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Keywords: NADPH oxidase
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Clin Sci (Lond) (2022) 136 (5): 379–382.
Published: 11 March 2022
... & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with EBSCO. NADPH oxidase osteoprotegerin RANKL syndecans TRAIL Osteoprotegerin (OPG) has seven structural domains, with domain 7 containing both a heparin-binding region and the free cysteine...
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Clin Sci (Lond) (2021) 135 (24): 2665.
Published: 15 December 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Hepatic fibrosis NADPH oxidase Oxidative stress...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (13): 1675.
Published: 06 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Autophagy Hepatic fibrosis NADPH oxidase...
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Clin Sci (Lond) (2020) 134 (7): 853–869.
Published: 09 April 2020
...Yun Huang; Yang Li; Anni Lou; Guo zhen Wang; Ye Hu; Yijie Zhang; Weichang Huang; Jun Wang; Yue Li; Xintao Zhu; Tingting Chen; Jiayi Lin; Ying Meng; Xu Li Angiotensin II (Ang II) has been reported to aggravate hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Alamandine...
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Clin Sci (Lond) (2020) 134 (4): 403–417.
Published: 25 February 2020
... 03 02 2020 10 02 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Adipose Inflammation Diabetes Diabetic Kidney Disease NADPH oxidase obesity Oxidative Stress Diabetes mellitus (DM) [ 1 ] is one of the major...
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Clin Sci (Lond) (2017) 131 (16): 2109–2123.
Published: 24 July 2017
.... Soluble parenchymal Aβ was associated with elevated NADPH oxidase-2 (NOX2) which was exacerbated by 1-month hypoperfusion. We suggest that in response to hypoperfusion, increased Aβ production/deposition may contribute to degenerative processes by triggering oxidative stress promoting cerebrovascular...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (15): 1363–1374.
Published: 29 June 2016
... of vascular reactive oxygen species (ROS), NADPH oxidase (NOX) enzymes and immune-inflammatory processes remain to be fully elucidated. In the present study we investigated the roles of the NADPH oxidase subunit isoforms, NOX4 and NOX1, in immune cell activation and recruitment to the aortic sinus...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (9): 683–696.
Published: 18 March 2016
... typically occurs in response to corneal injury such as that caused by infection, physical trauma, chemical burns or in the setting of corneal transplant rejection. The NADPH oxidase enzyme complex is involved in cell signalling for wound-healing angiogenesis, but its role in corneal neovascularization has...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (7): 479–490.
Published: 17 February 2016
...Kelly L. Singel; Brahm H. Segal NADPH oxidase (NOX) isoforms together have multiple functions that are important for normal physiology and have been implicated in the pathogenesis of a broad range of diseases, including atherosclerosis, cancer and neurodegenerative diseases. The phagocyte NADPH...
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Clin Sci (Lond) (2016) 130 (3): 151–165.
Published: 17 December 2015
...Marcela Gimenez; Brandon M. Schickling; Lucia R. Lopes; Francis J. Miller, Jr Since its discovery in 1999, a number of studies have evaluated the role of Nox1 NADPH oxidase in the cardiovascular system. Nox1 is activated in vascular cells in response to several different agonists, with its activity...
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Clin Sci (Lond) (2015) 128 (12): 863–875.
Published: 27 March 2015
... of the family of NADPH oxidases (NOXs 1–5 and dual oxidases DUOX1/2) which are structural homologues of gp91 phox , the major membrane-bound component of the respiratory burst oxidase of leucocytes. Knowledge of the roles of the NOX isoforms in cancer is rapidly expanding. Recent evidence suggests that both...
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Clin Sci (Lond) (2015) 128 (8): 465–481.
Published: 23 December 2014
... requires DUOXA1 and DUOX2 requires DUOXA2 for full activity. Correspondence : Dr Christopher R.J. Kennedy (email ckennedy@uottawa.ca ). 9 6 2014 8 10 2014 13 11 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 NADPH oxidase reactive oxygen species...
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Clin Sci (Lond) (2015) 128 (6): 337–347.
Published: 28 November 2014
...Nathalie Grandvaux; Mélissa Mariani; Karin Fink Determining the role of NADPH oxidases in the context of virus infection is an emerging area of research and our knowledge is still sparse. The expression of various isoforms of NOX/DUOX (NADPH oxidase/dual oxidase) in the epithelial cells (ECs...
