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Keywords: Smad7
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Clin Sci (Lond) (2020) 134 (2): 103–122.
Published: 23 January 2020
.... Importantly, both in vivo and in vitro studies showed alcohol treatments decreased Smad7 and activated Smad3. We further determined how the alcohol affected the balance of Smad7 (inhibitory Smad) and Smad3 (regulatory Smad). Genome-wide methylation sequencing showed an increased DNA methylation of many genes...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (15): 1955–1969.
Published: 13 July 2017
...Sha Fu; Ying Tang; Xiao R. Huang; Min Feng; An P. Xu; Hui Y. Lan Smad7 plays a protective role in chronic kidney disease; however, its role in acute kidney injury (AKI) remains unexplored. Here, we report that Smad7 protects against AKI by rescuing the G1 cell cycle arrest of tubular epithelial...
Clin Sci (Lond) (2014) 127 (3): 195–208.
Published: 03 April 2014
... whether targeting these pathways by SMAD7, a downstream inhibitor of both pathways, blocks AngII (angiotensin II)-induced hypertensive kidney disease in mice. A doxycycline-inducible SMAD7-expressing plasmid was delivered into the kidney by a non-invasive ultrasound-microbubble technique before and after...