...-converting enzyme inhibitor (ramipril), or a combination of both drugs for 8 weeks to diabetic (db/db) mice. Vehicle-treated db/db and db/m mice were used as controls. At the end of the experiment, mice were killed, and the kidneys were saved to perform a differential high-throughput proteomic analysis...

... on behalf of the Biochemical Society 2018 epidermal growth factor receptor fibrosis paracrine signalling proteomics Hypertension is a well-known contributor to the development of cardiovascular diseases and serves as an early prognostic factor for ailments such as ischemic heart disease...

... are joint first authors. † These authors contributed equally to this work. 30 01 2018 09 03 2018 22 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 albuminuria cardiovascular disease metabolomics proteomics...

... diet (by addition of nonessential amino acid) ( Ctrl ) and trained (running on treadmill 5 days·week −1 ) ( ex ) or not. Maximal endurance activity and body composition were assessed, and muscle protein metabolism (protein synthesis, proteomic approach) and energy metabolism [energy expenditure...

... from four AAA patients and four controls were analysed by a label-free proteomic approach. Among identified proteins, paraoxonase-1 (PON1) was decreased in plasma of AAA patients compared with controls, which was further validated in a bigger cohort of samples by ELISA. The phenylesterase enzymatic...

... mechanism and causal risk factors for plaque rupture remain unclear. To identify a potential molecule that can influence atherosclerotic plaque rupture, we investigated protein expression in serum from patients with acute myocardial infarction (AMI) and stable angina (SA), using proteomic analysis...

...). However, the precise pathophysiological mechanisms underlying acute coronary occlusion are not fully understood. We have analysed proteomic profiles of systemic plasma and plasma derived from the site of coronary plaque rupture of non-diabetic patients with STEMI (ST-segment elevation myocardial...

... and high mortality rate. Its pathophysiology and molecular mechanisms are complicated and remain poorly understood. In the present study, we performed a proteomics investigation to characterize early host responses to sepsis as determined by an altered plasma proteome in a porcine model of peritonitis...

... 26 10 2007 26 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 early insulin response plasma protein proteomics surface-enhanced laser-desorption ionization–time-of-flight MS (SELDI-TOF MS) Type 2 diabetes mellitus ULSAM (Uppsala Longitudinal Study...

...Laura Molero; Antonio García-Méndez; Sergio Alonso-Orgaz; Carolina Carrasco; Carlos Macaya; Antonio J. López Farré The aim of the present study was to use proteomics to analyse modifications in the level of expression of different proteins in BVSMCs (bovine vascular smooth muscle cells) incubated...

...Bernardo C. Vidal, Jr; Joseph V. Bonventre; Stephen I-Hong Hsu Proteomics is widely envisioned as playing a significant role in the translation of genomics to clinically useful applications, especially in the areas of diagnostics and prognostics. In the diagnosis and treatment of kidney disease...

...Walter KOLCH; Harald MISCHAK; Andrew R. PITT The enormous progress in proteomics, enabled by recent advances in MS (mass spectrometry), has brought protein analysis back into the limelight of cancer research, reviving old areas as well as opening new fields of study. In this review, we discuss...

... or isotopic (with in vivo radioactive labelling of proteins) two-dimensional electrophoresis/MS proteomic analyses, to study differential expression of proteins. Many of the differentially expressed proteins identified in blood were specifically synthesized by the liver to participate in the stress response...

... indicative of ‘diabetic renal damage’. We also found this pattern in 35% of those patients who had low-grade albuminuria and in 4% of patients with normal albumin excretion. Moreover, we could identify several of the indicative polypeptides using MS/MS sequencing. We conclude that proteomic analysis with CE...

...Pedro R. CUTILLAS; Anthony G.W. NORDEN; Rainer CRAMER; Alma L. BURLINGAME; Robert J. UNWIN Urinary proteomics has become a topical and potentially valuable field of study in relation to normal and abnormal renal function. Filtered bioactive peptides present in high concentration in the nephron...