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Keywords: amino acids
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Clin Sci (Lond) (2005) 108 (3): 185–194.
Published: 18 February 2005
...Philip NEWSHOLME; Lorraine BRENNAN; Blanca RUBI; Pierre MAECHLER Specific amino acids are now known to acutely and chronically regulate insulin secretion from pancreatic β-cells in vivo and in vitro . Understanding the molecular mechanisms by which amino acids regulate insulin secretion may...
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Clin Sci (Lond) (1997) 92 (5): 493–496.
Published: 01 May 1997
... acids, lactate and pyruvate change during the menstrual cycle. 2. Microdialysis was performed twice during the menstrual cycle in eight healthy women, in the breast and subcutaneous fat. Amino acids, lactate and pyruvate were analysed by HPLC. 3. None of the women showed any complications...
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Clin Sci (Lond) (1996) 91 (2): 121–130.
Published: 01 August 1996
... radicals and other oxidant molecules and remove nutrients from the bloodstream which might assist multiplication of pathogens. Amino acids, released by increased proteolysis in muscle, skin and bone, provide substrates for the synthesis of cells and soluble mediators by the immune system. Glutamine...
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Clin Sci (Lond) (1995) 88 (6): 687–693.
Published: 01 June 1995
... to the metabolic demands. In addition to allosteric regula- tion of enzyme activities, the actual flux rate will be Key words: amino acids, anaplerosir, citrate, fumarate, glycogen storage disease, glycogenolyris, malate, metabolic control, muscle contraction, oxidative metabolism. Abbreviations: HWR. high work...
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Clin Sci (Lond) (1993) 85 (6): 709–712.
Published: 01 December 1993
...Vince Brawley; Jatinder Bhatia; Warren B. Karp 1. Parenteral amino acid solutions undergo photo-oxidation, which may be an important factor in total parenteral nutrition-associated hepatic dysfunction. Light-exposed parenteral solutions containing amino acids, in addition to vitamins and trace...
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Clin Sci (Lond) (1993) 85 (4): 437–444.
Published: 01 October 1993
...Sylvia Heeneman; Nicolaas E. P. Deutz 1. It has recently been suggested that glutamine may be a conditionally essential nutrient rather than a non-essential amino acid. Therefore, administration of methionine sulphoximine was used to create a model of decreased arterial glutamine concentrations...
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Clin Sci (Lond) (1993) 85 (3): 337–342.
Published: 01 September 1993
... amino acids) was investigated during experimental inflammation induced by injection of human recombinant interleukin-1β or turpentine in young male rats. 2. Interleukin-1β induced a consistent increase of 3°C in body temperature between 3 and 5 h after injection, whereas turpentine induced a delayed...
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Clin Sci (Lond) (1993) 84 (2): 177–183.
Published: 01 February 1993
... amino acid. The alternative formula is: where E B and E F are the enrichments of bound and free amino acid, respectively (atom per cent excess), and C=1-( E F / E I ), where E I is the enrichment of the infusate. This approach defines the lowest possible value for the fractional synthesis rate...
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Clin Sci (Lond) (1991) 81 (3): 427–432.
Published: 01 September 1991
...A. A. El Sayed; J. Haylor; A. M. El Nahas 1. The response of the isolated rat kidney to a mixed amino acid solution was examined in the presence of three renal autacoid inhibitors, indomethacin (a cyclo-oxygenase inhibitor), sulpiride (a dopamine antagonist) and l -nitroarginine methyl ester...
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Clin Sci (Lond) (1991) 81 (2): 215–222.
Published: 01 August 1991
... of glutamine-enriched total parenteral nutrition is beneficial to septic rats and possibly to septic patients. 7 2 1991 4 3 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 amino acids glutamine metabolism muscle nitrogen balance parenteral nutrition sepsis...
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Clin Sci (Lond) (1991) 80 (5): 471–474.
Published: 01 May 1991
... of glutamate in each of 11 subjects. 3. In seven subjects, adipose tissue blood flow was measured and the measurements were continued for 6 h after eating a mixed meal. The pattern of amino acid metabolism across the adipose tissue was remarkably little disturbed after the meal, except for a short period...
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Clin Sci (Lond) (1990) 79 (4): 381–386.
Published: 01 October 1990
...A. A. El Sayed; J. Haylor; A. M. El Nahas 1. The direct effects of individual amino acids, including glycine (a neutral amino acid), l-glutamic acid (an acidic amino acid), l-leucine (a neutral, branched-chain amino acid) and l-arginine (a basic amino acid), on renal function were compared...
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Clin Sci (Lond) (1990) 79 (4): 331–337.
Published: 01 October 1990
...J. Bergström; P. Fürst; E. Vinnars 1. The effect of a protein-free meal and a protein-rich meal on the concentration of free amino acids in plasma and muscle tissue was studied in eight healthy subjects. The energy content of the protein-free meal was 3800 kJ. The protein-rich meal was identical...
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Clin Sci (Lond) (1990) 79 (2): 139–147.
Published: 01 August 1990
... in efflux and/or increased intracellular formation of glutamine and alanine. 15 11 1989 15 3 1990 26 3 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 amino acids glucocorticoids glutaminase glutamine glutamine synthetase metabolism muscle...
