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Keywords: aging
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Articles
Clin Sci (Lond) (2022) 136 (16): 1229–1240.
Published: 31 August 2022
... therapy. The most common form is referred to as ‘idiopathic’ since a causal agent or specific association has not been determined; the strongest risk factor for idiopathic pulmonary fibrosis is aging. Emerging studies indicate that targeting certain components of aging biology may be effective...
Articles
Clin Sci (Lond) (2022) 136 (13): 1025–1043.
Published: 04 July 2022
... are weak and there is little understanding of mechanism. Aging is by far the greatest risk factor for BC, and there are specific forms of inherited genetic risk that are well-understood to cause BC. We propose that bringing focus to the biology underlying these forms of risk will illuminate biological...
Articles
Clin Sci (Lond) (2022) 136 (1): 61–80.
Published: 05 January 2022
...Manon Chauvin; Delphine Sauce Massive CD4 + T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many...
Articles
Clin Sci (Lond) (2020) 134 (16): 2177–2187.
Published: 26 August 2020
...Edmund Battey; Matthew J. Stroud; Julien Ochala Skeletal muscle weakness is an important determinant of age-related declines in independence and quality of life but its causes remain unclear. Accelerated ageing syndromes such as Hutchinson–Gilford Progerin Syndrome, caused by mutations in genes...
Articles
Clin Sci (Lond) (2020) 134 (7): 727–746.
Published: 07 April 2020
... Beusekom; Mohsen Ghanbari; Jan H.J. Hoeijmakers; Radislav Sedlacek; Rhian M. Touyz; Augusto C. Montezano; Ingrid van der Pluijm; A.H. Jan Danser; Kristian A. Haanes; Anton J.M. Roks We previously identified genomic instability as a causative factor for vascular aging. In the present study, we determined...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (16): 1765–1777.
Published: 30 August 2018
...Lawrence C. Johnson; Christopher R. Martens; Jessica R. Santos-Parker; Candace J. Bassett; Talia R. Strahler; Charmion Cruickshank-Quinn; Nichole Reisdorph; Matthew B. McQueen; Douglas R. Seals Advancing age is associated with impairments in numerous physiological systems, leading to an increased...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (13): 1367–1382.
Published: 09 July 2018
...Vanessa Obas; Ramachandran S. Vasan As the elderly segment of the world population increases, it is critical to understand the changes in cardiac structure and function during the normal aging process. In this review, we outline the key molecular pathways and cellular processes that underlie...
Articles
Clin Sci (Lond) (2018) 132 (3): 313–325.
Published: 02 February 2018
...Eva Latorre; Luke C. Pilling; Benjamin P. Lee; Stefania Bandinelli; David Melzer; Luigi Ferrucci; Lorna W. Harries Coronary heart disease (CHD) is a leading cause of morbidity in people over 65 years of age; >40% of all deaths are due to this condition. The association between increasing age...
Articles
Clin Sci (Lond) (2017) 131 (23): 2807–2812.
Published: 28 November 2017
... (oxidative–nitrosative stress). However, it remains to be determined whether this extends to the cerebrovasculature. To examine this, 38 (19 young (≤35 years) and 19 aged (≥60 years)) healthy males were recruited. Cerebrovascular function (middle cerebral artery velocity, MCAv) and cerebrovascular reactivity...
Articles
Clin Sci (Lond) (2017) 131 (15): 1941–1953.
Published: 13 July 2017
... is an important contributor to endothelial dysfunction and age-related vascular disease. Recently, we demonstrated in a DNA repair-deficient, prematurely aging mouse model ( Ercc1 Δ/− mice) that dietary restriction (DR) strongly increases life- and health span, including ameliorating endothelial dysfunction...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (19): 1711–1725.
Published: 23 August 2016
...Rita Ostan; Daniela Monti; Paola Gueresi; Mauro Bussolotto; Claudio Franceschi; Giovannella Baggio Data showing a remarkable gender difference in life expectancy and mortality, including survival to extreme age, are reviewed starting from clinical and demographic data and stressing the importance...
Articles
Clin Sci (Lond) (2016) 130 (16): 1407–1416.
Published: 07 July 2016
...Sergej M. Ostojic Beneficial effects of physical activity on mitochondrial health are well substantiated in the scientific literature, with regular exercise improving mitochondrial quality and quantity in normal healthy population, and in cardiometabolic and neurodegenerative disorders and aging...
Articles
Clin Sci (Lond) (2016) 130 (15): 1285–1305.
Published: 29 June 2016
... the transcriptional process, acting at the epigenomic interface between metabolism and the genome. Within this framework, we review existing evidence showing that preservation of mitochondrial network function is directly involved in decreasing the rate of damage accumulation thus slowing aging and improving...
