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Keywords: acute kidney injury
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Articles
Clin Sci (Lond) (2023) 137 (1): 47–63.
Published: 05 January 2023
...Nada J. Habeichi; Rana Ghali; Ali Mroueh; Abdullah Kaplan; Cynthia Tannous; Abdo Jurjus; Ghadir Amin; Mathias Mericskay; George W. Booz; Ahmed El-Yazbi; Fouad A. Zouein Acute kidney injury (AKI) is a common complication of cardiovascular diseases (CVDs) in both males and females, increasing...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (24): 1877–1891.
Published: 22 December 2022
...Honglin Li; Zhiwen Liu; Ying Wang; Hui Wang; Juan Cai; Chengyuan Tang; Zheng Dong Sepsis is a leading cause of acute kidney injury (AKI), and the pathogenesis of septic AKI remains largely unclear. Parkinson disease protein 7 (PARK7) is a protein of multiple functions that was recently implicated...
Articles
Clin Sci (Lond) (2022) 136 (11): 825–840.
Published: 01 June 2022
...Riyaz Mohamed; Gene R. Crislip; Sarah McLarnon; Qingqing Wei; Paul M. O’Connor; Jennifer C. Sullivan Acute kidney injury (AKI) due to ischemia is a serious and frequent clinical complication with mortality rates as high as 80%. Vascular congestion in the renal outer medulla occurs early after...
Articles
Clin Sci (Lond) (2021) 135 (23): 2607–2618.
Published: 08 December 2021
...Laurie Bruzzese; Gwénaël Lumet; Donato Vairo; Claire Guiol; Régis Guieu; Alice Faure Ischaemia–reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) and chronic kidney disease, which consists of cellular damage and renal dysfunction. AKI is a major complication...
Articles
Clin Sci (Lond) (2021) 135 (20): 2341–2356.
Published: 18 October 2021
..., the increased concentration of vasoconstrictor mediators together with the preservation (and even increase) of the response to them may help to explain sepsis-induced acute kidney injury. Levels of urea and creatinine in plasma were measured according to the manufacturer’s instructions, using commercially...
Articles
Clin Sci (Lond) (2020) 134 (23): 3093–3106.
Published: 02 December 2020
... Cristina Simões e Silva Acute Kidney Injury (AKI) comprises a rapidly developed renal failure and is associated with high mortality rates. The Renin–Angiotensin System (RAS) plays a pivotal role in AKI, as the over-active RAS axis exerts major deleterious effects in disease progression. In this sense...
Articles
Clin Sci (Lond) (2020) 134 (16): 2223–2234.
Published: 28 August 2020
... and vascular rarefaction. Mechanistically, the protective effect of miR-20a-5p on acute kidney injury (AKI) was associated with inhibition of TECs mitochondrial injury and apoptosis in vitro and in vivo . In conclusion, miR-20a-5p is enriched in hypoxia-derived tubular exosomes and protects against acute...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate...
Articles
Clin Sci (Lond) (2020) 134 (14): 1887–1909.
Published: 23 July 2020
...Jose L. Viñas; Christopher J. Porter; Adrianna Douvris; Matthew Spence; Alex Gutsol; Joseph A. Zimpelmann; Karishma Tailor; Pearl A. Campbell; Kevin D. Burns Female sex protects against development of acute kidney injury (AKI). While sex hormones may be involved in protection, the role...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (13): 1593–1612.
Published: 30 June 2020
... in tubular epithelial cells, are not well-known. To elucidate the adaptive expression, protective effects on kidney injury, and signaling pathways of TAZ in response to acute kidney injury (AKI), we used in vitro (hypoxia-treated human renal proximal tubular epithelial cells [RPTECs]) and in vivo (mouse...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 139–154.
Published: 23 January 2020
...Yiling Cao; Xuhua Mi; Dongmei Zhang; Zheng Wang; Yongdi Zuo; Wanxin Tang Acute kidney injury (AKI) is a common serious syndrome characterized by rapid decrease of glomerular filtration rate and the progressive increase of serum creatinine. Circular RNAs (circRNAs) are regulatory RNAs that recently...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (9): 1031–1047.
