Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
NARROW
Format
Subjects
Article Type
Date
Availability
1-50 of 53
Keywords: age
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1179–1189.
Published: 22 May 2017
...) and Physician Global Assessment (PGA), and etanercept and anti-etanercept antibody concentrations were determined every 3 months for a period of 1 year. The present study demonstrated that the association between etanercept concentration and psoriasis severity is age-dependent: when patients were stratified...
Articles
Allan D. Sniderman, Patrick R. Lawler, Ken Williams, George Thanassoulis, Jacqueline de Graaf, Curt D. Furberg
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (8): 369–373.
Published: 14 December 2011
... associations, but which has important limitations: most critically, that effective treatment to reduce arterial damage is often delayed until the age at which cardiovascular events become common. This delay means that many of the early victims of vascular disease will not be identified in time. This delay also...
Articles
Maksim O. Emel'yanov, Antonina F. Korystova, Ludmila N. Kublik, Maria Kh. Levitman, Vera V. Shaposhnikova, Yuri N. Korystov
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (2): 75–81.
Published: 20 September 2011
... -nitro- L -arginine methyl ester) or dexamethasone and the effect of low doses of ethanol (0.2–1.2 g/kg of body weight, daily for 8–12 days) on this activity were studied. We found that ACE activity increased with age and in response to L -NAME and dexamethasone treatment. Ethanol at a dose of 0.4 g/kg...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (6): 279–284.
Published: 27 May 2011
... and haemodynamic evaluation. TO and TS significantly correlated with Phe-slope ( r =−0.39, P <0.0001 and r =0.66, P <0.0001 respectively). Age, baseline heart rate, LVEF (left ventricular ejection fraction), PCP (pulmonary capillary pressure), CI (cardiac index) and sodium were significant and independent...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (12): 719–727.
Published: 14 May 2008
...Natalie El Haber; Bircan Erbas; Keith D. Hill; John D. Wark An age-related decline in balance, gait and lower-extremity muscle strength measures may lead to increased risk of falls and fractures. Previous studies have reported a possible non-linear age-related decline in these measures...
Articles
Bart Verheyden, Janneke Gisolf, Frank Beckers, John M. Karemaker, Karel H. Wesseling, André E. Aubert, Wouter Wieling
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (7): 329–337.
Published: 03 September 2007
...Bart Verheyden; Janneke Gisolf; Frank Beckers; John M. Karemaker; Karel H. Wesseling; André E. Aubert; Wouter Wieling NTG (nitroglycerine) is used in routine tilt testing to elicit a vasovagal response. In the present study we hypothesized that with increasing age NTG triggers a more gradual BP...
Articles
Kim G. JACKSON, Jacky M. E. KNAPPER-FRANCIS, Linda M. MORGAN, Diane H. WEBB, Antonis ZAMPELAS, Christine M. WILLIAMS
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (4): 457–466.
Published: 01 October 2003
... for coronary heart disease. A small number of limited studies have compared postprandial lipaemia in subjects of varying age, but have not investigated mechanisms underlying age-associated changes in postprandial lipaemia. In order to test the hypothesis that impaired lipaemia in older subjects is associated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (1): 31–38.
Published: 03 December 2001
...Yoshiyuki FUKUOKA; Yoko NAKAGAWA; Katsutoshi OGOH; Tomoyuki SHIOJIRI; Yoshiyuki FUKUBA The purpose of the present study was to define the influence of age and exercise training on the heart rate (HR) dynamic response (i.e. kinetics) to sinusoidal work. A total of 63 healthy subjects (31 men and 32...
Articles
J. GAMBLE, D. BETHELL, N. P. J. DAY, P. P. LOC, N. H. PHU, I. B. GARTSIDE, J. F. FARRAR, N. J. WHITE
Journal:
Clinical Science
Clin Sci (Lond) (2000) 98 (2): 211–216.