Articles
Clin Sci (Lond) (2016) 130 (10): 761–771.
Published: 01 April 2016
... that therapies targeting the RAS could be optimized for discrete epochs in life. Correspondence: Professor Kate M. Denton (email kate.denton@monash.edu ). 4 1 2016 1 2 2016 © 2016 Authors; published by Portland Press Limited 2016 aging angiotensin receptors cardiovascular disease...
Articles
Clin Sci (Lond) (2016) 130 (5): 317–335.
Published: 26 January 2016
...Sanghamitra Sahoo; Daniel N. Meijles; Patrick J. Pagano Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial fibrillation (AF). NADPH oxidases (Nox) are a major source...
Articles
Clin Sci (Lond) (2015) 129 (12): 1061–1075.
Published: 13 October 2015
... Dehghan; Anton J.M. Roks Reduced nitric oxide (NO)/cGMP signalling is observed in age-related vascular disease. We hypothesize that this disturbed signalling involves effects of genomic instability, a primary causal factor in aging, on vascular smooth muscle cells (VSMCs) and that the underlying mechanism...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (12): 1077–1081.
Published: 13 October 2015
...Chen Yan VSMCs (vascular smooth muscle cells) play critical roles in arterial remodelling with aging, hypertension and atherosclerosis. VSMCs exist in diverse phenotypes and exhibit phenotypic plasticity, e.g. changing from a quiescent/contractile phenotype to an active myofibroblast-like, often...
Articles
Clin Sci (Lond) (2015) 129 (7): 529–531.
Published: 03 July 2015
... are poorly understood. Our current understanding of the effects of aging on the physical and immunological properties of the intestinal epithelial barrier is also very limited. In this issue of Clinical Science , Man et al. provide further insight into the effects of aging on small intestinal barrier...
Articles
Clin Sci (Lond) (2015) 129 (7): 515–527.
Published: 03 July 2015
...Angela L. Man; Eugenio Bertelli; Silvia Rentini; Mari Regoli; Graham Briars; Mario Marini; Alastair J. M. Watson; Claudio Nicoletti The physical and immunological properties of the human intestinal epithelial barrier in aging are largely unknown. Ileal biopsies from young (7–12 years), adult (20–40...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (6): 367–377.
Published: 28 November 2014
... length in peripheral blood mononuclear cells (PBMCs) with age is well documented from cross-sectional studies. But the actual in vivo changes in telomere lengths and its relationship with the contributing factors within the individuals with age have not been fully addressed. In the present paper, we...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (11): 645–654.
Published: 29 July 2014
...Ashley E. Walker; Rachelle E. Kaplon; Gary L. Pierce; Molly J. Nowlan; Douglas R. Seals Habitual aerobic exercise prevents age-related impairments in endothelium-dependent dilation (EDD). We have hypothesized that the pro-inflammatory transcription factor nuclear factor κB (NF-κB) impairs EDD...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (6): 415–421.
Published: 04 June 2014
... of physiological stressors. Although the age-related shortening of TL (telomere length) in highly proliferative tissue is predominantly due to the replication process, the mechanism for telomere shortening in skeletal muscle, which is minimally proliferative, is unclear. By studying TL in both the upper and lower...
Articles
Clin Sci (Lond) (2014) 127 (6): 367–373.
Published: 29 May 2014
... Commons Attribution Non-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. aging cardiovascular disease haplotype hepatotoxicity...
Articles
Clin Sci (Lond) (2014) 126 (10): 739–752.
Published: 03 February 2014
... aging is associated with a low-grade inflammation and IR (insulin resistance), we aimed to: (i) analyse the concentration of eHSP72 in elderly people and determine correlation with insulin resistance, and (ii) determine the effects of eHSP72 on β-cell function and viability in human and rodent...
Articles
Clin Sci (Lond) (2014) 126 (8): 581–592.
Published: 08 December 2013
...Gwenael Layec; Joel D. Trinity; Corey R. Hart; Seong-Eun Kim; Henderik Jonathan Groot; Yann Le Fur; Jacob R. Sorensen; Eun-Kee Jeong; Russell S. Richardson Impaired skeletal muscle efficiency potentially contributes to the age-related decline in exercise capacity and may explain the altered...
Articles
Clin Sci (Lond) (2013) 124 (9): 579–587.
Published: 21 January 2013
...Markos Klonizakis; Ahmad Alkhatib; Geoff Middleton; Mark F. Smith The aging effect on microvascular integrity, marked by endothelial dysfunction and reduction in exercise tolerance, is a major cause of CVD (cardiovascular disease). Improved dietary habits, known to reduce morbidity and mortality...
