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Keywords: Type 2 diabetes
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Articles
Roy Taylor, Alison C. Barnes, Kieren G. Hollingsworth, Keaton M. Irvine, Alexandra S. Solovyova, Lucy Clark, Tara Kelly, Carmen Martin-Ruiz, Davide Romeres, Albert Koulman, Claire M. Meek, Benjamin Jenkins, Claudio Cobelli, Rury R. Holman
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1333–1346.
Published: 31 August 2023
... thresholds for lipid overspill and adverse effects on β-cell function. To test this hypothesis, people with Type 2 diabetes and body mass index <27kg/m 2 ( n = 20) underwent repeated 5% weight loss cycles. Metabolic assessments were carried out at stable weight after each cycle and after 12 months...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1471–1483.
Published: 02 November 2022
...Kalie L. Tommerdahl; Jessica Kendrick; Robert G. Nelson; Petter Bjornstad Type 2 diabetes (T2D) is a global health pandemic with significant humanitarian, economic, and societal implications, particularly for youth and young adults who are experiencing an exponential rise in incident disease. Youth...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (4): 593–595.
Published: 18 February 2021
... 07 02 2021 10 02 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cognition hippocampus mitochondria Platelets type 2 diabetes The mitochondria, the cellular organelles concerned with energy and regulating Ca 2...
Articles
In Collection
Celebrating 100 years of insulin research
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 589–591.
Published: 10 February 2021
... diabetes mellitus: the epidemic continues . Arterioscler. Thromb. Vasc. Biol. 38 , e1 – e8 10.1161/ATVBAHA.117.310221 29282247 5. Porter K.E. and Riches K. ( 2013 ) The vascular smooth muscle cell: a therapeutic target in Type 2 diabetes? Clin. Sci. (Lond.) 125 , 167 – 182...
Articles
In Collection
Celebrating 100 years of insulin research
Joshua A. Beckman, Jiun-Ruey Hu, Shi Huang, Eric Farber-Eger, Quinn S. Wells, Thomas J. Wang, Robert E. Gerszten, Jane F. Ferguson
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2369–2379.
Published: 16 September 2020
...Joshua A. Beckman; Jiun-Ruey Hu; Shi Huang; Eric Farber-Eger; Quinn S. Wells; Thomas J. Wang; Robert E. Gerszten; Jane F. Ferguson Objective: Type 2 diabetes mellitus (T2DM) reduces exercise capacity, but the mechanisms are incompletely understood. We probed the impact of ischemic stress...
Includes: Supplementary data
Articles
Barbara Toffoli, Federica Tonon, Veronica Tisato, Andrea Michelli, Giorgio Zauli, Paola Secchiero, Bruno Fabris, Stella Bernardi
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2337–2352.
Published: 10 September 2020
... studies have shown that TRAIL delivery ameliorated glucose control in type 1 and type 2 diabetes. It is currently unknown whether TRAIL positive effects are maintained in more severe forms of type 2 diabetes, and whether they include renoprotection. Our study aimed at evaluating TRAIL effects in a severe...
Includes: Supplementary data
Articles
Hongli Ma, Tao Jiang, Wenxin Tang, Zhi Ma, Kairui Pu, Fuxing Xu, Haiqing Chang, Ge Zhao, Wei Gao, Yansong Li, Qiang Wang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (16): 2161–2175.
Published: 24 August 2020
... 2020 cognitive impairment hippocampus mitochondrial transplantation oxidative stress platelet type 2 diabetes The global convergence of lifestyle variation and population aging has resulted in the increased incidence of diabetes [ 1 ]. According to epidemiological analysis, the number...
Includes: Supplementary data
Articles
Miroslava Kacířová, Anna Zmeškalová, Lucia Kořínková, Blanka Železná, Jaroslav Kuneš, Lenka Maletínská
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (5): 547–570.
