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Clin Sci (Lond) (2022) 136 (21): 1571–1590.
Published: 11 November 2022
... are caused by SARS-CoV-2 infection of ECs through the angiotensin-converting enzyme 2 (ACE2) receptor and the cellular transmembrane protease serine 2 (TMPRSS2) and the consequent dysfunction of the infected vascular cells. Meanwhile, other factors associated with SARS-CoV-2 entry into the host cells have...
Clin Sci (Lond) (2022) 136 (13): 1047–1052.
Published: 06 July 2022
...Erin B. Taylor Dysregulation of neutrophil extracellular trap (NET) formation has been shown to mediate disease pathology in multiple viral infections, including SARS-CoV-2. At the beginning of COVID-19 pandemic, Thierry and Roch wrote a perspective on the mechanisms by which severe SARS-CoV-2...
Martin Sebastian Winkler, Ralf Alexander Claus, Mareike Schilder, Stefan Pöhlmann, Sina M. Coldewey, Julian Grundmann, Torben Fricke, Onnen Moerer, Konrad Meissner, Michael Bauer, Heike Hofmann-Winkler, Markus H. Gräler
Clin Sci (Lond) (2021) 135 (24): 2781–2791.
Published: 22 December 2021
... article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . endothelial cell barrier erythrocytes high-density lipoprotein hypoxia infection SARS-CoV-2 The clinical course of severe...
Clin Sci (Lond) (2021) 135 (19): 2217–2242.
Published: 08 October 2021
... interplay between DC subsets and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Despite being initiated by a vast array of immune receptors, DC-mediated antiviral responses often converge towards the same endpoint, that is the production of proinflammatory cytokines and the activation...
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
... (ACE) 2 (ACE2), the main receptor for SARS-CoV-2, in human placentas indicates that this organ can be vulnerable for viral infection during pregnancy. However, for this to happen, additional molecular processes are critical to allow viral entry in cells, its replication and disease manifestation...
In CollectionACE2, a multifunctional protein – from cardiovascular regulation to COVID-19 , Coronavirus
Clin Sci (Lond) (2021) 135 (3): 535–554.
Published: 03 February 2021
... is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is threating public health worldwide. The main complications of SARS-CoV-2 infected death patients include many energy metabolism-related chronic diseases, such as diabetes. The specific mechanism leading to this phenomenon...
Clin Sci (Lond) (2021) 135 (1): 1–17.
Published: 05 January 2021
...Ravindra K. Sharma; Jing Li; Suraj Krishnan; Elaine M. Richards; Mohan K. Raizada; Rajesh Mohandas The rapid spread of the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought into focus the key role of angiotensin-converting enzyme 2 (ACE2), which serves...
Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Published: 07 December 2020
... is hijacked by SARS-CoV-2 as a cellular receptor to gain entry to alveolar epithelial cells, causing COVID-19, a severe respiratory disease in humans. COVID-19 is frequently life-threatening especially in elderly or people with other medical conditions. As an unprecedented number of COVID-19 patients have...
Clin Sci (Lond) (2020) 134 (21): 2791–2805.
Published: 02 November 2020
... localization of ACE2 within the kidney and the importance of this enzyme in the metabolism of Angiotensin II and the formation of Angiotensin 1–7. With the recognition early in 2020 of ACE2 being the main receptor of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), the interest in this protein has...
Clin Sci (Lond) (2020) 134 (17): 2315–2317.
Published: 09 September 2020
... Figure 3 Signaling pathways involved in COVID-19 pathophysiology Toll-like receptors (TLRs) 3 and TLR 7/8 recognize SARS-CoV-2 RNA and initiate the inflammatory cascade via type I and type II IFN gene expression and NF-κB nuclear translocation [ 5 , 6 ]. Via NF-κB, the expression...
Clin Sci (Lond) (2020) 134 (17): 2235–2241.
Published: 01 September 2020
...Mohamad Aman Jairajpuri; Shoyab Ansari Human serine protease inhibitors (serpins) are the main inhibitors of serine proteases, but some of them also have the capability to effectively inhibit cysteine proteases. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) main protease (Mpro...
Daniella S. Battagello, Guilherme Dragunas, Marianne O. Klein, Ana L.P. Ayub, Fernando J. Velloso, Ricardo G. Correa
Clin Sci (Lond) (2020) 134 (16): 2137–2160.
Published: 21 August 2020
...Daniella S. Battagello; Guilherme Dragunas; Marianne O. Klein; Ana L.P. Ayub; Fernando J. Velloso; Ricardo G. Correa The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of coronaviruses – the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – discovered...
Thiago Gomes Heck, Mirna Stela Ludwig, Matias Nunes Frizzo, Alberto Antonio Rasia-Filho, Paulo Ivo Homem de Bittencourt, Jr
Clin Sci (Lond) (2020) 134 (15): 1991–2017.
Published: 04 August 2020
...”. Interestingly, some species of bats that are natural reservoirs of zoonotic viruses, including SARS-CoV-2, possess an IFN-based antiviral inflammatory response perpetually activated but do not show any sign of disease or cytokine storm. This is possible because bats present a constitutive HSR that is by far...
Clin Sci (Lond) (2020) 134 (12): 1301–1304.
Published: 16 June 2020
...Jameel M. Inal The novel strain of coronavirus that appeared in 2019, SARS-CoV-2, is the causative agent of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that caused the SARS 2003 epidemic, the receptor on host cells that promotes uptake, through attachment...
Katharina Lanza, Lucas G. Perez, Larissa B. Costa, Thiago M. Cordeiro, Vitria A. Palmeira, Victor T. Ribeiro, Ana Cristina Simões e Silva
Clin Sci (Lond) (2020) 134 (11): 1259–1264.
Published: 08 June 2020
...Katharina Lanza; Lucas G. Perez; Larissa B. Costa; Thiago M. Cordeiro; Vitria A. Palmeira; Victor T. Ribeiro; Ana Cristina Simões e Silva The emergency of SARS-CoV-2 in China started a novel challenge to the scientific community. As the virus turns pandemic, scientists try to map the cellular...
Clin Sci (Lond) (2020) 134 (10): 1143–1150.
Published: 22 May 2020
...Sayeed ur Rehman; Mohammad Tabish Angiotensin-converting enzyme 2 (ACE2) plays an essential role in maintaining the balance of the renin–angiotensin system and also serves as a receptor for the SARS-CoV-2, SARS-CoV, and HCoV-NL63. Following the recent outbreak of SARS-CoV-2 infection, there has...
Includes: Supplementary data