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Keywords: amino acids
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Clin Sci (Lond) (2005) 108 (3): 185–194.
Published: 18 February 2005
...Philip NEWSHOLME; Lorraine BRENNAN; Blanca RUBI; Pierre MAECHLER Specific amino acids are now known to acutely and chronically regulate insulin secretion from pancreatic β-cells in vivo and in vitro . Understanding the molecular mechanisms by which amino acids regulate insulin secretion may...
Clin Sci (Lond) (2001) 101 (2): 159–168.
Published: 20 June 2001
...David E. FLEMING; Wilhelm VAN BRONSWIJK; Rosemary Lyons RYALL To assess the binding of individual amino acids to the principal calcium minerals found in human kidney stones, the adsorption of 20 amino acids on to calcium oxalate monohydrate, CaHPO 4 .2H 2 O, Ca 3 (PO 4 ) 2 and Ca 5 (PO 4 ) 3 OH...
Clin Sci (Lond) (1999) 97 (5): 547–555.
Published: 28 September 1999
... microflora in normal individuals. Correspondence : Professor Alan A. Jackson (e-mail iohn@soton.ac.uk ). 5 3 1999 4 6 1999 22 7 1999 The Biochemical Society and the Medical Research Society © 1999 1999 amino acids colon nitrogen protein stable isotopes urea...
Clin Sci (Lond) (1999) 97 (5): 557–567.
Published: 17 September 1999
...G. VAN HALL; B. SALTIN; A. J. M. WAGENMAKERS The aim of this study was to investigate whether prolonged one-leg knee-extensor exercise enhances net protein degradation in muscle with a normal or low glycogen content. Net amino acid production, as a measure of net protein degradation, was estimated...
Clin Sci (Lond) (1997) 92 (5): 493–496.
Published: 01 May 1997
... acids, lactate and pyruvate change during the menstrual cycle. 2. Microdialysis was performed twice during the menstrual cycle in eight healthy women, in the breast and subcutaneous fat. Amino acids, lactate and pyruvate were analysed by HPLC. 3. None of the women showed any complications...
Clin Sci (Lond) (1996) 91 (4): 431–439.
Published: 01 October 1996
...Eva Selldén; Robert Bränstróam; Tomas Brundin 1. Intravenous infusion of amino acid mixtures stimulates human oxidative heat production more effectively under general anaesthesia than in the unanaesthetized state. To analyse the splanchnic and extra-splanchnic regional distribution...
Clin Sci (Lond) (1996) 91 (4): 489–496.
Published: 01 October 1996
...Jesper Melchior Hansen; Niels Vidiendal Olsen; Paul Peter Leyssac 1. The nephrotoxic effects of cyclosporin A may diminish the ability of the transplanted kidney to increase the glomerular filtration rate and effective renal plasma flow during infusion of dopamine or amino acids. 2. The present...
Clin Sci (Lond) (1996) 91 (2): 121–130.
Published: 01 August 1996
... radicals and other oxidant molecules and remove nutrients from the bloodstream which might assist multiplication of pathogens. Amino acids, released by increased proteolysis in muscle, skin and bone, provide substrates for the synthesis of cells and soluble mediators by the immune system. Glutamine...
Clin Sci (Lond) (1996) 91 (1): 79–86.
Published: 01 July 1996
... 3 1996 © 1996 The Biochemical Society and the Medical Research Society 1996 S-adenosylhomocysteine S-adenosylmethionine amino acids blood homocysteine human metabolism 5-methyltetrahydrofolate Clinical Science (1996) 91, 79-86 (Printed in Great Britain) 79 Effect of methionine...
Clin Sci (Lond) (1995) 88 (6): 687–693.
Published: 01 June 1995
... rate in healthy subjects, and that the attenuated peak level in patients with McArdle's disease may be a limitation for aerobic energy transduction. © 1995 The Biochemical Society and the Medical Research Society 1995 amino acids anaplerosis citrate fumarate glycogen storage disease...
Clin Sci (Lond) (1994) 87 (5): 619–626.
Published: 01 November 1994
... for at least 10 days. Changes in amino acid and protein metabolism were studied in both phases. 2. Differences between this modified and the original zymosan model are a lower mortality (16%), which is limited to the first 36 critical hours, and the absence of signs of severe illness during the prolonged...
Clin Sci (Lond) (1994) 86 (5): 611–618.
Published: 01 May 1994
...EVA Selldén; Tomas Brundin; John Wahren 1. Intravenous infusion of amino acids stimulates energy expenditure and heat accumulation in normal man. To find out whether such stimulation also occurs during general anaesthesia, thermogenesis was measured in 21 patients before, during and after...
Clin Sci (Lond) (1993) 85 (6): 709–712.
