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Keywords: Platelets
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Articles
Clin Sci (Lond) (2021) 135 (4): 593–595.
Published: 18 February 2021
...Shaimaa Nasr Amin This commentary highlights the research entitled: Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice, presented by Ma et al. appearing in Clinical Science (2020) 134 (16), https://doi.org/10.1042/CS20200530...
Articles
Clin Sci (Lond) (2020) 134 (21): 2807–2822.
Published: 03 November 2020
...Sarah M. Hicks; Christine S.M. Lee; Sidra A. Ali; Philip Y. Choi; Elizabeth E. Gardiner Platelets have a predominant role in haemostasis, the maintenance of blood volume and emerging roles as innate immune cells, in wound healing and in inflammatory responses. Platelets express receptors...
Articles
Clin Sci (Lond) (2017) 131 (12): 1245–1260.
Published: 07 June 2017
...Erik Westein; Thomas Hoefer; Anna C. Calkin Cardiovascular events are the major cause of morbidity and mortality in Type 2 diabetes (T2D). This condition is associated with heightened platelet reactivity, contributing to increased atherothrombotic risk. Indeed, individuals with diabetes respond...
Articles
Clin Sci (Lond) (2016) 130 (24): 2295–2303.
Published: 10 November 2016
...Joan Raouf; Fariborz Mobarrez; Karin Larsson; Per-Johan Jakobsson; Marina Korotkova Microsomal prostaglandin E 2 synthase-1 (mPGES-1) constitutes an essential player in inflammation and is involved in the pathogenesis of rheumatoid arthritis. Platelets participate in the regulation of inflammatory...
Articles
Clin Sci (Lond) (2016) 130 (13): 1089–1104.
Published: 23 May 2016
...Xiao-Ming Gao; Xiao-Lei Moore; Yang Liu; Xin-Yu Wang; Li-Ping Han; Yidan Su; Alan Tsai; Qi Xu; Ming Zhang; Gavin W. Lambert; Helen Kiriazis; Wei Gao; Anthony M. Dart; Xiao-Jun Du Acute myocardial infarction (AMI) is characterized by a rapid increase in circulating platelet size but the mechanism...
Articles
Clin Sci (Lond) (2016) 130 (6): 441–442.
Published: 04 February 2016
...David W. Essex; A. Koneti Rao Platelets play a major role in the complex interactions involved in blood coagulation via multiple mechanisms. As reported in this issue, Schoergenhofer et al. tested the hypothesis that platelet inhibition by prasugrel, a potent platelet P2Y 12 ADP receptor antagonist...
Articles
Clin Sci (Lond) (2005) 109 (3): 267–276.
Published: 24 August 2005
... in the ischaemic region. In conclusion, IP abolished angioplasty-induced myeloperoxidase release by preventing activated platelet-induced P-selectin release via a K ATP -channel-initiated pathway. Therefore, in addition to its primary effect on cardioprotection, IP may also provide beneficial anti-inflammatory...
Articles
Clin Sci (Lond) (1999) 96 (4): 431–436.
Published: 01 April 1999
... released from platelets. We herein summarize recent observations that collectively support the hypothesis that LPA may play a key role in the pathogenesis of initiation and progression of proliferative glomerulonephritis. LPA synergistically stimulates mesangial cell proliferation in combination...
Articles
Clin Sci (Lond) (1998) 94 (4): 395–404.
Published: 01 April 1998
... determines normal plasma and serum VEGF ranges, determines which are more likely to reflect circulating VEGF levels and investigates a potential contribution of VEGF from platelets to VEGF levels detected in serum. 2. The presence of soluble VEGF receptor, sflt-1, at a molar excess of 7:1 significantly...
Articles
Clin Sci (Lond) (1998) 94 (1): 79–85.
Published: 01 January 1998
... fluorescent probes exploring either the outer membrane leaflet [trimethylamino-diphenylhexatriene (TMA-DPH)] or the lipid membrane core [diphenylhexatriene (DPH)], in platelets and erythrocytes of genetically hypertensive rats of the Prague hereditary hypertriglyceridaemic (HTG) strain. The relationships...