Published: 02 May 2019
...Hitesh Soni; Dieniffer Peixoto-Neves; Michael A. Olushoga; Adebowale Adebiyi Renal vasoconstriction, an early manifestation of ischemic acute kidney injury (AKI), results in renal hypoperfusion and a rapid decline in kidney function. The pathophysiological mechanisms that underlie ischemia...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (19): 2121–2133.
Published: 05 October 2018
... by 84 days of reperfusion. Consistently, 20-min IRI induced reversible mild AKI followed by renal structural recovery. In contrast, 45-min IRI resulted in severe AKI. Although serum creatinine, urinary albumin excretion, and acute kidney injury score returned to baseline level within 14 days ( Figure 1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (19): 2087–2101.
Published: 02 October 2018
... function in Fibro-TSC1 −/− mice with LPS-induced AKI. Renal fibroblast mTORC1 plays an important role in septic AKI. acute kidney injury endothelin-1 fibroblast mTORC1 sepsis TSC1 Sepsis, a dysregulated host response to severe infection [ 1 ], has been shown to occur in 32.4–47.5...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (16): 1725–1739.
Published: 22 August 2018
...; Denise Maria Avancini Costa Malheiros; Marlene Antonia Reis; Clarice Kazue Fujihara; Roberto Zatz; Alvaro Pacheco-Silva; Niels Olsen Saraiva Câmara; Danilo Candido de Almeida Acute kidney injury (AKI) is considered an inflammatory disease in which toll-like receptors (TLRs) signaling pathways play...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (3): 339–359.
Published: 02 February 2018
... side effects, for instance bone marrow suppression and nephrotoxicity. In the present study, we utilized a murine model of cisplatin-induced acute kidney injury (AKI) and a highly selective inhibitor of HDAC6, tubastatin A (TA), to assess the role of HDAC6 in nephrotoxicity and its associated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 1955–1969.
Published: 13 July 2017
...Sha Fu; Ying Tang; Xiao R. Huang; Min Feng; An P. Xu; Hui Y. Lan Smad7 plays a protective role in chronic kidney disease; however, its role in acute kidney injury (AKI) remains unexplored. Here, we report that Smad7 protects against AKI by rescuing the G1 cell cycle arrest of tubular epithelial...
Articles
Clin Sci (Lond) (2017) 131 (14): 1617–1629.
Published: 30 June 2017
... Ortiz ( aortiz@fjd.es ) 09 01 2017 06 04 2017 07 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 acute kidney injury chronic kidney disease implementation patient outcomes prevention translational research...
Articles
Clin Sci (Lond) (2016) 130 (5): 349–363.
Published: 26 January 2016
... they undergo AKI (acute kidney injury). An incomplete repair of renal tubules can result in progressive fibrotic CKD (chronic kidney disease). Studies have revealed the relationship between tubular epithelial cells and kidney fibrogenesis. However, the underlying mechanism remains unclear. Hippo pathway...
Articles
Clin Sci (Lond) (2015) 128 (11): 749–750.
Published: 17 March 2015
... medicine after renal injury. Correspondence : Dr Anton J.M. Roks (email a.roks@erasmusmc.nl ) 26 1 2015 27 1 2015 27 1 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 acute kidney injury bone marrow renin–angiotensin system Stem...
Articles
Clin Sci (Lond) (2015) 128 (11): 735–747.
Published: 17 March 2015
...Esko Kankuri; Elina E. Mervaala; Markus Storvik; Aija M.J. Ahola; Jouko Levijoki; Dominik N. Müller; Piet Finckenberg; Eero M. Mervaala Hypertension and persistent activation of the renin–angiotensin system (RAS) are predisposing factors for the development of acute kidney injury (AKI). Although...
Articles
Clin Sci (Lond) (2010) 119 (9): 385–394.
Published: 23 July 2010
... enzyme) and the AT 1 receptor (AngII type 1 receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia/reperfusion). However, Ang-(1–7) [angiotensin-(1–7)], ACE2 (angiotensin I-converting enzyme 2) and the Mas receptor...