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Keywords: angiogenesis
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Articles
Clin Sci (Lond) (2021) 135 (24): 2709–2728.
Published: 15 December 2021
... is accompanied by gut dysbiosis whereas dysbiosis induces liver fibrosis, splanchnic angiogenesis and dysregulated vascular tones vice versa , making portal hypertension aggravated. It has been proved that intestinal microbiota transplantation alleviates dysbiosis. Nevertheless, the influences of microbiota...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (16): 1981–1997.
Published: 20 August 2021
..., we analyze some emerging circulating biomarkers related to inflammation, ECM and lipid infiltration, angiogenesis, metalloproteinases and microRNA (miRNA), as possible diagnostic and prognostic indicators of plaque vulnerability. Correspondence: Silvana Balzan ( balzan@ifc.cnr.it ) 20 04...
Articles
Clin Sci (Lond) (2021) 135 (9): 1127–1143.
Published: 11 May 2021
...Shuhan Ji; Diane Gumina; Kathryn McPeak; Radu Moldovan; Miriam D. Post; Emily J. Su Pregnancies complicated by severe, early-onset f etal g rowth r estriction with a bnormal D oppler v elocimetry (FGRadv) have a sparse villous vascular tree secondary to impaired angiogenesis. As endothelial cell...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (18): 2503–2520.
Published: 29 September 2020
... antibodies that target angiogenesis by inhibiting vascular endothelial growth factor (VEGF) signaling pathways. Despite their anti-angiogenic and anti-cancer benefits, the use of VEGF inhibitors (VEGFi) and other tyrosine kinase inhibitors (TKIs) has been hampered by potent vascular toxicities especially...
Articles
Clin Sci (Lond) (2020) 134 (13): 1613–1629.
Published: 30 June 2020
... The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . angiogenesis c-reactive protein diabetic retinopathy inflammation oxidative stress...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (11): 1219–1242.
Published: 05 June 2020
... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cirrhosis diabetes angiogenesis portosystemic collaterals insulin The authors of the original article “Insulin reverses the major portal hypertension-related derangements in rats...
Articles
Clin Sci (Lond) (2019) 133 (14): 1603–1607.
Published: 22 July 2019
... of the obesity/T2D model warrants further consideration. This is an interesting study from the perspective of understanding the stroke pathology in T2D; however, the interaction of microvascular changes (including vascular modelling, angiogenesis), oxidative stress and insulin resistance (IR) associated with T2D...
Articles
Clin Sci (Lond) (2019) 133 (12): 1309–1320.
Published: 19 June 2019
...–mesenchymal transition, and suppression of inflammation and angiogenesis. In this article, we summarize the mechanisms and efficacy of nintedanib in the treatment of fibrotic diseases in animal models and clinical trials, provide an update on recent advances in the development of other novel antifibrotic...
Articles
Clin Sci (Lond) (2019) 133 (12): 1271–1280.
Published: 17 June 2019
... of the Biochemical Society 2019 angiogenesis hypoxia Mycobacterium tuberculosis vascular endothelial growth factor The conserved vascular pathologies of TB granulomas and tumours have also been well described, and open the door to ‘Robin Hood’ well-known vascular-targeting strategies from the cancer...
Articles
Clin Sci (Lond) (2019) 133 (9): 1115–1135.
Published: 14 May 2019
... factors) might help address this challenge. Anastomosis Angiogenesis Blood vessels Blood Blood-contacting surface Biomaterials Clinical Microfabrication Neovascularization Regenerative medicine Tissue engineering Scaffolds Stem cells Vascular disease Vascular cells Vascular tissue...
Articles
Clin Sci (Lond) (2019) 133 (8): 953–970.
Published: 29 April 2019
... harbors cancer-associated fibroblasts, leads to angiogenesis, fibrosis, immune evasion and neuropathic pain. Hedgehog-related genetic alterations occur frequently in basal cell carcinoma (BCC) (85%) and Sonic Hedgehog (SHH)-subgroup medulloblastoma (87%) and less frequently in breast cancer, colorectal...
Articles
Clin Sci (Lond) (2018) 132 (22): 2391–2405.
Published: 19 November 2018
...I-Fang Hsin; Hui-Chun Huang; Ching-Chih Chang; Shao-Jung Hsu; Fa-Yauh Lee; Teh-Ia Huo; Chiao-Lin Chuang; Ming-Chih Hou; Shou-Dong Lee Liver cirrhosis is accompanied by increased intrahepatic resistance and angiogenesis-related portosystemic collaterals formation. Diabetic patients suffer from...
Articles
Clin Sci (Lond) (2018) 132 (20): 2261–2267.
Published: 29 October 2018
.... Given the importance of ET-1 and CYR61 in contributing to angiogenesis, cell migration and extracellular matrix development, all of which is dysregulated in fibroids, we conducted the current study examining the impact of ET A receptor blockade on CYR61 production in the presence of hypoxia...
