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Keywords: angiotensin
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Clin Sci (Lond) (2021) 135 (14): 1727–1731.
Published: 22 July 2021
...Edwyn O. Cruz-López; Estrellita Uijl; A.H. Jan Danser Although the existence of a brain renin–angiotensin system (RAS) had been proposed five decades ago, we still struggle to understand how it functions. The main reason for this is the virtual lack of renin at brain tissue sites. Moreover...
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Clin Sci (Lond) (2021) 135 (6): 725–730.
Published: 17 March 2021
...Alberto Javier Ramos Epilepsy is a highly prevalent neurological disease and anti-epileptic drugs (AED) are almost the unique clinical treatment option. A disbalanced brain renin–angiotensin system (RAS) has been proposed in epilepsy and several reports have shown that angiotensin II (Ang II...
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Coronavirus
Clin Sci (Lond) (2021) 135 (3): 465–481.
Published: 01 February 2021
...Maria A. Pedrosa; Rita Valenzuela; Pablo Garrido-Gil; Carmen M. Labandeira; Gemma Navarro; Rafael Franco; Jose L. Labandeira-Garcia; Ana I. Rodriguez-Perez The key link between renin–angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin-converting enzyme 2), which acts as a double-edged sword...
Includes: Supplementary data
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In Collection
Coronavirus
Clin Sci (Lond) (2020) 134 (7): 747–750.
Published: 07 April 2020
...Rhian M. Touyz; Hongliang Li; Christian Delles Angiotensin converting enzyme 2 (ACE2) is the major enzyme responsible for conversion of Ang II into Ang-(1-7). It also acts as the receptor for severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2, which causes Co rona vi rus D isease (COVID...
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Clin Sci (Lond) (2018) 132 (16): 1837–1853.
Published: 30 August 2018
... dehydrogenase (GAPDH, mouse monoclonal, 1/10000, Santa Cruz, Cat sc32233) were used for the aortic wall and circulating leukocytes and LV, respectively. angiotensin ERM hypertension MYPT1 Rho kinase reverse remodeling Asymptomatic organ damage due to cardiovascular remodeling and continuing...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (10): 1055–1067.
Published: 25 May 2018
.... Consequently, there remains a need for agents that will protect neurones against death following ischemic stroke. Here, we evaluate angiotensin II (Ang II) type 2 (AT 2 ) receptor agonists as a possible therapeutic target for this disease. We first provide an overview of stroke epidemiology, pathophysiology...
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Clin Sci (Lond) (2018) 132 (8): 839–850.
Published: 30 April 2018
...Estrellita Uijl; Liwei Ren; A.H. Jan Danser The existence of a so-called brain renin-angiotensin system (RAS) is controversial. Given the presence of the blood–brain barrier, angiotensin generation in the brain, if occurring, should depend on local synthesis of renin and angiotensinogen. Yet...
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Clin Sci (Lond) (2016) 130 (10): 773–783.
Published: 01 April 2016
... of this article is to review the available literature regarding sex differences in T-cells in hypertension followed by highlighting the potential pathways that may result in sex-specific effects on T-cell activation and differentiation. angiotensin blood pressure regulation inflammation sex differences...
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Clin Sci (Lond) (2014) 126 (3): 195–205.
Published: 01 October 2013
...Robert W. Regenhardt; Douglas M. Bennion; Colin Sumners The goal of the present review is to examine the evidence for beneficial actions of manipulation of the RAS (renin–angiotensin system) in stroke, with particular focus on Ang-(1–7) [angiotensin-(1–7)] and its receptor Mas. The RAS appears...
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Clin Sci (Lond) (2012) 123 (9): 531–543.
Published: 13 July 2012
... diseases in humans that appear to have distinct pathologies and mechanisms. Despite this divergence, there are numerous and consistent demonstrations that overactivation of the RAS (renin–angiotensin system) promotes both AAAs and TAAs in animal models. For example, in mice, both AAAs and TAAs are formed...
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Clin Sci (Lond) (2012) 123 (8): 519–529.