Articles
Clin Sci (Lond) (1997) 93 (3): 243–248.
Published: 01 September 1997
... side of the cell membrane. This co-transporter has been studied extensively, mainly in erythrocytes of many species, in which it plays a key role in cell volume regulation. Here we present evidence that human platelets contain K+/Cl − co-transporters. 2. We have studied the efflux of 86 Rb + (a marker...
Articles
Clin Sci (Lond) (1997) 93 (3): 249–255.
Published: 01 September 1997
...H. A. de Silva; J. G. Carver; J. K. Aronson 1. Previous electrophysiological studies have suggested the presence of K Ca and K v channels in human platelets. However, the pharmacology of these channels has not been defined. 2. We have studied potassium channels in human platelets by measuring...
Articles
Clin Sci (Lond) (1996) 91 (6): 725–731.
Published: 01 December 1996
...-transporter has been described in a number of animal and human tissues. However, its presence in human platelets, although inferred, has not been demonstrated directly. 2. We have studied the efflux of 86 Rb + (a marker for K + ) from Rb + -loaded platelets, and have defined their response to stimulation...
Articles
Clin Sci (Lond) (1996) 90 (5): 363–368.
Published: 01 May 1996
...Philip R. Belcher; Angela J. Drake-Holland; John W. Hynd; Mark I. M. Noble 1. Recurrent occlusion after thrombolysis may be caused by thrombin receptor-mediated platelet thrombosis occurring in a residual stenosis. To test the relative importance of the platelet thrombin receptor under conditions...
Articles
Clin Sci (Lond) (1996) 90 (1): 13–19.
Published: 01 January 1996
... with urinary albumin excretion rates. 2. We have estimated platelet sodium-activated proton efflux (Na + /H + exchange rate), based on a fluorimetric method, in 43 type 2 diabetic patients, of whom 29 were normoalbuminuric and 14 microalbuminuric, and in 10 non-diabetic control subjects. The factors measured...
Articles
Clin Sci (Lond) (1994) 87 (5): 575–580.
Published: 01 November 1994
...Nicolas A. F. Chronos; Darren J. Wilson; Sarah L. Janes; Ronald A. Hutton; Nigel P. Buller; Alison H. Goodall 1. Aspirin inhibits the conversion of arachidonic acid to thromboxane A 2 which reinforces the effects of weak agonists such as ADP in platelets. 2. In this study the effect of aspirin (300...
Articles
Clin Sci (Lond) (1994) 86 (6): 731–739.
Published: 01 June 1994
...Sarah L. Janes; Alison H. Goodall 1. Platelet activation status and response to stimulation with agonists ex vivo were studied by whole blood flow cytometry in 15 women with pre-eclampsia, 20 age- and gestational-age-matched women who completed a normal pregnancy, and 20 age-matched non-pregnant...
Articles
Clin Sci (Lond) (1994) 86 (3): 263–268.
Published: 01 March 1994
... on platelet membrane microviscosity in hypertension-prone and -resistant Sabra rats. 2. Sixteen hypertension-prone and 14 hypertension-resistant Sabra rats were submitted to either a low-salt (0.25% NaCl) or a high-salt (4% NaCl) diet for 3–4 weeks. Platelet membrane anisotropy was determined, in the presence...
Articles
Clin Sci (Lond) (1993) 84 (6): 611–617.
Published: 01 June 1993
..., dietary habits and clinical signs of atherosclerosis. 2. Serum selenium concentration and platelet glutathione peroxidase activity were measured in 45 patients with chronic renal failure subdivided into three groups according to the type of treatment: 15 non-dialysed, 15 on haemodialysis, 15 on continuous...
Articles
Clin Sci (Lond) (1992) 83 (3): 313–318.
Published: 01 September 1992
...M. P. Gordge; G. H. Neild 1. Platelets from patients on haemodialysis showed a loss of sensitivity to nitric oxide, reflected by a reduction in the ability of nitric oxide both to inhibit thrombin-induced aggregation and to increase intraplatelet cyclic GMP levels. Responses of platelets from...
Articles
Clin Sci (Lond) (1992) 82 (5): 493–504.
