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Keywords: Senescence
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Clin Sci (Lond) (2022) 136 (22): 1591–1614.
Published: 14 November 2022
... testing revealed p38 deficiency prevented AEC senescence, EMT, cell migration, and inflammation. To functionally validate in vitro findings, fetal membrane-specific conditional KO (cKO) mice were developed by injecting Cre-recombinase encoded exosomes intra-amniotically into p38α loxP/loxP mice. Amnion...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (10): 1209–1212.
Published: 20 May 2021
.... In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described. References 1. Cramer J...
Clin Sci (Lond) (2020) 134 (20): 2681–2706.
Published: 21 October 2020
... show signs of growth arrest and resistance to apoptosis, which are indicative of cellular senescence. It was recently postulated that cellular senescence contributes to the pathogenesis of chronic fibrotic diseases in the heart, kidney, liver and lung. Senescent cells negatively impact tissue...
Clin Sci (Lond) (2020) 134 (7): 889–905.
Published: 17 April 2020
...Michael Schuliga; Jane Read; Kaj E.C. Blokland; David W. Waters; Janette Burgess; Cecilia Prêle; Steven E. Mutsaers; Jade Jaffar; Glen Westall; Andrew Reid; Allen James; Christopher Grainge; Darryl A. Knight Senescence and mitochondrial stress are mutually reinforcing age-related processes...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (2): 315–330.
Published: 30 January 2020
... senescence is one of the common features in obesity and ageing. Although cellular senescence is a defensive mechanism preventing tumorigenesis, its occurrence in adipose tissue causatively induces defective adipogenesis, inflammation, aberrant adipocytokines production and insulin resistance, leading...
Clin Sci (Lond) (2011) 121 (8): 343–353.
Published: 24 June 2011
... Society 2011 antitumour cytotoxicity exercise hypoxia natural killer cell senescence The human NPC cell line (NPC 076) was kindly provided by Dr J.-K. Chen (Department of Physiology, Chang Gung University, Tao-Yuan, Taiwan). The cells were cultured in DMEM (Dulbecco's modified Eagle's...