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Keywords: aging
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Clin Sci (Lond) (2024) 138 (8): 515–536.
Published: 23 April 2024
..., a heterogeneous group of glial cells, play key roles in regulating the metabolic and inflammatory landscape of the CNS and have emerged as potential therapeutic targets for a variety of disorders. This review will outline astrocyte functions in the CNS in healthy ageing, obesity, and neurodegeneration...
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Clin Sci (Lond) (2023) 137 (11): 913–930.
Published: 14 June 2023
...Kishore Chittimalli; Jesmin Jahan; Anil Sakamuri; Zachary L. McAdams; Aaron C. Ericsson; Yagna P.R. Jarajapu Compromised barrier function of colon epithelium with aging is largely due to gut microbial dysbiosis. Recent studies implicate an important role for angiotensin converting enzymes, ACE...
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Clin Sci (Lond) (2022) 136 (16): 1229–1240.
Published: 31 August 2022
... therapy. The most common form is referred to as ‘idiopathic’ since a causal agent or specific association has not been determined; the strongest risk factor for idiopathic pulmonary fibrosis is aging. Emerging studies indicate that targeting certain components of aging biology may be effective...
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Clin Sci (Lond) (2022) 136 (13): 1025–1043.
Published: 04 July 2022
... are weak and there is little understanding of mechanism. Aging is by far the greatest risk factor for BC, and there are specific forms of inherited genetic risk that are well-understood to cause BC. We propose that bringing focus to the biology underlying these forms of risk will illuminate biological...
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Clin Sci (Lond) (2022) 136 (1): 61–80.
Published: 05 January 2022
...Manon Chauvin; Delphine Sauce Massive CD4 + T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many...
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Clin Sci (Lond) (2020) 134 (16): 2177–2187.
Published: 26 August 2020
...Edmund Battey; Matthew J. Stroud; Julien Ochala Skeletal muscle weakness is an important determinant of age-related declines in independence and quality of life but its causes remain unclear. Accelerated ageing syndromes such as Hutchinson–Gilford Progerin Syndrome, caused by mutations in genes...
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Clin Sci (Lond) (2018) 132 (13): 1367–1382.
Published: 09 July 2018
...Vanessa Obas; Ramachandran S. Vasan As the elderly segment of the world population increases, it is critical to understand the changes in cardiac structure and function during the normal aging process. In this review, we outline the key molecular pathways and cellular processes that underlie...
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Clin Sci (Lond) (2016) 130 (16): 1407–1416.
Published: 07 July 2016
...Sergej M. Ostojic Beneficial effects of physical activity on mitochondrial health are well substantiated in the scientific literature, with regular exercise improving mitochondrial quality and quantity in normal healthy population, and in cardiometabolic and neurodegenerative disorders and aging...
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Clin Sci (Lond) (2016) 130 (15): 1285–1305.
Published: 29 June 2016
... the transcriptional process, acting at the epigenomic interface between metabolism and the genome. Within this framework, we review existing evidence showing that preservation of mitochondrial network function is directly involved in decreasing the rate of damage accumulation thus slowing aging and improving...
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Clin Sci (Lond) (2016) 130 (10): 761–771.
Published: 01 April 2016
... studied but it opens the possibility that the AT 2 R may have a greater influence on renal function at this stage of life. Recently it has been demonstrated that at 3 weeks of age in male rats, the AT 2 R modulates the response to AngII, blunting renal vasoconstriction [ 26 ]. Moreover, this effect...
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Clin Sci (Lond) (2016) 130 (5): 317–335.
Published: 26 January 2016
...Sanghamitra Sahoo; Daniel N. Meijles; Patrick J. Pagano Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial fibrillation (AF). NADPH oxidases (Nox) are a major source...
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Clin Sci (Lond) (2015) 129 (12): 1077–1081.
Published: 13 October 2015
...Chen Yan VSMCs (vascular smooth muscle cells) play critical roles in arterial remodelling with aging, hypertension and atherosclerosis. VSMCs exist in diverse phenotypes and exhibit phenotypic plasticity, e.g. changing from a quiescent/contractile phenotype to an active myofibroblast-like, often...
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Clin Sci (Lond) (2015) 129 (7): 529–531.
Published: 03 July 2015
... are poorly understood. Our current understanding of the effects of aging on the physical and immunological properties of the intestinal epithelial barrier is also very limited. In this issue of Clinical Science , Man et al. provide further insight into the effects of aging on small intestinal barrier...
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Clin Sci (Lond) (2015) 129 (7): 515–527.
Published: 03 July 2015
...Angela L. Man; Eugenio Bertelli; Silvia Rentini; Mari Regoli; Graham Briars; Mario Marini; Alastair J. M. Watson; Claudio Nicoletti The physical and immunological properties of the human intestinal epithelial barrier in aging are largely unknown. Ileal biopsies from young (7–12 years), adult (20–40...
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Clin Sci (Lond) (2013) 124 (9): 579–587.
Published: 21 January 2013
...Markos Klonizakis; Ahmad Alkhatib; Geoff Middleton; Mark F. Smith The aging effect on microvascular integrity, marked by endothelial dysfunction and reduction in exercise tolerance, is a major cause of CVD (cardiovascular disease). Improved dietary habits, known to reduce morbidity and mortality...
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Clin Sci (Lond) (2013) 124 (3): 153–164.
