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Clin Sci (Lond) (2022) 136 (12): 1005–1017.
Published: 29 June 2022
... of the main drivers for testing the efficacy of finerenone in non-diabetic CKD patients in the ongoing FIND-CKD trial. aldosterone fibrosis inflammation Chronic kidney disease (CKD) is a growing health problem, with an estimated global prevalence of 11% and affecting approximately 850 million...
Clin Sci (Lond) (2022) 136 (1): 103–120.
Published: 07 January 2022
...Yong Wu; Huan Yang; Sujuan Xu; Ming Cheng; Jie Gu; Weichen Zhang; Shaojun Liu; Minmin Zhang Inflammatory response and renal fibrosis are the hallmarks of chronic kidney disease (CKD). However, the specific mechanism of aldosterone-induced renal injury in the progress of CKD requires elucidation...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (1): 229.
Published: 11 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...
Clin Sci (Lond) (2020) 134 (15): 2053.
Published: 10 August 2020
... The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. aldosterone cardiac remodeling inflammation microRNA-34a TRIF ©...
Clin Sci (Lond) (2020) 134 (12): 1319–1331.
Published: 16 June 2020
...Shaojun Li; Wei Cao; Bai Wang; Enbo Zhan; Jian Xu; Shufeng Li Aldosterone, as a major product of renin–angiotensin–aldosterone system (RAAS), determines multiple pathophysiological processes in cardiovascular diseases. The excess inflammatory response is one of the key profiles in aldosterone...
Includes: Supplementary data
Francesca Torresan, Giacomo Rossitto, Valeria Bisogni, Silvia Lerco, Giuseppe Maiolino, Maurizio Cesari, Rui Zhu, Maurizio Iacobone, Teresa Maria Seccia, Gian Paolo Rossi
Clin Sci (Lond) (2020) 134 (11): 1265–1278.
Published: 15 June 2020
... aldosteronism (PA) is commonly overlooked. Hence, we aimed at determining if (1) adrenal vein sampling (AVS) can identify PA in RH patients, who are challenging because of receiving multiple interfering drugs; (2) AVS-guided adrenalectomy can resolve high blood pressure (BP) resistance to treatment...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (1): 75–82.
Published: 08 January 2019
... electrolyte transport mechanisms in principal cells of the cortical collecting duct, and their regulation by renin–angiotensin–aldosterone system (RAAS). In recent years, however, accumulating data indicate that intercalated cells, another cell type that is present in the cortical collecting duct, also play...
Paul-Emmanuel Vanderriele, Brasilina Caroccia, Teresa Maria Seccia, Maria Piazza, Livia Lenzini, Francesca Torresan, Maurizio Iacobone, Thomas Unger, Gian Paolo Rossi
Clin Sci (Lond) (2018) 132 (6): 627–640.
Published: 20 March 2018
... protective role by counter-regulating Ang II type 1 receptor (AT1R)-mediated effects, but whether this involves blunting of adrenocortical hormone secretion is unknown. We investigated the presence of AT1R, AT2R, and MasR in aldosterone-producing adenoma (APA), a condition featuring hyperaldosteronism...
Includes: Supplementary data
Alison H.M. Taylor, Alastair J. Rankin, Emily P. McQuarrie, E. Marie Freel, Natalie Z.M. Homer, Ruth Andrew, Alan G. Jardine, Patrick B. Mark
Clin Sci (Lond) (2018) 132 (2): 285–294.
Published: 25 January 2018
... or high salt diet for 5 days and then crossed over to the alternate diet. Angiotensin-II stimulation testing was performed in both salt states. BP, urea and electrolytes, and plasma aldosterone concentration (PAC) were measured. Results: Twenty-seven subjects were recruited (12 CKD, 15 control...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (2): 173–183.
Published: 19 January 2018
...William C. Valinsky; Rhian M. Touyz; Alvin Shrier Hyperaldosteronism, a common cause of hypertension, is strongly connected to Na + , K + , and Mg 2+ dysregulation. Owing to its steroidal structure, aldosterone is an active transcriptional modifier when bound to the mineralocorticoid receptor (MR...
Clin Sci (Lond) (2018) 132 (1): 145–156.
