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Keywords: Renal fibrosis
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Articles
Clin Sci (Lond) (2022) 136 (1): 103–120.
Published: 07 January 2022
...Yong Wu; Huan Yang; Sujuan Xu; Ming Cheng; Jie Gu; Weichen Zhang; Shaojun Liu; Minmin Zhang Inflammatory response and renal fibrosis are the hallmarks of chronic kidney disease (CKD). However, the specific mechanism of aldosterone-induced renal injury in the progress of CKD requires elucidation...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2022) 136 (1): 29–44.
Published: 05 January 2022
... as WNT1-inducible signaling pathway protein 1 (WISP1) [ 11 ], has been shown to be increased in mouse models of progressive CKD, in association with development of renal fibrosis [ 8 ]. However, it is unclear whether the association of WISP1 with kidney fibrosis is due to an effect of WISP1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (17): 2127–2142.
Published: 10 September 2021
... of renal fibrosis via regulation of multiple profibrotic pathways. Correspondence: Yufeng Huang ( Yufeng.huang@hsc.utah.edu ) or Patrice N. Mimche ( Patrice.mimche@path.utah.edu ) or Mark Henkemeyer ( mark.henkemeyer@utsouthwestern.edu ) 21 06 2021 24 08 2021 27 08 2021 31 08...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (15): 1873–1895.
Published: 06 August 2021
...Wangqiu Gong; Congwei Luo; Fenfen Peng; Jing Xiao; Yiqun Zeng; Bohui Yin; Xiaowen Chen; Shuting Li; Xiaoyang He; Yanxia Liu; Huihui Cao; Jiangping Xu; Haibo Long Although accelerated cellular senescence is closely related to the progression of chronic kidney disease (CKD) and renal fibrosis...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (10): 1273–1288.
Published: 26 May 2021
...Hao Zhao; Yachun Han; Na Jiang; Chenrui Li; Ming Yang; Ying Xiao; Ling Wei; Xiaofen Xiong; Jinfei Yang; Chengyuan Tang; Li Xiao; Fuyou Liu; Yu Liu; Lin Sun Cisplatin (Cis) can cause chronic kidney disease (CKD) and promote renal fibrosis, but the underlying mechanism is not fully understood...
Articles
Clin Sci (Lond) (2021) 135 (3): 429–446.
Published: 01 February 2021
... in the kidney, and depletion of endogenous kallistatin by antibody injection resulted in aggravated renal fibrosis, which was accompanied by enhanced Wnt/β-catenin activation. Conversely, overexpression of kallistatin attenuated renal inflammation, interstitial fibroblast activation and tubular injury in UUO...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (2): 409–427.
Published: 29 January 2021
...Daqian Gu; Dandong Fang; Mingming Zhang; Jingwen Guo; Hongmei Ren; Xinyue Li; Ziyue Zhang; Donghai Yang; Xue Zou; Yukai Liu; Wei Eric Wang; Gengze Wu; Pedro A. Jose; Yu Han; Chunyu Zeng Hypertensive nephropathy (HN) is a common cause of end-stage renal disease with renal fibrosis; chronic kidney...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (2): 275–303.
Published: 22 January 2021
... chronic kidney disease renal fibrosis transforming growth factor-beta Progressive aristolochic acid (AA)-induced renal insult correlates with SMAD7 loss in mice [ 83 ]. SMAD7-knockout mice subjected to intraperitoneal injection of AA exhibited worsening histopathological features, including...
Articles
Clin Sci (Lond) (2021) 135 (1): 143–159.
Published: 08 January 2021
... with MI. Renal fibrosis is a potent predictor of progression in patients and is often accompanied by inflammation and oxidative stress; however, the mechanisms involved in these alterations are not well established. Endoplasmic reticulum (ER) plays a central role in protein processing and folding...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (21): 2873–2891.
Published: 13 November 2020
... of extracellular matrix (ECM) proteins in the tubulointerstitium and induction of epithelial–mesenchymal transition (EMT) during renal fibrosis. We tested the anti-fibrotic potential of vorapaxar, a clinically approved PAR-1 antagonist for cardiovascular protection, in an experimental kidney fibrosis model...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (17): 2337–2352.
