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Keywords: adrenomedullin
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Articles

Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma

Lars M. Ittner, Kerstin Schwerdtfeger, Thomas H. Kunz, Roman Muff, Knut Husmann, Christian Grimm, Farhad Hafezi, Karl S. Lang, Michael O. Kurrer, Jürgen Götz, Walter Born, Jan A. Fischer
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (1): 49–58.
https://doi.org/10.1042/CS20070163
Published: 30 November 2007
.... Expression of CLR under the control of a smooth muscle α-actin promoter in these mice augmented signalling of the smooth-muscle-relaxing peptide adrenomedullin in the pupillary sphincter muscle and resulted in pupillary palsy. Elevated IOP was prevented in CLR transgenic mice when mated with hemizygote...
View article titled, Transgenic mice with ocular overexpression of an <span class="search-highlight">adrenomedullin</span> receptor reflect human acute angle-closure glaucoma
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Articles

Effects of adrenomedullin on acute ischaemia-induced collateral development and mobilization of bone-marrow-derived cells

Minami Abe, Masataka Sata, Etsu Suzuki, Ryo Takeda, Masao Takahashi, Hiroaki Nishimatsu, Daisuke Nagata, Kenji Kangawa, Hisayuki Matsuo, Ryozo Nagai, Yasunobu Hirata
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (6): 381–387.
https://doi.org/10.1042/CS20060137
Published: 14 November 2006
...Minami Abe; Masataka Sata; Etsu Suzuki; Ryo Takeda; Masao Takahashi; Hiroaki Nishimatsu; Daisuke Nagata; Kenji Kangawa; Hisayuki Matsuo; Ryozo Nagai; Yasunobu Hirata Adrenomedullin exerts not only vasodilatory effects, but also angiogenic effects. In the present study, we investigated the effects...
View article titled, Effects of <span class="search-highlight">adrenomedullin</span> on acute ischaemia-induced collateral development and mobilization of bone-marrow-derived cells
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Articles

Tissue expression and plasma levels of adrenomedullin in renal cancer patients

Jens Michelsen, Helle Thiesson, Steen Walter, Peter D. Ottosen, Ole Skøtt, Boye L. Jensen
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (1): 61–70.
https://doi.org/10.1042/CS20060030
Published: 14 June 2006
...Jens Michelsen; Helle Thiesson; Steen Walter; Peter D. Ottosen; Ole Skøtt; Boye L. Jensen The peptide AM (adrenomedullin) is stimulated by hypoxia through HIF-1 (hypoxia-inducible factor-1). The majority of human CC-RCCs (clear cell renal cell carcinomas) display mutations in the tumour suppressor...
View article titled, Tissue expression and plasma levels of <span class="search-highlight">adrenomedullin</span> in renal cancer patients
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Articles

Expression of adrenomedullin mRNA is altered with gestation and labour in human placenta and fetal membranes

Alfia Al-Ghafra, Shaun P. Brennecke, Roger G. King, Neil M. Gude
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (3): 337–342.
https://doi.org/10.1042/CS20050303
Published: 10 February 2006
...Alfia Al-Ghafra; Shaun P. Brennecke; Roger G. King; Neil M. Gude The aim of the present study was to investigate whether placental and fetal membrane AdM (adrenomedullin) mRNA expression changes with gestation and human labour, as we have previously found labour-associated changes in AdM content...
View article titled, Expression of <span class="search-highlight">adrenomedullin</span> mRNA is altered with gestation and labour in human placenta and fetal membranes
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Articles

Biodistribution, plasma kinetics and quantification of single-pass pulmonary clearance of adrenomedullin

Jocelyn DUPUIS, Alexandre CARON, Nathalie RUËL
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (1): 97–102.
https://doi.org/10.1042/CS20040357
Published: 23 June 2005
...Jocelyn DUPUIS; Alexandre CARON; Nathalie RUËL The biodistribution, pharmacokinetics and multi-organ clearance of the vasodilator peptide AM (adrenomedullin) were evaluated in rats and its single-pass pulmonary clearance was measured in dogs by the indicator-dilution technique. Intravenously...
View article titled, Biodistribution, plasma kinetics and quantification of single-pass pulmonary clearance of <span class="search-highlight">adrenomedullin</span>
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Articles

