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Study protocol and Establishments of active immunization models  ( A ) Stud...
Published: 27 January 2023
Figure 1 Study protocol and Establishments of active immunization models ( A ) Study protocol. ECL2 was injected at four time points and per stage persisted 2 weeks (control group, n =10; β1-AAb group, n =8; bisoprolol group, n =8). Bisoprolol was administered after 8-week active immunization ... More
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The β1-AAb decreases the atrial electrical instability and increases the AF...
Published: 27 January 2023
Figure 2 The β1-AAb decreases the atrial electrical instability and increases the AF Susceptibility ( A–C ) typical images of AF induction with burst pacing at 50 ms S1-S1 interval among three groups. ( D ) repeating AERP measurements per animal for 5 times of three groups, ( n =7) per group. ( E... More
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The β1-AAb promotes the atrial enlargements and atrial fibrosis  ( A ) Sche...
Published: 27 January 2023
Figure 3 The β1-AAb promotes the atrial enlargements and atrial fibrosis ( A ) Schematic diagram of echocardiography of three groups. Yellow circle indicates LA location. ( B–F ) comparison of LAD, RAD, LVEF, LVEDd, and LVESd among three groups at the baseline and endpoint, ( n =7) per group. ( G... More
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The β1-AAb involves in the APD alterations via  ex vivo  optical mapping  (...
Published: 27 January 2023
Figure 4 The β1-AAb involves in the APD alterations via ex vivo optical mapping ( A ) Maps of APD80 with four recording sites of three groups under sinus rhythm. ( B ) Quantitative calculation from APD90 to APD20 of three groups, ( n =4) per group. ( C ) APD80 tracks of four recording sites per... More
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The β1-AAb facilitates CaD alterations at the isolated-heart level  ( A ) C...
Published: 27 January 2023
Figure 5 The β1-AAb facilitates CaD alterations at the isolated-heart level ( A ) CaD80 maps with four recording sites of three groups under sinus rhythm. ( B ) Difference quantitation from CaD90 to CaD20 of three groups, ( n =4) per group, # P <0.05 vs. control group; * P <0.05 vs. bisop... More
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The β1-AAb impedes the atrial conduction properties  ( A ) Typical sketch m...
Published: 27 January 2023
Figure 6 The β1-AAb impedes the atrial conduction properties ( A ) Typical sketch map of pacing in a S1-S2 mode at 3 Hz. ( B ) Measurements of AERP at the ex vivo level per left atrium for at least two times among three groups, ( n =4) per group. ( C) Pacing-induced CV recording of three group... More
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The β1-AAb prolongs Ca 2+  transient refractoriness  ( A ) Overlapped CaT t...
Published: 27 January 2023
Figure 7 The β1-AAb prolongs Ca 2+ transient refractoriness ( A ) Overlapped CaT traces of four recording locations among three groups. ( B ) For four sites, intuitionistic heat maps of the recovery ratio of CaT with the decreased S2 intervals in three groups. ( C ) Depiction of recovery ratio o... More
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The β1-AAb potentiates the arrhythmogenic SDA  ( A ) Representative graphs ...
Published: 27 January 2023
Figure 8 The β1-AAb potentiates the arrhythmogenic SDA ( A ) Representative graphs of AF induction process. ( B ) Counting of the numbers of inducible AF per isolated heart among three groups, ( n =4) per group. ( C ) Contrast in the duration of AF episodes in a S1-S1 protocol at 50 Hz, ( n =4) p... More
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The β1-AAb augments the arrhythmogenic atrial alternans and re-entry  ( A )...
Published: 27 January 2023
Figure 9 The β1-AAb augments the arrhythmogenic atrial alternans and re-entry ( A ) Symbolic arrhythmogenic AP alternans at the whole-atrium dimension. ( B ) Quantitative statistics of APD alternans among three groups, ( n =4) per group. ( C ) Representative images of CaT alternans under the burs... More
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The potential mechanisms of atrial Ca 2+  mishandling induced by β1-AAb  ( ...