Published: 03 July 2012
...Chris Tikellis; Raelene Pickering; Despina Tsorotes; Xiao-Jun Du; Helen Kiriazis; Thu-Phuc Nguyen-Huu; Geoffrey A. Head; Mark E. Cooper; Merlin C. Thomas Local and systemic AngII (angiotensin II) levels are regulated by ACE2 (angiotensin-converting enzyme 2), which is reduced in diabetic tissues...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 123 (6): 333–346.
Published: 29 May 2012
...Danielle Zimmerman; Kevin D. Burns Ang-(1–7) [angiotensin-(1–7)] is a biologically active heptapeptide component of the RAS (renin–angiotensin system), and is generated in the kidney at relatively high levels, via enzymatic pathways that include ACE2 (angiotensin-converting enzyme 2...
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Clin Sci (Lond) (2012) 123 (4): 205–223.
Published: 24 April 2012
...Matej Durik; Bruno Sevá Pessôa; Anton J. M. Roks Modulation of the RAS (renin–angiotensin system), in particular of the function of the hormones AngII (angiotensin II) and Ang-(1–7) [angiotensin-(1–7)], is an important target for pharmacotherapy in the cardiovascular system. In the classical view...
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Clin Sci (Lond) (2009) 116 (4): 301–314.
Published: 15 January 2009
...Cheng Qian; Regien G. Schoemaker; Wiek H. van Gilst; Anton J. M. Roks Intervention in the RAAS (renin–angiotensin–aldosterone system) is one of the leading pharmacotherapeutic strategies, among others, used for the treatment of cardiovascular disease to improve the prognosis after myocardial...
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Clin Sci (Lond) (2004) 107 (2): 145–147.
Published: 27 July 2004
...Jean-Baptiste MICHEL In the present issue of Clinical Science , Brown and co-workers report preliminary results of Ang I (angiotensin I) immunization in humans. They demonstrate the presence of antibodies in human plasma and report that the procedure is well tolerated, but the blood pressure does...
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Clin Sci (Lond) (2002) 103 (1): 101–106.
Published: 20 June 2002
...Sabine HERTWIG; Henry VÖLZKE; Daniel M. ROBINSON; Wolfgang MOTZ; Rainer RETTIG The present study was designed to prospectively test the hypothesis that gene polymorphisms of the renin-angiotensin system are associated with recurrent restenosis after repeated percutaneous transluminal coronary...
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Clin Sci (Lond) (2001) 101 (6): 559–566.
Published: 24 October 2001
...J. C. VAILE; S. CHOWDHARY; F. OSMAN; H. F. ROSS; J. FLETCHER; W. A. LITTLER; J. H. COOTE; J. N. TOWNEND The objective of the present study was to determine the autonomic effects of angiotensin II (AT 1 ) receptor blocker therapy in heart failure. In a randomized double-blind cross-over study, we...
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Clin Sci (Lond) (2001) 100 (5): 481–492.
Published: 27 March 2001
...Diem T. DINH; Albert G. FRAUMAN; Colin I. JOHNSTON; Maurice E. FABIANI Angiotensin II (Ang II) is a multi-functional hormone that plays a major role in regulating blood pressure and cardiovascular homoeostasis. The actions of Ang II are mediated by at least two receptor subtypes, designated AT 1...
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Clin Sci (Lond) (1995) 89 (3): 273–276.
Published: 01 September 1995
...Evelyn A. Millar; Robert M. Angus; Jane E. Nally; Robin Clayton; Neil C. Thomson 1. We have reported that the renin-angiotensin system is activated in acute asthma, and also by high-dose nebulized β 2 -agonists. The contribution of other possible stimuli such as hypoxia is unknown. The present...
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Clin Sci (Lond) (1990) 79 (5): 523–530.
Published: 01 November 1990
...James J. Morton; Elisabeth C. Beattie; Sheila A. Griffin; Fiona MacPherson; Fiona Lyall; Domenico Russo 1. Cardiovascular reactivity, blood vessel morphology, blood pressure and the activity of the renin—angiotensin system were determined in the 3-week-old spontaneously hypertensive (SHR), Wistar...