Published: 01 December 1993
...Vince Brawley; Jatinder Bhatia; Warren B. Karp 1. Parenteral amino acid solutions undergo photo-oxidation, which may be an important factor in total parenteral nutrition-associated hepatic dysfunction. Light-exposed parenteral solutions containing amino acids, in addition to vitamins and trace...
Clin Sci (Lond) (1993) 85 (4): 437–444.
Published: 01 October 1993
...Sylvia Heeneman; Nicolaas E. P. Deutz 1. It has recently been suggested that glutamine may be a conditionally essential nutrient rather than a non-essential amino acid. Therefore, administration of methionine sulphoximine was used to create a model of decreased arterial glutamine concentrations...
Clin Sci (Lond) (1993) 85 (4): 445–449.
Published: 01 October 1993
... acidosis seems to be an important aetio-logical factor. 2. In uraemic patients abnormalities in blood amino acid profiles are present after a protein meal, suggesting impaired metabolism of ingested proteins. 3. This study demonstrates that acidosis induces changes in arterial amino acid profiles in fed...
Clin Sci (Lond) (1993) 85 (3): 337–342.
Published: 01 September 1993
... amino acids) was investigated during experimental inflammation induced by injection of human recombinant interleukin-1β or turpentine in young male rats. 2. Interleukin-1β induced a consistent increase of 3°C in body temperature between 3 and 5 h after injection, whereas turpentine induced a delayed...
Clin Sci (Lond) (1993) 84 (2): 177–183.
Published: 01 February 1993
... amino acid. The alternative formula is: where E B and E F are the enrichments of bound and free amino acid, respectively (atom per cent excess), and C=1-( E F / E I ), where E I is the enrichment of the infusate. This approach defines the lowest possible value for the fractional synthesis rate...
Clin Sci (Lond) (1992) 83 (5): 607–614.
Published: 01 November 1992
...N. E. P. Deutz; P. L. M. Reijven; G. Athanasas; P. B. Soeters 1. After operation, changes in nitrogen metabolism occur. Although increased flux of amino acids from peripheral to splanchnic organs after operation has been described, substrate utilization by the individual organs in the splanchnic...
Clin Sci (Lond) (1992) 82 (2): 199–203.
Published: 01 February 1992
...R. A. van Lingen; J. B. van Goudoever; I. H. T. Luijendijk; J. L. D. Wattimena; P. J. J. Sauer 1. We investigated the effects of starting amino acid administration on post-natal day 2 on protein turnover and nitrogen balance in appropriate-for-gestational-age, very-low-birth-weight infants...
Clin Sci (Lond) (1991) 81 (3): 427–432.
Published: 01 September 1991
...A. A. El Sayed; J. Haylor; A. M. El Nahas 1. The response of the isolated rat kidney to a mixed amino acid solution was examined in the presence of three renal autacoid inhibitors, indomethacin (a cyclo-oxygenase inhibitor), sulpiride (a dopamine antagonist) and l -nitroarginine methyl ester...
Clin Sci (Lond) (1991) 81 (2): 215–222.
Published: 01 August 1991
...-incorporation of amino acids (Preliminary experiments were performed to establish the effects of puromycin as appropriate). Incubations were terminated after 2 h as described above and the tyrosine concentration in the medium was determined as described previously [8]. In preliminary experiments, the release...
Clin Sci (Lond) (1991) 80 (5): 471–474.
Published: 01 May 1991
... of glutamate in each of 11 subjects. 3. In seven subjects, adipose tissue blood flow was measured and the measurements were continued for 6 h after eating a mixed meal. The pattern of amino acid metabolism across the adipose tissue was remarkably little disturbed after the meal, except for a short period...
Clin Sci (Lond) (1990) 79 (4): 331–337.
Published: 01 October 1990
...J. Bergström; P. Fürst; E. Vinnars 1. The effect of a protein-free meal and a protein-rich meal on the concentration of free amino acids in plasma and muscle tissue was studied in eight healthy subjects. The energy content of the protein-free meal was 3800 kJ. The protein-rich meal was identical...
Clin Sci (Lond) (1990) 79 (4): 381–386.
Published: 01 October 1990
...A. A. El Sayed; J. Haylor; A. M. El Nahas 1. The direct effects of individual amino acids, including glycine (a neutral amino acid), l-glutamic acid (an acidic amino acid), l-leucine (a neutral, branched-chain amino acid) and l-arginine (a basic amino acid), on renal function were compared...
Clin Sci (Lond) (1990) 79 (2): 139–147.
Published: 01 August 1990
... in efflux and/or increased intracellular formation of glutamine and alanine. 15 11 1989 15 3 1990 26 3 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 amino acids glucocorticoids glutaminase glutamine glutamine synthetase metabolism muscle...
Clin Sci (Lond) (1990) 78 (6): 613–619.
Published: 01 June 1990
... to be a fall in muscle protein synthesis, which is accompanied by an overall fall in whole-body protein turnover. 22 12 1989 16 1 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 amino acids cirrhosis leg muscle protein turnover stable-isotope tracers...
Clin Sci (Lond) (1990) 78 (5): 497–501.
Published: 01 May 1990
...N. V. Olsen; J. M. Hansen; S. D. Ladefoged; N. Fogh-Andersen; S. Levin Nielsen; P. P. Leyssac 1. Amino acids have been used to test renal reserve filtration capacity. Previous studies suggest that amino acids increase glomerular filtration rate (GFR) by reducing distal tubular flow...
Clin Sci (Lond) (1989) 76 (4): 447–454.
Published: 01 April 1989
... taken 30 min after the beginning of leucine infusion (when plasma 13 C enrichment was steady), 240 min later during continued fasting and again after 240 min of infusion of a mixed amino acid solution which increased plasma total amino acid concentrations by 37%. The mean enrichment of 13 C in plasma α...
Clin Sci (Lond) (1988) 75 (6): 637–640.
Published: 01 December 1988
...-eight patients with chronic leg ulcers were admitted to hospital for a minimum of 6 weeks bed-rest. During this time the ulcers were continuously irrigated by one of four test solutions. The solutions were: normal saline; a dilute amino acid solution isotonic with the normal saline; a hyperosmolar...
Clin Sci (Lond) (1988) 74 (5): 539–545.
Published: 01 May 1988
...Hans Heindorff; Hendrik Vilstrup; Ditlev Bucher; Per Billesbølle; Vibeke Thygesen 1. The effect of elective, uncomplicated cholecystectomy on plasma clearances of amino acids and on amino acid-stimulated urea synthesis was investigated in 10 patients, pre-operatively and on the first post-operative...
Clin Sci (Lond) (1986) 71 (5): 487–496.
Published: 01 November 1986
...J. Lund; H. Stjernström; U. Bergholm; L. Jorfeldt; E. Vinnars; L. Wiklund 1. The exchange of plasma amino acids and glucose, lactate, glycerol and 3-hydroxybutyrate in the leg was studied in otherwise healthy patients undergoing elective cholecystectomy. 2. Seven patients were given a constant...
Clin Sci (Lond) (1986) 71 (4): 429–436.
Published: 01 October 1986
... on amino acid uptake and glucose disposal, three separate 120 min studies employing the euglycaemic insulin clamp technique (20, 80 and 200 m-units min −1 m −2 ) were performed on five ambulatory patients with myotonic dystrophy. The results were compared with findings obtained in identical studies in 21...
Clin Sci (Lond) (1986) 70 (1): 31–38.
Published: 01 January 1986
.... The intravenous administration of alanine appears to be a suitable stimulus for urea synthesis. 25 7 1985 25 7 1985 © 1986 The Biochemical Society and the Medical Research Society 1986 alanine amino acids biological models systems theory urea metabolism Clinical Science (1986) 70, 31...
Clin Sci (Lond) (1985) 69 (2): 143–151.
Published: 01 August 1985
...Giacomo Deferrari; Giacomo Garibotto; Cristina Robaudo; Alberto Canepa; Serena Bagnasco; Alberto Tizianello 1. Leg metabolism of amino acids and ammonia in the postabsorptive state was evaluated in 10 patients with chronic renal failure (CRF) and in 10 patients with normal renal function (controls...
Clin Sci (Lond) (1985) 68 (2): 151–157.
Published: 01 February 1985
...Richard T. Moxley; William Kingston; Robert C. Griggs 1. The concentration of amino acids in whole blood was measured before and during standard 5 h oral glucose tolerance testing in six male patients with myotonic dystrophy and five normal males. The plasma levels of insulin and glucose were also...
Clin Sci (Lond) (1982) 62 (3): 285–293.
Published: 01 March 1982
...L. S. Eriksson; L. Hagenfeldt; J. Wahren 1. The metabolic effect of α-oxoisocaproate (4-methyl-2-oxovalerate) infusion was examined in six patients with cirrhosis and in nine healthy control subjects. The arterial concentrations of amino acids, urea, ammonia, insulin and catecholamines were...
Clin Sci (Lond) (1982) 62 (1): 83–91.
Published: 01 January 1982
... essential amino acids in the septic patients, but not in those with undernutrition, is consistent with the increased catabolic rate of sepsis. 5. However, the branched-chain amino acids, and lysine, threonine, arginine, and histidine, were present in lower concentrations than might be expected from...
Clin Sci (Lond) (1981) 61 (6): 743–749.
Published: 01 December 1981
...D. E. L. Wilcken; Vatsala J. Gupta; A. K. Betts 1. Homocysteine which is formed during the metabolism of methionine is readily oxidized and is measured by the amino acid analyser as cysteine—homocysteine mixed disulphide and homocystine. We measured plasma amino acid concentrations after...
Clin Sci (Lond) (1980) 59 (3): 173–181.
Published: 01 September 1980
...L. Hagenfeldt; S. Eriksson; J. Wahren 1. l -Leucine was given to healthy, post-absorptive subjects as a continuous intravenous infusion (300 μmol/min) during 2 1/2 h. Arterial blood concentrations and regional exchange of amino acids were measured across the splanchnic region, the brain and a leg...
Clin Sci (Lond) (1980) 59 (1): 19–27.
Published: 01 July 1980
...H. B. Stoner; K. N. Frayn; R. A. Little; C. J. Threlfall; D. W. Yates; R. N. Barton; D. F. Heath 1. Plasma concentrations of glucose, lactate, amino acids, non-esterified fatty acids, glycerol, ketone bodies, insulin and cortisol were measured in 43 elderly patients with hypothermia. In 15...
Clin Sci (Lond) (1980) 58 (6): 507–515.
Published: 01 June 1980
... concentrations of metabolites and hormones in blood and urine nitrogen excretion in patients receiving (a) sodium chloride solution (saline), (b) 1.5 g of glucose day −1 kg −1 body weight, (c) 1.5 g of glucose day −1 kg −1 with insulin (0.56 unit day −1 kg −1 ) or (d) mixed amino acids (1.5 g day −1 kg −1...
Clin Sci (Lond) (1980) 58 (5): 427–430.
Published: 01 May 1980
...D. E. L. Wilcken; Vatsala J. Gupta; S. G. Reddy 1. Plasma sulphur-containing amino acids were measured in 19 patients with renal failure on chronic haemodialysis and in 22 normal subjects, to determine the rate of accumulation of these amino acids in chronic azotaemia. 2. Cysteine-homocysteine...
Clin Sci (Lond) (1979) 57 (6): 521–527.
Published: 01 December 1979
... of tissue and k t 33 mmol/l. 2. Glycyl-l-leucine uptake is inhibited by a wide variety of amino acids, although to a variable extent. The inhibition was shown to be competitive with leucine used as the representative amino acid. Phenylalanine, methionine, alanine and leucine are the most potent...
Clin Sci (Lond) (1979) 56 (6): 563–573.
Published: 01 June 1979
...H. B. Stoner; K. N. Frayn; R. N. Barton; C. J. Threlfall; R. A. Little 1. The plasma concentrations of glucose, lactate, amino acids, non-esterified fatty acids, glycerol, ketone bodies, ethanol, cortisol and insulin were measured in patients within a few hours of injury and before treatment...
Clin Sci (Lond) (1979) 56 (5): 427–432.
Published: 01 May 1979
...P. Möller; J. Bergström; S. Eriksson; P. Fürst; K. Hellström 1. The concentrations of electrolytes and free amino acids in plasma and the quadriceps femoris muscle were studied in ten apparently healthy elderly men, 52–77 years of age. The results were compared with those previously recorded...
Clin Sci Mol Med (1978) 54 (6): 589–593.
Published: 01 June 1978
...P. Richards © 1978 The Biochemical Society and the Medical Research Society 1978 amino acids keto acid analogues transamination Clinical Science and Molecular Medicine (1978), 54, 589-593 EDITORIAL REVIEW The metabolism and clinical relevance of the keto acid analogues of essential...
Clin Sci Mol Med (1978) 54 (1): 51–60.
Published: 01 January 1978
...J. Bergström; P. Fürst; L.-O. Norée; E. Vinnars 1. Free amino acids were determined in the plasma and in the muscle tissue of 14 patients with chronic uraemia; eight were not on dialysis and six were having regular peritoneal dialysis. The concentration of each amino acid in muscle water...
Clin Sci Mol Med (1977) 53 (3): 215–220.
Published: 01 September 1977
... arginine remains unexplained. 24 11 1976 4 4 1977 © 1977 The Biochemical Society and the Medical Research Society 1977 alanine amino acids glutamine nitrogen steroids Clinical Science and Molecular Medicine (1977) 53,215-220. The role of alanine and glutamine in steroid...
Clin Sci Mol Med (1977) 53 (1): 27–33.
Published: 01 July 1977
...P. D. Fairclough; D. B. A. Silk; M. L. Clark; D. M. Matthews; T. C. Marrs; D. Burston; K. M. Clegg 1. A jejunal perfusion technique has been used in normal volunteer subjects to study jejunal absorption of amino acid residues from a partial enzymic hydrolysate of casein in which about 50...
Clin Sci Mol Med (1977) 52 (5): 485–498.
Published: 01 May 1977
...% of total daily protein synthesis. 6. These results are discussed in relation to published estimates of whole-body protein synthesis and breakdown at various ages. Their possible significance in the assessment of a ‘maintenance’ requirement for protein and amino acids during the period of rapid growth...