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Clin Sci (Lond) (2014) 127 (5): 331–340.
Published: 15 May 2014
.... In the present study, we have shown that human dilated cardiomyopathy is associated with increased NOX2 (NADPH oxidase 2) levels, increased oxidative stress with adverse myocardial remodelling and activation of MAPKs (mitogen-activated protein kinases). Advanced heart failure in mice was also associated...
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Clin Sci (Lond) (2014) 126 (2): 111–121.
Published: 13 September 2013
... between NADPH oxidase and mitochondria, the main ROS sources in hypertension, which may represent a vicious feed-forward cycle of ROS production. In recent years, there is experimental evidence showing a relationship between ROS and COX-derived products. Thus ROS can activate COX and the COX/PG...
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Clin Sci (Lond) (2013) 125 (6): 291–300.
Published: 22 May 2013
...María U. Moreno; Idoia Gallego; Begoña López; Arantxa González; Ana Fortuño; Gorka San José; Félix Valencia; Juan José Gómez-Doblas; Eduardo de Teresa; Ajay M. Shah; Javier Díez; Guillermo Zalba The NADPH oxidases are a key family of ROS (reactive oxygen species)-producing enzymes which may...
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Clin Sci (Lond) (2013) 124 (10): 597–615.
Published: 04 February 2013
... synthase. The family of NADPH oxidase (Nox) enzymes are likely to be important given that their primary function is to produce ROS. Seven isoforms of Nox have been identified named Nox1–5, Duox (dual oxidase) 1 and Duox2. Nox1, Nox2 and Nox4 have been most extensively studied and are implicated...
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Clin Sci (Lond) (2013) 124 (3): 191–202.
Published: 17 October 2012
...Mona Sedeek; Alex Gutsol; Augusto C. Montezano; Dylan Burger; Aurelie Nguyen Dinh Cat; Chris R. J. Kennedy; Kevin D. Burns; Mark E. Cooper; Karin Jandeleit-Dahm; Patrick Page; Cedric Szyndralewiez; Freddy Heitz; Richard L. Hebert; Rhian M. Touyz Nox (NADPH oxidase)-derived ROS (reactive oxygen...
Includes: Supplementary data
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Clin Sci (Lond) (2011) 121 (7): 305–312.
Published: 07 June 2011
... factor)-α and IL (interleukin)-6 were evaluated by real-time PCR and Western blotting in SHRs (spontaneously hypertensive rats), diabetic SHRs, diabetic SHRs treated with RGZ (5 mg/kg of body weight) and control WKY (Wistar–Kyoto) rats. Cardiac NADPH oxidase activity was quantified using a SOD...
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Clin Sci (Lond) (2008) 114 (3): 173–182.
Published: 08 January 2008
... the cardiovascular system, a family of multisubunit NADPH oxidases appears to be a predominant contributor of superoxide anion. Recent findings suggest a significant role of the genetic background in NADPH oxidase regulation. Common genetic polymorphisms within the promoter and exonic sequences of CYBA , the gene...
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Clin Sci (Lond) (2006) 110 (2): 205–206.
Published: 17 January 2006
... hypertension mitochondria NADPH oxidase reactive oxygen species (ROS) A major focus within the basic science community studying hypertension is related to the role of ROS (reactive oxygen species). The broad definition of ROS includes oxygen-containing species that are all capable of reacting...
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Clin Sci (Lond) (2005) 109 (3): 217–226.
Published: 24 August 2005
...Robin Ray; Ajay M. Shah Intracellular ROS (reactive oxygen species) such as superoxide and H 2 O 2 have been increasingly appreciated to have a role in endothelial pathophysiology. Of the several sources within the vasculature, a family of multi-subunit NADPH oxidases appears to be a predominant...
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Clin Sci (Lond) (2002) 103 (4): 403–408.
Published: 09 September 2002
...Tania Cristina PITHON-CURI; Adriana C. LEVADA; Lúcia R. LOPES; Sonia Q. DOI; Rui CURI The effect of glutamine on the activity of the NADPH oxidase complex from rat neutrophils was investigated. Superoxide anion (O 2 - ) production was assessed: (1) by scintillation counting by using lucigenin...