... Teixeira; Vivian Vasconcelos Costa; Steyner F. Cortes; Virginia S. Lemos Poor disease outcomes and lethality are directly related to endothelial dysfunction in betacoronavirus infections. Here, we investigated the mechanisms underlying the vascular dysfunction caused by the betacoronaviruses MHV-3 and SARS...

...) exposure, worsens vascular function and if so, whether the antioxidant ebselen alleviates this vascular dysfunction. Male BALB/c mice were exposed to either room air or CS for 8 weeks followed by inoculation with IAV (Mem71, 1 × 10 4.5 pfu). Mice were treated with ebselen (10 mg/kg) or vehicle (5% w/v CM...

... and redox stress but only partially restore endothelial function in mesenteric vessels. We investigated whether sympatho-adrenal overactivation evokes coronary vascular dysfunction when a high salt intake is combined with insulin resistance in male Goto–Kakizaki (GK) and Wistar rats treated with two...

...Tamara Sáez; Floor Spaans; Raven Kirschenman; Tatsuya Sawamura; Sandra T. Davidge The lectin-like oxidized low-density-lipoprotein (oxLDL) receptor-1 (LOX-1) has been shown to induce angiotensin II (AngII) type 1 receptor (AT 1 ) activation, contributing to vascular dysfunction. Preeclampsia...

... for induction of localized PVAT inflammation and subsequent vascular dysfunction in early stages of metabolic deterioration ( A ) Under physiological conditions, PVAT receives enough oxygen and maintains healthy vascular function. ( B ) The unique properties of PVAT render it more sensitive to hypoxia...

... vessel tone are altered by oxidative damage of vascular endothelial cells, thus promoting vascular dysfunction, a key driver of CVD. In this review, the detrimental role of oxidative stress in COPD and comorbid CVD are discussed and we propose that targeting oxidant-dependent mechanisms represents...

... oligomers (SPOs) that contribute to the inflammation and vascular dysfunction observed in sepsis via the activation of one or more PRRs including FPR. Our laboratory has shown increased levels of SPOs in the heart and intrarenal arteries of septic mice. We have also observed that exposure of resistance...

... reverse vascular dysfunction in aged human skin through NO-dependent mechanisms [ 4 , 13 ]. However, the high cost and relative unavailability of oral formulations of BH 4 underscore the need for a readily available, inexpensive, intervention strategy to effectively improve microvascular function...

... improvement. The aim of the present study was to evaluate the effects of metformin treatment on vascular dysfunction in ovariectomized rats. At 8 weeks of age, female Wistar rats were subjected to ovariectomy or a sham surgery. After 21 days, the animals were divided into three groups: SHAM (sham-operated...

... effects on the vasculature, augmenting vascular responses to contractile stimuli. As NO/cGMP signalling plays a role in vascular dysfunction associated with obesity and the metabolic syndrome, we hypothesized that chemerin induces vascular dysfunction by decreasing NO/cGMP signalling. Aortic rings from...

...Kathleen M. Lukaszewicz; John R. Falck; Vijaya L. Manthati; Julian H. Lombard The present study tested the hypothesis that the Dahl SS (salt-sensitive) rat has vascular dysfunction due, in part, to the up-regulation of the CYP4A/20-HETE (cytochrome P450 ω-hydroxylase 4A)/20-hydroxyeicosatetraenoic...

... response and to produce systemic maternal inflammation and vascular dysfunction that lead to hypertension and IUGR (intra-uterine growth restriction). The proposed hypothesis implicates mtDNA in the development of PE via activation of the immune system and may have important preventative and therapeutic...

...Ahmed A. Elmarakby; John D. Imig Obesity and hypertension are the two major risk factors that contribute to the progression of end-stage renal disease. To examine whether hypertension further exacerbates oxidative stress and vascular dysfunction and inflammation in obese rats, four groups of male...

...Faisel Khan; Dean Patterson; Jill J.F. Belch; Kumiko Hirata; Chim C. Lang Vascular dysfunction in the coronary and peripheral circulations is an early prognostic marker of future cardiovascular events. Measurements of coronary and peripheral vascular function in resistance vessels can be made...

... studies and experimental models have revealed underlying the adult cardiovascular phenotype dictated by the perinatal experience, as well as the probable key causal or triggering elements. Programmed elevated blood pressure in the adult human or animal is characterized by vascular dysfunction...

... to moderate hypertriglyceridaemia. Correspondence: Dr E. K. Naderali (e-mail naderali@liverpool.ac.uk ). 13 3 2001 23 5 2001 9 7 2001 The Biochemical Society and the Medical Research Society © 2001 2001 diet-induced obesity insulin resistance vascular dysfunction...