Published: 01 May 1992
... concentration and platelet cytosolic free calcium concentration in 109 twin pairs. 2. Total plasma calcium concentration was positively associated with systolic ( r = 0.26, P < 0.001) but not diastolic blood pressure, a relationship which remained significant after adjustment for albumin, age and body mass...
Articles
Clin Sci (Lond) (1992) 82 (4): 353–355.
Published: 01 April 1992
...S. D. Kristensen; J. F. Martin © 1992 The Biochemical Society and the Medical Research Society 1992 atherosclerosis megakaryocytes platelet volume platelet-derived growth factor platelets Clinical Science (1992) 82, 353-355 (Printed in Great Britain) Editorial Review 353...
Articles
Clin Sci (Lond) (1992) 82 (1): 113–116.
Published: 01 January 1992
...C. C. T. Smith; B. N. C. Prichard; D. J. Betteridge 1. Plasma and platelet free catecholamine concentrations were measured in 22 normal subjects and in 10 treated and 11 untreated patients with heterozygous familial hypercholesterolaemia. 2. Plasma noradrenaline concentrations were significantly...
Articles
Clin Sci (Lond) (1991) 81 (1): 11–15.
Published: 01 July 1991
...C. Rångemark; Å. Wennmalm 1. Cigarette smoking is known to increase the risk of cardiovascular disease in both men and women. Experimental and epidemiological studies have demonstrated that cigarette smoking is associated with several indices of increased platelet activation and platelet/vessel...
Articles
Clin Sci (Lond) (1991) 80 (3): 205–211.
Published: 01 March 1991
...Kim-Hanh Le Quan Sang; Thérèse Montenay-Garestier; Marie-Aude Devynck 1. The metabolism of blood platelets, taken as an accessible model of excitable cells, has been reported to be altered in hypertension. Most of the identified alterations concern the functions of various plasma membrane...
Articles
Clin Sci (Lond) (1991) 80 (2): 101–105.
Published: 01 February 1991
...Pietro Amedeo Modesti; Rosanna Abbate; Gian Franco Gensini; Andrea Colella; Gian Gastone Neri Serneri 1. Human platelet thromboxane A 2 receptor expression on the membrane surface is possibly dynamically regulated by changes either in the ligand concentration or in membrane fluidity. An increased...
Articles
Clin Sci (Lond) (1990) 79 (6): 613–618.
Published: 01 December 1990
... observed to activate ion channels and cell metabolism and to facilitate erythrocyte and platelet aggregation. 2. The present study was designed to evaluate the participation of shear stresses in the control of apparent platelet cytosolic free Ca 2+ concentration in hypertensive patients. 3. Shear...
Articles
Clin Sci (Lond) (1990) 79 (6): 639–645.
Published: 01 December 1990
...Å. Wennmalm; G. Benthin; K. Caidahl; E. F. Granström; B. Lanne; L. Persson; A.-S. Petersson; S. Winell 1. We studied, in a random sample of 385 nonsmoking men born in 1968–1969 and 31 men born in 1913 or 1923, whether inheritance and environmental factors influenced platelet activity and vessel...
Articles
Clin Sci (Lond) (1990) 78 (1): 75–80.
Published: 01 January 1990
...M. D. Kilby; F. Broughton Pipkin; S. Cockbill; S. Heptinstall; E. M. Symonds 1. The intracellular free calcium concentration ([Ca 2+ ] i ) in washed human platelets was measured using the fluorescent indicator, fura-2, in a cross-sectional study of 36 normotensive, primigravid volunteers, 12...
Articles
Clin Sci (Lond) (1989) 77 (2): 183–188.
Published: 01 August 1989
...A. F. Dominiczak; J. J. Morton; G. Murray; P. F. Semple 1. Resting and stimulated free calcium concentrations have been measured in platelets loaded with the fluorescent probe quin2 from 30 patients with essential hypertension and from 30 age-matched controls. 2. Cytosolic free calcium...
Articles
Clin Sci (Lond) (1989) 76 (1): 67–71.