Articles
Clin Sci (Lond) (2018) 132 (6): 669–683.
Published: 26 March 2018
... splanchnic blood flow did not reduce during cirrhosis resolution. The extrahepatic pathological angiogenesis was not ameliorated (% of mesenteric window area: 1.2 ± 0.3, 7.3 ± 1.1, 8.3 ± 1.0, 11.3 ± 2.7). In collateral system, the shunting degree reduced while the vessels structure remained. The vascular...
Articles
Clin Sci (Lond) (2017) 131 (15): 1763–1780.
Published: 05 July 2017
...Mitra Farnoodian; Shoujian Wang; Joel Dietz; Robert W. Nickells; Christine M. Sorenson; Nader Sheibani Angiogenesis contributes to the pathogenesis of many diseases including exudative age-related macular degeneration (AMD). It is normally kept in check by a tightly balanced production of pro...
Articles
Clin Sci (Lond) (2017) 131 (12): 1225–1243.
Published: 31 May 2017
...Nikita Ved; Richard P. Hulse; Samuel M. Bestall; Lucy F. Donaldson; James W. Bainbridge; David O. Bates Diabetic retinopathy (DR) is one of the leading causes of blindness in the developed world. Characteristic features of DR are retinal neurodegeneration, pathological angiogenesis and breakdown...
Articles
Clin Sci (Lond) (2017) 131 (2): 159–168.
Published: 23 December 2016
... in the accumulation of pulmonary intravascular macrophages and angiogenesis, possibly by activating Akt and ERK, with additional regulation by TNF-α that enhanced pulmonary angiogenesis by directly acting on the pulmonary tissue. Finally, the present study may provide novel targets for the treatment of HPS...
Articles
Clin Sci (Lond) (2017) 131 (1): 87–103.
Published: 09 December 2016
...) receptor pathway, the angiopoietin (Ang)–Tie system is a second endothelial cell specific ligand–receptor signalling system necessary for embryonic cardiovascular and lymphatic development. The Ang–Tie system also regulates postnatal angiogenesis, vessel remodelling, vascular permeability and inflammation...
Articles
Clin Sci (Lond) (2017) 131 (1): 69–86.
Published: 09 December 2016
... been found with influences on vasoresponsiveness and angiogenesis. However, their relevant effects in liver cirrhosis have not been investigated. In the present study, liver cirrhosis was induced by common bile duct ligation (BDL) in Sprague–Dawley rats. In acute study, the results showed...
Articles
Clin Sci (Lond) (2016) 130 (14): 1269–1284.
Published: 13 June 2016
... that mice living under conditions that mimic THS exposure in humans display delayed wound closure, impaired collagen deposition, altered inflammatory response, decreased angiogenesis, microvessels with fibrin cuffs and a highly proteolytic wound environment. Moreover, THS-exposed mouse wounds have high...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (3): 127–150.
Published: 17 December 2015
... to manage PAD which can be applied to patients unlikely to benefit from interventional approaches. Many of the therapeutic agents successful in inducing angiogenesis and arteriogenesis in pre-clinical animal models of PAD have failed to have efficacy in human randomized control trials. One possible reason...
Articles
Clin Sci (Lond) (2015) 129 (12): 1173–1193.
Published: 11 November 2015
.... Correspondence: Professor Tiziana Crepaldi (email tiziana.crepaldi@unito.it ). 17 7 2015 21 9 2015 30 9 2015 © 2015 Authors; published by Portland Press Limited 2015 angiogenesis cardioprotection fibrosis HGF/Met immunomodulation regeneration Growth factors...
Articles
Clin Sci (Lond) (2015) 129 (12): 1115–1129.
Published: 22 October 2015
.../year in the U.S.A. alone, in addition to the morbidity and mortality that occur when the burns are extensive. We previously showed that insulin, when topically applied to skin excision wounds, accelerates re-epithelialization and stimulates angiogenesis. More recently, we developed an alginate sponge...
Articles
Clin Sci (Lond) (2015) 129 (3): 217–234.
Published: 08 May 2015
... that PECAM-1 and its isoforms play during angiogenesis, and its molecular mechanisms of action in the endothelium. In the endothelium, PECAM-1 not only plays a role as an adhesion molecule but also participates in intracellular signalling pathways which have an impact on various cell adhesive mechanisms...
Articles
Clin Sci (Lond) (2015) 129 (2): 147–158.
Published: 24 April 2015
.... It is imperative to explore novel remedies. Angiogenesis is a rate-limiting step in progression that explains neovessel formation for blood supply in the tumour microenvironment. Numerous studies indicate that EPCs (endothelial progenitor cells) promote angiogenesis and contribute to tumour growth. bFGF (basic...