Labour-associated changes in adrenomedullin content in human placenta and fetal membranes

A. AL-GHAFRA, N. M. GUDE, S. P. BRENNECKE, R. G. KING
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (4): 419–423.
https://doi.org/10.1042/CS20030027
Published: 01 October 2003
...A. AL-GHAFRA; N. M. GUDE; S. P. BRENNECKE; R. G. KING The aim of the present study was to determine the effects of labour and mode of delivery on human placental and fetal membrane content of adrenomedullin (AdM). Placentas and fetal membranes were collected either at term or pre-term gestation...
View article titled, Labour-associated changes in <span class="search-highlight">adrenomedullin</span> content in human placenta and fetal membranes
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Articles

Three vasoactive peptides, endothelin-1, adrenomedullin and urotensin-II, in human tumour cell lines of different origin: expression and effects on proliferation

Kazuhiro TAKAHASHI, Kazuhito TOTSUNE, Tomomi KITAMURO, Masahiko SONE, Osamu MURAKAMI, Shigeki SHIBAHARA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 35S–38S.
https://doi.org/10.1042/CS103S035S
Published: 01 September 2002
...Kazuhiro TAKAHASHI; Kazuhito TOTSUNE; Tomomi KITAMURO; Masahiko SONE; Osamu MURAKAMI; Shigeki SHIBAHARA Evidence has accumulated showing that vasoactive peptides, such as endothelin-1, adrenomedullin and urotensin-II, are expressed in various kinds of tumour cells. In the present study...
View article titled, Three vasoactive peptides, endothelin-1, <span class="search-highlight">adrenomedullin</span> and urotensin-II, in human tumour cell lines of different origin: expression and effects on proliferation
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Articles

Molecular forms of adrenomedullin in pericardial fluid and plasma in patients with ischaemic heart disease

Toshio NISHIKIMI, Ikuko SHIBASAKI, Hiroshi IIDA, Hiroshi ASAKAWA, Yasushi MATSUSHITA, Hideaki MORI, Yoshihiko MOCHIZUKI, Yoshitaka OKAMURA, Shigeo HORINAKA, Kenji KANGAWA, Koichiro SHIMADA, Hiroaki MATSUOKA
Journal: Clinical Science
Clin Sci (Lond) (2002) 102 (6): 669–677.
https://doi.org/10.1042/cs1020669
Published: 17 May 2002
...Toshio NISHIKIMI; Ikuko SHIBASAKI; Hiroshi IIDA; Hiroshi ASAKAWA; Yasushi MATSUSHITA; Hideaki MORI; Yoshihiko MOCHIZUKI; Yoshitaka OKAMURA; Shigeo HORINAKA; Kenji KANGAWA; Koichiro SHIMADA; Hiroaki MATSUOKA Experimental studies have demonstrated that adrenomedullin (AM) has a positive inotropic...
View article titled, Molecular forms of <span class="search-highlight">adrenomedullin</span> in pericardial fluid and plasma in patients with ischaemic heart disease
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Articles

Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure

Miriam T. RADEMAKER, Chris J. CHARLES, Garth J.S. COOPER, David H. COY, Eric A. ESPINER, Lynley K. LEWIS, M. Gary NICHOLLS, A. Mark RICHARDS
Journal: Clinical Science
Clin Sci (Lond) (2002) 102 (6): 653–660.
https://doi.org/10.1042/cs1020653
Published: 14 May 2002
... of angiotensin-converting enzyme (ACE) inhibition. Importantly, since new treatments are likely to be used in conjunction with ACE inhibition therapy, the effects of the combination of agents need to be assessed. Adrenomedullin (ADM) is a peptide with potent vasodilator and natriuretic actions. ADM and an ACE...
View article titled, Combined angiotensin-converting enzyme inhibition and <span class="search-highlight">adrenomedullin</span> in an ovine model of heart failure
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Articles

Differing thresholds for modulatory effects of adrenomedullin infusion on haemodynamic and hormone responses to angiotensin II and adrenocorticotrophic hormone in healthy volunteers

