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Keywords: acetylcholine
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Clin Sci (Lond) (2016) 130 (21): 1913–1928.
Published: 22 September 2016
...-overexpressing transgenic mice ( ChAT tgm), i.e. an in vivo model of the cardiac non-neuronal acetylcholine (NNA) system or non-neuronal cardiac cholinergic system (NNCCS). By using this murine model, we determined that this system was responsible for characteristics of resistance to ischaemia, or hypoxia, via...
Clin Sci (Lond) (2012) 123 (5): 307–312.
Published: 16 May 2012
...). Endothelium-dependent vasodilatation was evaluated by the invasive ACH (acetylcholine)-induced forearm vasodilatation technique. A panel of biomarkers of biological pathways was measured: BNP, haemostatic factors PAI-1 (plasminogen-activator inhibitor 1) and tPA (tissue plasminogen activator), inflammatory...
Clin Sci (Lond) (2011) 121 (10): 449–458.
Published: 25 July 2011
... phosphorylation and contractile responses were also studied. Simvastatin (1 μM, 2 h) significantly reduced constriction to U46619 and phenylephrine and enhanced dilations to ACh (acetylcholine) in depolarized, but not in U46619-pre-constricted arteries. These effects were completely and partially prevented by L...
Clin Sci (Lond) (2009) 117 (10): 365–374.
Published: 07 September 2009
...Javier Blanco-Rivero; Ma Angeles Aller; Jaime Arias; Mercedes Ferrer; Gloria Balfagón In the present study, we have analysed both the effect of long-term portal hypertension on the vasomotor response to acetylcholine in rat aorta and the mechanism involved in this response. For this purpose, sham...
Clin Sci (Lond) (2006) 111 (2): 145–151.
Published: 13 July 2006
... and time course of inhibition, and (v) the effect on nitric oxide production. Aortic rings were incubated (1 h) with NEFA–albumin complexes derived from lauric (C 12:0 ), myristic (C 14:0 ), palmitic (C 16:0 ), stearic (C 18:0 ) and linolenic (C 18:3 ) acids. EDR induced by acetylcholine (0.1–10 μmol/l...
Clin Sci (Lond) (2006) 110 (2): 217–225.
Published: 17 January 2006
.... We studied the ACh (acetylcholine)-induced relaxation response in aortic and carotid rings of young (9–11 weeks) and aged (22–24 weeks) female bGH transgenic mice and littermate control mice, without and with the addition of a free radical scavenger {MnTBAP [Mn(III)tetrakis(4-benzoic acid)porphyrin...
Clin Sci (Lond) (2005) 109 (1): 45–54.
Published: 23 June 2005
...Melanie J. EASTER; Janice M. MARSHALL In 15 women with PR (primary Raynaud's) disease and in 15 matched control women, ACh (acetylcholine) was delivered by iontophoresis to the dorsum of the finger (seven 20 s pulses of 0.1 mA, followed by one 20 s pulse of 0.2 mA, applied at 60 s intervals...
Clin Sci (Lond) (2004) 107 (3): 323–330.
Published: 24 August 2004
...Ross G. HENDRY; Janice M. MARSHALL In healthy young men (age, 20–22 years), we tested the role of prostanoids produced by the COX (cyclo-oxygenase) pathway in cutaneous vasodilatation evoked in the finger by ACh (acetylcholine). To this end, changes in cutaneous RCF (red cell flux), recorded...
Clin Sci (Lond) (2004) 106 (2): 115–120.
Published: 01 February 2004
... to the potential risk for an ischaemic coronary event. In the present study, we have investigated the relationship between coronary vasomotor function and the extent of CAD. The response to acetylcholine and nitrate infusion was assessed by quantitative coronary angiography. The extent of CAD was categorized...
Clin Sci (Lond) (2002) 103 (4): 409–415.
Published: 09 September 2002
... are unclear. The aim of the present study was to determine the effects of intra-arterial TNF-α on ET-1 spillover, vascular tone and endothelial function in the healthy human forearm. Brachial arterial and deep venous blood samples, forearm plasma flow measurements and blood flow responses to acetylcholine...
Clin Sci (Lond) (2002) 103 (s2002): 194S–197S.
Published: 01 September 2002
...Maria Angeles MARTÍNEZ; Nuria FERNÁNDEZ; Luis MONGE; Angel Luis GARCÍA-VILLALÓN; Elena SANZ; Godofredo DIÉGUEZ To examine coronary reactivity to acetylcholine and endothelin-1 (ET-1) during partial ischaemia and reperfusion, flow in the left circumflex coronary artery was measured...
