Page 1 | Search Results | Clinical Science

1-50 of 102

Sort by

Sort Order Select

Articles

Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice

Nada J. Habeichi, Rana Ghali, Ali Mroueh, Abdullah Kaplan, Cynthia Tannous, Abdo Jurjus, Ghadir Amin, Mathias Mericskay, George W. Booz, Ahmed El-Yazbi, Fouad A. Zouein

Clin Sci (Lond) (2023) 137 (1): 47–63.

https://doi.org/10.1042/CS20220513

Published: 05 January 2023

... mortality rate substantially. Premenopausal females appear to be more protected, suggesting a potential protective role of female sex hormones. Here, we tested the hypothesis that ovariectomy (OVX) eliminates the beneficial effect of female sex on renal protection following acute myocardial infarction (MI...

View article titled, Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice

Includes: Supplementary data

Articles

Visualization of regenerating and repairing hearts

Nevan Powers, Guo N. Huang

Clin Sci (Lond) (2022) 136 (10): 787–798.

https://doi.org/10.1042/CS20211116

Published: 27 May 2022

.... Correspondence: Guo N. Huang ( Guo.Huang@ucsf.edu ) 04 03 2022 03 05 2022 05 05 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 imaging techniques model organisms myocardial infarction regeneration stem cell therapy wound...

View article titled, Visualization of regenerating and repairing hearts

Articles

Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

Jan Neckář, Petra Alánová, Veronika Olejníčková, František Papoušek, Lucie Hejnová, Jan Šilhavý, Michal Behuliak, Michal Bencze, Jaroslav Hrdlička, Marek Vecka, Dagmar Jarkovská, Jitka Švíglerová, Eliška Mistrová, Milan Štengl, Jiří Novotný, Bohuslav Ošťádal, Michal Pravenec, František Kolář

Clin Sci (Lond) (2021) 135 (17): 2143–2163.

https://doi.org/10.1042/CS20210648

Published: 17 September 2021

... Increased level of C-reactive protein (CRP) is a risk factor for cardiovascular diseases, including myocardial infarction and hypertension. Here, we analyzed the effects of CRP overexpression on cardiac susceptibility to ischemia/reperfusion (I/R) injury in adult spontaneously hypertensive rats (SHR...

View article titled, Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

Includes: Supplementary data

Articles

Role of endoplasmic reticulum stress in renal damage after myocardial infarction

Beatriz Delgado-Valero, Lucía de la Fuente-Chávez, Ana Romero-Miranda, María Visitación Bartolomé, Bunty Ramchandani, Fabián Islas, María Luaces, Victoria Cachofeiro, Ernesto Martínez-Martínez

Clin Sci (Lond) (2021) 135 (1): 143–159.

https://doi.org/10.1042/CS20201137

Published: 08 January 2021

...Beatriz Delgado-Valero; Lucía de la Fuente-Chávez; Ana Romero-Miranda; María Visitación Bartolomé; Bunty Ramchandani; Fabián Islas; María Luaces; Victoria Cachofeiro; Ernesto Martínez-Martínez Myocardial infarction (MI) is associated with renal alterations resulting in poor outcomes in patients...

View article titled, Role of endoplasmic reticulum stress in renal damage after myocardial infarction

Includes: Supplementary data

Articles

IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture

Rana Ghali, Nada J. Habeichi, Abdullah Kaplan, Cynthia Tannous, Emna Abidi, Amira Bekdash, Rima Farhat, Hana Itani, Abdo Jurjus, George W. Booz, Ziad Mallat, Fouad A. Zouein

Clin Sci (Lond) (2020) 134 (11): 1191–1218.

https://doi.org/10.1042/CS20200402

Published: 03 June 2020

...Rana Ghali; Nada J. Habeichi; Abdullah Kaplan; Cynthia Tannous; Emna Abidi; Amira Bekdash; Rima Farhat; Hana Itani; Abdo Jurjus; George W. Booz; Ziad Mallat; Fouad A. Zouein Myocardial infarction (MI) is the leading cause of mortality worldwide. Interleukin (IL)-33 (IL-33) is a cytokine present...