Published: 16 January 2018
...Iris Hardege; Lu Long; Raya Al Maskari; Nicola Figg; Kevin M. O’Shaughnessy Aldosterone is released from adrenal zona glomerulosa (ZG) cells and plays an important role in Na and K homoeostasis. Mutations in the human inwardly rectifying K channel CNJ type ( KCNJ ) 5 ( KCNJ5 ) gene encoding the G...
Includes: Supplementary data
Akiko Tanino, Takafumi Okura, Tomoaki Nagao, Masayoshi Kukida, Zuowei Pei, Daijiro Enomoto, Ken-ichi Miyoshi, Haruki Okamura, Jitsuo Higaki
Clin Sci (Lond) (2016) 130 (19): 1727–1739.
Published: 23 August 2016
...Akiko Tanino; Takafumi Okura; Tomoaki Nagao; Masayoshi Kukida; Zuowei Pei; Daijiro Enomoto; Ken-ichi Miyoshi; Haruki Okamura; Jitsuo Higaki Interleukin (IL)-18 is a member of the IL-1 family of cytokines and was described originally as an interferon γ-inducing factor. Aldosterone plays a central...
Clin Sci (Lond) (2015) 128 (9): 527–535.
Published: 27 January 2015
... and podocytes within the glomerulus. Activation of MRs in these cells appears to lead to glomerular sclerosis. Mechanistically, aldosterone induces excess production of reactive oxygen species (ROS) and oxidative stress in glomerular cells through activation of NADPH oxidase. In mesangial cells, aldosterone...
Clin Sci (Lond) (2014) 126 (8): 537–544.
Published: 17 December 2013
...Koen Verdonk; Willy Visser; Anton H. Van Den Meiracker; A. H. Jan Danser Pregnancy demands major changes of the cardiovascular system, and this involves, among others, activation of the RAAS (renin–angiotensin–aldosterone system), allowing an aldosterone-dependent increase in volume. Remarkably...
Clin Sci (Lond) (2014) 126 (4): 267–274.
Published: 14 October 2013
... oxygenase) [ 46 ] leading to production of CO, a vasodilator and anti-inflammatory agent that acts via p38 MAPK. aldosterone blood pressure endothelin inflammation innate and adaptive immunity interleukin renin–angiotensin system (RAS) target organ damage regulatory T-cell (T reg -cell...
Clin Sci (Lond) (2013) 125 (9): 409–421.
Published: 27 June 2013
... 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 aldosterone cardiac function glucocorticoid hypertension inflammation mineralocorticoid receptor As previously noted, myo-MRKO mice showed no detectable baseline differences in cardiac morphology following...
Clin Sci (Lond) (2013) 124 (10): 597–615.
Published: 04 February 2013
.... In terms of retinopathy, there is growing evidence that Nox contribute to vascular injury. The RAAS (renin–angiotensin–aldosterone system), and particularly AngII (angiotensin II), is a key stimulator of Nox. It is known that a local RAAS exists in the retina and that blockade of AngII and aldosterone...
Emily P. McQuarrie, E. Marie Freel, Patrick B. Mark, Robert Fraser, Rajan K. Patel, Henry G. Dargie, John M. C. Connell, Alan G. Jardine
Clin Sci (Lond) (2012) 123 (5): 285–294.
Published: 16 May 2012
... be activated by aldosterone, cortisol and DOC (deoxycorticosterone). The aim of the present study was to explore the influence of mineralocorticoids on LVMI and proteinuria in patients with CKD. A total of 70 patients with CKD and 30 patients with EH (essential hypertension) were recruited. Patients underwent...
Clin Sci (Lond) (2012) 122 (2): 63–73.
Published: 20 September 2011
... expansion markedly decreased the plasma levels of renin, AngII (angiotensin II) and aldosterone (all P <0.001), while MABP (oscillometry), heart rate, cardiac output (impedance cardiography), RPF (by p -aminohippurate), GFR [glomerular filtration rate; by using 51 Cr-labelled EDTA] and plasma [Na...
Clin Sci (Lond) (2009) 116 (4): 301–314.
Published: 15 January 2009
...Cheng Qian; Regien G. Schoemaker; Wiek H. van Gilst; Anton J. M. Roks Intervention in the RAAS (renin–angiotensin–aldosterone system) is one of the leading pharmacotherapeutic strategies, among others, used for the treatment of cardiovascular disease to improve the prognosis after myocardial...
Clin Sci (Lond) (2008) 114 (1): 37–47.