Clin Sci (Lond) (2002) 103 (2): 163–169.
Published: 17 July 2002
... of 8weeks pentoxifylline and 8weeks placebo. Endothelium-dependent and-independent vasodilation in resistance arteries was assessed via bilateral forearm venous occlusion plethysmography during intra-brachial infusions of acetylcholine (ACh), sodium nitroprusside (SNP) and N G -monomethyl- l -arginine ( l...
Clin Sci (Lond) (2002) 102 (5): 495–500.
Published: 10 April 2002
... by venous occlusion plethysmography during brachial artery infusions of saline, acetylcholine and nitroprusside before, and at 1 and 2h. Lipid/heparin infusion had no significant effect on vasodilation to nitroprusside but progressively increased responses to acetylcholine (from 6.3±2.0 during 30 μ gċmin -1...
Clin Sci (Lond) (2002) 102 (3): 307–314.
Published: 08 February 2002
...) in response to intra-arterially administered diazoxide, acetylcholine and dipyridamole and to forearm ischaemia was measured. The diazoxide-mediated increase in the forearm blood flow ratio (infused/control arm) was significantly less pronounced after glibenclamide than after acarbose (290±58% and 561±101...
Clin Sci (Lond) (2001) 101 (1): 59–64.
Published: 24 May 2001
.... Patients and matched controls were studied after an overnight fast. SBF was determined with laser Doppler perfusion imaging before and after iontophoresis of acetylcholine (Ach; endothelium-dependent) and sodium nitroprusside (SNP; endothelium-independent). Basal SBF did not differ significantly between...
Clin Sci (Lond) (2000) 99 (1): 57–63.
Published: 14 June 2000
... reduces nitric oxide (NO) bioavailability, using endothelium-dependent (acetylcholine) and -independent (phentolamine) vasodilators, and the antioxidant ascorbic acid. Ten patients (nine male and one female) with primary left ventricular failure participated in the study. Forearm venous occlusion...
Clin Sci (Lond) (1999) 97 (6): 625–631.
Published: 29 October 1999
...Mercedes FERRER; Nuria TEJERA; Jesús MARÍN; Gloria BALFAGÓN The aim of the present study was to assess the role of superoxide anions in the relaxation induced by acetylcholine (ACh) in aortic segments from male rats, and to investigate if their production is altered by sex hormone deprivation...
Clin Sci (Lond) (1999) 97 (2): 141–147.
Published: 16 June 1999
...A. S. McALLISTER; A. B. ATKINSON; G. D. JOHNSTON; D.R. HADDEN; P. M. BELL; D. R. McCANCE There is considerable evidence that endothelium-dependent nitric oxide (NO)-mediated vasodilatation in response to acetylcholine is impaired in essential hypertension, whereas the endothelium-independent...
Clin Sci (Lond) (1998) 96 (1): 41–47.
Published: 01 January 1999
... and the Medical Research Society © 1999 1999 acetylcholine aorta noradrenaline phenylephrine portal hypertension SpragueDawley rat Wistar rat 41Clinical Science (1999) 96, 41 47 (Printed in Great Britain) Portal hypertension increases vasoconstrictor responsiveness of rat aorta Claire CONNOLLY...
Clin Sci (Lond) (1998) 95 (3): 303–309.
Published: 01 September 1998
... accordingly. Correspondence : Dr Sven-Olof Granstam. 5 1 1998 18 3 1998 14 4 1998 The Biochemical Society and the Medical Research Society © 1998 1998 acetylcholine blood flow carvedilol haemodynamics hypertension spontaneously hypertensive rat 303Clinical Science...
Clin Sci (Lond) (1998) 95 (3): 361–367.
Published: 01 September 1998
.... of vitamin E twice daily for 4 weeks. Endothelium-dependent and -independent vasodilatation were assessed by intrabrachial infusion of acetylcholine and sodium nitroprusside, and forearm blood flow was measured by strain-gauge plethysmography. Basal ·NO function was assessed by infusion of N G -monomethyl- l...
Clin Sci (Lond) (1998) 94 (3): 231–238.
Published: 01 March 1998
...Stuart J. Bund 1. Endothelium-dependent acetylcholine-mediated relaxations of small coronary arteries (∼200 μm internal diameter) from 20 weeks old spontaneously hypertensive rats (SHR) and normotensive Wistar—Kyoto (WKY) controls were compared under pressurized no-flow conditions after...
Clin Sci (Lond) (1998) 94 (2): 129–134.