Richard W. TROUGHTON, Christopher M. FRAMPTON, Lynley K. LEWIS, Timothy G. YANDLE, A. Mark RICHARDS, M. Gary NICHOLLS
Journal: Clinical Science
Clin Sci (Lond) (2001) 101 (1): 103–109.
https://doi.org/10.1042/cs1010103
Published: 14 June 2001
...Richard W. TROUGHTON; Christopher M. FRAMPTON; Lynley K. LEWIS; Timothy G. YANDLE; A. Mark RICHARDS; M. Gary NICHOLLS Experimental data indicate that adrenomedullin (AM) interacts at various levels with the renin–angiotensin–aldosterone system and the hypothalamic–pituitary–adrenal axis, but data...
View article titled, Differing thresholds for modulatory effects of <span class="search-highlight">adrenomedullin</span> infusion on haemodynamic and hormone responses to angiotensin II and adrenocorticotrophic hormone in healthy volunteers
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Articles

Effect of adrenomedullin on the production of endothelin-1 and on its vasoconstrictor action in resistance arteries: evidence for a receptor-specific functional interaction in patients with heart failure

Chris HILLIER, Mark C. PETRIE, Michael P. LOVE, Fiona JOHNSTON, Margaret R. MACLEAN, John J. V. MCMURRAY
Journal: Clinical Science
Clin Sci (Lond) (2001) 101 (1): 45–51.
https://doi.org/10.1042/cs1010045
Published: 24 May 2001
...Chris HILLIER; Mark C. PETRIE; Michael P. LOVE; Fiona JOHNSTON; Margaret R. MACLEAN; John J. V. MCMURRAY Endothelin-1 (ET-1) and adrenomedullin (ADM) are both produced in the arterial wall, but have opposing biological actions. Evidence from experimental animals suggests a functional interaction...
View article titled, Effect of <span class="search-highlight">adrenomedullin</span> on the production of endothelin-1 and on its vasoconstrictor action in resistance arteries: evidence for a receptor-specific functional interaction in patients with heart failure
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Articles

The active molecular form of plasma adrenomedullin is extracted in the pulmonary circulation in patients with mitral stenosis: possible role of adrenomedullin in pulmonary hypertension

Toshio NISHIKIMI, Seiki NAGATA, Tatsuya SASAKI, Fumiki YOSHIHARA, Noritoshi NAGAYA, Takeshi HORIO, Hisayuki MATSUO, Hiroaki MATSUOKA, Kenji KANGAWA
Journal: Clinical Science
Clin Sci (Lond) (2001) 100 (1): 61–66.
https://doi.org/10.1042/cs1000061
Published: 13 December 2000
...Toshio NISHIKIMI; Seiki NAGATA; Tatsuya SASAKI; Fumiki YOSHIHARA; Noritoshi NAGAYA; Takeshi HORIO; Hisayuki MATSUO; Hiroaki MATSUOKA; Kenji KANGAWA Adrenomedullin (AM), a novel hypotensive peptide, preferentially dilates pulmonary vessels rather than systemic vessels. This suggests the possibility...
View article titled, The active molecular form of plasma <span class="search-highlight">adrenomedullin</span> is extracted in the pulmonary circulation in patients with mitral stenosis: possible role of <span class="search-highlight">adrenomedullin</span> in pulmonary hypertension
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Articles

Elevation of two molecular forms of adrenomedullin in plasma and urine in patients with acute myocardial infarction treated with early coronary angioplasty

Hiroshi ASAKAWA, Toshio NISHIKIMI, Takeshi SUZUKI, Suomi HARA, Yusuke TSUBOKOU, Hiroshi YAGI, Akihisa YABE, Noriaki TSUCHIYA, Shigeo HORINAKA, Kenji KANGAWA, Hiroaki MATSUOKA
Journal: Clinical Science
Clin Sci (Lond) (2001) 100 (1): 117–126.
https://doi.org/10.1042/cs1000117
Published: 13 December 2000
...Hiroshi ASAKAWA; Toshio NISHIKIMI; Takeshi SUZUKI; Suomi HARA; Yusuke TSUBOKOU; Hiroshi YAGI; Akihisa YABE; Noriaki TSUCHIYA; Shigeo HORINAKA; Kenji KANGAWA; Hiroaki MATSUOKA Adrenomedullin (AM) has vasodilatory, diuretic and natriuretic actions. Two molecular forms of AM circulate in human plasma...
View article titled, Elevation of two molecular forms of <span class="search-highlight">adrenomedullin</span> in plasma and urine in patients with acute myocardial infarction treated with early coronary angioplasty
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Articles

Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure

Kazuhito TOTSUNE, Kazuhiro TAKAHASHI, Harald S. MACKENZIE, Osamu MURAKAMI, Zenei ARIHARA, Masahiko SONE, Toraichi MOURI, Barry M. BRENNER, Sadayoshi ITO
Journal: Clinical Science
Clin Sci (Lond) (2000) 99 (6): 541–546.
https://doi.org/10.1042/cs0990541
Published: 21 November 2000
...Kazuhito TOTSUNE; Kazuhiro TAKAHASHI; Harald S. MACKENZIE; Osamu MURAKAMI; Zenei ARIHARA; Masahiko SONE; Toraichi MOURI; Barry M. BRENNER; Sadayoshi ITO Adrenomedullin is a vasodilator peptide produced in various organs, including heart and kidney. A novel adrenomedullin receptor complex has...
View article titled, Increased gene expression of <span class="search-highlight">adrenomedullin</span> and <span class="search-highlight">adrenomedullin</span>-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure
Open the PDF for Increased gene expression of <span class="search-highlight">adrenomedullin</span> and <span class="search-highlight">adrenomedullin</span>-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure in another window
Articles

Adrenomedullin in monocytes and macrophages: possible involvement of macrophage-derived adrenomedullin in atherogenesis

Masaharu NAKAYAMA, Kazuhiro TAKAHASHI, Osamu MURAKAMI, Hiroshi MURAKAMI, Hironobu SASANO, Kunio SHIRATO, Shigeki SHIBAHARA
Journal: Clinical Science
Clin Sci (Lond) (1999) 97 (2): 247–251.
https://doi.org/10.1042/cs0970247
Published: 15 July 1999
...Masaharu NAKAYAMA; Kazuhiro TAKAHASHI; Osamu MURAKAMI; Hiroshi MURAKAMI; Hironobu SASANO; Kunio SHIRATO; Shigeki SHIBAHARA Macrophages secrete a variety of growth factors, cytokines and vasoactive peptides, which are related to the progression of atherosclerosis. Adrenomedullin (ADM) is a potent...
View article titled, <span class="search-highlight">Adrenomedullin</span> in monocytes and macrophages: possible involvement of macrophage-derived <span class="search-highlight">adrenomedullin</span> in atherogenesis
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Articles

Elevated plasma levels of adrenomedullin in congenital cyanotic heart disease

Muneo YOSHIBAYASHI, Tetsuro KAMIYA, Toshio NISHIKIMI, Yoshihiko SAITO, Hisayuki MATSUO, Kenji KANGAWA
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (6): 543–547.
https://doi.org/10.1042/cs0960543
Published: 20 April 1999
...Muneo YOSHIBAYASHI; Tetsuro KAMIYA; Toshio NISHIKIMI; Yoshihiko SAITO; Hisayuki MATSUO; Kenji KANGAWA Adrenomedullin is a novel hypotensive peptide originally isolated from human pheochromocytoma. Accumulating evidence suggests the possible involvement of adrenomedullin in the physiology...
View article titled, Elevated plasma levels of <span class="search-highlight">adrenomedullin</span> in congenital cyanotic heart disease
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Articles

Co-expression of prepro-adrenomedullin with a putative adrenomedullin receptor gene in vascular smooth muscle

Dominic J. AUTELITANO, F. TANG
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (5): 493–498.
https://doi.org/10.1042/cs0960493
Published: 14 April 1999
...Dominic J. AUTELITANO; F. TANG The prepro-adrenomedullin (prepro-AM) gene encodes several biologically active peptides, including the potent vasodilator AM. At least part of the vasodilator action of AM appears to be mediated via interactions with receptors on vascular smooth muscle cells (VSMC...
View article titled, Co-expression of prepro-<span class="search-highlight">adrenomedullin</span> with a putative <span class="search-highlight">adrenomedullin</span> receptor gene in vascular smooth muscle
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Articles

