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Keywords: age
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Articles
Clin Sci (Lond) (2017) 131 (11): 1179–1189.
Published: 22 May 2017
...) and Physician Global Assessment (PGA), and etanercept and anti-etanercept antibody concentrations were determined every 3 months for a period of 1 year. The present study demonstrated that the association between etanercept concentration and psoriasis severity is age-dependent: when patients were stratified...
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Clin Sci (Lond) (2012) 122 (8): 369–373.
Published: 14 December 2011
... associations, but which has important limitations: most critically, that effective treatment to reduce arterial damage is often delayed until the age at which cardiovascular events become common. This delay means that many of the early victims of vascular disease will not be identified in time. This delay also...
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Clin Sci (Lond) (2008) 114 (12): 719–727.
Published: 14 May 2008
...Natalie El Haber; Bircan Erbas; Keith D. Hill; John D. Wark An age-related decline in balance, gait and lower-extremity muscle strength measures may lead to increased risk of falls and fractures. Previous studies have reported a possible non-linear age-related decline in these measures...
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Clin Sci (Lond) (2003) 105 (4): 457–466.
Published: 01 October 2003
... for coronary heart disease. A small number of limited studies have compared postprandial lipaemia in subjects of varying age, but have not investigated mechanisms underlying age-associated changes in postprandial lipaemia. In order to test the hypothesis that impaired lipaemia in older subjects is associated...
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Clin Sci (Lond) (2002) 102 (1): 31–38.
Published: 03 December 2001
...Yoshiyuki FUKUOKA; Yoko NAKAGAWA; Katsutoshi OGOH; Tomoyuki SHIOJIRI; Yoshiyuki FUKUBA The purpose of the present study was to define the influence of age and exercise training on the heart rate (HR) dynamic response (i.e. kinetics) to sinusoidal work. A total of 63 healthy subjects (31 men and 32...
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Clin Sci (Lond) (1998) 95 (2): 165–169.
Published: 01 August 1998
... and 85.3±37.3 ;min respectively ( P < 0.05). Delayed transit characterized constipation-predominant patients with irritable bowel syndrome, whereas accelerated transit was observed in diarrhoea-predominant patients with irritable bowel syndrome. The ages of constipation-predominant and diarrhoea...
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Clin Sci (Lond) (1991) 81 (s25): 531–538.
Published: 01 October 1991
... baroreceptor (head-up tilt) and non-baroreceptor (cold stress, isometric exercise) afferent pathways. 2. In 15 healthy elderly control subjects blood pressure did not change with 60° head-up tilting and there was a moderate increase in heart rate, whereas in 13 subjects with age-related orthostatic hypotension...
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Clin Sci (Lond) (1990) 78 (1): 89–93.
Published: 01 January 1990
...Tsutomu Imaizumi; Akira Takeshita; Satoshi Suzuki; Megumu Yoshida; Shinichi Ando; Motoomi Nakamura 1. Forearm vasodilator responses to acetylcholine, ATP and sodium nitroprusside were examined in healthy young (20 ± 1 years, n = 9), middle-aged (46 ± 2 years, n = 6) and old (57 ± 1 years, n = 6...
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Clin Sci (Lond) (1989) 76 (6): 667–671.
Published: 01 June 1989
... BDI rats, whereas in the adult animals vasopressin had the greater pressor effect in the BDI rats compared with the LE rats of comparable age. 4. There was little effect of vasopressin on cardiac output after the initial decrease, particularly in the BDI rats whether immature or adult, despite more...
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Clin Sci (Lond) (1989) 76 (6): 619–623.
Published: 01 June 1989
...E. A. Messenger; C. Stonier; G. M. Aber 1. Glomerular angiotensin II (ANG II) binding has been studied in normotensive (NTR) and spontaneously hypertensive (SHR) rats at 5, 10, 15 and 20 weeks of age. 2. Binding of 125 I-labelled ANG II by glomeruli from NTR and SHR was similar at 5 and 10 weeks...
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Clin Sci (Lond) (1989) 76 (2): 195–198.
