin substrate...

... occurred when animals which had been pretreated with angiotensin II antiserum were infused with renin. 3. Infusion of an angiotensin II antagonist (1-sarcosine-8-alanine angiotensin II) restored the blood pressure of both groups of animals to normal. 4. These observations support the hypothesis that renin...