Published: 01 January 1989
...S. M. Barr; K. R. Lees; L. Butters; A. O'Donnell; P. C. Rubin 1. Basal and stimulated platelet intracellular free calcium concentrations were measured in non-pregnant women and in third trimester patients who were either normotensive or who had pregnancy-induced hypertension or pre-eclampsia...
Articles
Clin Sci (Lond) (1988) 74 (2): 213–218.
Published: 01 February 1988
...Ernesto L. Schiffrin 1. Binding sites for atrial natriuretic peptide (ANP) with a specificity similar to that of vascular ANP receptors have been demonstrated previously in human platelets. The density of these binding sites for ANP on platelets is decreased after increased dietary sodium intake...
Articles
Clin Sci (Lond) (1987) 73 (5): 525–529.
Published: 01 November 1987
...A. M. Van Rij; C. Wade; I. Kirk; C. Thomson; M. F. Robinson 1. Arachidonic acid metabolism through the lipoxygenase pathway in platelets was investigated in 11 patients with low selenium (Se) nutritional status and compared with 14 patients with a normal Se status. 2. Plasma and whole blood Se...
Articles
Clin Sci (Lond) (1986) 71 (1): 121–123.
Published: 01 July 1986
...Koh-Ichi Murakawa; Yoshiharu Kanayama; Masakazu Kohno; Takahiko Kawarabayashi; Kenichi Yasunari; Tadanao Takeda; Atsushi Hyono 1. The cytoplasmic free calcium concentration ([Ca 2+ ] i ) in the platelets of spontaneously hypertensive rats (SHR), Wistar–Kyoto rats (WKY), deoxycorticosterone–salt...
Articles
Clin Sci (Lond) (1986) 70 (5): 495–500.
Published: 01 May 1986
...C. C. T. Smith; A. P. Wilson; B. N. C. Prichard; D. J. Betteridge 1. Using high-performance liquid chromatography with electrochemical detection, we have studied the release of endogenous catecholamines from washed platelets induced to aggregate by ADP and thrombin. 2. Washed platelets exhibit...
Articles
Clin Sci (Lond) (1985) 69 (2): 235–238.
Published: 01 August 1985
...N. Mishra; C. A. Hamilton; C. R. Jones; C. Leslie; J. L. Reid 1. α 2 -Adrenoceptors on blood platelets have been widely used as a model for α-adrenoceptors in less accessible tissues. 2. The effect of oestrogen (200 μg/day intramuscularly) on α 2 -adrenoceptor number and function was studied...
Articles
Clin Sci (Lond) (1985) 69 (1): 1–6.
Published: 01 July 1985
...C. C. T. Smith; L. D. Curtis; A. P. Delamothe; B. N. C. Prichard; D. J. Betteridge 1. We have used high-performance liquid chromatography with electrochemical detection to measure content of adrenaline and noradrenaline in platelets in 13 normal subjects at rest. 2. Subjects were exercised to raise...
Articles
Clin Sci (Lond) (1985) 68 (6): 701–707.
Published: 01 June 1985
...R. D. Hughes; D. A. Lane; H. Ireland; P. G. Langley; A. E. S. Gimson; Roger Williams 1. The concentration in plasma of fibrinogen derivatives fibrinopeptide A (FPA) and Bβ1-42 and the platelet release products β-thromboglobulin (βTG) and platelet factor 4 (PF4) have been determined in patients...
Articles
Clin Sci (Lond) (1985) 68 (5): 581–587.
Published: 01 May 1985
...M. Boberg; L. B. Croon; I.-B. Gustafsson; B. Vessby 1. The fatty acid composition in platelet phospholipids and in the plasma lipid esters as well as the serum lipoprotein lipid concentrations were determined in 67 healthy male subjects in order to establish the relationships between blood lipids...
Articles
Clin Sci (Lond) (1985) 68 (s10): 141s–146s.
Published: 01 January 1985
.... 2. α 2 -Adrenoceptor stimulation in platelets showed an increased sensitivity to adrenaline, as determined by sensitivity in counteracting the inhibitor effect of PGI 2 on intracellular free calcium concentration in untreated patients with essential hypertension, when compared with treated patients...