Published: 01 February 1989
...Roger R. Taylor; Marian Sturm; Philip J. Kendrew; Robert Vandongen; Lawrence J. Beilin 1. The effect of age on the plasma level of the lyso-derivative of platelet-activating factor (lyso-PAF) was studied in 72 normal subjects, (32 females, 40 males) aged 12–64 years. Lyso-PAF was acetylated...
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Clin Sci (Lond) (1988) 75 (4): 341–343.
Published: 01 October 1988
...P. Y. Scarabin; P. Van Dreden; C. Bonithon-Kop; G. Orssaud; L. Bara; J. Conard; M. Samama 1. To investigate the age-related changes in factor VII activation in healthy women, a regular factor VII clotting assay (factor VIIc) was carried out simultaneously with a new enzyme immunoassay...
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Clin Sci (Lond) (1988) 75 (2): 159–165.
Published: 01 August 1988
... pressures, ± 10.0 (− 16.9) and ± 5.4 (− 10.1) mmHg, respectively. 5. Control values and responses to neck suction at − 30 mmHg were compared in subjects grouped in four age bands between 19 and 80 years. With increasing age, the control value of cardiac index (cardiac output divided by calculated body...
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Clin Sci (Lond) (1988) 74 (1): 17–22.
Published: 01 January 1988
...R. Hainsworth; Y. M. H. Al-Shamma 1. The cardiovascular responses to passive upright tilting were determined in healthy human subjects of various ages using entirely ‘non-invasive’ techniques. Cardiac output was determined by a single breath method and arterial blood pressure by an automatic...
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Clin Sci (Lond) (1987) 72 (5): 571–576.
Published: 01 May 1987
...Seiya Okuda; Kenichi Motomura; Tohru Sanai; Hiroshi Tsuruda; Yukinori Oh; Kaoru Onoyama; Masatoshi Fujishima 1. To investigate the influence of age on the remnant kidney, unilateral nephrectomy was performed in rats at 1 day (group N-0), 2 weeks (group N-2), 4 weeks (group N-4) or 8 weeks (group N...
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Clin Sci (Lond) (1987) 72 (3): 335–341.
Published: 01 March 1987
...J. H. A. Dambrink; W. Wieling 1. The initial heart rate (HR) response evoked by standing up and 70° head-up tilt from the supine resting position, as well as the changes in HR and blood pressure after 1–2 min in the upright position, was analysed in teenage boys (aged 10–15 years) and healthy old...
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Clin Sci (Lond) (1986) 71 (3): 291–297.
Published: 01 September 1986
... and capacity, were observed in different groups of subjects. Sig- nificantly lower concentrations were found in adults and in pre-term and stillborn infants than in older infants and children. Key words: age, brown adipose tissue, mitochon- drion, premature infants, radioimmunoassay, thermogenesis, uncoupling...
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Clin Sci (Lond) (1985) 69 (5): 525–532.
Published: 01 November 1985
... 1985 The Biochemical Society and the Medical Research Society 1985 age thermoregulation undernutrition Clinical Science (1985) 69, 525-532 525 The effect of undernutrition on thermoregulation in the elderly I . W. F E L L O W S , I . A. M A C D O N A L D , T . B E N N E T T A N D S . P . A L...
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Clin Sci (Lond) (1985) 68 (5): 601–604.
Published: 01 May 1985
...A. Barden; L. J. Beilin; R. Vandongen; I. Rouse 1. Measurement of urinary 6-ketoprostaglandin (PG) F 1α and PGE 2 excretion in 83 healthy children, aged 5-15 years, revealed that supervised 4 h urine collections under mild water diuresis provided more consistent results than overnight 12 h urine...
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Clin Sci (Lond) (1984) 67 (2): 213–218.
Published: 01 August 1984
...Michael Horowitz; Guy J. Maddern; Barry E. Chatterton; Peter J. Collins; Philip E. Harding; David J. C. Shearman 1. A dual isotope technique which measures simultaneously the emptying of solids and liquids by the stomach was used to study gastric emptying in 35 subjects in the age range 21-84 years...
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Clin Sci (Lond) (1983) 65 (6): 653–660.
Published: 01 December 1983
...Rolf E. Ehrsam; André Perruchoud; Martin Oberholzer; Felix Burkart; Heinrich Herzog 1. To determine the effects of age on the pulmonary circulation at rest and on exercise we analysed the results of right heart catheterization studies performed in 125 asymptomatic subjects aged 14-68 years, who...