Published: 13 March 2020
... play a role in inflammation. In this review, we try to elucidate the connections between peripheral inflammation at obesity and Type 2 diabetes and the central inflammatory process. Multiple lines of evidence highlight the importance of peripheral inflammation and its link to neuroinflammation, which...
Articles
Jizheng Chen, Fang Wang, Yue Zhou, Jing Jiang, Sulaiman Ksimu, Xu Zhang, John Zhong Li, Junqi Niu, Qian Wang
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (5): 529–542.
Published: 13 March 2020
...Jizheng Chen; Fang Wang; Yue Zhou; Jing Jiang; Sulaiman Ksimu; Xu Zhang; John Zhong Li; Junqi Niu; Qian Wang Chronic hepatitis C virus (HCV) infection has a close association with type 2 diabetes mellitus. Although the mechanisms of insulin resistance in chronic hepatitis C (CHC) patients have been...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (22): 2317–2327.
Published: 26 November 2019
...Nicolás Gómez-Banoy; James C. Lo The growing prevalence of obesity and its related metabolic diseases, mainly Type 2 diabetes (T2D), has increased the interest in adipose tissue (AT) and its role as a principal metabolic orchestrator. Two decades of research have now shown that ATs act...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... rat dorsal root ganglia neurons [ 229 , 230 ]. Finally, the direct effects of SPMs on neuropathy has been demonstrated, with RvD1 and E1 shown to be a key component of DHA supplementation in type 2 diabetic mice for treatment of neuropathy [ 231 ]. Similarly, other derivatives of the DHA pathway...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (19): 2029–2044.
Published: 14 October 2019
... was a gift from Dr. Peirre Maechler. We also thank Dr. Kwok Wing Tsui and Dr. Ye Cao’s IPAs of the RNA-sequencing results. The authors declare that there are no competing interests associated with the manuscript. Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized...
Includes: Supplementary data
Articles
Mei Xue, Ting Li, Yue Wang, Yunpeng Chang, Ying Cheng, Yunhong Lu, Xiangyang Liu, Linxin Xu, Xiaoyu Li, Xiaochen Yu, Bei Sun, Liming Chen
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (15): 1705–1720.
Published: 02 August 2019
...Mei Xue; Ting Li; Yue Wang; Yunpeng Chang; Ying Cheng; Yunhong Lu; Xiangyang Liu; Linxin Xu; Xiaoyu Li; Xiaochen Yu; Bei Sun; Liming Chen Cardiovascular complications contribute to the major mortality and morbidity in type 2 diabetes. Diabetic cardiomyopathy (DCM) is increasingly recognized...
Includes: Supplementary data
Articles
Hiranya Pintana, Grazyna Lietzau, Ingrid Lovise Augestad, Fausto Chiazza, Thomas Nyström, Cesare Patrone, Vladimer Darsalia
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (13): 1367–1386.
Published: 01 July 2019
...Hiranya Pintana; Grazyna Lietzau; Ingrid Lovise Augestad; Fausto Chiazza; Thomas Nyström; Cesare Patrone; Vladimer Darsalia Type 2 diabetes (T2D) hampers stroke recovery though largely undetermined mechanisms. Few preclinical studies have investigated the effect of genetic/toxin-induced diabetes...
Includes: Supplementary data
Articles
Soumyalekshmi Nair, Nanthini Jayabalan, Dominic Guanzon, Carlos Palma, Katherin Scholz-Romero, Omar Elfeky, Felipe Zuñiga, Valeska Ormazabal, Emilio Diaz, Gregory E. Rice, Gregory Duncombe, Thomas Jansson, Harold David McIntyre, Martha Lappas, Carlos Salomon
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (22): 2451–2467.
