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Keywords: airway remodellingClose
Clin Sci (Lond) (2023) 137 (19): 1547–1562.
Published: 03 October 2023
... to airway adiposity was considered in the present study through kisspeptin/kisspeptin receptor signalling, known to modulate systemic adiposity and potentially drive airway remodelling. Therefore, the aim of the study was to determine the effects of kisspeptin/kisspeptin receptor signalling in the lung...
Clin Sci (Lond) (2023) 137 (15): 1209.
Published: 16 August 2023
... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . airway remodelling asthma biologics chronic rhinosinusitis precision medicine type 2 inflammation ...
Ilja Striz, Kornel Golebski, Zuzana Strizova, Stelios Loukides, Petros Bakakos, Nicola A. Hanania, Milos Jesenak, Zuzana Diamant
Clin Sci (Lond) (2023) 137 (9): 727–753.
Published: 18 May 2023
... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . airway remodelling asthma biologics chronic rhinosinusitis precision medicine type 2 inflammation Asthma is a chronic respiratory disease, that is often associated...
Mathew S. Eapen, Anudeep Kota, Howard Vindin, Kielan D. McAlinden, Dia Xenaki, Brian G. Oliver, Deepak A. Deshpande, Sukhwinder Singh Sohal, Pawan Sharma
Clin Sci (Lond) (2018) 132 (14): 1615–1627.
Published: 31 July 2018
... and negatively affects lung function in these patients. Thus, there is clear unmet clinical need for finding new therapies which can target airway remodeling and disease progression in COPD. Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein kinase (MAPK) kinase...
Simon G. Royce, Anna M. Tominaga, Matthew Shen, Krupesh P. Patel, Brooke M. Huuskes, Rebecca Lim, Sharon D. Ricardo, Chrishan S. Samuel
Clin Sci (Lond) (2016) 130 (23): 2151–2165.
Published: 20 October 2016
...Simon G. Royce; Anna M. Tominaga; Matthew Shen; Krupesh P. Patel; Brooke M. Huuskes; Rebecca Lim; Sharon D. Ricardo; Chrishan S. Samuel Current asthma therapies primarily target airway inflammation (AI) and suppress episodes of airway hyperresponsiveness (AHR) but fail to treat airway remodelling...
Clin Sci (Lond) (2016) 130 (21): 1983–1991.
Published: 30 September 2016
...Jian Ping Zhou; Wei Tang; Yun Feng; Ning Li; Chen Juan Gu; Qing Yun Li; Huan Ying Wan Previous studies have shown that the RAS (renin–angiotensin system) might participate in airway remodelling in asthma. As a main component of the RAS, Ang-(1–7) [angiotensin-(1–7)] has been reported in few studies...
Clin Sci (Lond) (2013) 124 (1): 41–51.
Published: 07 September 2012
... with these agents, probably due to progressive airway remodelling. Identifying novel therapies that can target airway remodelling and/or airway reactivity may improve symptom control in these patients. We have demonstrated previously that the anti-fibrotic hormone RLN (relaxin) can reverse airway remodelling...
Scott G. RAMSAY, Christopher J. KENYON, Niall WHYTE, Ian C. MCKAY, Neil C. THOMSON, George B. M. LINDOP
Clin Sci (Lond) (2000) 98 (1): 1–7.
Published: 19 November 1999
...Scott G. RAMSAY; Christopher J. KENYON; Niall WHYTE; Ian C. MCKAY; Neil C. THOMSON; George B. M. LINDOP Airway remodelling occurs in chronic asthma. Angiotensin II promotes growth in cardiovascular remodelling. Since the renin–angiotensin system is activated in acute severe asthma, we hypothesized...