Published: 05 October 2012
... restriction conditions and are considered anti-aging molecules. SIRT1 has been the most extensively studied. SIRT1 deacetylates target proteins using the coenzyme NAD + and is therefore linked to cellular energy metabolism and the redox state through multiple signalling and survival pathways. SIRT1 deficiency...
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Clin Sci (Lond) (2012) 122 (7): 337–348.
Published: 07 December 2011
... in vasoconstrictor response to EFS, vasomotor responses or neurotransmitter release when compared with age-matched SO animals. In conclusion, the mesenteric innervation may participate in the development of the characteristic hyperdynamic circulation observed in STPH through the joint action of decreased adrenergic...
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Clin Sci (Lond) (2011) 121 (8): 315–329.
Published: 24 June 2011
...Anna Sheydina; Daniel R. Riordon; Kenneth R. Boheler Western societies are rapidly aging, and cardiovascular diseases are the leading cause of death. In fact, age and cardiovascular diseases are positively correlated, and disease syndromes affecting the heart reach epidemic proportions in the very...
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Clin Sci (Lond) (2011) 121 (7): 313–314.
Published: 07 June 2011
...Vanja Kljajevic Correspondence: Dr Vanja Kljajevic (email vanja.kljajevic@gmail.com ). 4 5 2011 18 5 2011 18 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging biological age congitive age longevity telomere telomere length...
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Clin Sci (Lond) (2011) 120 (11): 485–491.
Published: 15 February 2011
... in several pathologies associated with human aging, including hypertension, Type 2 diabetes and coronary artery disease. However, it is currently unknown whether the decline in endothelial vasodilatation with advancing age is due to elevated ET-1 vasconstrictor activity. Accordingly, we tested the hypothesis...
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Clin Sci (Lond) (2011) 120 (10): 427–440.
Published: 28 January 2011
...Haidong Zhu; Matthew Belcher; Pim van der Harst Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease, Type 2 diabetes, neurological diseases and cancer...
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Clin Sci (Lond) (2011) 120 (9): 357–375.
Published: 18 January 2011
...Douglas R. Seals; Kristen L. Jablonski; Anthony J. Donato Advancing age is the major risk factor for the development of CVD (cardiovascular diseases). This is attributable, in part, to the development of vascular endothelial dysfunction, as indicated by reduced peripheral artery EDD (endothelium...
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Clin Sci (Lond) (2011) 120 (1): 13–23.
Published: 14 September 2010
...Gary L. Pierce; Iratxe Eskurza; Ashley E. Walker; Tara N. Fay; Douglas R. Seals Brachial artery FMD (flow-mediated dilation) is impaired with aging and is associated with an increased risk of CVD (cardiovascular disease). In the present study, we determined whether regular aerobic exercise improves...
Includes: Supplementary data
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Clin Sci (Lond) (2009) 117 (10): 365–374.
Published: 07 September 2009
...). In contrast with the situation in short-term PH, endothelial dysfunction and an increase in endothelium-dependent contraction have been reported during aging. This effect of aging is mainly mediated by an increase in vasoconstrictor prostanoids [ 9 , 10 ] and/or a decrease in vasodilator factors, such as PGI...
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Clin Sci (Lond) (2004) 107 (4): 355–364.
Published: 24 September 2004
...Mikhail F. ALEXEYEV; Susan P. LeDOUX; Glenn L. WILSON Among the numerous theories that explain the process of aging, the mitochondrial theory of aging has received the most attention. This theory states that electrons leaking from the ETC (electron transfer chain) reduce molecular oxygen to form O...
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Clin Sci (Lond) (2004) 107 (1): 29–35.
Published: 23 June 2004
... level aging autonomic nervous system female orthostatic stress parasympathetic modulation HR (heart rate) is mainly controlled by autonomic nerve activity to the sinoatrial node. Sympathetic and parasympathetic drive can be non-invasively investigated using HRV (HR variability) analysis [ 1...
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Clin Sci (Lond) (2004) 106 (3): 239–240.
Published: 01 March 2004
..., individuals. The main features of the study as well as its potential limitations will be also highlighted. Correspondence: Professor Guido Grassi (e-mail guido.grassi@unimib.it ). 18 11 2003 19 11 2003 19 11 2003 © 2004 The Biochemical Society 2004 aging endothelial...
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Clin Sci (Lond) (2004) 106 (3): 329–335.
Published: 01 March 2004
...Ferdinando FRANZONI; Fabio GALETTA; Carmela MORIZZO; Valter LUBRANO; Carlo PALOMBO; Gino SANTORO; Eleuterio FERRANNINI; Alfredo QUIÑONES-GALVAN Sedentary aging is associated with endothelial dysfunction and nitric oxide (NO) impairment. The aim of the present study was to assess the effects...
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Clin Sci (Lond) (2003) 105 (6): 699–707.
Published: 01 December 2003
... by increasing age and related to an ongoing inflammation. The responses to local warming and iontophoretically administered endothelium-dependent and -independent vasodilators were investigated in healthy young adults, healthy elderly adults and elderly adults with CHF. The results were correlated with plasma...
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Clin Sci (Lond) (2003) 104 (3): 267–273.
Published: 14 February 2003
...Sonia KATYAL; Michael FREEMAN; Judith A. MILLER; Scott G. THOMAS The physiological basis of training responses in women, and particularly older women, is not well understood. Short-term aerobic training (STAT) was used to probe the effects of age and hormone-replacement therapy (HRT) on women's...
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