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Neville H. McClenaghan, Siobhan M. Scullion, Brian Mion, Chandralal Hewage, J. Paul G. Malthouse, Peter R. Flatt, Philip Newsholme, Lorraine Brennan
Clin Sci (Lond) (2009) 116 (4): 341–351.
Published: 15 January 2009
... exposure to amino acids. The present study examined the effects of prolonged exposure of β-cells to the metabolizable amino acid L -alanine. Basal insulin release or cellular insulin content were not significantly altered by alanine culture, but acute alanine-induced insulin secretion was suppressed by 74...
Clin Sci (Lond) (2002) 103 (6): 633–639.
Published: 19 November 2002
... containing 18% (w/w) casein (CON), a low-protein diet containing 9% casein (MLP), or the low-protein diet supplemented with 3% glycine (MLPG), alanine (MLPA) or urea (MLPU). The offspring were weaned on to standard laboratory chow, and blood pressure was measured at 4 weeks of age. Blood pressure...
Clin Sci (Lond) (2001) 101 (4): 339–344.
Published: 04 September 2001
... effects of dehydration on the hepatic kinetics of urea synthesis, quantified by functional hepatic nitrogen clearance (FHNC), in healthy volunteers. Seven healthy men were studied twice in random order. On both study days, a primed continuous infusion of alanine was given. On the day of dehydration...
Gianni BIOLO, R. Y. Declan FLEMING, Sergio P. MAGGI, Thuan T. NGUYEN, David N. HERNDON, Robert R. WOLFE
Clin Sci (Lond) (2000) 99 (3): 189–194.
Published: 02 August 2000
... effects of glutamine supplementation in critically ill patients. However, the response of endogenous glutamine formation to severe stress is poorly understood. The rates of net protein balance, leucine oxidative decarboxylation, and alanine and glutamine synthesis de novo were determined in leg skeletal...
Susanne LEIJ-HALFWERK, Pieter C. DAGNELIE, J. Willem O. VAN DEN BERG, J. H. Paul WILSON, Paul E. SIJENS
Clin Sci (Lond) (2000) 98 (2): 167–174.
Published: 19 January 2000
...) spectroscopy, reflect elevated whole-body glucose turnover and gluconeogenesis from alanine. Patients with advanced non-small-cell lung cancer without liver metastases ( n = 24; weight loss 0–24%) and healthy control subjects ( n = 13) were studied after an overnight fast. 31 P MR spectra of the liver in vivo...
Kjell Malmlöf, Zuzana Cortova, Henri Saxerholt, Eivor Karlsson, Vibeke Arrhenius-Nyberg, Anna Skottner
Clin Sci (Lond) (1995) 88 (3): 285–292.
Published: 01 March 1995
... respectively. This response was also closely reflected in the group of non-essential amino acids. 4. The net efflux of alanine from the hind limbs was also significantly ( P < 0.002) reduced, whereas glutamine was less affected. 5. On post-operative day 2, there was a general drop in cortisol and urea...
Clin Sci (Lond) (1991) 81 (5): 603–609.
Published: 01 November 1991
...M. Salleh M. Ardawi 1. The metabolism of glutamine and alanine in the lung was studied in rats made septic by a caecal ligation and puncture technique. 2. The blood glucose concentration was not significantly different in septic rats, but blood pyruvate, lactate, glutamine and alanine...
Clin Sci (Lond) (1991) 80 (5): 471–474.
Published: 01 May 1991
...K. N. Frayn; K. Khan; S. W. Coppack; M. Elia 1. Arteriovenous differences for alanine, glutamate and glutamine were measured across subcutaneous adipose tissue and forearm muscle in normal subjects. 2. After an overnight fast, adipose tissue showed net production of alanine and glutamine and uptake...
Erich Roth, Josef Karner, Günter Ollenschläger, Judith Karner, Annette Simmel, Peter Fürst, Josef Funovics
Clin Sci (Lond) (1988) 75 (6): 641–648.