Published: 30 November 2007
...Jessica M. Osmond; Christine' S. Rigsby; Anne M. Dorrance In recent years, it has become increasingly clear that the extra-renal effects of aldosterone play an important role in the pathogenesis of cardiovascular disease. Stroke is one of the leading causes of death in the Western world, and MR...
Clin Sci (Lond) (2007) 113 (6): 267–278.
Published: 13 August 2007
...Annis M. Marney; Nancy J. Brown Aldosterone concentrations are inappropriately high in many patients with hypertension, as well as in an increasing number of individuals with metabolic syndrome and sleep apnoea. A growing body of evidence suggests that aldosterone and/or activation of the MR...
Clin Sci (Lond) (2007) 112 (9): 467–475.
Published: 02 April 2007
... for moderate-to-severe heart failure and heart failure post-myocardial infarction. Given that few patients had elevated plasma aldosterone, novel mechanisms involved in activating the MR in the failing heart are now being investigated. Correspondence: Dr Morag Young (email firstname.lastname@example.org...
Clin Sci (Lond) (2006) 111 (5): 319–324.
Published: 13 October 2006
... of median OPN levels into a high-OPN group and a low-OPN group. The mean IMT and aldosterone levels were higher ( P =0.024 and 0.031 respectively) and V d / V s was lower ( P =0.007) in the high-OPN group than in the low-OPN group. Plasma OPN levels were positively correlated with mean IMT ( r =0.308, P...
Clin Sci (Lond) (2003) 104 (4): 389–395.
Published: 13 March 2003
... of collecting duct sodium transport is the epithelial sodium channel (ENaC). We examined the abundance of ENaC subunit mRNAs and proteins in puromycin aminonucleoside (PAN)-induced nephrotic syndrome. The time courses of urinary sodium excretion, plasma aldosterone concentration and proteinuria were studied...
Clin Sci (Lond) (2002) 103 (4): 425–431.
Published: 09 September 2002
...Colin A.J. FARQUHARSON; Allan D. STRUTHERS Experimental studies have suggested a role for aldosterone and glucocorticoids in the pathogenesis of endothelial dysfunction. We therefore set out to characterize the acute effects of these hormones on vascular function in vivo in normal humans...
Concepción MARTÍNEZ-PRIETO, M. Clara ORTÍZ, Lourdes A. FORTEPIANI, Jose Antonio RUIZ-MACIÁ, Noemí M. ATUCHA, Joaquín GARCÍA-ESTAÑ
Clin Sci (Lond) (2000) 98 (5): 611–617.
Published: 26 April 2000
... the controls. Sodium retention increased progressively, and at day 20 BDL rats had retained 0.7 mmol/100 g more than the control animals (accumulated retention: BDL, 2.2±0.2 mmol/100 g; sham-operated, 1.5±0.2 mmol/100 g). Plasma renin activity and aldosterone concentration were not elevated in the BDL animals...
Clin Sci (Lond) (1998) 96 (1): 5–15.
Published: 01 January 1999
..., and it is likely that the impaired natriuretic response was caused by a reduced responsiveness in the distal part of the nephron. Correspondence : Dr K. Jensen. 4 3 1998 15 6 1998 6 8 1998 The Biochemical Society and the Medical Research Society © 1999 1999 aldosterone angiotensin...
Clin Sci (Lond) (1998) 95 (6): 687–692.
Published: 01 December 1998
...K. M. YEE; A. D. STRUTHERS 1. Recent animal evidence suggests that aldosterone, like angiotensin II, may possess detrimental autonomic modulating properties. Aldosterone has been shown to impair the baroreflex response in animal models. This study is designed to test the hypothesis that aldosterone...
Clin Sci (Lond) (1998) 95 (4): 513–517.
Published: 01 October 1998
...Andrew M. WILSON; Erika J. SIMS; Allan D. STRUTHERS; Brian J. LIPWORTH 1. As mineralocorticoid and adrenocorticoid activity are both under the diurnal control of adrenocorticotropic hormone secretion, we aimed to evaluate whether the normal circadian rhythm of cortisol and aldosterone secretion...
Clin Sci (Lond) (1997) 92 (3): 255–260.