View article titled, IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture

Includes: Supplementary data

Articles

Therapeutic potential of miR-21 regulation by human peripheral blood derived-small extracellular vesicles in myocardial infarction

Ji-Young Kang, Hyoeun Kim, Dasom Mun, Nuri Yun, Boyoung Joung

Clin Sci (Lond) (2020) 134 (8): 985–999.

https://doi.org/10.1042/CS20191077

Published: 24 April 2020

... to be involved in the initiation and development of myocardial infarction (MI). Here, we examined whether miR-21 regulation using human peripheral blood-derived sEVs (PB-sEVs) could serve as a potential therapeutic strategy for MI. First, we examined miR-21 levels in hypoxic conditions and validated the ability...

View article titled, Therapeutic potential of miR-21 regulation by human peripheral blood derived-small extracellular vesicles in myocardial infarction

Includes: Supplementary data

Articles

Targeting mitochondria to protect the heart: a matter of balance?

Fouad A. Zouein, George W. Booz

Clin Sci (Lond) (2020) 134 (7): 885–888.

https://doi.org/10.1042/CS20200236

Published: 14 April 2020

... fusion Myocardial infarction References 1. Mohsin A.A. , Chen Q. , Quan N. , Rousselle T. , Maceyka M.W. , Samidurai A. et al . ( 2019 ) Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury . J. Pharmacol. Exp. Ther. 369 , 282...

View article titled, Targeting mitochondria to protect the heart: a matter of balance?

Articles

Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats

Jan Neckář, Md. Abdul Hye Khan, Garrett J. Gross, Michaela Cyprová, Jaroslav Hrdlička, Alena Kvasilová, John R. Falck, William B. Campbell, Lenka Sedláková, Šárka Škutová, Veronika Olejníčková, Martina Gregorovičová, David Sedmera, František Kolář, John D. Imig

Clin Sci (Lond) (2019) 133 (8): 939–951.

https://doi.org/10.1042/CS20180728

Published: 29 April 2019

...) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart failure in spontaneously hypertensive rats (SHR). Adult male SHR were divided into vehicle- and EET-B (10 mg/kg/day; p.o., 9...

View article titled, Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats

Articles

Protective cardiac conditioning by an atypical cytokine

Jürgen Bernhagen

Clin Sci (Lond) (2019) 133 (8): 933–937.

https://doi.org/10.1042/CS20190036

Published: 18 April 2019

... intervention in ST segment elevation myocardial infarction (STEMI) patients or in the setting of elective cardiac surgery, damages the heart muscle, a phenomenon known as myocardial ischemia-reperfusion (I/R) injury (IRI). Ischemic preconditioning (IPC) is defined by episodes of ‘sub-lethal’ ischemia...

View article titled, Protective cardiac conditioning by an atypical cytokine

Articles

Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2

Yinlan Hu, Guoqing Jin, Bing Li, Yanmei Chen, Lintao Zhong, Guojun Chen, Xiaoqiang Chen, Jiayuan Zhong, Wangjun Liao, Yulin Liao, Yuegang Wang, Jianping Bin

Clin Sci (Lond) (2019) 133 (3): 425–441.

https://doi.org/10.1042/CS20181002

Published: 05 February 2019

... facilitated CM proliferation. E2F2 and CCND2 were identified as the targets of let-7i-5p, mediating its effect in regulating the cell cycle of CMs. Supperession of let-7i-5p promoted the recovery of heart function post-myocardial infarction by enhancing E2F2 and CCND2. Collectively, our results revealed...