Articles
Clin Sci (Lond) (2015) 128 (11): 805–823.
Published: 19 March 2015
..., including neuroprotection, angiogenesis, fibrogenesis and inflammation. The present review summarizes the temporal and spatial distribution patterns of PEDF in a variety of developing and adult organs, and discusses its functions in maintaining physiological homoeostasis. The major focus of the present...
Articles
Clin Sci (Lond) (2014) 127 (1): 47–55.
Published: 10 March 2014
... Kisspeptin-10 suppressed endothelial cell growth in both in vivo and in vitro studies. The adverse effect of kisspeptin on endothelial cells was attributable, at least in part, to the induction of cellular senescence. angiogenesis cellular senescence endothelial cell kisspeptin...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (11): 775–791.
Published: 13 February 2014
... activation, inflammation, fibrosis and angiogenesis. Therefore inhibiting multiple pathological processes using a single drug can be an effective choice to curb the progression of HCC. In the present study, we used the mTOR inhibitor everolimus to observe its effect on the in vitro activation of hepatic...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (9): 631–632.
Published: 14 January 2014
... hypertension by decreasing both hepatic resistance and splanchnic hyperdynamic circulation. The main underlying mechanism of the benefits of GTPs appears related to the down-regulation of splanchnic angiogenesis. The present study adds further evidence supporting the potential of natural compounds...
Articles
Clin Sci (Lond) (2014) 126 (9): 633–644.
Published: 14 January 2014
...Shao-Jung Hsu; Sun-Sang Wang; I-Fang Hsin; Fa-Yauh Lee; Hui-Chun Huang; Teh-Ia Huo; Wen-Shin Lee; Han-Chieh Lin; Shou-Dong Lee Abnormal angiogenesis in liver cirrhosis often leads to severe complications such as variceal haemorrhage and encephalopathy. Furthermore, splanchnic angiogenesis elevates...
Articles
Clin Sci (Lond) (2013) 125 (12): 575–585.
Published: 02 August 2013
... days after skin injury for measurements of VEGF mRNA and protein synthesis, SDF-1α (stromal cell-derived factor-1α) mRNA and eNOS (endothelial NO synthase) expression. Furthermore, we evaluated wound-breaking strength, histological changes, angiogenesis and vasculogenesis at day 12. Diabetic animals...
Articles
Clin Sci (Lond) (2013) 124 (7): 457–466.
Published: 07 December 2012
... abnormal pulmonary vasodilatation and/or angiogenesis. In the present study, we evaluated anti-angiogenesis therapy using sorafenib in experimental HPS animals. HPS was induced by CBDL (common bile duct ligation) in rats. A 2-week 10 mg·(kg of body weight) −1 ·day −1 treatment regimen of sorafenib...
Articles
Clin Sci (Lond) (2012) 123 (4): 241–249.
Published: 24 April 2012
... in a hindlimb ischaemia model. We sought to determine whether donepezil affects angiogenesis. A hindlimb ischaemia model was created by unilateral femoral artery ligation. Blood flow recovery examined by laser Doppler perfusion imaging and capillary density by immunohistochemical staining of CD31-positive cells...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (3): 147–159.
Published: 05 April 2012
... angiogenesis. In the present study, we have investigated the effect of cilostazol in promoting angiogenesis and vasculogenesis in a hindlimb ischaemia model and have also examined its potential mechanism of action in vitro and in vivo . We found that cilostazol treatment significantly increased colony...
Articles
Clin Sci (Lond) (2012) 122 (10): 449–465.
Published: 20 January 2012
... with this, we found that DMXAA, 2-MeXAA and 6-MeXAA were able to block angiogenesis in zebrafish embryos and also inhibit VEGFR2 signalling in HUVECs (human umbilical vein endothelial cells). Taken together, these results indicate that at least part of the effects of DMXAA are due to it acting as a multi-kinase...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 122 (2): 43–52.
Published: 20 September 2011
... to be implemented in the diagnostic algorithm of pre-eclampsia. In the present review, we aim to provide an overview of the vast literature on angiogenesis and anti-angiogenesis factors in pre-eclampsia that have been published over the last decade. We introduce work from basic research groups who have focused...
Articles
Clin Sci (Lond) (2011) 121 (12): 555–564.
Published: 22 August 2011
..., was evaluated. We found that GV was significantly different between S and V groups, whereas no significant difference in the mean glycaemic values was detected. Laser Doppler perfusion imaging and histological analyses revealed that the ischaemia-induced angiogenesis was significantly impaired in V mice...
Articles
Clin Sci (Lond) (2011) 120 (12): 493–504.
Published: 01 March 2011
... 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis atherosclerosis bilirubin cardiovascular disease haem oxygenase-1 (HO-1) vascular repair HO (haem oxygenase) was first discovered in the late 1960s to catalyse the rate-limiting step of haem...