Published: 30 November 2018
... common pregnancy complications with a worldwide prevalence rate of 9–15% [ 8 ]. Women with GDM are at significantly higher risk for hypertensive disorders, preterm delivery, cesarean sections, fetal macrosomia, future development of type 2 diabetes, and cardiovascular diseases [ 9 , 10 ]. Despite its...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
...Sara Baqar; Dorothy Liu; Lisa F. Lincz; Yee Wen Kong; George Jerums; Elif I. Ekinci Objective: Low sodium intake is paradoxically associated with adverse cardiovascular outcomes in individuals with type 2 diabetes mellitus (T2D), possibly from renin–angiotensin–aldosterone system (RAAS) activation...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (15): 1699–1709.
Published: 16 August 2018
...James G. Boyle; Rachel Livingstone; John R. Petrie Type 2 diabetes (T2D) carries risks of both cardiovascular (CV) (myocardial infarction, stroke, and peripheral vascular disease) and microvascular (retinopathy/nephropathy/neuropathy) complications. Glucose-lowering is an effective strategy...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (15): 1629–1643.
Published: 14 August 2018
...-producing pancreatic β-cells (reviewed in [ 1 ]), while type 2 diabetes mellitus (T2DM) is a polygenic condition characterised by loss of insulin secretion and sensitivity, strongly influenced by environmental factors such as obesity [ 2 ]. Single gene disorders, such as neonatal diabetes, Maturity Onset...
Articles
Frank J. Ong, Basma A. Ahmed, Stephan M. Oreskovich, Denis P. Blondin, Tahniyah Haq, Norman B. Konyer, Michael D. Noseworthy, Francois Haman, Andre C. Carpentier, Katherine M. Morrison, Gregory R. Steinberg
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (10): 1039–1054.
Published: 25 May 2018
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 brown adipose tissue beige adipose tissue insulin resistance obesity type 2 diabetes Since the re-discovery and definitive identification of functional brown adipose tissue (BAT) in adult humans...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (4): 489–507.
Published: 28 February 2018
...Keizo Kanasaki Emerging evidence suggests that dipeptidyl peptidase-4 (DPP-4) inhibitors used to treat type 2 diabetes may have nephroprotective effects beyond the reduced renal risk conferred by glycemic control. DPP-4 is a ubiquitous protein with exopeptidase activity that exists in cell membrane...
Articles
Functional blocking of Ninjurin1 as a strategy for protecting endothelial cells in diabetes mellitus
Xin Wang, Jinbao Qin, Xing Zhang, Zhiyou Peng, Kaichuang Ye, Xiaoyu Wu, Xinrui Yang, Huihua Shi, Zhen Zhao, Xin Guo, Xiaobing Liu, Minyi Yin, Xinwu Lu
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (2): 213–229.
Published: 19 January 2018
... protein 1 (Ninj1) is an adhesion molecule that not only contributes to inflammation but also regulates the apoptosis of endothelial cells. In the present study, Ninj1 was found highly expressed in endothelial cells in Type 2 diabetic mice and increased in high-glucose (HG) cultured HUVECs. Furthermore, we...
Includes: Supplementary data
Articles
Stella Bernardi, Barbara Toffoli, Veronica Tisato, Fleur Bossi, Stefania Biffi, Andrea Lorenzon, Giorgio Zauli, Paola Secchiero, Bruno Fabris
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (1): 69–83.
Published: 05 January 2018
... diabetes. It has been shown that TRAIL deficiency worsens diabetes and that TRAIL delivery, when it is given before disease onset, slows down its development. The present study aimed at evaluating whether TRAIL had the potential not only to prevent, but also to treat type 2 diabetes. Thirty male C57BL/6J...
Includes: Supplementary data
Articles
Bram Brouwers, Vera B. Schrauwen-Hinderling, Tomas Jelenik, Anne Gemmink, Bas Havekes, Yvonne Bruls, Dennis Dahlmans, Michael Roden, Matthijs K.C. Hesselink, Patrick Schrauwen
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1905–1917.