Articles
Clin Sci (Lond) (1985) 68 (s10): 21s–24s.
Published: 01 January 1985
... antagonists in blocking the B-HT 933-induced contractile responses of the dog saphenous vein and preventing adrenaline-induced aggregation of human platelets. 5. Together with previously published data derived from tritium overflow studies on rabbit pulmonary arteries and displacement of [ 3 H]-rauwolscine...
Articles
Clin Sci (Lond) (1984) 67 (5): 511–514.
Published: 01 November 1984
...A. J. Cowley; Karen Stainer; S. Cockbill; S. Heptinstall 1. Drugs that cause vasodilatation tend to inhibit platelet behaviour whereas compounds that cause vasoconstriction stimulate platelet behaviour. Thus there appears to be a similarity between platelet behaviour and vascular tone...
Articles
Clin Sci (Lond) (1984) 67 (5): 551–555.
Published: 01 November 1984
...C. A. Jackson; M. Greaves; A. J. M. Boulton; J. D. Ward; F. E. Preston 1. The effect of improved glycaemic control, effected by 16 weeks continuous subcutaneous insulin infusion (CSII), on platelet aggregation and platelet prostaglandin biosynthesis has been assessed in a group of 11 diabetic...
Articles
Clin Sci (Lond) (1984) 66 (6): 717–723.
Published: 01 June 1984
...I. Aracon-Birlouez; T. Montenay-Carestier; M. A. Devynck 1. Fluorescence Dolarization of dbhenvlhexa-triene embedded in membranes was used as an index of ‘microviscosity’ in platelets and ervthro—cyte ghosts of spontaneously hypertensive rats of the Okamoto-Aoki strain (SHR), Wistar-Kyoto strain...
Articles
Clin Sci (Lond) (1984) 66 (6): 725–731.
Published: 01 June 1984
...Yuan Ding; Christopher J. Kenyon; Peter F. Semple 1. Platelets were prepared from peripheral venous blood on iso-osmotic density gradients of Percoll, resulting in a good recovery of cells (50–80%) which were relatively free of contaminating blood cells (erythrocyte <0.1%, leucocyte <0.1%). 2...
Articles
Clin Sci (Lond) (1984) 66 (5): 605–612.
Published: 01 May 1984
...L. Neyses; R. Locher; M. Wehling; H. Pech; W. Tenschert; W. Vetter 1. It has recently been claimed that there are angiotensin II (ANG II) receptors on human mononuclear cells and on platelets and this has been used for investigating the regulation of the renin-angiotensin system in hypertension. We...
Articles
Clin Sci (Lond) (1984) 66 (4): 443–451.
Published: 01 April 1984
...R. F. W. Moulds; V. Iwanov; R. L. Medcalf 1. The contractile responses of spiral strips of human digital arteries to samples of a suspension of human platelets aggregated by thrombin have been studied at different time intervals after aggregation. 2. Platelets added to the arterial strips 1 min...
Articles
Clin Sci (Lond) (1984) 66 (1): 55–62.
Published: 01 January 1984
... clearance that was closer than the reciprocal of the t 1/2 of HD-RBC clearance ( r = 0.89, P < 0.001 at high coating; r = 0.76, P < 0.05 at low coating) but significantly closer only at high coating. 4. Splenic blood flow, measured using indium labelled platelets in ten subjects, correlated closely...
Articles
Clin Sci (Lond) (1983) 64 (6): 637–642.
Published: 01 June 1983
... lipoprotein-cholesterol levels decreased markedly, but pre-exchange levels were not achieved within 2 weeks. High density lipoprotein-cholesterol and apolipoprotein A-I levels also fell but returned to the original concentration after only 5 days. 2. Platelet aggregation and [ 14 C]serotonin release were...
Articles
Clin Sci (Lond) (1983) 64 (1): 63–68.
Published: 01 January 1983
...F. J. Lofts; P. K. Moore 1. Human platelet-rich plasma incubated at 37°C generates an antiaggregatory prostaglandin which is spasmogenic on gastrointestinal smooth muscle. 2. Platelet-rich plasma from female donors generated more biological activity and was more sensitive to the anti-aggregatory...