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Keywords: NF-κB
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1877–1891.
Published: 22 December 2022
..., whereas they were alleviated by PARK7 overexpression. Mechanistically, silencing Park7 facilitated nuclear translocation and phosphorylation of p65 (a key component of the nuclear factor kappa B [NF-κB] complex) during LPS treatment, whereas PARK7 overexpression partially prevented these changes. Moreover...
Articles
Da Zhang, Xiuli Wang, Siyao Chen, Selena Chen, Wen Yu, Xin Liu, Guosheng Yang, Yinghong Tao, Xinjing Tang, Dingfang Bu, Heng Zhang, Wei Kong, Chaoshu Tang, Yaqian Huang, Junbao Du, Hongfang Jin
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (20): 2045–2059.
Published: 16 October 2019
... in vivo and in vitro findings demonstrated, for the first time, that endogenous H 2 S directly inactivated IKKβ via sulfhydrating IKKβ at Cys 179 to inhibit nuclear factor-κB (NF-κB) pathway activation and thereby control PAEC inflammation in PAH. Figure 1 MCTP down-regulated the endogenous H 2 S/CSE...
Includes: Supplementary data
Articles
Zhou Jiang, Juan-Juan Qin, Yaxing Zhang, Wen-Lin Cheng, Yan-Xiao Ji, Fu-Han Gong, Xue-Yong Zhu, Yan Zhang, Zhi-Gang She, Zan Huang, Hongliang Li
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (17): 2275–2288.
Published: 10 August 2017
... of atherosclerosis. In vivo and in vitro analyses revealed that the proinflammatory effects of LILRB4 deficiency were mediated by the increased activation of NF-κB signaling due to decreased src homolog 2 domain containing phosphatase (Shp) 1 phosphorylation. In conclusion, the present study indicates that LILRB4...
Articles
Janine Müller, Johannes F.W. Greiner, Marie Zeuner, Viktoria Brotzmann, Johanna Schäfermann, Frederique Wieters, Darius Widera, Holger Sudhoff, Barbara Kaltschmidt, Christian Kaltschmidt
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (15): 1339–1352.
Published: 29 June 2016
... unclear. In the present study, we demonstrate for the first time that 1,8-cineole potentiates poly(I:C)-induced activity of the antiviral transcription factor interferon regulatory factor 3 (IRF3), while simultaneously reducing proinflammatory nuclear factor (NF)-κB activity in human cell lines, inferior...
Includes: Supplementary data
Articles
Sylvain Recoquillon, Nunzia Carusio, Anne-Hélène Lagrue-Lakhal, Simon Tual-Chalot, Amelia Filippelli, Ramaroson Andriantsitohaina, M. Carmen Martinez
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (8): 687–698.
Published: 22 July 2015
... of lipopolysaccharide (LPS)-induced vascular alterations as well as studying a probable functional association of nmMLCK with nuclear factor κ-light-chain enhancer of activated B cells (NF-κB). Aortic rings from mice were exposed in vitro to LPS and, then, vascular reactivity was measured. Human aortic endothelial...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 68S–71S.
Published: 01 September 2002
... injury. We also found that FK409 substantially reduced endothelin-1 (ET-1) production in cultured vascular endothelial cells (ECs). Nuclear factor κB (NF-κB) is known to play a key role in the development of ischaemic disorders through regulation of the expression of a variety of genes. In the present...