Coronary sinus adrenomedullin rises in response to myocardial injury

Palaniswamy VIJAY, Laszlo SZEKELY, Thomas X. AUFIERO, Thomas G. SHARP
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (4): 415–420.
https://doi.org/10.1042/cs0960415
Published: 01 April 1999
...Palaniswamy VIJAY; Laszlo SZEKELY; Thomas X. AUFIERO; Thomas G. SHARP Human adrenomedullin (ADM), a peptide comprising 52 amino acids, is a circulating hormone with vasodilator properties. We have evaluated its release by the heart following ischaemic myocardial damage, as indicated by elevated...
View article titled, Coronary sinus <span class="search-highlight">adrenomedullin</span> rises in response to myocardial injury
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Articles

Increased plasma levels of adrenomedullin in patients with pulmonary hypertension

Mikio KAKISHITA, Toshio NISHIKIMI, Yoshiaki OKANO, Toru SATOH, Shingo KYOTANI, Noritoshi NAGAYA, Kengo FUKUSHIMA, Norifumi NAKANISHI, Shuichi TAKISHITA, Atsuro MIYATA, Kenji KANGAWA, Hisayuki MATSUO, Takeyoshi KUNIEDA
Journal: Clinical Science
Clin Sci (Lond) (1998) 96 (1): 33–39.
https://doi.org/10.1042/cs0960033
Published: 01 January 1999
...Mikio KAKISHITA; Toshio NISHIKIMI; Yoshiaki OKANO; Toru SATOH; Shingo KYOTANI; Noritoshi NAGAYA; Kengo FUKUSHIMA; Norifumi NAKANISHI; Shuichi TAKISHITA; Atsuro MIYATA; Kenji KANGAWA; Hisayuki MATSUO; Takeyoshi KUNIEDA Adrenomedullin, a potent hypotensive peptide, reduces blood pressure...
View article titled, Increased plasma levels of <span class="search-highlight">adrenomedullin</span> in patients with pulmonary hypertension
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Articles

Increased Plasma Adrenomedullin Concentrations during Cardiac Surgery

Toshio Nishikimi, Yukio Hayashi, Gentaro Iribu, Shuichi Takishita, Yoshio Kosakai, Naoto Minamino, Atsuro Miyata, Hisayuki Matsuo, Masakazu Kuro, Kenji Kangawa
Journal: Clinical Science
Clin Sci (Lond) (1998) 94 (6): 585–590.
https://doi.org/10.1042/cs0940585
Published: 01 June 1998
...Toshio Nishikimi; Yukio Hayashi; Gentaro Iribu; Shuichi Takishita; Yoshio Kosakai; Naoto Minamino; Atsuro Miyata; Hisayuki Matsuo; Masakazu Kuro; Kenji Kangawa 1. Adrenomedullin (AM), a potent hypotensive peptide, was originally isolated from human phaeochromocytoma. Plasma AM concentrations...
View article titled, Increased Plasma <span class="search-highlight">Adrenomedullin</span> Concentrations during Cardiac Surgery
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Articles

Differential Regulation of Ventricular Adrenomedullin and Atrial Natriuretic Peptide Gene Expression in Pressure and Volume Overload in the Rat

Michael Kaiser, Ole Kahr, Yasuyuki Shimada, Pamela Smith, Martin Kelly, Harin Mahadeva, Matthew Adams, David Lodwick, Christian Aalkjaer, Metin Avkiran, Nilesh J. Samani
Journal: Clinical Science
Clin Sci (Lond) (1998) 94 (4): 359–365.
https://doi.org/10.1042/cs0940359
Published: 01 April 1998
...Michael Kaiser; Ole Kahr; Yasuyuki Shimada; Pamela Smith; Martin Kelly; Harin Mahadeva; Matthew Adams; David Lodwick; Christian Aalkjaer; Metin Avkiran; Nilesh J. Samani 1. Adrenomedullin is a recently discovered vasodilating and natriuretic peptide whose physiological and pathophysiological roles...
View article titled, Differential Regulation of Ventricular <span class="search-highlight">Adrenomedullin</span> and Atrial Natriuretic Peptide Gene Expression in Pressure and Volume Overload in the Rat
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Articles