Published: 01 March 1997
.../creatinine ratio, P < 0.02) occurred with the higher dose. Blood pressure, haematocrit, plasma cGMP, atrial natriuretic peptide and aldosterone were unaffected by either dose. 3. Compared with brain natriuretic peptide (0.5 pmol min −1 kg −1 ) alone, SCH 32615 pretreatment increased peak plasma brain...
Clin Sci (Lond) (1994) 87 (4): 435–439.
Published: 01 October 1994
... in bicarbonate concentration, and blood acid-base equilibrium showed a mixed metabolic and respiratory alkalosis (pH 7.57, partial pressure of CO 2 29 mmHg, base excess + 5.5 mmol/l), and aldosterone concentration was increased 3-fold as compared with the control value. When hyponatraemia (110 mmol/l...
Clin Sci (Lond) (1994) 87 (4): 397–401.
Published: 01 October 1994
...P. B. M. Clarkson; N. M. Wheeldon; C. MacLeod; M. Tennent; T. M. MacDonald 1. Doppler echocardiographic indices of diastolic function and systemic haemodynamics were studied in response to infusions of angiotensin II (1, 2, 5 and 10 ng min −1 kg −1 ), D-aldosterone (2, 4, 10 and 20 ng min −1 kg −1...
Clin Sci (Lond) (1994) 86 (4): 383–390.
Published: 01 April 1994
..., angiotension II, aldosterone, noradrenaline, adrenaline, atrial natriuretic factor and digoxin-like factor. 3. Diabetic patients and control subjects did not differ in blood pressure, body mass index, clearances of creatinine, sodium or lithium, intracellular sodium, Na + −K + co-transport and Na + −Li...
Clin Sci (Lond) (1994) 86 (4): 391–397.
Published: 01 April 1994
... © 1994 The Biochemical Society and the Medical Research Society 1994 aldosterone blood pressure catecholamines ouabain renin Clinical Science (1994) 86, 391-397 (Printed i n Great Britain) 39 I Acute effects of intravenous ouabain in healthy volunteers G. B. PIDGEON', A. M. RICHARDS?, M...
Clin Sci (Lond) (1993) 85 (5): 607–614.
Published: 01 November 1993
... urine output. These changes occurred without significant alterations in effective renal plasma flow and glomerular filtration rate. 4. Both 5-hydroxy-L-tryptophan and γ-L-glutamyl-5-hydroxy-L-tryptophan significantly increased plasma aldosterone concentration without a concomitant rise in plasma renin...
Clin Sci (Lond) (1993) 85 (2): 157–163.
Published: 01 August 1993
... in cardiac output, and was much less sensitive to angiotensin II infusion, rising only at the highest rate of infusion during both D-glucose and losartan infusion. 3. Losartan infusion alone caused a rise in plasma angiotensin II concentration with a fall in aldosterone concentration. During pressor...
Clin Sci (Lond) (1993) 85 (1): 19–26.
Published: 01 July 1993
... in clearing angiotensin II from the circulation. 8 3 1993 15 3 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 aldosterone angiotensin II atrial natriuretic peptide neutral endopeptidase renal function renin sodium balance Clinical Science (1993) 85...
Clin Sci (Lond) (1992) 82 (2): 127–131.
Published: 01 February 1992
... to hypervolaemia, another factor may also be responsible for the elevated plasma hBNP-li seen in these patients. 19 7 1991 6 9 1991 © 1992 The Biochemical Society and the Medical Research Society 1992 aldosterone atrial natriuretic peptide brain natriuretic peptide chronic renal failure...
Ross C. Cuneo, Franco Salomon, Peter Wilmshurst, Chris Byrne, C. Mark Wiles, Richard Hesp, Peter H. Sönksen
Clin Sci (Lond) (1991) 81 (5): 587–592.
Published: 01 November 1991
... ventricular myocardial mass increased in the group given recombinant human growth hormone. 3. The supine plasma renin activity was increased and remained elevated over the 6 months, whereas the plasma aldosterone concentration was unchanged, after treatment with recombinant human growth hormone. Clinical...
Clin Sci (Lond) (1991) 81 (3): 305–311.
Published: 01 September 1991
...K. Peter Öhman; Bengt E. Karlberg 1. This study aims to further elucidate the role of the tissue and plasma kallikrein-kinin systems in blood pressure, electrolyte and volume homoeostasis. Components thereof and of the renin-angiotensin-aldosterone system were measured in conjunction with frusemide...