Published: 31 January 2000
... controls, age-matched to children with dengue shock syndrome, gave high values of filtration capacity ( K f ), a factor describing vascular permeability. We hypothesized that K f might be age dependent. Calf K f was studied in 89 healthy Vietnamese subjects aged 5 to 77 years. The K f was highest...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 95 (2): 165–169.
Published: 01 August 1998
... and 85.3±37.3 ;min respectively ( P < 0.05). Delayed transit characterized constipation-predominant patients with irritable bowel syndrome, whereas accelerated transit was observed in diarrhoea-predominant patients with irritable bowel syndrome. The ages of constipation-predominant and diarrhoea...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (3): 331–337.
Published: 01 March 1993
...E. J. Bassey; U. J. Harries 1. The maximal grip strength of the hand has been measured in a random sample of 359 men and 561 women aged over 65 years living in their own homes. The response rate was 80% from a representative demographic area of the U.K. Measurements were made of body mass, skeletal...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (s25): 531–538.
Published: 01 October 1991
... baroreceptor (head-up tilt) and non-baroreceptor (cold stress, isometric exercise) afferent pathways. 2. In 15 healthy elderly control subjects blood pressure did not change with 60° head-up tilting and there was a moderate increase in heart rate, whereas in 13 subjects with age-related orthostatic hypotension...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (1): 89–93.
Published: 01 January 1990
...Tsutomu Imaizumi; Akira Takeshita; Satoshi Suzuki; Megumu Yoshida; Shinichi Ando; Motoomi Nakamura 1. Forearm vasodilator responses to acetylcholine, ATP and sodium nitroprusside were examined in healthy young (20 ± 1 years, n = 9), middle-aged (46 ± 2 years, n = 6) and old (57 ± 1 years, n = 6...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1989) 76 (6): 667–671.
Published: 01 June 1989
... BDI rats, whereas in the adult animals vasopressin had the greater pressor effect in the BDI rats compared with the LE rats of comparable age. 4. There was little effect of vasopressin on cardiac output after the initial decrease, particularly in the BDI rats whether immature or adult, despite more...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1989) 76 (6): 619–623.
Published: 01 June 1989
...E. A. Messenger; C. Stonier; G. M. Aber 1. Glomerular angiotensin II (ANG II) binding has been studied in normotensive (NTR) and spontaneously hypertensive (SHR) rats at 5, 10, 15 and 20 weeks of age. 2. Binding of 125 I-labelled ANG II by glomeruli from NTR and SHR was similar at 5 and 10 weeks...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1989) 76 (2): 195–198.
Published: 01 February 1989
...Roger R. Taylor; Marian Sturm; Philip J. Kendrew; Robert Vandongen; Lawrence J. Beilin 1. The effect of age on the plasma level of the lyso-derivative of platelet-activating factor (lyso-PAF) was studied in 72 normal subjects, (32 females, 40 males) aged 12–64 years. Lyso-PAF was acetylated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (4): 341–343.
Published: 01 October 1988
...P. Y. Scarabin; P. Van Dreden; C. Bonithon-Kop; G. Orssaud; L. Bara; J. Conard; M. Samama 1. To investigate the age-related changes in factor VII activation in healthy women, a regular factor VII clotting assay (factor VIIc) was carried out simultaneously with a new enzyme immunoassay...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (2): 159–165.
Published: 01 August 1988
... pressures, ± 10.0 (− 16.9) and ± 5.4 (− 10.1) mmHg, respectively. 5. Control values and responses to neck suction at − 30 mmHg were compared in subjects grouped in four age bands between 19 and 80 years. With increasing age, the control value of cardiac index (cardiac output divided by calculated body...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 74 (1): 17–22.
Published: 01 January 1988
...R. Hainsworth; Y. M. H. Al-Shamma 1. The cardiovascular responses to passive upright tilting were determined in healthy human subjects of various ages using entirely ‘non-invasive’ techniques. Cardiac output was determined by a single breath method and arterial blood pressure by an automatic...
Articles
Seiya Okuda, Kenichi Motomura, Tohru Sanai, Hiroshi Tsuruda, Yukinori Oh, Kaoru Onoyama, Masatoshi Fujishima
Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (5): 571–576.