Articles
Clin Sci (Lond) (2013) 124 (5): 325–331.
Published: 12 November 2012
...Allison E. DeVan; Iratxe Eskurza; Gary L. Pierce; Ashley E. Walker; Kristen L. Jablonski; Rachelle E. Kaplon; Douglas R. Seals In the present study, we tested the hypothesis that age-associated vascular endothelial dysfunction is exacerbated by IFG (impaired fasting plasma glucose) and that regular...
Articles
Clin Sci (Lond) (2013) 124 (3): 153–164.
Published: 05 October 2012
... restriction conditions and are considered anti-aging molecules. SIRT1 has been the most extensively studied. SIRT1 deacetylates target proteins using the coenzyme NAD + and is therefore linked to cellular energy metabolism and the redox state through multiple signalling and survival pathways. SIRT1 deficiency...
Articles
Clin Sci (Lond) (2012) 122 (7): 337–348.
Published: 07 December 2011
... in vasoconstrictor response to EFS, vasomotor responses or neurotransmitter release when compared with age-matched SO animals. In conclusion, the mesenteric innervation may participate in the development of the characteristic hyperdynamic circulation observed in STPH through the joint action of decreased adrenergic...
Articles
Clin Sci (Lond) (2012) 122 (6): 271–279.
Published: 11 November 2011
... (intraduodenal) glucose loads on BP, HR (heart rate), SMA (superior mesenteric artery) flow and vascular conductance and plasma NA (noradrenaline) in ‘young’ and ‘older’ subjects. A total of 12 ‘young’ (six male and six female; age, 22.2±2.3 years) and 12 ‘older’ (six male and six female; age, 68.7±1.0 years...
Articles
Clin Sci (Lond) (2011) 121 (8): 315–329.
Published: 24 June 2011
...Anna Sheydina; Daniel R. Riordon; Kenneth R. Boheler Western societies are rapidly aging, and cardiovascular diseases are the leading cause of death. In fact, age and cardiovascular diseases are positively correlated, and disease syndromes affecting the heart reach epidemic proportions in the very...
Articles
Clin Sci (Lond) (2011) 121 (7): 313–314.
Published: 07 June 2011
...Vanja Kljajevic Correspondence: Dr Vanja Kljajevic (email vanja.kljajevic@gmail.com ). 4 5 2011 18 5 2011 18 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging biological age congitive age longevity telomere telomere length...
Articles
Clin Sci (Lond) (2011) 120 (11): 485–491.
Published: 15 February 2011
... in several pathologies associated with human aging, including hypertension, Type 2 diabetes and coronary artery disease. However, it is currently unknown whether the decline in endothelial vasodilatation with advancing age is due to elevated ET-1 vasconstrictor activity. Accordingly, we tested the hypothesis...
Articles
Clin Sci (Lond) (2011) 120 (10): 427–440.
Published: 28 January 2011
...Haidong Zhu; Matthew Belcher; Pim van der Harst Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease, Type 2 diabetes, neurological diseases and cancer...
Articles
Clin Sci (Lond) (2011) 120 (9): 357–375.
Published: 18 January 2011
...Douglas R. Seals; Kristen L. Jablonski; Anthony J. Donato Advancing age is the major risk factor for the development of CVD (cardiovascular diseases). This is attributable, in part, to the development of vascular endothelial dysfunction, as indicated by reduced peripheral artery EDD (endothelium...
Articles
Clin Sci (Lond) (2011) 120 (1): 13–23.
Published: 14 September 2010
...Gary L. Pierce; Iratxe Eskurza; Ashley E. Walker; Tara N. Fay; Douglas R. Seals Brachial artery FMD (flow-mediated dilation) is impaired with aging and is associated with an increased risk of CVD (cardiovascular disease). In the present study, we determined whether regular aerobic exercise improves...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 118 (4): 303–311.
Published: 16 November 2009
... cell number and function, and (ii) whether oxidative stress affected these factors. Participants included men with a history of more than 30 years of moderate-to-high-intensity exercise (HI group) and healthy low-active age- and BMI (body mass index)-matched control subjects (LO group). Vascular...
Articles
Clin Sci (Lond) (2009) 117 (10): 365–374.
Published: 07 September 2009
...). In contrast with the situation in short-term PH, endothelial dysfunction and an increase in endothelium-dependent contraction have been reported during aging. This effect of aging is mainly mediated by an increase in vasoconstrictor prostanoids [ 9 , 10 ] and/or a decrease in vasodilator factors, such as PGI...