View article titled, Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2

Includes: Supplementary data

Articles

Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection

Vanlata H. Patel, Emmanouil Karteris, Jing Chen, Ioannis Kyrou, Harman S. Mattu, Georgios K. Dimitriadis, Glenn Rodrigo, Charalambos Antoniades, Alexios Antonopoulos, Bee K. Tan, Edward W. Hillhouse, Andre Ng, Harpal S. Randeva

Clin Sci (Lond) (2018) 132 (24): 2547–2564.

https://doi.org/10.1042/CS20180150

Published: 13 December 2018

... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . myocardial infarction orexins orexin receptors Cardiovascular disease (CVD), including myocardial infarction...

View article titled, Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection

Articles

Cardiac-specific inducible overexpression of human plasma membrane Ca 2+ ATPase 4b is cardioprotective and improves survival in mice following ischemic injury

Al Muktafi Sadi, Talat Afroze, M. Ahsan Siraj, Abdul Momen, Colin White-Dzuro, Dorrin Zarrin-Khat, Shivalika Handa, Kiwon Ban, M. Golam Kabir, Maria G. Trivieri, Robert Gros, Peter Backx, Mansoor Husain

Clin Sci (Lond) (2018) 132 (6): 641–654.

https://doi.org/10.1042/CS20171337

Published: 26 March 2018

... vivo , and HF following experimental myocardial infarction (MI) in vivo . Methods and results: Doxycycline-regulated cardiomyocyte-specific overexpression and activity of hPMCA4b produced adaptive changes in expression levels of Ca 2+ -regulatory genes, and induced hypertrophy without significant...

View article titled, Cardiac-specific inducible overexpression of human plasma membrane Ca 2+ ATPase 4b is cardioprotective and improves survival in mice following ischemic injury

Includes: Supplementary data

Articles

Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction

Dezhong Yang, Wenbin Fu, Liangpeng Li, Xuewei Xia, Qiao Liao, Rongchuan Yue, Hongmei Chen, Xiongwen Chen, Songzhu An, Chunyu Zeng, Wei Eric Wang

Clin Sci (Lond) (2017) 131 (24): 2919–2932.

https://doi.org/10.1042/CS20171256

Published: 08 December 2017

...Dezhong Yang; Wenbin Fu; Liangpeng Li; Xuewei Xia; Qiao Liao; Rongchuan Yue; Hongmei Chen; Xiongwen Chen; Songzhu An; Chunyu Zeng; Wei Eric Wang After myocardial infarction (MI), the heart is difficult to repair because of great loss of cardiomyoctyes and lack of cardiac regeneration. Novel drug...

View article titled, Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction

Includes: Supplementary data

Articles

Cardiovascular susceptibility to in vivo ischemic myocardial injury in male and female rat offspring exposed to prenatal hypoxia

Amin Shah, Nobutoshi Matsumura, Anita Quon, Jude S. Morton, Jason R.B. Dyck, Sandra T. Davidge

Clin Sci (Lond) (2017) 131 (17): 2303–2317.

https://doi.org/10.1042/CS20171122

Published: 10 August 2017

... and its pathophysiological mechanisms following acute myocardial infarction (MI) in adult rat offspring exposed to prenatal hypoxia. Male and female rat offspring, which experienced normoxia (21% O 2 ) or hypoxia (11% O 2 ) in utero underwent sham or MI surgery at 12 weeks of age. Echocardiographic data...

View article titled, Cardiovascular susceptibility to in vivo ischemic myocardial injury in male and female rat offspring exposed to prenatal hypoxia

Articles

Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease

Carolina N. França, Maria C.O. Izar, Marinella N.S. Hortêncio, Jônatas B. do Amaral, Carlos E.S. Ferreira, Izabela D. Tuleta, Francisco A.H. Fonseca

Clin Sci (Lond) (2017) 131 (12): 1215–1224.

https://doi.org/10.1042/CS20170009

Published: 31 May 2017

... in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI). This review presents the importance of these monocyte subsets in cardiovascular...