Published: 01 May 1987
...Seiya Okuda; Kenichi Motomura; Tohru Sanai; Hiroshi Tsuruda; Yukinori Oh; Kaoru Onoyama; Masatoshi Fujishima 1. To investigate the influence of age on the remnant kidney, unilateral nephrectomy was performed in rats at 1 day (group N-0), 2 weeks (group N-2), 4 weeks (group N-4) or 8 weeks (group N...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (3): 335–341.
Published: 01 March 1987
...J. H. A. Dambrink; W. Wieling 1. The initial heart rate (HR) response evoked by standing up and 70° head-up tilt from the supine resting position, as well as the changes in HR and blood pressure after 1–2 min in the upright position, was analysed in teenage boys (aged 10–15 years) and healthy old...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 71 (3): 291–297.
Published: 01 September 1986
... and capacity, were observed in different groups of subjects. Sig- nificantly lower concentrations were found in adults and in pre-term and stillborn infants than in older infants and children. Key words: age, brown adipose tissue, mitochon- drion, premature infants, radioimmunoassay, thermogenesis, uncoupling...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (5): 489–494.
Published: 01 May 1986
...Kazuyuki Shimada; Tadao Kitazumi; Hisakazu Ogura; Noriko Sadakane; Toshio Ozawa 1. Inter-relationship between age, systolic blood pressure and baroreflex sensitivity index derived from the Valsalva manoeuvre was investigated in either combined or separated groups of normal and hypertensive subjects...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 70 (3): 249–255.
Published: 01 March 1986
... patients <30 years of age, 13 patients ≥.30 years of age and in 15 patients with peripheral vascular disease (PVD). With increasing age the SPP and SVR were increased. The SPP was similar to the mean arterial pressure in normal individuals but was decreased in patients with PVD. The SPP is a useful...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 69 (5): 525–532.
Published: 01 November 1985
... 1985 The Biochemical Society and the Medical Research Society 1985 age thermoregulation undernutrition Clinical Science (1985) 69, 525-532 525 The effect of undernutrition on thermoregulation in the elderly I . W. F E L L O W S , I . A. M A C D O N A L D , T . B E N N E T T A N D S . P . A L...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (5): 601–604.
Published: 01 May 1985
...A. Barden; L. J. Beilin; R. Vandongen; I. Rouse 1. Measurement of urinary 6-ketoprostaglandin (PG) F 1α and PGE 2 excretion in 83 healthy children, aged 5-15 years, revealed that supervised 4 h urine collections under mild water diuresis provided more consistent results than overnight 12 h urine...
Articles
Michael Horowitz, Guy J. Maddern, Barry E. Chatterton, Peter J. Collins, Philip E. Harding, David J. C. Shearman
Journal:
Clinical Science
Clin Sci (Lond) (1984) 67 (2): 213–218.
Published: 01 August 1984
...Michael Horowitz; Guy J. Maddern; Barry E. Chatterton; Peter J. Collins; Philip E. Harding; David J. C. Shearman 1. A dual isotope technique which measures simultaneously the emptying of solids and liquids by the stomach was used to study gastric emptying in 35 subjects in the age range 21-84 years...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 65 (6): 653–660.
Published: 01 December 1983
...Rolf E. Ehrsam; André Perruchoud; Martin Oberholzer; Felix Burkart; Heinrich Herzog 1. To determine the effects of age on the pulmonary circulation at rest and on exercise we analysed the results of right heart catheterization studies performed in 125 asymptomatic subjects aged 14-68 years, who...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 65 (5): 521–526.
Published: 01 November 1983
...J. M. Patrick; E. J. Bassey; P. H. Fentem 1. Submaximal bicycle exercise tests have been performed in nine healthy men on seven annual occasions between the ages of 64 and 70 years. Ten younger men (average age 33 years) have also been studied once for comparison. 2. The ventilatory cost...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 393s–394s.