Published: 07 July 2017
...Bram Brouwers; Vera B. Schrauwen-Hinderling; Tomas Jelenik; Anne Gemmink; Bas Havekes; Yvonne Bruls; Dennis Dahlmans; Michael Roden; Matthijs K.C. Hesselink; Patrick Schrauwen Non-alcoholic fatty liver (NAFL) is an independent risk factor for the development of type 2 diabetes (T2DM). We examined...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (10): 991–1000.
Published: 09 May 2017
...Ashish Patidar; Dhruv K. Singh; Shori Thakur; Peter Winocour; Ken Farrington; Anwar R. Baydoun Although vascular calcification (VC) is prevalent in Type 2 diabetes mellitus (T2DM), underlying mechanisms remain unclear. Neither is it known whether T2DM confers calcific potential (CP) on serum...
Articles
Emilie Pastel, Laura J. McCulloch, Rebecca Ward, Shivam Joshi, Kim M. Gooding, Angela C. Shore, Katarina Kos
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (5): 343–353.
Published: 15 February 2017
... AT that expresses the GLP-1 receptor (GLP-1R). The present study aimed to assess the impact of GLP-1 analogue treatment on subcutaneous AT (SCAT) inflammatory and fibrotic responses, compared with weight loss by calorie reduction (control). Among the 39 participants with Type 2 diabetes recruited, 30 age-matched...
Includes: Supplementary data
Articles
Rikke Kruse, Andreas J.T. Pedersen, Jonas M. Kristensen, Stine J. Petersson, Jørgen F.P. Wojtaszewski, Kurt Højlund
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (1): 37–47.
Published: 09 December 2016
...Rikke Kruse; Andreas J.T. Pedersen; Jonas M. Kristensen; Stine J. Petersson; Jørgen F.P. Wojtaszewski; Kurt Højlund Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy...
Includes: Supplementary data
Articles
Dorinne Desposito, Catherine Chollet, Christopher Taveau, Vincent Descamps, François Alhenc-Gelas, Ronan Roussel, Nadine Bouby, Ludovic Waeckel
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (1): 45–56.
Published: 30 November 2015
... Type 1 diabetes Type 2 diabetes • Impairment of skin wound repair is a major complication of diabetes, favouring development of foot ulcers and contributing to their poor prognosis. Improving skin healing is a therapeutic issue in diabetic patients. • Our study revealed that treatment...
Articles
Angela X. Chen, George Jerums, Sara Baqar, Elisabeth Lambert, Goji Somarajah, Georgina Thomas, Christopher O’Callaghan, Richard J. MacIsaac, Elif I. Ekinci
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (5): 415–422.
Published: 11 June 2015
... aldosterone level and estimated glomerular filtration rate (eGFR) in hypertensive patients with type 2 diabetes. In a randomized, double-blind, placebo-controlled study (RCT), 28 patients with type 2 diabetes, treated with telmisartan (40 mg daily), received 2 weeks of placebo or NaCl capsules (100 mmol/24 h...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (10): 707–713.
Published: 27 February 2015
...Mavin Macauley; Fiona E Smith; Peter E Thelwall; Kieren G Hollingsworth; Roy Taylor Storage of food-derived glucose as muscle and liver glycogen is vital to avoid damaging swings plasma osmolarity. We report that in Type 2 diabetes, muscle glycogen storage was completely inactive although liver...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (7): 405–410.
Published: 09 December 2014
...Roy Taylor; Rury R. Holman Type 2 diabetes (T2DM) is frequently regarded as a disease of obesity and its occurrence in individuals of normal body mass index (BMI) is often regarded as indicating a non-obesity-related subtype. However, the evidence for such a distinct, common subtype is lacking...
Articles
Thiago Bruder-Nascimento, Glaucia E. Callera, Augusto C. Montezano, Ying He, Tayze T. Antunes, Aurelie Nguyen Dinh Cat, Rita C. Tostes, Rhian M. Touyz
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (7): 411–423.