Published: 27 January 2023
Figure 10 The potential mechanisms of atrial Ca 2+ mishandling induced by β1-AAb ( A ) Comparison of the differential phospho-sites on different genes between two groups from the mass spectrum results, ( n =3) per group. ( B ) Volcano profile contains the differential phosphor-sites on genes rel... More
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Exogenous β1-AAb intervention elicits cellular phenotypes to arrhythmia pro...
Published: 27 January 2023
Figure 11 Exogenous β1-AAb intervention elicits cellular phenotypes to arrhythmia propensity of HL-1 cells and atrial fibroblasts ( A–E ) Western blot results and quantitative statistics of HL-1 samples for CaMKII, p-CaMKII (Thr286), p-CaMKII/CaMKII, RyR2, p-RyR2 (Ser2814), p-RyR2/RyR2, PLB, p-PL... More
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A schematic diagram of the potential mechanisms of the β1-AAbs in increasin...
Published: 27 January 2023
Figure 12 A schematic diagram of the potential mechanisms of the β1-AAbs in increasing AF vulnerability The β1-AAbs contribute to the AF vulnerable substates via two pathways in the autoimmune models. The one is through mediating the calcium mishandling in atrial myocytes, the other is through pr... More
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Flowchart of records retrieved from systematic searches, full texts retriev...
Published: 27 January 2023
Figure 1 Flowchart of records retrieved from systematic searches, full texts retrieved, and records included in screening comparison analysis More
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Histograms showing the number of studies against the number of regex matche...
Published: 27 January 2023
Figure 2 Histograms showing the number of studies against the number of regex matches with (A) title and abstract and (B) full text. Histograms showing the number of studies against the number of regex matches with ( A ) title and abstract and ( B ) full text. More
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Receiver Operating Characteristic (ROC) curve showing the performance of al...
Published: 27 January 2023
Figure 3 Receiver Operating Characteristic (ROC) curve showing the performance of all screening types at all thresholds Horizontal dashed lines show 99% (0.99) and 95% (0.95) sensitivity. FPR = false positive rate. Inset shows the top left of the graph in more detail. More
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ROC curve showing both the initial and corrected performance of the machine...
Published: 27 January 2023
Figure 4 ROC curve showing both the initial and corrected performance of the machine learning algorithm at all thresholds The vertical dashed lines show the optimal threshold (0.25 for the initial performance and 0.29 for the corrected performance); FPR, false positive rate. More
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CSE increased nuclear and mitochondrial DNA damage in human endothelial cel...
Published: 24 January 2023
Figure 1 CSE increased nuclear and mitochondrial DNA damage in human endothelial cells ( A ) Immunofluorescent staining of the γH2AX (green) in HUVECs. Scale bar = 20 μm. Time course of γH2AX formation by CSE. * P <0.05 compared with corresponding control ( n =4). ( B ) Immunofluorescent stain... More
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CSE causes minority MOMP and activation of sublethal apoptotic pathways  ( ...
Published: 24 January 2023
Figure 2 CSE causes minority MOMP and activation of sublethal apoptotic pathways ( A ) Immunofluorescent staining of BAX 6A7 in HUVECs. Scale bar = 20 μm. Cells were treated with CSE for 72 h. As a positive control, cells were treated with ABT-263 for 6 h, which is an inhibitor of Bcl-2. The samp... More
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Increase in the mRNA level of inflammatory cytokine expression by CSE  ( A ...
Published: 24 January 2023
Figure 3 Increase in the mRNA level of inflammatory cytokine expression by CSE ( A ) Time schedule for CSE treatment. ( B ) Cells treated with CSE as described in the text. Quantification of mRNA expression of inflammatory cytokines including IL-6, IL-1α, MCP-1, and IFN-β was performed real-time ... More
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CSE causes the accumulation of cytosolic DNA and activation of cytosolic DN...
