...Jane E. Tighe; Franco Calabi 1. The (8;21) translocation, which is consistently associated with a subgroup of acute myeloid leukaemia, involves two loci: runt on chromosome 21 and MTG8 on chromosome 8. 2. Breakpoints in runt fall within a single intron that is located immediately downstream...

... is secreted by primitive but not by mature leukaemic cells and normal bone marrow cells. Key words: acute myeloid leukaemia, cultured cells, ouabain, sodium efflux. Introduction Recent studies from our laboratory have shown that myeloid leukaemic blast cells [l] and cultured leukaemic promyelocytes [2...

... a pathway which was not inhibited by ouabain or frusemide. 5. These studies suggest that leukaemic promyelocytes secrete the previously identified passive sodium transport inhibitory factor. © 1984 The Biochemical Society and the Medical Research Society 1984 acute myeloid leukaemia erythrocyte...