Plasma Levels of Adrenomedullin in Patients with Acute Myocardial Infarction

Yuji Yoshitomi, Toshio Nishikimi, Shunichi Kojima, Morio Kuramochi, Shuichi Takishita, Hiroaki Matsuoka, Atsuro Miyata, Hisayuki Matsuo, Kenji Kangawa
Journal: Clinical Science
Clin Sci (Lond) (1998) 94 (2): 135–139.
https://doi.org/10.1042/cs0940135
Published: 01 February 1998
...Yuji Yoshitomi; Toshio Nishikimi; Shunichi Kojima; Morio Kuramochi; Shuichi Takishita; Hiroaki Matsuoka; Atsuro Miyata; Hisayuki Matsuo; Kenji Kangawa 1. Adrenomedullin, a newly identified vasorelaxant peptide, participates in the regulation of the cardiovascular system. To investigate...
View article titled, Plasma Levels of <span class="search-highlight">Adrenomedullin</span> in Patients with Acute Myocardial Infarction
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Articles

Increased Plasma Levels of Adrenomedullin in Patients with Hypertrophic Cardiomyopathy: Its Relation to Endothelin-1, Natriuretic Peptides and Noradrenaline

Mareomi Hamada, Yuji Shigematsu, Hideo Kawakami, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Kunio Hiwada
Journal: Clinical Science
Clin Sci (Lond) (1998) 94 (1): 21–28.
https://doi.org/10.1042/cs0940021
Published: 01 January 1998
...Mareomi Hamada; Yuji Shigematsu; Hideo Kawakami; Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo; Kunio Hiwada 1. The aim of this study was to elucidate the pathophysiological role of adrenomedullin and the relation between adrenomedullin and other hormones in patients with hypertrophic...
View article titled, Increased Plasma Levels of <span class="search-highlight">Adrenomedullin</span> in Patients with Hypertrophic Cardiomyopathy: Its Relation to Endothelin-1, Natriuretic Peptides and Noradrenaline
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Articles

Adrenomedullin: A Hypotensive Hormone in Man

John G. Lainchbury, Garth J. S. Cooper, David H. Coy, Ning-Yi Jiang, Lynley K. Lewis, Timothy G. Yandle, A. Mark Richards, M. Gary Nicholls
Journal: Clinical Science
Clin Sci (Lond) (1997) 92 (5): 467–472.
https://doi.org/10.1042/cs0920467
Published: 01 May 1997
...John G. Lainchbury; Garth J. S. Cooper; David H. Coy; Ning-Yi Jiang; Lynley K. Lewis; Timothy G. Yandle; A. Mark Richards; M. Gary Nicholls 1. Adrenomedullin, a recently discovered 52-amino-acid peptide hormone, circulates in plasma at low picomolar levels in man. Animal studies and studies...
View article titled, <span class="search-highlight">Adrenomedullin</span>: A Hypotensive Hormone in Man
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Articles

Elevated Plasma Levels of Human Adrenomedullin in Cardiovascular, Respiratory, Hepatic and Renal Disorders

Bernard Cheung, Raymond Leung
Journal: Clinical Science
Clin Sci (Lond) (1997) 92 (1): 59–62.
https://doi.org/10.1042/cs0920059
Published: 01 January 1997
...Bernard Cheung; Raymond Leung 1. Adrenomedullin is a potent vasodilating peptide first isolated from phaeochromocytoma and adrenal medulla but also found in the heart, lungs and kidneys. It may also be a paracrine factor because endothelial and smooth muscle cells synthesize adrenomedullin as well...
View article titled, Elevated Plasma Levels of Human <span class="search-highlight">Adrenomedullin</span> in Cardiovascular, Respiratory, Hepatic and Renal Disorders
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Articles

Behaviour of Adrenomedullin during Acute and Chronic Salt Loading in Normotensive and Hypertensive Subjects

Toshihiko Ishimitsu, Toshio Nishikimi, Hiroaki Matsuoka, Kenji Kangawa, Kazuo Kitamura, Jun-Ichi Minami, Hisayuki Matsuo, Tanenao Eto
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (3): 293–298.
https://doi.org/10.1042/cs0910293
Published: 01 September 1996
...Toshihiko Ishimitsu; Toshio Nishikimi; Hiroaki Matsuoka; Kenji Kangawa; Kazuo Kitamura; Jun-Ichi Minami; Hisayuki Matsuo; Tanenao Eto 1. Responses of adrenomedullin to acute and chronic salt loading were examined in normotensive and hypertensive subjects. 2. In the acute salt load study, isotonic...
View article titled, Behaviour of <span class="search-highlight">Adrenomedullin</span> during Acute and Chronic Salt Loading in Normotensive and Hypertensive Subjects
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