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Clin Sci (Lond) (1983) 65 (5): 521–526.
Published: 01 November 1983
...J. M. Patrick; E. J. Bassey; P. H. Fentem 1. Submaximal bicycle exercise tests have been performed in nine healthy men on seven annual occasions between the ages of 64 and 70 years. Ten younger men (average age 33 years) have also been studied once for comparison. 2. The ventilatory cost...
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Clin Sci (Lond) (1981) 61 (s7): 393s–394s.
Published: 01 December 1981
... than 60 years of age. Each patient was matched with respect to mean arterial pressure, body surface area, race and sex with a patient that was younger than 42 years of age. 2. When compared with the younger group, elderly patients had a lower cardiac output, impaired myocardial reserve, lesser aortic...
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Clin Sci (Lond) (1981) 61 (s7): 311s–313s.
Published: 01 December 1981
...A. Salvetti; R. Pedrinelli; F. Arzilli; P. Sassano; G. Leonetti; L. Terzoli; C. Bianchini; M. Fruscio 1. A stepwise infusion of phentolamine was administered to 26 patients with mild uncomplicated essential hypertension, whose basal renin was inversely related to age. 2. Phentolamine caused a dose...
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Clin Sci (Lond) (1981) 61 (2): 151–157.
Published: 01 August 1981
... and decrease in lung function. 5. Three non-atopic asthmatic patients had a significantly higher mean plasma histamine concentration during exercise than had the atopic subjects. 6. A strong positive correlation in asthmatic patients, and asthmatic and control subjects together was found between age and mean...
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Clin Sci (Lond) (1981) 60 (2): 217–219.
Published: 01 February 1981
...M. Esler; H. Skews; P. Leonard; G. Jackman; A. Bobik; P. Korner 1. The influence of age on the rate of spillover of noradrenaline into plasma, clearance of noradrenaline from plasma, and plasma noradrenaline concentration at rest was studied in 34 healthy subjects aged 20–69 years. 2. The plasma...
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Clin Sci (Lond) (1980) 59 (6): 479–483.
Published: 01 December 1980
...A. F. MacKlon; M. Barton; O. James; M. D. Rawlins 1. After intravenous administration to 19 subjects, aged 18–95 years, plasma diazepam concentrations were measured over 160 h. Plasma protein binding of diazepam was also measured in each subject. 2. The terminal plasma half-life of diazepam ranged...
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Clin Sci (Lond) (1980) 59 (s6): 427s–429s.
Published: 01 December 1980
...B. Rajagopalan; G. W. Thomas; L. J. Beilin; J. G. G. Ledingham 1. Plasma volume, 24 h urine sodium and total body potassium were similar among 89 previously untreated patients with mild hypertension and 89 control subjects matched for age and sex. 2. Total body potassium correlated with renin...
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Clin Sci (Lond) (1980) 59 (s6): 401s–404s.
Published: 01 December 1980
...G. Mancia; A. Ferrari; L. Gregorini; G. Parati; G. Pomidossi; G. Bertinieri; G. Grassi; A. Zanchetti 1. Intra-arterial blood pressure and heart rate were recorded for 24 h in ambulant hospitalized patients of variable age who had normal blood pressure or essential hypertension. Mean 24 h values...
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Clin Sci (Lond) (1979) 57 (3): 273–275.
Published: 01 September 1979
... before puberty. 2 2 1979 24 4 1979 © 1979 The Biochemical Society and the Medical Research Society 1979 age diabetes insipidus hypertension Clinical Science (1979) 51,273-275 SHORT COMMUNICATION Effect of age on hypertensive stimuli and the development of hypertension...
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Clin Sci Mol Med (1978) 55 (s4): 73s–75s.
Published: 01 December 1978
...D. H. Jones; C. A. Hamilton; J. L. Reid 1. Mean supine plasma noradrenaline was lower in 12 male laboratory staff (0·24 ± 0·02 μg/l) than similarly normotensive out-patients (0·44 ± 0·07 μg/l). 2. In 164 non-medical hospital staff, plasma noradrenaline increased with age in white males only. 3...
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Clin Sci Mol Med (1978) 55 (s4): 377s–379s.
