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Keywords: NADPH oxidase (Nox)
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Articles

Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways

Thiago Bruder-Nascimento, Glaucia E. Callera, Augusto C. Montezano, Ying He, Tayze T. Antunes, Aurelie Nguyen Dinh Cat, Rita C. Tostes, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (7): 411–423.
https://doi.org/10.1042/CS20140456
Published: 09 December 2014
..., which underlie vascular damage in diabetes. Statins are cholesterol-lowering drugs that are vasoprotective in diabetes through unknown mechanisms. We tested the hypothesis that atorvastatin decreases NADPH oxidase (Nox)-derived ROS generation and associated vascular injury in diabetes. Lepr db /Lepr db...
View article titled, Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways
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Includes: Supplementary data
Articles

Valsartan slows the progression of diabetic nephropathy in db / db mice via a reduction in podocyte injury, and renal oxidative stress and inflammation

Guangyu Zhou, Alfred K. Cheung, Xia Liu, Yufeng Huang
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (10): 707–720.
https://doi.org/10.1042/CS20130223
Published: 27 January 2014
... from a standard curve produced by serially diluting MDA. Urinary TBARS excretion was expressed as the total amount excreted over 24 h. albuminuria angiotensin II diabetic nephropathy inflammation NADPH oxidase (Nox) podocyte Total RNA was extracted from renal cortex tissue using Tri...
View article titled, Valsartan slows the progression of diabetic nephropathy in db / db mice via a reduction in podocyte injury, and renal oxidative stress and inflammation
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Articles

Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis

Ji-Youn Youn, Andrew Nguyen, Hua Cai
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (8): 509–518.
https://doi.org/10.1042/CS20110407
Published: 29 June 2012
...@mednet.ucla.edu ). 12 8 2011 8 5 2012 8 5 2012 8 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 combinatorial therapy diethylstilbestrol (DES) LNCaP cell NADPH oxidase (NOX) nitric oxide reactive oxygen species superoxide anion xanthine oxidase...
View article titled, Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis
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Articles

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5

Augusto C. Montezano, Dylan Burger, Graziela S. Ceravolo, Hiba Yusuf, Maria Montero, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (4): 131–141.
https://doi.org/10.1042/CS20100384
Published: 02 November 2010
... decreased after stimulation with AngII and ET-1. However, Nox5 appears to be critical in growth and inflammatory responses by AngII and not for ET-1 [ 78 ]. © The Authors Journal compilation © 2011 Biochemical Society 2011 endothelium hydrogen peroxide NADPH oxidase (Nox) reactive oxygen...
View article titled, Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5
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