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Keywords: PAR-1
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Clin Sci (Lond) (2021) 135 (3): 447–463.
Published: 01 February 2021
... negatively regulated VSMC proliferation in culture. The possible mechanism may involve serpina3c inhibition of ERK1/2 and JNK signaling in thrombin/PAR-1 system-mediated VSMC proliferation. Our results highlight a protective role for serpina3c as a novel thrombin inhibitor in the development...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (21): 2873–2891.
Published: 13 November 2020
...Sarah W.Y. Lok; Wai Han Yiu; Hongyu Li; Rui Xue; Yixin Zou; Bin Li; Kam Wa Chan; Loretta Y.Y. Chan; Joseph C.K. Leung; Kar Neng Lai; Sydney C.W. Tang Protease-activated receptor (PAR)-1 has emerged as a key profibrotic player in various organs including kidney. PAR-1 activation leads to deposition...
Includes: Supplementary data