Articles
Clin Sci (Lond) (2011) 120 (8): 307–319.
Published: 22 December 2010
... (angiotensin-converting enzyme inhibitors). A recent meta-analysis revealed an association between ARBs and tumour development, possibly due to enhancement of angiogenesis. However, published evidence is conflicting on the effects of ARBs on angiogenesis or the expansion of the existing vascular network. ARBs...
Articles
Clin Sci (Lond) (2010) 118 (8): 507–518.
Published: 26 January 2010
... expression, mitochondrial biogenesis and angiogenesis. AMPK mediates these processes primarily through alterations in gene expression. The present review examines the role of AMPK in skeletal muscle transcription and provides an overview of the known transcriptional substrates mediating the effects of AMPK...
Articles
Clin Sci (Lond) (2009) 117 (11): 387–395.
Published: 14 September 2009
...Jingzhou Chen; Hui Yu; Weihua Song; Kai Sun; Yan Song; Kejia Lou; Tao Yang; Yinhui Zhang; Rutai Hui Angiopoietin-2 is an important mediator of angiogenesis, and we hypothesized that genetic variants of ANGPT2 (the gene encoding angiopoietin-2) would result in abnormal angiogenesis and contribute...
Articles
Clin Sci (Lond) (2009) 117 (5): 201–208.
Published: 03 August 2009
...Mei Shen; Jing Gao; Jianan Li; Juan Su The present study was designed to test the hypothesis that local exercise of a normal limb can promote angiogenesis in a pathological ischaemic limb. New Zealand White rabbits underwent left femoral artery ligation (Lig) and electrode implantation on the right...
Articles
Clin Sci (Lond) (2009) 117 (3): 95–109.
Published: 02 July 2009
... of protective ER (endoplasmic reticulum) stress chaperones by MCP-1. Under sustained ER stress caused by chronic exposure to MCP-1, the protection would break down resulting in the development of heart failure. MCP-1 is also involved in ischaemic angiogenesis. The recent advances in our understanding...
Articles
Clin Sci (Lond) (2009) 116 (7): 575–583.
Published: 02 March 2009
... pathways. Correspondence: Dr Hang Chang (email m002018@ms.skh.org.tw ). 10 6 2008 23 9 2008 26 9 2008 26 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis discoidin domain receptor 2 (DDR2) hyperbaric oxygen matrix...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2009) 116 (3): 231–232.
Published: 08 January 2009
..., such as VEGF (vascular endothelial growth factor) or PlGF (placental growth factor), and factors inhibiting angiogenesis, such as sFlt1 (soluble fms-like tyrosine kinase 1) and sEng (soluble endoglin), are closely related to the pathogenesis of pre-eclampsia. In the present issue of Clinical Science , Bills...
Articles
Clin Sci (Lond) (2009) 116 (3): 265–272.
Published: 08 January 2009
... factor) pre-mRNA, inhibits VEGF 165 -mediated vasodilation and angiogenesis, but has not been quantified in pregnancy. ELISAs were used to measure means±S.E.M. plasma VEGF 165 b, sEng (soluble endoglin) and sFlt-1 (soluble fms-like tyrosine kinase-1). At 12 weeks of gestation, the plasma VEGF 165 b...
Articles
Clin Sci (Lond) (2008) 114 (12): 707–718.
Published: 14 May 2008
...Alessandra Bitto; Letteria Minutoli; Maria Rosaria Galeano; Domenica Altavilla; Francesca Polito; Tiziana Fiumara; Margherita Calò; Patrizia Lo Cascio; Lorena Zentilin; Mauro Giacca; Francesco Squadrito Ang-1 (angiopoietin-1) improves the ineffective angiogenesis and impaired wound healing...
Articles
Clin Sci (Lond) (2008) 114 (10): 643–650.
Published: 14 April 2008
... monocytes) or SDF-1 (for THP-1 cells) was considered as chemokine-dependent. 25 9 2007 15 11 2007 19 12 2007 19 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 angiogenesis atherosclerosis cell migration chemokine cytokine embryogenesis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2008) 114 (7): 467–477.
Published: 29 February 2008
...Pamela Romanque; Anne-Christine Piguet; Jean-François Dufour The process of blood vessel proliferation, known as angiogenesis, is essential during embryonic development and organogenesis. In adult life, it participates in normal tissue repair, wound healing, and cyclical growth of the corpus luteum...
Articles
Clin Sci (Lond) (2007) 112 (12): 607–616.
Published: 14 May 2007
... investigated the effect of ONO-1301, a synthetic prostacyclin agonist with thromboxane-synthase-inhibitory activity, on expression of endogenous growth factors and angiogenesis. ONO-1301 induced secretion of HGF (hepatocyte growth factor) and VEGF (vascular endothelial growth factor) from cultured normal human...