Published: 24 January 2023
Figure 4 CSE causes the accumulation of cytosolic DNA and activation of cytosolic DNA sensor ( A ) Immunofluorescent staining of dsDNA in HUVECs. Scale bar = 20 μm. Cells were treated with CSE for 24 h. The cell outline (orange dotted line) was determined by observation in bright field. Quantific... More
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CSE causes accumulation of both nDNA and mtDNA in the cytosol and extracell...
Published: 24 January 2023
Figure 5 CSE causes accumulation of both nDNA and mtDNA in the cytosol and extracellular space ( A ) Cytosolic nDNA and mtDNA were quantitated via qPCR using nDNA primers (β-globin) or mtDNA primers (NADH1). * P <0.05, ** P <0.01 compared with control ( n =7 or 9). ( B ) Cells were treated ... More
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The cf-DNA of atherosclerosis patients  ( A ) The cfDNA copy number in norm...
Published: 24 January 2023
Figure 6 The cf-DNA of atherosclerosis patients ( A ) The cfDNA copy number in normal subject (Plaque [-]) and subjects with carotid plaques. * P <0.05, ** P <0.01 compared with Plaque (-). Closed circles represent current smokers. ( B ) Comparison of mt-cfDNA and n-cfDNA among four groups.... More
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Graphical illustration of the  in situ  perfusion systems used in the study...
Published: 18 January 2023
Figure 1 Graphical illustration of the in situ perfusion systems used in the study The upper panel ( A ) shows dual rat term placenta perfusion, which was performed in an open-circuit setting and was used to study maternal-to-fetal transport of 3 H-dopamine and 3 H-norepinephrine. The uterine... More
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Absolute transcript quantification of monoamine transporters in HRP-1 cells...
Published: 18 January 2023
Figure 2 Absolute transcript quantification of monoamine transporters in HRP-1 cells and rat term placenta by ddPCR Gene expression of monoamine transporters in HRP-1 cells ( A ) and rat term placenta ( B ). The final output is reported as target transcripts/ng RNA. The results are shown as mean ... More
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Uptake of monoamines by the HRP-1 cell line  Time course of  3 H-dopamine (...
Published: 18 January 2023
Figure 3 Uptake of monoamines by the HRP-1 cell line Time course of 3 H-dopamine ( A ) and 3 H-norepinephrine ( B ) uptake shown in pmol/mg protein. Transport kinetics was evaluated in the presence of increasing dopamine ( C ) and norepinephrine ( D ) concentrations. Additionally, uptake of 3 ... More
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Transport of monoamines across the dually perfused rat term placenta in the...
Published: 18 January 2023
Figure 4 Transport of monoamines across the dually perfused rat term placenta in the maternal-to-fetal direction Total placental clearance (presented in ml/min/g) of 3 H-dopamine ( A ) and 3 H-norepinephrine ( B ) in the absence and presence of phenelzine (PHE) and entacapone (ENT). Effect of 1... More
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Extraction of dopamine and norepinephrine from the fetal circulation by the...
Published: 18 January 2023
Figure 5 Extraction of dopamine and norepinephrine from the fetal circulation by the rat term placenta 3 H-dopamine ( A ) and 3 H-norepinephrine ( B ) uptake from the fetal circulation was evaluated in the presence of increasing substrate concentrations. Subsequently, the effect of 10 µM decyni... More
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The simplification score of blastocyst morphological were divided into two ...
Published: 18 January 2023
Figure 1 The simplification score of blastocyst morphological were divided into two groups: high-quality (≥BB) and moderate/low-quality (<BB) Among them, the graded of blastocyst 4AA, 4AB, 5BB, and 4BB were considered as high-grade blastocyst ( n =7) and those 4BC, 4CB, and 4CC as low-grade bl... More
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Analytical characterization of spent blastocyst medium cell-free RNA  ( A )...
Published: 18 January 2023
Figure 2 Analytical characterization of spent blastocyst medium cell-free RNA ( A ) The sequencing reads length distribution in spent blastocyst medium. The X -axis shows the different reads length (bp), whereas the Y -axis shows the rate each different size of sequence fragment. The different ... More
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The consistency analysis of cell-free RNAs between spent blastocyst medium ...