Clin Sci (Lond) (1991) 80 (6): 599–604.
Published: 01 June 1991
... or is the consequence of changes in hormonal activities is still a matter of discussion. 2. Using the model of puromycin aminonucleoside-induced nephrotic syndrome in the rat, we measured Na + ,K + -ATPase activity in nephron segments from control and nephrotic rats and investigated the regulatory role of aldosterone...
Leonard C. Warner, Gilles A. Morali, Judith A. Miller, Alexander G. Logan, Karl L. Skorecki, Laurence M. Blendis
Clin Sci (Lond) (1991) 80 (5): 475–480.
Published: 01 May 1991
..., the increase in the plasma atrial natriuretic factor level was similar on both diets (peak plasma atrial natriuretic factor level 23.1 ± 1.9 versus 26.2 ± 1 pg/ml; not significant). As expected, the baseline serum aldosterone level was higher on the 20 mmol of sodium/day diet and, despite a significant...
D. R. J. Singer, D. G. Shirley, N. D. Markandu, M. A. Miller, M. G. Buckley, A. L. Sugden, G. A. Sagnella, G. A. MacGregor
Clin Sci (Lond) (1991) 80 (4): 293–299.
Published: 01 April 1991
...D. R. J. Singer; D. G. Shirley; N. D. Markandu; M. A. Miller; M. G. Buckley; A. L. Sugden; G. A. Sagnella; G. A. MacGregor 1. Aldosterone is suppressed by sodium loading. We studied the contribution of this decrease in plasma aldosterone to the natriuresis after acute sodium loading in healthy...
Clin Sci (Lond) (1991) 80 (3): 219–225.
Published: 01 March 1991
... (Ins III) pmol of angiotensin I h −1 ml −1 ; on the control day, a decline from 1.28 ± 0.24 (basal) to 0.81 ± 0.13 (Ins III) pmol of angiotensin I h −1 ml −1 was noted ( P < 0.001). Despite this rise no concomitant rise in plasma aldosterone occurred. 4. Chronic hyperinsulinaemia may lead to blood...
Clin Sci (Lond) (1990) 79 (1): 57–65.
Published: 01 July 1990
...H. Tuchelt; G. Eschenhagen; V. Bähr; G. Schwietzer; H. M. Thiede; W. Oelkers 1. Sodium loading blunts the response of aldosterone to infusion of angiotensin II, whereas sodium depletion leads to an enhanced response. The hypothesis was tested that these changes in responsiveness of the zona...
D. J. S. Carmichael, M. S. Sutters, R. J. Unwin, D. Gordon, J. Few, V. H. T. James, J. Wadsworth, W. S. Peart
Clin Sci (Lond) (1990) 78 (6): 605–612.
Published: 01 June 1990
...D. J. S. Carmichael; M. S. Sutters; R. J. Unwin; D. Gordon; J. Few; V. H. T. James; J. Wadsworth; W. S. Peart 1. The fall in renal sodium excretion after dietary sodium restriction is prompt and reproducible. The importance of increased aldosterone secretion during the early phase (within 48 h...
Clin Sci (Lond) (1990) 78 (3): 327–334.
Published: 01 March 1990
... factor. Plasma aldosterone and plasma renin activity increased during the sodium-depleted period but only plasma renin activity was significantly correlated with fractional excretion of filtered sodium. 3. The predominant role of atrial natriuretic factor compared with that of aldosterone in the renal...
D. R. J. Singer, N. D. Markandu, M. G. Buckley, M. A. Miller, A. L. Sugden, G. A. Sagnella, G. A. MacGregor
Clin Sci (Lond) (1989) 77 (3): 253–258.
Published: 01 September 1989
... with placebo during or after ANP infusion. However, plasma aldosterone was significantly greater than placebo values after the end of ANP infusion on both low and high sodium diets. 5. The sustained fall in blood pressure after ANP infusion appears to be unexplained by changes in sodium balance, packed cell...
Clin Sci (Lond) (1989) 76 (5): 553–557.
Published: 01 May 1989
... or rectal temperature during exercise were observed between the two salt intakes. 4. Plasma sodium, potassium and osmolality were similar on the two salt intakes both before and during exercise. Plasma renin activity and aldosterone concentration were elevated after 2 weeks on the reduced salt intake...