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Xiaohong Sun, Kaipeng Huang, Xiao Haiming, Zeyuan Lin, Yan Yang, Meng Zhang, Peiqing Liu, Heqing Huang
Clin Sci (Lond) (2020) 134 (13): 1573–1592.
Published: 30 June 2020
... protein expression was down-regulated in the kidney tissues of db/db mice as well as in high glucose (HG)-induced NRK-52E cells. Overexpression of Cx43 improved renal function in db/db spontaneous diabetic model mice, increased SIRT1 levels, decreased hypoxia-inducible factor (HIF)-1α expression...
Jingjing Zhang, Yanli Cheng, Junlian Gu, Shudong Wang, Shanshan Zhou, Yuehui Wang, Yi Tan, Wenke Feng, Yaowen Fu, Nicholas Mellen, Rui Cheng, Jianxing Ma, Chi Zhang, Zhanquan Li, Lu Cai
Clin Sci (Lond) (2016) 130 (8): 625–641.
Published: 08 March 2016
... with vehicle or FF by gavage every other day for 3 or 6 months. FF prevented diabetes-induced cardiac dysfunction (e.g. decreased ejection fraction and hypertrophy), inflammation and remodelling. FF also increased cardiac expression of fibroblast growth factor 21 (FGF21) and sirtuin 1 (Sirt1) in non-diabetic...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (7): 507–516.
Published: 11 December 2013
...), that ACE2 expression is increased under conditions of cell stress, including hypoxic conditions, IL (interleukin)-1β treatment and treatment with the AMP mimic AICAR (5-amino-4-imidazolecarboxamide riboside). The NAD + -dependent deacetylase SIRT1 (silent information regulator T1) was found to be up...