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Keywords: Type 2 diabetes
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Clin Sci (Lond) (2021) 135 (4): 593–595.
Published: 18 February 2021
...) by different molecular connections like, junctions and cell fusion [ 1 ]. cognition hippocampus mitochondria Platelets type 2 diabetes © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 24 11 2020 07 02 2021 10 02 2021...
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Clin Sci (Lond) (2021) 135 (3): 589–591.
Published: 10 February 2021
... 2021 cardiovascular disease Metabolites type 2 diabetes Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and defect in metabolism of energy substrate—carbohydrate, fat and protein [ 1 ]. Most organs and systems are affected including brain, heart, kidney, eyes...
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Clin Sci (Lond) (2020) 134 (17): 2337–2352.
Published: 10 September 2020
... studies have shown that TRAIL delivery ameliorated glucose control in type 1 and type 2 diabetes. It is currently unknown whether TRAIL positive effects are maintained in more severe forms of type 2 diabetes, and whether they include renoprotection. Our study aimed at evaluating TRAIL effects in a severe...
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Clin Sci (Lond) (2020) 134 (16): 2161–2175.
Published: 24 August 2020
... 2020 cognitive impairment hippocampus mitochondrial transplantation oxidative stress platelet type 2 diabetes The global convergence of lifestyle variation and population aging has resulted in the increased incidence of diabetes [ 1 ]. According to epidemiological analysis, the number...
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Clin Sci (Lond) (2020) 134 (5): 529–542.
Published: 13 March 2020
...Jizheng Chen; Fang Wang; Yue Zhou; Jing Jiang; Sulaiman Ksimu; Xu Zhang; John Zhong Li; Junqi Niu; Qian Wang Chronic hepatitis C virus (HCV) infection has a close association with type 2 diabetes mellitus. Although the mechanisms of insulin resistance in chronic hepatitis C (CHC) patients have been...
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Clin Sci (Lond) (2019) 133 (22): 2317–2327.
Published: 26 November 2019
...Nicolás Gómez-Banoy; James C. Lo The growing prevalence of obesity and its related metabolic diseases, mainly Type 2 diabetes (T2D), has increased the interest in adipose tissue (AT) and its role as a principal metabolic orchestrator. Two decades of research have now shown that ATs act...
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Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... rat dorsal root ganglia neurons [ 229 , 230 ]. Finally, the direct effects of SPMs on neuropathy has been demonstrated, with RvD1 and E1 shown to be a key component of DHA supplementation in type 2 diabetic mice for treatment of neuropathy [ 231 ]. Similarly, other derivatives of the DHA pathway...
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Clin Sci (Lond) (2019) 133 (19): 2029–2044.
Published: 14 October 2019
... was a gift from Dr. Peirre Maechler. We also thank Dr. Kwok Wing Tsui and Dr. Ye Cao’s IPAs of the RNA-sequencing results. The authors declare that there are no competing interests associated with the manuscript. Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized...
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Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
...Sara Baqar; Dorothy Liu; Lisa F. Lincz; Yee Wen Kong; George Jerums; Elif I. Ekinci Objective: Low sodium intake is paradoxically associated with adverse cardiovascular outcomes in individuals with type 2 diabetes mellitus (T2D), possibly from renin–angiotensin–aldosterone system (RAAS) activation...
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Clin Sci (Lond) (2018) 132 (15): 1629–1643.
Published: 14 August 2018
...-producing pancreatic β-cells (reviewed in [ 1 ]), while type 2 diabetes mellitus (T2DM) is a polygenic condition characterised by loss of insulin secretion and sensitivity, strongly influenced by environmental factors such as obesity [ 2 ]. Single gene disorders, such as neonatal diabetes, Maturity Onset...
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Clin Sci (Lond) (2018) 132 (10): 1039–1054.
Published: 25 May 2018
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 brown adipose tissue beige adipose tissue insulin resistance obesity type 2 diabetes Since the re-discovery and definitive identification of functional brown adipose tissue (BAT) in adult humans...
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Clin Sci (Lond) (2018) 132 (4): 489–507.
Published: 28 February 2018
...Keizo Kanasaki Emerging evidence suggests that dipeptidyl peptidase-4 (DPP-4) inhibitors used to treat type 2 diabetes may have nephroprotective effects beyond the reduced renal risk conferred by glycemic control. DPP-4 is a ubiquitous protein with exopeptidase activity that exists in cell membrane...
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Clin Sci (Lond) (2018) 132 (2): 213–229.