Published: 01 December 1978
...C. E. Grim; M. H. Weinberger; D. P. Henry; F. C. Luft; N. S. Fineberg 1. Blood pressure, plasma renin activity, plasma aldosterone, urinary noradrenaline during sleep (U NA-S ) and several estimates of sodium intake were determined in 379 normotensive subjects (age 13–70) to investigate...
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Clin Sci Mol Med (1978) 55 (2): 213–220.
Published: 01 August 1978
... groups. 6. It is suggested that there is a defect in intestinal absorption of cholecalciferol in the elderly. 12 1 1978 16 4 1978 © 1978 The Biochemical Society and the Medical Research Society 1978 age cholecalciferol intestinal absorption Clinical Science andMolecular...
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Clin Sci Mol Med (1978) 54 (1): 111–113.
Published: 01 January 1978
...J. N. MacPherson; P. Tothill 1. The proportion of the cardiac output delivered to the skeleton and individual bones has been determined in rats of differing ages and weights with radioactive microspheres. 2. There was a decrease in the blood flow to the tibia—fibula, jaw, femur, pelvis, humerus...
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Clin Sci Mol Med (1977) 52 (4): 405–412.
Published: 01 April 1977
... blood flow were significantly lower in low-renin hypertension. Total peripheral and renal vascular resistance were markedly higher in this group. 3. Plasma renin concentration correlated inversely with both total peripheral and renal vascular resistance as well as with age. Multiple regression analysis...
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Clin Sci Mol Med (1976) 51 (s3): 185s–188s.
Published: 01 December 1976
...G. W. Thomas; J. G. G. Ledingham; L. J. Beilin; A. N. Stott 1. Supine plasma renin activity and its responsiveness to erect posture and frusemide were reduced in fifty-one patients with essential hypertension, compared with fifty-one age- and sex-matched control subjects. 2. Twenty-four hour...
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Clin Sci Mol Med (1976) 51 (s3): 695s–696s.
Published: 01 December 1976
...T. Thulin; R. W. Pero; C. Bryngelsson; F. Mitelman; Å. Nordén; B. Scherstén 1. The level of DNA repair synthesis has been compared in males diagnosed as having hypertension (diastolic blood pressure ≥ 100 mmHg), males with slightly elevated blood pressure (>95th percentile corrected for age...
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Clin Sci Mol Med (1976) 51 (2): 185–188.
Published: 01 August 1976
...P. M. Tweeddale; R. J. E. Leggett; D. C. Flenley 1. Oxygen-binding, plasma and intra-erythrocytic pH, and haemoglobin, 2,3-diphosphoglycerate and inorganic phosphate concentrations were measured in sixty-two healthy non-smokers aged between 18 and 89 years. 2. P 50 (oxygen tension at 50% oxygen...
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Clin Sci Mol Med (1976) 50 (5): 409–414.
Published: 01 May 1976
... and in fifteen control subjects. 2. GFR and RPF were similar in the hypertensive group and in the control group, whereas the renal vascular resistance was significantly higher in the hypertensive patients. GFR and RPF decreased with increasing blood pressure in both groups. Increasing age induced a further...
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Clin Sci Mol Med (1976) 50 (2): 103–107.
Published: 01 February 1976
... was significantly higher in young spontaneously hypertensive than in normotensive rats of the same age (5–7 weeks). After the ninth week plasma renin activity decreased and, at week 45, became significantly lower in hypertensive than in normotensive rats. 4. When hypertension was established a significant inverse...
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Clin Sci Mol Med (1973) 45 (s1): 107s–110s.
Published: 01 August 1973
...M. Ulrych; J. Tauber; A. P. Shapiro 1. In 404 male steelmill workers blood pressure and body weight were followed for 15–25 years and their relationships analysed. 2. It appears that age on average has a negligible influence on diastolic pressure and has a positive influence on systolic pressure...
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Clin Sci Mol Med (1973) 45 (s1): 23s–33s.
Published: 01 August 1973
...W. E. Miall; Susan Chinn 1. Several recent studies of the relation between blood pressure and ageing have been re-examined, and it is concluded that none satisfactorily investigates the possibility of separate influences of age and attained pressure in determining the rate of change of pressure...