... vascular myogenic tone and blood pressure. The function of Ca V 1.2 channel can be subtly modulated by alternative splicing (AS), and its aberrant splicing involves in the pathogenesis of multiple cardiovascular diseases. The RNA-binding protein Rbfox1 is reported to regulate the AS events of Ca V 1.2...

... in the mature transcript may remove the critical ACE2 residues responsible for the interaction with the receptor-binding domain (RBD) of SARS-CoV-2, thus preventing their binding and entry into the cell. Additionally, inclusion of a novel predicted exons located in the 3′UTR by alternative splicing may remove...

...). Published by Portland Press Limited on behalf of the Biochemical Society 2018 aging senescence alternative splicing coronary artery disease Cardiovascular disease is the major cause of mortality and morbidity in the developed world [ 1 , 2 ]. Age is one of the predominant risk factors...

... to the clinic, and are already changing clinical approaches. Correspondence: Dr Emanuele Buratti (email buratti@icgeb.org ) 6 10 2016 6 12 2016 15 12 2016 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 alternative splicing...