Published: 01 December 1981
... than 60 years of age. Each patient was matched with respect to mean arterial pressure, body surface area, race and sex with a patient that was younger than 42 years of age. 2. When compared with the younger group, elderly patients had a lower cardiac output, impaired myocardial reserve, lesser aortic...
Articles
A. Salvetti, R. Pedrinelli, F. Arzilli, P. Sassano, G. Leonetti, L. Terzoli, C. Bianchini, M. Fruscio
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (s7): 311s–313s.
Published: 01 December 1981
...A. Salvetti; R. Pedrinelli; F. Arzilli; P. Sassano; G. Leonetti; L. Terzoli; C. Bianchini; M. Fruscio 1. A stepwise infusion of phentolamine was administered to 26 patients with mild uncomplicated essential hypertension, whose basal renin was inversely related to age. 2. Phentolamine caused a dose...
Articles
J. P. R. Hartley, T. J. Charles, R. D. H. Monie, A. Seaton, W. H. Taylor, A. Westwood, J. D. Williams
Journal:
Clinical Science
Clin Sci (Lond) (1981) 61 (2): 151–157.
Published: 01 August 1981
... and decrease in lung function. 5. Three non-atopic asthmatic patients had a significantly higher mean plasma histamine concentration during exercise than had the atopic subjects. 6. A strong positive correlation in asthmatic patients, and asthmatic and control subjects together was found between age and mean...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1981) 60 (2): 217–219.
Published: 01 February 1981
...M. Esler; H. Skews; P. Leonard; G. Jackman; A. Bobik; P. Korner 1. The influence of age on the rate of spillover of noradrenaline into plasma, clearance of noradrenaline from plasma, and plasma noradrenaline concentration at rest was studied in 34 healthy subjects aged 20–69 years. 2. The plasma...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (6): 479–483.
Published: 01 December 1980
...A. F. MacKlon; M. Barton; O. James; M. D. Rawlins 1. After intravenous administration to 19 subjects, aged 18–95 years, plasma diazepam concentrations were measured over 160 h. Plasma protein binding of diazepam was also measured in each subject. 2. The terminal plasma half-life of diazepam ranged...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 427s–429s.
Published: 01 December 1980
...B. Rajagopalan; G. W. Thomas; L. J. Beilin; J. G. G. Ledingham 1. Plasma volume, 24 h urine sodium and total body potassium were similar among 89 previously untreated patients with mild hypertension and 89 control subjects matched for age and sex. 2. Total body potassium correlated with renin...
Articles
G. Mancia, A. Ferrari, L. Gregorini, G. Parati, G. Pomidossi, G. Bertinieri, G. Grassi, A. Zanchetti
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (s6): 401s–404s.
Published: 01 December 1980
...G. Mancia; A. Ferrari; L. Gregorini; G. Parati; G. Pomidossi; G. Bertinieri; G. Grassi; A. Zanchetti 1. Intra-arterial blood pressure and heart rate were recorded for 24 h in ambulant hospitalized patients of variable age who had normal blood pressure or essential hypertension. Mean 24 h values...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (3): 273–275.
Published: 01 September 1979
... before puberty. 2 2 1979 24 4 1979 © 1979 The Biochemical Society and the Medical Research Society 1979 age diabetes insipidus hypertension Clinical Science (1979) 51,273-275 SHORT COMMUNICATION Effect of age on hypertensive stimuli and the development of hypertension...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (s4): 73s–75s.
Published: 01 December 1978
...D. H. Jones; C. A. Hamilton; J. L. Reid 1. Mean supine plasma noradrenaline was lower in 12 male laboratory staff (0·24 ± 0·02 μg/l) than similarly normotensive out-patients (0·44 ± 0·07 μg/l). 2. In 164 non-medical hospital staff, plasma noradrenaline increased with age in white males only. 3...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (s4): 377s–379s.
Published: 01 December 1978
...C. E. Grim; M. H. Weinberger; D. P. Henry; F. C. Luft; N. S. Fineberg 1. Blood pressure, plasma renin activity, plasma aldosterone, urinary noradrenaline during sleep (U NA-S ) and several estimates of sodium intake were determined in 379 normotensive subjects (age 13–70) to investigate...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (2): 213–220.