Published: 10 September 2020
... of the Biochemical Society 2020 renal fibrosis TRAIL type 2 diabetes TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that can be cleaved to form a circulating ligand, which belongs to the TNF family of apoptosis-inducing ligands. Both membrane-bound and circulating...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate...
Articles
Clin Sci (Lond) (2020) 134 (12): 1433–1448.
Published: 18 June 2020
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . inflammation renal fibrosis RNA-binding protein Chronic kidney disease (CKD) is characterized by persistent inflammation...
Articles
Clin Sci (Lond) (2020) 134 (2): 103–122.
Published: 23 January 2020
... mechanism of the alcoholic kidney disease remains largely unknown. In the present study, an alcoholic renal fibrosis animal model was first employed which mice received liquid diet containing alcohol for 4 to 12 weeks. The Masson’s Trichrome staining analysis showed that kidney fibrosis increased at week 8...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1587–1602.
Published: 22 July 2019
... blunted these effects and led to significantly higher plasma erythropoietin (EPO) levels. Adenine-induced renal fibrosis, endoplasmic reticulum (ER) stress and apoptosis were significantly decreased by PBI-4050. In parallel, Gpr40 −/− mice were more susceptible to adenine-induced fibrosis, renal function...
Articles
Clin Sci (Lond) (2019) 133 (12): 1309–1320.
Published: 19 June 2019
... Limited on behalf of the Biochemical Society 2019 angiogenesis epithelial-mesenchymal transition inflammation myofibroblasts Nintedanib renal fibrosis Nearly 45% of deaths in the developed world are attributable to some type of chronic fibro-proliferative disease, including idiopathic...
Articles
Clin Sci (Lond) (2018) 132 (21): 2339–2355.
Published: 13 November 2018
...Zhenzhen Li; Xianghua Liu; Fengyan Tian; Ji Li; Qingwei Wang; Chaohui Gu Epithelial-to-mesenchymal transition (EMT) is a phenotypic conversion that plays a crucial role in renal fibrosis leading to chronic renal failure. Mitogen-activated protein kinase phosphatase 2 (MKP2) is a member of the dual...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (21): 2299–2322.
Published: 02 November 2018
... of renal fibroblasts and development of renal fibrosis and suggest that inhibition of autophagy may represent a potential therapeutic strategy for HN. After 3 weeks of daily feeding of the mixture of adenine and potassium oxonate with or without 3-MA administration, collected kidney samples were ground...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (13): 1403–1415.
Published: 09 July 2018
... the progression of renal fibrosis in a mouse model of unilateral ureteral obstructive nephropathy (UUO). We found that preventive treatment with SIS3 at the time of disease induction largely suppressed progressive renal fibrosis by inhibiting α-smooth muscle actin (α-SMA) + myofibroblast accumulation...
Articles
Clin Sci (Lond) (2017) 131 (16): 2125–2143.
Published: 24 July 2017
...), and Src family kinase, which has recently been approved by FDA to treat idiopathic pulmonary fibrosis. Whether it affects renal fibrosis remains unknown. Here, we demonstrated that administration of nintedanib immediately or 3 days after unilateral ureteral obstruction (UUO) injury and with folic acid (FA...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (7): 567–581.
Published: 17 March 2017
...Xing Wei; Peng Gao; Yunfei Pu; Qiang Li; Tao Yang; Hexuan Zhang; Shiqiang Xiong; Yuanting Cui; Li Li; Xin Ma; Daoyan Liu; Zhiming Zhu Hypertension-induced renal fibrosis contributes to the progression of chronic kidney disease, and apigenin, an anti-hypertensive flavone that is abundant in celery...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (7): 423–433.
Published: 17 June 2014
...Chunling Huang; Carol A. Pollock; Xin-Ming Chen There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointerstitial fibrosis has been shown to be the final...
Articles
Clin Sci (Lond) (2013) 124 (4): 243–254.
Published: 31 October 2012
...-regulated. In the context of renal fibrosis, Smad3 is pathogenic, whereas Smad2 and Smad7 are renoprotective. However, this counter-balancing mechanism is also altered because TGF-β1 induces Smurf2, a ubiquitin E3-ligase, to target Smad7 as well as Smad2 for degradation. Thus overexpression of renal Smad7...