Published: 01 December 1988
...Erich Roth; Josef Karner; Günter Ollenschläger; Judith Karner; Annette Simmel; Peter Fürst; Josef Funovics 1. The present study examined the effect of an infusion of the dipeptide alanylglutamine or of the corresponding amino acids alanine and glutamine in equimolar amounts (10 μmol min −1 kg −1...
Clin Sci (Lond) (1988) 74 (2): 165–172.
Published: 01 February 1988
... production accounting for over 90% of total glutamine produced by the hindlimb. 3. Injury produced decreases in the concentrations of skeletal muscle glutamine (36%, P < 0.001), glutamate (39%, P < 0.001), alanine (24%, P < 0.001), pyruvate (35%, P < 0.001), 2-oxoglutarate (51%, P < 0.001...
Clin Sci (Lond) (1988) 74 (1): 41–48.
Published: 01 January 1988
...A. M. Umpleby; D. Chubb; M. A. Boroujerdi; P. H. Sonksen 1. The effect of an infusion of sodium β-hydroxybutyrate on leucine and alanine metabolism was investigated in dogs starved for 12 h. To determine whether the metabolic changes produced by this infusion were due to the resultant alkalaemia...
Clin Sci (Lond) (1987) 72 (2): 187–193.
Published: 01 February 1987
...J. D. S. Kay; V. G. Oberholzer; J. W. T. Seakins; M. Hjelm 1. The biochemical response to an intravenous alanine load of 0.25 g/kg was studied in nine adult female relatives of children with ornithine carbamoyltransferase deficiency. Six were classified as affected by partial deficiency and three...
Clin Sci (Lond) (1986) 71 (4): 429–436.
Published: 01 October 1986
... at the low physiological elevations of insulin produced by the 20 m-units min −1 m −2 infusion. 3. Alanine levels fell significantly below baseline in patients with myotonic dystrophy after 60 and 120 min of insulin infusion with all three rates of insulin infusion. Normal subjects had only a minimal...
Clin Sci (Lond) (1986) 70 (6): 627–634.
Published: 01 June 1986
...Rita A. Klim; Marta Albajar; Reginald Hems; Dermot H. Williamson 1. The effects of chronic uraemia on glucose production and nitrogen release (urea plus ammonia formation) from alanine, glutamine or serine in isolated rat hepatocytes were studied. 2. Uraemia increased the rate of formation of urea...
Clin Sci (Lond) (1986) 70 (1): 31–38.
Published: 01 January 1986
...J. D. S. Kay; J. W. T. Seakins; D. Geiseler; M. Hjelm 1. The response of the plasma concentration of urea to the oral and intravenous administration of alanine was studied in healthy adult humans. 2. The instantaneous rate of urea synthesis was calculated by using a model-dependent procedure...
Clin Sci (Lond) (1985) 69 (2): 123–133.
Published: 01 August 1985
...Marinos Elia; Graham Neale; Geoffrey Livesey 1. The effect of glucose infusion alone (175 mg/kg bolus dose followed by 4 mg min −1 kg −1 for 70 min) and in combination with forearm exercise on the exchange of glucose, alanine, glutamine and other metabolites and amino acids across forearm muscle...
Clin Sci (Lond) (1985) 68 (3): 271–282.
Published: 01 March 1985
... the urinary excretion of ammonia and total urea over a 12 h experimental period. 2. Except with oral glycine and alanine, the synthesis rates given by ammonia and urea were appreciably different within each study when calculated on the assumption of a single pool of metabolic nitrogen in the body. In general...
Clin Sci (Lond) (1985) 68 (2): 151–157.
Published: 01 February 1985
... determined. 2. From 90 to 240 min after glucose ingestion there was a striking decline in venous alanine concentration in the patients with myotonic dystrophy in contrast to a slight rise in alanine in the normal group. 3. The patients displayed normal glucose tolerance, and there was a sustained fall...
Clin Sci (Lond) (1985) 68 (2): 201–208.
Published: 01 February 1985
...D. Geiseler; J. D. S. Kay; V. G. Oberholzer; J. W. T. Seakins; M. Hjelm 1. A method is described by which the rate of synthesis of urea can be calculated from the change of plasma concentration of urea after an alanine load. 2. The results can be expressed in terms of f , the maximum increase...