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Clin Sci (Lond) (1990) 79 (5): 505–511.
Published: 01 November 1990
... hypertension are able to stimulate release of active renin. 2. Active plasma renin concentration was measured as the generation of angiotensin I at physiological pH in the presence of excess renin substrate, and total renin concentration was determined in the same way after trypsin activation. Inactive plasma...
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Clin Sci (Lond) (1984) 67 (3): 365–368.
Published: 01 September 1984
...Theodore A. Kotchen; Tam T. Guyenne; Pierre Corvol; Joel Menard 1. Plasma renin reactivity (PRR) is the rate of angiotensin I production after addition of renin to plasma, minus endogenous renin activity. PRR is increased in plasma of patients with renal failure compared with that of normal...
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Clin Sci (Lond) (1982) 63 (s8): 223s–225s.
Published: 01 October 1982
... with essential hypertension, whereas the renal response was unchanged in normotensive subjects. angiotensin converting enzyme essential hypertension volume expansion © 1982 The Biochemical Society and the Medical Research Society 1982 Clinical Science (1982) 63 ,223~225s 223s Effect of captopril...
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Clin Sci (Lond) (1982) 62 (2): 169–176.
Published: 01 February 1982
...R. A. Banks; L. J. Beilin; J. Soltys; L. Davidson 1. The role of prostaglandins and angiotensin II in blood flow regulation was studied in conscious rabbits subjected to mild haemorrhage. 2. Haemorrhage caused a 13% fall in arterial pressure and a 21% fall in cardiac output, responses which were...
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Clin Sci (Lond) (1981) 61 (s7): 285s–287s.
Published: 01 December 1981
... circulating angiotensin II may be one of the determinants of the natriuretic response to volume expansion in normal man. © 1981 The Biochemical Society and the Medical Research Society 1981 angiotensin captopril converting enzyme angiotensin II volume expansion ChicalScience (1981) 6 1 , 2 8 5...
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Clin Sci (Lond) (1981) 61 (s7): 245s–247s.
Published: 01 December 1981
... specifically bound 125 I-labelled angiotensin II (ANG II) with high affinity ( K d ≅ 1.0 nmol/l). Saralasin ANG III and ANG II competed with tracer for ligand whereas ANG I did so less effectively and neurotensin not at all. 3. These results suggest the presence of specific nuclear intracellular ANG II...
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Clin Sci (Lond) (1981) 61 (s7): 249s–251s.
Published: 01 December 1981
...P. Brecher; Vandana Hingorani; Karen Reininga; A. V. Chobanian 1. Angiotensin-converting enzyme (ACE) activity was threefold greater in isolated cerebral microvessels obtained from rabbit brain than rat brain. 2. ACE activity was distributed throughout the cerebral microvasculature, since...
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Clin Sci (Lond) (1981) 61 (s7): 265s–268s.
Published: 01 December 1981
... that the renin—angiotensin system may interact with the pituitary—adrenal axis to influence circulating levels of cortisol. This effect might conceivably contribute to the pathogenesis of certain high-renin states. © 1981 The Biochemical Society and the Medical Research Society 1981 adrenocorticotrophin...
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Clin Sci (Lond) (1981) 61 (5): 535–539.
Published: 01 November 1981
...J. P. M. Finberg; H. A. Syrop; O. S. Better 1. The pressor and heart rate response to angiotensin II, noradrenaline, isoprenaline, tyramine and β-phenylethylamine were examined before and after bile-duct ligation in conscious trained dogs. 2. The pressor response to angiotensin II was markedly...
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Clin Sci (Lond) (1981) 61 (5): 553–557.
Published: 01 November 1981
...P. C. Wong; B. G. Zimmerman 1. Successive infusions of SQ 20 881 given intra-arterially (i.a.) to the kidney at 0.4 and 0.8 μg min −1 kg −1 for 50 min each did not alter renal blood flow and renal vascular resistance in spite of 40–47% blockade of the angiotensin I (ANG I i.a.)-induced...
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