View article titled, Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease

Articles

Ultrasound-targeted microbubble destruction enhances delayed BMC delivery and attenuates post-infarction cardiac remodelling by inducing engraftment signals

Yanmei Chen, Chuanxi Zhang, Shuxin Shen, Shengcun Guo, Lintao Zhong, Xinzhong Li, Guojun Chen, Gangbin Chen, Xiang He, Chixiong Huang, Nvqin He, Wangjun Liao, Yulin Liao, Jianping Bin

Clin Sci (Lond) (2016) 130 (23): 2105–2120.

https://doi.org/10.1042/CS20160085

Published: 20 October 2016

... myocardial infarction (MI) does not improve cardiac function. The reduction in engraftment signals observed following this time interval might impair the effects of delayed BMC treatment. In the present study, we aimed to determine whether ultrasound-targeted microbubble destruction (UTMD) treatment could...

View article titled, Ultrasound-targeted microbubble destruction enhances delayed BMC delivery and attenuates post-infarction cardiac remodelling by inducing engraftment signals

Includes: Supplementary data

Articles

Vasopressin type 1A receptor deletion enhances cardiac contractility, β-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction

Melissa A. Wasilewski, Laurel A. Grisanti, Jianliang Song, Rhonda L. Carter, Ashley A. Repas, Valerie D. Myers, Erhe Gao, Walter J. Koch, Joseph Y. Cheung, Arthur M. Feldman, Douglas G. Tilley

Clin Sci (Lond) (2016) 130 (22): 2017–2027.

https://doi.org/10.1042/CS20160363

Published: 06 October 2016

... and responsiveness to catecholamine stimulation at the level of the cardiomyocyte. βAR cardiac contractility cardiomyocyte myocardial infarction V1AR • Cardiac V1AR expression is increased in small and large animal models of left ventricular dysfunction, as well as in patients with HFrEF...

View article titled, Vasopressin type 1A receptor deletion enhances cardiac contractility, β-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction

Includes: Supplementary data

Articles

Splenic release of platelets contributes to increased circulating platelet size and inflammation after myocardial infarction

Xiao-Ming Gao, Xiao-Lei Moore, Yang Liu, Xin-Yu Wang, Li-Ping Han, Yidan Su, Alan Tsai, Qi Xu, Ming Zhang, Gavin W. Lambert, Helen Kiriazis, Wei Gao, Anthony M. Dart, Xiao-Jun Du

Clin Sci (Lond) (2016) 130 (13): 1089–1104.

https://doi.org/10.1042/CS20160234

Published: 23 May 2016

...Xiao-Ming Gao; Xiao-Lei Moore; Yang Liu; Xin-Yu Wang; Li-Ping Han; Yidan Su; Alan Tsai; Qi Xu; Ming Zhang; Gavin W. Lambert; Helen Kiriazis; Wei Gao; Anthony M. Dart; Xiao-Jun Du Acute myocardial infarction (AMI) is characterized by a rapid increase in circulating platelet size but the mechanism...

View article titled, Splenic release of platelets contributes to increased circulating platelet size and inflammation after myocardial infarction

Articles

Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases

Raffaele Altara, Marco Manca, Rita D. Brandão, Asad Zeidan, George W. Booz, Fouad A. Zouein

Clin Sci (Lond) (2016) 130 (7): 463–478.

https://doi.org/10.1042/CS20150666

Published: 17 February 2016

... ]. The recruited mononuclear cells trigger activation of inhibitory pathways, mostly directed by the cytokine TGF-β, suppressing the inflammatory state while inducing cardiac fibrosis [ 30 ]. Hence, MCP-1 downstream signalling post-myocardial infarction (MI) initially activates a pro-inflammatory response, which...

View article titled, Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases

Articles

Cardiomyocyte-specific overexpression of oestrogen receptor β improves survival and cardiac function after myocardial infarction in female and male mice

Iris Schuster, Shokoufeh Mahmoodzadeh, