... vascular myogenic tone and blood pressure. The function of Ca V 1.2 channel can be subtly modulated by alternative splicing (AS), and its aberrant splicing involves in the pathogenesis of multiple cardiovascular diseases. The RNA-binding protein Rbfox1 is reported to regulate the AS events of Ca V 1.2...

... in the mature transcript may remove the critical ACE2 residues responsible for the interaction with the receptor-binding domain (RBD) of SARS-CoV-2, thus preventing their binding and entry into the cell. Additionally, inclusion of a novel predicted exons located in the 3′UTR by alternative splicing may remove...

... different physiological conditions [ 15 ]. Splice-site usage and patterns of alternative splicing are driven by a battery of splicing regulatory proteins termed as splicing factors [ 16 , 17 ]. Some studies have shown that genes encoding splicing factors are strongly dysregulated with aging in population...

... to the clinic, and are already changing clinical approaches. Correspondence: Dr Emanuele Buratti (email buratti@icgeb.org ) 6 10 2016 6 12 2016 15 12 2016 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 alternative splicing...