Published: 09 December 2014
... (db/db) mice, a model of Type 2 diabetes and control Lepr db /Lepr + (db/+) mice were administered atorvastatin (10 mg/kg per day, 2 weeks). Atorvastatin improved glucose tolerance in db/db mice. Systemic and vascular oxidative stress in db/db mice, characterized by increased plasma TBARS...
Includes: Supplementary data
Articles
Patricia Prieto, María Teresa Vallejo-Cremades, Gemma Benito, Pilar González-Peramato, Daniel Francés, Noelia Agra, Verónica Terrón, Silvia Gónzalez-Ramos, Carmen Delgado, Mariano Ruiz-Gayo, Ivette Pacheco, Juan P. Velasco-Martín, Javier Regadera, Paloma Martín-Sanz, Eduardo López-Collazo, Lisardo Boscá, María Fernández-Velasco
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (12): 665–677.
Published: 08 August 2014
... Boscá; María Fernández-Velasco Type 2 diabetes has a complex pathology that involves a chronic inflammatory state. Emerging evidence suggests a link between the innate immune system receptor NOD1 (nucleotide-binding and oligomerization domain 1) and the pathogenesis of diabetes, in monocytes and hepatic...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (2): 91–100.
Published: 17 March 2014
... of the present study was to investigate the role of GdCl 3 in hepatic gluconeogenesis and explore the precise molecular mechanism. Animals from a classical Type 2 diabetic mouse model, created by exposing C57BL/6J mice to a high-fat diet for 4 months, were treated with GdCl 3 or saline. Body weight, blood...
Articles
Mauricio Krause, Kevin Keane, Josianne Rodrigues-Krause, Domenico Crognale, Brendan Egan, Giuseppe De Vito, Colin Murphy, Philip Newsholme
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (10): 739–752.
Published: 03 February 2014
... lipopolysaccharide OCR O 2 consumption rate OxPAPC oxidized 1-palmitoyl-2-arachidonoyl- sn -glycero-3-phosphocholine PPR proton production rate ROS reactive oxygen species T1DM Type 1 diabetes T2DM Type 2 diabetes TLR Toll-like receptor TNF tumour necrosis factor...
Articles
Pam R. Taub, Israel Ramirez-Sanchez, Theodore P. Ciaraldi, Silvia Gonzalez-Basurto, Ramon Coral-Vazquez, Guy Perkins, Michael Hogan, Alan S. Maisel, Robert R. Henry, Guillermo Ceballos, Francisco Villarreal
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (8): 383–389.
Published: 14 June 2013
...Pam R. Taub; Israel Ramirez-Sanchez; Theodore P. Ciaraldi; Silvia Gonzalez-Basurto; Ramon Coral-Vazquez; Guy Perkins; Michael Hogan; Alan S. Maisel; Robert R. Henry; Guillermo Ceballos; Francisco Villarreal HF (heart failure) and T2D (Type 2 diabetes) associate with detrimental alterations in SkM...
Articles
Giovanni Targher, Alessandro Mantovani, Isabella Pichiri, Riccardo Rigolon, Marco Dauriz, Giacomo Zoppini, Giovanni Morani, Corrado Vassanelli, Enzo Bonora
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (6): 301–310.
Published: 22 May 2013
... countries and share multiple risk factors. The relationship between NAFLD and AF in Type 2 diabetes is currently unknown. We studied a hospital-based sample of 702 patients with Type 2 diabetes discharged from our Division of Endocrinology during 2007–2011. The diagnosis of AF was confirmed in affected...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (4): 167–182.
Published: 26 April 2013
...Karen E. Porter; Kirsten Riches The rising epidemic of T2DM (Type 2 diabetes mellitus) worldwide is of significant concern. The inherently silent nature of the disease in its early stages precludes early detection; hence cardiovascular disease is often established by the time diabetes is diagnosed...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (6): 375–386.
Published: 29 May 2012
... in their controls, but the total PP1α protein level was not different. These results suggest that the aortic relaxation responses, NO production, and eNOS activity mediated by CaMKII phosphorylation are decreased in this Type 2 diabetic model, and that these impairments of CaMKII signalling may be, at least in part...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (6): 253–270.