Published: 19 January 2018
... protein 1 (Ninj1) is an adhesion molecule that not only contributes to inflammation but also regulates the apoptosis of endothelial cells. In the present study, Ninj1 was found highly expressed in endothelial cells in Type 2 diabetic mice and increased in high-glucose (HG) cultured HUVECs. Furthermore, we...
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Clin Sci (Lond) (2018) 132 (1): 69–83.
Published: 05 January 2018
... diabetes. It has been shown that TRAIL deficiency worsens diabetes and that TRAIL delivery, when it is given before disease onset, slows down its development. The present study aimed at evaluating whether TRAIL had the potential not only to prevent, but also to treat type 2 diabetes. Thirty male C57BL/6J...
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Clin Sci (Lond) (2017) 131 (10): 991–1000.
Published: 09 May 2017
...Ashish Patidar; Dhruv K. Singh; Shori Thakur; Peter Winocour; Ken Farrington; Anwar R. Baydoun Although vascular calcification (VC) is prevalent in Type 2 diabetes mellitus (T2DM), underlying mechanisms remain unclear. Neither is it known whether T2DM confers calcific potential (CP) on serum...
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Clin Sci (Lond) (2017) 131 (5): 343–353.
Published: 15 February 2017
... AT that expresses the GLP-1 receptor (GLP-1R). The present study aimed to assess the impact of GLP-1 analogue treatment on subcutaneous AT (SCAT) inflammatory and fibrotic responses, compared with weight loss by calorie reduction (control). Among the 39 participants with Type 2 diabetes recruited, 30 age-matched...
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Clin Sci (Lond) (2016) 130 (1): 45–56.
Published: 30 November 2015
... Type 1 diabetes Type 2 diabetes • Impairment of skin wound repair is a major complication of diabetes, favouring development of foot ulcers and contributing to their poor prognosis. Improving skin healing is a therapeutic issue in diabetic patients. • Our study revealed that treatment...
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Clin Sci (Lond) (2015) 128 (7): 411–423.
Published: 09 December 2014
... (db/db) mice, a model of Type 2 diabetes and control Lepr db /Lepr + (db/+) mice were administered atorvastatin (10 mg/kg per day, 2 weeks). Atorvastatin improved glucose tolerance in db/db mice. Systemic and vascular oxidative stress in db/db mice, characterized by increased plasma TBARS...
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Clin Sci (Lond) (2014) 127 (12): 665–677.
Published: 08 August 2014
... Boscá; María Fernández-Velasco Type 2 diabetes has a complex pathology that involves a chronic inflammatory state. Emerging evidence suggests a link between the innate immune system receptor NOD1 (nucleotide-binding and oligomerization domain 1) and the pathogenesis of diabetes, in monocytes and hepatic...
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Clin Sci (Lond) (2012) 122 (6): 253–270.
Published: 11 November 2011
...-line oral therapy for T2D (Type 2 diabetes). The main effect of this drug from the biguanide family is to acutely decrease hepatic glucose production, mostly through a mild and transient inhibition of the mitochondrial respiratory chain complex I. In addition, the resulting decrease in hepatic energy...
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Clin Sci (Lond) (2012) 122 (5): 203–214.
Published: 28 October 2011
.... 12 7 2011 1 9 2011 8 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 hyperglycaemia inflammation insulin resistance oxidative stress Toll-like receptor Type 2 diabetes Diabetes affects more than 348 million people worldwide and around 36...
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Clin Sci (Lond) (2009) 117 (5): 173–190.
Published: 03 August 2009
...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...
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Clin Sci (Lond) (2009) 116 (10): 741–760.
Published: 15 April 2009
..., provided the original work is properly cited. diabetic cardiomyopathy heart failure hyperglycaemia Type 2 diabetes The link between HF (heart failure) and diabetes is well documented, but the existence of diabetic cardiomyopathy as a distinct clinical entity continues to be the subject...
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Clin Sci (Lond) (2009) 116 (7): 565–574.
Published: 02 March 2009
... in diabetes. C-peptide G-protein-coupled receptor proinsulin Type 1 diabetes Type 2 diabetes To exert hormone-like activity, C-peptide must have a receptor. Specific displaceable binding of C-peptide to pancreatic islet β-cells was initially described by Flatt et al. [ 6 ]. Ido and co...
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Clin Sci (Lond) (2009) 116 (2): 113–123.
Published: 15 December 2008
... understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors...
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