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In CollectionClinical and translational research highlights
Simon T. Christensen, Kristian A. Haanes, Stine Spray, Anne-Sofie Grell, Karin Warfvinge, Lars Edvinsson, Sara E. Johansson
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (16): 1797–1811.
Published: 20 August 2019
... were screened and the two most potent inhibitors from the organ culture screening, trametinib and PD0325901, were tested in an in vivo experimental rat SAH model with intrathecal injections. Subsequently, the successful inhibitor trametinib was administered intraperitoneally in a second in vivo study...
Includes: Supplementary data