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Keywords: SIRT1
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Clin Sci (Lond) (2020) 134 (13): 1573–1592.
Published: 30 June 2020
... protein expression was down-regulated in the kidney tissues of db/db mice as well as in high glucose (HG)-induced NRK-52E cells. Overexpression of Cx43 improved renal function in db/db spontaneous diabetic model mice, increased SIRT1 levels, decreased hypoxia-inducible factor (HIF)-1α expression...
Clin Sci (Lond) (2016) 130 (8): 625–641.
Published: 08 March 2016
... with vehicle or FF by gavage every other day for 3 or 6 months. FF prevented diabetes-induced cardiac dysfunction (e.g. decreased ejection fraction and hypertrophy), inflammation and remodelling. FF also increased cardiac expression of fibroblast growth factor 21 (FGF21) and sirtuin 1 (Sirt1) in non-diabetic...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (7): 507–516.
Published: 11 December 2013
...), that ACE2 expression is increased under conditions of cell stress, including hypoxic conditions, IL (interleukin)-1β treatment and treatment with the AMP mimic AICAR (5-amino-4-imidazolecarboxamide riboside). The NAD + -dependent deacetylase SIRT1 (silent information regulator T1) was found to be up...