Published: 01 February 1998
... placebo ( n = 10) or vitamin E, 400 i.u. daily, ( n = 10) for 8 weeks. Endothelium-dependent and independent vasodilatation within forearm vasculature was assessed by brachial artery infusion of acetylcholine (co-infused with saline vehicle and l-arginine) and nitroprusside before and after...
Clin Sci (Lond) (1997) 92 (2): 123–131.
Published: 01 February 1997
...Masanari Shiramoto; Tsutomu Imaizumi; Yoshitaka Hirooka; Toyonari Endo; Takashi Namba; Jun-Ichi Oyama; Kiyoshi Hironaga; Akira Takeshita 1. It has been shown in animals that substance P as well as acetylcholine releases endothelium-derived nitric oxide and evokes vasodilatation and that ATP-induced...
Clin Sci (Lond) (1997) 92 (2): 133–138.
Published: 01 February 1997
...David E. Newby; Nicholas A. Boon; David J. Webb 1. Forearm blood flow responses to incremental challenges of acetylcholine and substance P, administered via the brachial artery, were measured by venous occlusion plethysmography in eight subjects in the presence of saline, the nitric oxide synthase...
Clin Sci (Lond) (1996) 91 (6): 739–743.
Published: 01 December 1996
.... Morphological measurements revealed a significant increase in media thickness/lumen diameter ratio in arteries from patients with Syndrome X. Contractile responses to U46619 were similar in arteries from patients and control subjects. Endothelium-dependent relaxation induced with acetylcholine and bradykinin...
Clin Sci (Lond) (1996) 91 (6): 733–738.
Published: 01 December 1996
... and that of the endothelium in the response to phenylephrine and acetylcholine of isolated aortic rings from chronic bile duct-ligated (29 days) rats and their corresponding controls. Experiments were performed in rings with or without endothelium, in rings pretreated with N -ω-nitro-l-arginine methyl ester (10 −4 mol/l...
Clin Sci (Lond) (1996) 90 (1): 21–29.
Published: 01 January 1996
... rats were treated with either perindopril (1 mg day −1 kg −1 ) or quinapril (3 or 30mg day −1 kg −1 ). After 6 weeks mesenteric resistance arteries were mounted in a myograph for measurements of vascular structure. The endothelium-dependent relaxation response to acetylcholine and bradykinin...
Clin Sci (Lond) (1995) 88 (5): 519–524.
Published: 01 May 1995
...-induced diabetic rats and age-matched controls were investigated using two endothelium-dependent vasodilators, bradykinin and acetylcholine, and the endothelium-independent vasodilator sodium nitroprusside. The contractile responses to the α 1 -adrenergic agonist phenylephrine were also studied. 2...
Clin Sci (Lond) (1994) 86 (3): 245–249.
Published: 01 March 1994
... rabbit kidney perfused in the presence of indomethacin (10 μmol/l) and preconstricted with noradrenaline (7.2 nmol/min). 2. Under control conditions, bolus administrations of acetylcholine (10 μmol/l), an NO-dependent renal vasodilator, verapamil (0.1 mmol/l), an NO-independent renal vasodilator...
Clin Sci (Lond) (1990) 79 (3): 273–278.
Published: 01 September 1990
... relaxing factor synthesis, caused concentration-dependent but only partial inhibition of maximal relaxation induced by acetylcholine in human subcutaneous resistance arteries. 3. The inhibitory action of N G -monomethyl-l-arginine on acetylcholine-induced maximal relaxation was partially reversed...
Clin Sci (Lond) (1990) 78 (1): 101–104.
Published: 01 January 1990
...Joe Collier; Patrick Vallance 1. The dose-response to acetylcholine has been examined in dorsal hand veins of healthy volunteers before and after removal of the endothelium. 2. Measurements were made in single dorsal hand veins during local infusions of acetylcholine. The vein was irrigated...
Clin Sci (Lond) (1980) 58 (1): 7–13.
Published: 01 January 1980
...J. D. Marker; T. S. Miles; G. C. Scroop 1. The effects of vascular infusions of acetylcholine, angiotensin II, noradrenaline and prostaglandin F 2α on the baroreceptor reflex were studied in the anaesthetized greyhound. 2. Vertebral artery infusions of low doses of angiotensin II...
Clin Sci (1972) 43 (3): 401–411.
Published: 01 September 1972
... by an indicator-dilution technique. 2. Increases in renal blood flow during graded intravenous iso-osmotic saline or hyperosmotic mannitol infusions and during renal arterial infusions of acetylcholine or prostaglandin E 1 were consistently associated with reduced E PAH . 3. The cortical fraction of renal blood...