Clin Sci (Lond) (1983) 65 (3): 247–253.
Published: 01 September 1983
.... There was a small increase in arterial blood glucose concentration, and a decrease in blood alanine concentration during drug infusion. Blood lactate was not affected by phentolamine. The arterial concentrations of free fatty acids and glycerol increased, and the concentration of triglycerides decreased during...
Clin Sci (Lond) (1983) 64 (5): 517–526.
Published: 01 May 1983
... small. 3. Within 2 h of ingestion of steak, BCAA accounted for approx. 50% of those amino acids with a positive A—V and glutamine for up to 75% of those with a negative A—V; the negative A—V for alanine decreased to 10% of its basal value. Infusion of leucine produced a large positive A—V for leucine...
Clin Sci (Lond) (1983) 64 (1): 33–40.
Published: 01 January 1983
...A. R. Thomassen; T. T. Nielsen; J. P. Bagger; P. Henningsen 1. Myocardial exchanges of plasma alanine, glutamate, citrate, lactate, glucose and free fatty acids were determined in 17 patients with coronary artery disease and in seven control subjects during rest, atrial pacing and recovery. 2...
Clin Sci (Lond) (1982) 62 (5): 553–556.
Published: 01 May 1982
...G. T. Royle; J. A. Molnar; Marta H. Wolfe; R. R. Wolfe; J. F. Burke 1. The simultaneous effects of an intravenous glucose infusion on plasma urea, glucose and alanine kinetics were investigated in normal post-absorptive man. 2. The primed constant intravenous infusion of compounds labelled...
Clin Sci (Lond) (1982) 62 (1): 77–81.
Published: 01 January 1982
...R. Swaminathan; D. B. Morgan; J. K. Wales 1. The blood concentrations of 3-hydroxybutyrate and alanine were measured before and after they were separately injected into obese patients who were taking a 1.68 MJ (400 kcal) diet and again when they had starved for 4 days and 28 days. 2...
K. J. Foster, K. G. M. M. Alberti, C. Binder, Leslie Hinks, S. Karran, Patricia Smythe, S. Talbot, D. Turnell, H. Ørskov
Clin Sci (Lond) (1980) 58 (6): 507–515.
Published: 01 June 1980
... glucose by approximately 1 mmol/l. Total nitrogen excretion during glucose/insulin infusion was significantly less than during saline infusion. 4. Infusion of amino acids, compared with saline infusion, resulted in raised blood glucose, alanine, serum insulin and plasma glucagon concentrations but lower...
Clin Sci (Lond) (1980) 58 (4): 301–309.
Published: 01 April 1980
...M. Elia; Vera Ilic; Susan Bacon; D. H. Williamson; R. Smith 1. Blood alanine was measured in six patients undergoing total hip replacement and in four normal subjects starved for 4 days. Hypoalaninaemia occurred in both groups and persisted in the surgical patients despite an adequate diet...
Clin Sci (Lond) (1980) 58 (2): 153–155.
Published: 01 February 1980
...M. Nattrass; Karen Sizer; K. G. M. M. Alberti 1. Circulating concentrations of intermediary metabolites have been measured after administration of 50 mg of phenformin to normal subjects. 2. Phenformin caused a significant increase in blood lactate, alanine and the lactate/pyruvate ratio but did...
Clin Sci Mol Med (1978) 55 (2): 199–204.
Published: 01 August 1978
... with that in the control subjects. 4. Fasting blood glucose, lactate and pyruvate concentrations were similar in all groups, whereas blood ketone bodies were increased in the malnourished and septic groups, and blood alanine was decreased only in the septic group. 5. The changes in hepatic metabolism and function were...
Clin Sci Mol Med (1977) 53 (3): 215–220.
Published: 01 September 1977
... of protein day −1 kg −1 body weight the cumulative increment in urea nitrogen excretion averaged + 12·5 g (sem 2·8, P < 0·01) over the 5 days of glucocorticoid administration. 3. Increases in urinary urea nitrogen excretion could be related to both plasma alanine and blood glutamine changes by using...