Published: 18 January 2023
Figure 3 The consistency analysis of cell-free RNAs between spent blastocyst medium and blastocyst ( A ) The correlation analysis between spent blastocyst medium cell-free RNAs and blastocyst genes. ( B ) Coexpression analysis of spent blastocyst medium cell-free RNAs and blastocyst genes. ( C ) ... More
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The cell-free mRNAs of spent blastocyst medium were highly fragmented, and ...
Published: 18 January 2023
Figure 4 The cell-free mRNAs of spent blastocyst medium were highly fragmented, and CDSs and UTRs regions were released equally ( A ) Percentage of gene coverage for spent blastocyst medium. ( B ) Length distribution of 100% coverage cell-free mRNAs in spent blastocyst medium. The relative expres... More
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The cell-free RNAs of differentially expressed were closely related to the ...
Published: 18 January 2023
Figure 5 The cell-free RNAs of differentially expressed were closely related to the quality of spent blastocyst medium ( A ) Schematics of the study design. First, whole transcriptome sequencing was performed by different grade spent blastocyst medium. Then, the differential expression and enrich... More
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Cell-free RNA profiling reveals gene signatures that correlate with blastoc...
Published: 18 January 2023
Figure 6 Cell-free RNA profiling reveals gene signatures that correlate with blastocyst quality ( A ) The analysis of principal components analysis (PCA) was performed by spent blastocyst medium differentially expressed genes. Four gene cluster subtypes are presented by different color. ( B ) Top... More
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Summary of studies implicating BRAF in cardiac hypertrophy and fibrosis  He...
Published: 18 January 2023
Figure 1 Summary of studies implicating BRAF in cardiac hypertrophy and fibrosis Heart targeted knockout studies have implicated BRAF in pathological hypertrophy and interstitial fibrosis. These studies were performed on male mice only and a sex difference was not studied. Divergent results were ... More
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Overexpression of NotchIC in renin cells leads to a polycystic phenotype  (...
Published: 05 January 2023
Figure 1 Overexpression of NotchIC in renin cells leads to a polycystic phenotype ( A ) There was no difference in body weight between control and mutant mice. ( B ) Kidneys from mutant mice weighed significantly more than kidneys from control mice, and this difference increased with advancing ag... More
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Overexpression of NotchIC in renin-expressing cells leads to decreased reni...
Published: 05 January 2023
Figure 2 Overexpression of NotchIC in renin-expressing cells leads to decreased renin production and renal insufficiency ( A ) Immunohistochemistry staining for renin in tissue sections from kidney of control and mutant mice at 3 and 6 months of age. There was decreased renin staining in mutant m... More
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Animals with constitutive Notch signaling in renin-expressing cells develop...
Published: 05 January 2023
Figure 3 Animals with constitutive Notch signaling in renin-expressing cells develop anemia, splenomegaly, and early death ( A ) Mutant mice developed anemia that worsened with age. ( B ) Mutant mice developed splenomegaly when compared with control mice, and this also worsened with age. ( C ) Mu... More
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Overexpression of Notch signaling in renin-expressing cells results in incr...
Published: 05 January 2023
Figure 4 Overexpression of Notch signaling in renin-expressing cells results in increased proliferation ( A ) Mutant animals had increased proliferation in their kidneys as measured by Ki67 staining compared with control animals. Scale bars, 100 µm. ( B ) Proliferation was especially pronounced i... More
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Overexpression of NotchIC leads to increased  Myc  expression  ( A ) Mutant...
Published: 05 January 2023
Figure 5 Overexpression of NotchIC leads to increased Myc expression ( A ) Mutant mice had increased Notch1 expression compared with control mice. ( B ) Mutant mice had increased Myc expression compared with control mice. ( C ) Mutant mice had increased Notch1 protein in kidneys compared wi... More