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Clin Sci (Lond) (1990) 78 (6): 613–619.
Published: 01 June 1990
... to be a fall in muscle protein synthesis, which is accompanied by an overall fall in whole-body protein turnover. 22 12 1989 16 1 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 amino acids cirrhosis leg muscle protein turnover stable-isotope tracers...
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Clin Sci (Lond) (1988) 75 (6): 637–640.
Published: 01 December 1988
...-eight patients with chronic leg ulcers were admitted to hospital for a minimum of 6 weeks bed-rest. During this time the ulcers were continuously irrigated by one of four test solutions. The solutions were: normal saline; a dilute amino acid solution isotonic with the normal saline; a hyperosmolar...
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Clin Sci (Lond) (1988) 74 (5): 539–545.
Published: 01 May 1988
...Hans Heindorff; Hendrik Vilstrup; Ditlev Bucher; Per Billesbølle; Vibeke Thygesen 1. The effect of elective, uncomplicated cholecystectomy on plasma clearances of amino acids and on amino acid-stimulated urea synthesis was investigated in 10 patients, pre-operatively and on the first post-operative...
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Clin Sci (Lond) (1986) 71 (4): 429–436.
Published: 01 October 1986
... on amino acid uptake and glucose disposal, three separate 120 min studies employing the euglycaemic insulin clamp technique (20, 80 and 200 m-units min −1 m −2 ) were performed on five ambulatory patients with myotonic dystrophy. The results were compared with findings obtained in identical studies in 21...
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Clin Sci (Lond) (1985) 68 (2): 151–157.
Published: 01 February 1985
...Richard T. Moxley; William Kingston; Robert C. Griggs 1. The concentration of amino acids in whole blood was measured before and during standard 5 h oral glucose tolerance testing in six male patients with myotonic dystrophy and five normal males. The plasma levels of insulin and glucose were also...
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Clin Sci (Lond) (1982) 62 (1): 83–91.
Published: 01 January 1982
... essential amino acids in the septic patients, but not in those with undernutrition, is consistent with the increased catabolic rate of sepsis. 5. However, the branched-chain amino acids, and lysine, threonine, arginine, and histidine, were present in lower concentrations than might be expected from...
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Clin Sci (Lond) (1981) 61 (6): 743–749.
Published: 01 December 1981
...D. E. L. Wilcken; Vatsala J. Gupta; A. K. Betts 1. Homocysteine which is formed during the metabolism of methionine is readily oxidized and is measured by the amino acid analyser as cysteine—homocysteine mixed disulphide and homocystine. We measured plasma amino acid concentrations after...
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Clin Sci (Lond) (1980) 59 (1): 19–27.
Published: 01 July 1980
...H. B. Stoner; K. N. Frayn; R. A. Little; C. J. Threlfall; D. W. Yates; R. N. Barton; D. F. Heath 1. Plasma concentrations of glucose, lactate, amino acids, non-esterified fatty acids, glycerol, ketone bodies, insulin and cortisol were measured in 43 elderly patients with hypothermia. In 15...
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Clin Sci (Lond) (1980) 58 (6): 507–515.
Published: 01 June 1980
... concentrations of metabolites and hormones in blood and urine nitrogen excretion in patients receiving (a) sodium chloride solution (saline), (b) 1.5 g of glucose day −1 kg −1 body weight, (c) 1.5 g of glucose day −1 kg −1 with insulin (0.56 unit day −1 kg −1 ) or (d) mixed amino acids (1.5 g day −1 kg −1...
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Clin Sci (Lond) (1979) 56 (6): 563–573.
Published: 01 June 1979
...H. B. Stoner; K. N. Frayn; R. N. Barton; C. J. Threlfall; R. A. Little 1. The plasma concentrations of glucose, lactate, amino acids, non-esterified fatty acids, glycerol, ketone bodies, ethanol, cortisol and insulin were measured in patients within a few hours of injury and before treatment...
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Clin Sci (Lond) (1979) 56 (5): 427–432.
Published: 01 May 1979
...P. Möller; J. Bergström; S. Eriksson; P. Fürst; K. Hellström 1. The concentrations of electrolytes and free amino acids in plasma and the quadriceps femoris muscle were studied in ten apparently healthy elderly men, 52–77 years of age. The results were compared with those previously recorded...
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Clin Sci Mol Med (1978) 54 (6): 589–593.
Published: 01 June 1978
...P. Richards Clinical Science and Molecular Medicine (1978), 54, 589-593 EDITORIAL REVIEW The metabolism and clinical relevance of the keto acid analogues of essential amino acids P. RICHARDS St George's Hospital and Medical School, London SfVll ORE Background Essential amino acids...
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Clin Sci Mol Med (1977) 53 (3): 215–220.
Published: 01 September 1977
... arginine remains unexplained. 24 11 1976 4 4 1977 © 1977 The Biochemical Society and the Medical Research Society 1977 alanine amino acids glutamine nitrogen steroids Clinical Science and Molecular Medicine (1977) 53,215-220. The role of alanine and glutamine in steroid...
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