Published: 11 November 2011
...-line oral therapy for T2D (Type 2 diabetes). The main effect of this drug from the biguanide family is to acutely decrease hepatic glucose production, mostly through a mild and transient inhibition of the mitochondrial respiratory chain complex I. In addition, the resulting decrease in hepatic energy...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (5): 203–214.
Published: 28 October 2011
.... 12 7 2011 1 9 2011 8 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 hyperglycaemia inflammation insulin resistance oxidative stress Toll-like receptor Type 2 diabetes Diabetes affects more than 348 million people worldwide and around 36...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (4): 169–177.
Published: 04 May 2011
..., but no direct measurement has tested this concept or its possible relationship to the reported impairment in insulin-stimulated muscle ATP production. Isoglycaemic–hyperinsulinaemic clamps with [ 13 C]glucose infusion were performed on Type 2 diabetic subjects and matched controls with measurement of glycogen...
Articles
Adriana Georgescu, Doina Popov, Anamaria Constantin, Miruna Nemecz, Nicoleta Alexandru, Daniel Cochior, Aura Tudor
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (10): 463–472.
Published: 28 January 2011
...Adriana Georgescu; Doina Popov; Anamaria Constantin; Miruna Nemecz; Nicoleta Alexandru; Daniel Cochior; Aura Tudor The aim of the present study was to examine the effects of obesity alone and obesity associated with Type 2 diabetes on the structure, vascular reactivity and response to insulin...
Articles
Ruth C. R. Meex, Esther Phielix, Vera B. Schrauwen-Hinderling, Esther Moonen-Kornips, Gert Schaart, Patrick Schrauwen, Matthijs K. C. Hesselink
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (7): 293–301.
Published: 25 June 2010
... function statin Type 2 diabetes Hyperlipidaemia and hyperglycaemia are frequently reported in obese subjects and are highly associated with the development of cardiovascular disorders, the primary cause of death in obesity. Whereas treatment with HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (10): 607–615.
Published: 23 February 2010
...Sandra J. Hamilton; Gerard T. Chew; Timothy M.E. Davis; Gerald F. Watts Dyslipidaemia contributes to endothelial dysfunction and CVD (cardiovascular disease) in Type 2 diabetes mellitus. While statin therapy reduces CVD in these patients, residual risk remains high. Fenofibrate corrects atherogenic...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (5): 173–190.
Published: 03 August 2009
...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...
Articles
Omar Asghar, Ahmed Al-Sunni, Kaivan Khavandi, Ali Khavandi, Sarah Withers, Adam Greenstein, Anthony M. Heagerty, Rayaz A. Malik
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (10): 741–760.
Published: 15 April 2009
..., provided the original work is properly cited. diabetic cardiomyopathy heart failure hyperglycaemia Type 2 diabetes The link between HF (heart failure) and diabetes is well documented, but the existence of diabetic cardiomyopathy as a distinct clinical entity continues to be the subject...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (7): 565–574.
Published: 02 March 2009
... in diabetes. C-peptide G-protein-coupled receptor proinsulin Type 1 diabetes Type 2 diabetes To exert hormone-like activity, C-peptide must have a receptor. Specific displaceable binding of C-peptide to pancreatic islet β-cells was initially described by Flatt et al. [ 6 ]. Ido and co...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (2): 113–123.
Published: 15 December 2008
... understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (2): 99–111.
Published: 15 December 2008
...Wanzhu Jin; Mary-Elizabeth Patti T2DM (Type 2 diabetes mellitus) has reached epidemic proportions worldwide, exerting major health consequences at an individual and public health level alike. Unfortunately, the molecular pathophysiology of diabetes remains incompletely understood, impairing...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (1): 81–86.
Published: 28 November 2008
..., we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy. Two control subgroups involved 340 healthy individuals and 132 patients with T2DM...
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