Articles
Clin Sci (Lond) (2007) 112 (8): 429–440.
Published: 13 March 2007
...Yves Harder; Michaela Amon; Mirko Georgi; Claudia Scheuer; Rene Schramm; Martin Rücker; Brigitte Pittet; Dominique Erni; Michael D. Menger In the present study in a murine model of chronic ischaemia, we analysed: (i) whether aging was associated with an increased susceptibility to ischaemic...
Articles
Clin Sci (Lond) (2007) 112 (2): 131–139.
Published: 11 December 2006
... (familial combined hyperlipidaemia). In 194 young adults (<25 years of age) recruited from families with FCH, we investigated how plasma lipids, (apo)lipoproteins and BMI (body mass index) varied with age. Furthermore, we performed a 5-year follow-up study of clinical and biochemical characteristics...
Articles
Clin Sci (Lond) (2004) 107 (4): 355–364.
Published: 24 September 2004
...Mikhail F. ALEXEYEV; Susan P. LeDOUX; Glenn L. WILSON Among the numerous theories that explain the process of aging, the mitochondrial theory of aging has received the most attention. This theory states that electrons leaking from the ETC (electron transfer chain) reduce molecular oxygen to form O...
Articles
Clin Sci (Lond) (2004) 107 (2): 183–190.
Published: 27 July 2004
... with CHF (chronic heart failure). In the present study, we evaluated factors (age, arterial pressures and HR) influencing LFP and HFP (high-frequency power) components in short-term recordings during controlled breathing in patients with CHF or hypertension, and healthy normotensive subjects. In patients...
Articles
Clin Sci (Lond) (2004) 107 (1): 29–35.
Published: 23 June 2004
... sinus arrhythmia and represents vagally mediated modulations in HR. The LF component is influenced by both sympathetic and parasympathetic activity. LF/HF is described as a classical marker of sympathovagal balance [ 33 ]. The Biochemical Society 2004 aerobic fitness level aging autonomic...
Articles
Clin Sci (Lond) (2004) 106 (3): 239–240.
Published: 01 March 2004
..., individuals. The main features of the study as well as its potential limitations will be also highlighted. Correspondence: Professor Guido Grassi (e-mail guido.grassi@unimib.it ). 18 11 2003 19 11 2003 19 11 2003 © 2004 The Biochemical Society 2004 aging endothelial...
Articles
Clin Sci (Lond) (2004) 106 (3): 329–335.
Published: 01 March 2004
...Ferdinando FRANZONI; Fabio GALETTA; Carmela MORIZZO; Valter LUBRANO; Carlo PALOMBO; Gino SANTORO; Eleuterio FERRANNINI; Alfredo QUIÑONES-GALVAN Sedentary aging is associated with endothelial dysfunction and nitric oxide (NO) impairment. The aim of the present study was to assess the effects...
Articles
Clin Sci (Lond) (2003) 105 (6): 699–707.
Published: 01 December 2003
... by increasing age and related to an ongoing inflammation. The responses to local warming and iontophoretically administered endothelium-dependent and -independent vasodilators were investigated in healthy young adults, healthy elderly adults and elderly adults with CHF. The results were correlated with plasma...
Articles
Clin Sci (Lond) (2003) 104 (3): 267–273.
Published: 14 February 2003
...Sonia KATYAL; Michael FREEMAN; Judith A. MILLER; Scott G. THOMAS The physiological basis of training responses in women, and particularly older women, is not well understood. Short-term aerobic training (STAT) was used to probe the effects of age and hormone-replacement therapy (HRT) on women's...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 118S–123S.
Published: 01 September 2002
...Seiji MAEDA; Takashi MIYAUCHI; Motoyuki IEMITSU; Takumi TANABE; Tomoko YOKOTA; Katsutoshi GOTO; Iwao YAMAGUCHI; Mitsuo MATSUDA Aging impairs endothelial function and the vascular tone regulation, although the precise mechanism remains unclear. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 455S–458S.
Published: 01 September 2002
... expression of ET-2/VIC in the old mice did not change after ethanol exposure. Based on these results, we conclude that aging influences the gene expression of ET-2/VIC but not lesion size or gene expression of ET-1 in ethanol-induced gastric injury in the mouse. We therefore suggest that regulation of gene...
Articles
Clin Sci (Lond) (2001) 101 (4): 429–438.
Published: 20 September 2001
... in QT interval on a single ECG lead-shows a trend towards positive values. Increased QT variability is a risk factor for sudden death. Aging lengthens the QT interval and reduces RR-interval variability. In the present study we investigated the influence of aging and the autonomic nervous system on QT...