Published: 01 August 1978
... of cholecalciferol in the elderly. Key words: age, cholecalciferol, intestinal ab- sorption. Abbreviation: 25(OH)D3, 25-hydroxychole- calciferol. Introduction It is probable that dietary vitamin D requirements are greater in the elderly than in young adults (Dent, 1970; Lester, Skinner & Wills, 1977). LOW...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 54 (1): 111–113.
Published: 01 January 1978
...J. N. MacPherson; P. Tothill 1. The proportion of the cardiac output delivered to the skeleton and individual bones has been determined in rats of differing ages and weights with radioactive microspheres. 2. There was a decrease in the blood flow to the tibia—fibula, jaw, femur, pelvis, humerus...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1977) 52 (4): 405–412.
Published: 01 April 1977
... blood flow were significantly lower in low-renin hypertension. Total peripheral and renal vascular resistance were markedly higher in this group. 3. Plasma renin concentration correlated inversely with both total peripheral and renal vascular resistance as well as with age. Multiple regression analysis...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1976) 51 (s3): 177s–180s.
Published: 01 December 1976
...R. Gordon; Freda Doran; M. Thomas; Frances Thomas; P. Cheras 1. As experimental models of reduced nephron population in man, (a) twelve men aged 15–32 years who had one kidney removed 1–13 years previously and (b) fourteen normotensive men aged 70–90 years were studied. Results were compared...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1976) 51 (s3): 185s–188s.
Published: 01 December 1976
...G. W. Thomas; J. G. G. Ledingham; L. J. Beilin; A. N. Stott 1. Supine plasma renin activity and its responsiveness to erect posture and frusemide were reduced in fifty-one patients with essential hypertension, compared with fifty-one age- and sex-matched control subjects. 2. Twenty-four hour...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1976) 51 (s3): 695s–696s.
Published: 01 December 1976
...T. Thulin; R. W. Pero; C. Bryngelsson; F. Mitelman; Å. Nordén; B. Scherstén 1. The level of DNA repair synthesis has been compared in males diagnosed as having hypertension (diastolic blood pressure ≥ 100 mmHg), males with slightly elevated blood pressure (>95th percentile corrected for age...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1976) 51 (2): 185–188.
Published: 01 August 1976
...P. M. Tweeddale; R. J. E. Leggett; D. C. Flenley 1. Oxygen-binding, plasma and intra-erythrocytic pH, and haemoglobin, 2,3-diphosphoglycerate and inorganic phosphate concentrations were measured in sixty-two healthy non-smokers aged between 18 and 89 years. 2. P 50 (oxygen tension at 50% oxygen...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1976) 50 (5): 409–414.
Published: 01 May 1976
... and in fifteen control subjects. 2. GFR and RPF were similar in the hypertensive group and in the control group, whereas the renal vascular resistance was significantly higher in the hypertensive patients. GFR and RPF decreased with increasing blood pressure in both groups. Increasing age induced a further...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1976) 50 (2): 103–107.
Published: 01 February 1976
... was significantly higher in young spontaneously hypertensive than in normotensive rats of the same age (5–7 weeks). After the ninth week plasma renin activity decreased and, at week 45, became significantly lower in hypertensive than in normotensive rats. 4. When hypertension was established a significant inverse...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (s1): 107s–110s.
Published: 01 August 1973
...M. Ulrych; J. Tauber; A. P. Shapiro 1. In 404 male steelmill workers blood pressure and body weight were followed for 15–25 years and their relationships analysed. 2. It appears that age on average has a negligible influence on diastolic pressure and has a positive influence on systolic pressure...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (s1): 23s–33s.
Published: 01 August 1973
...W. E. Miall; Susan Chinn 1. Several recent studies of the relation between blood pressure and ageing have been re-examined, and it is concluded that none satisfactorily investigates the possibility of separate influences of age and attained pressure in determining the rate of change of pressure...
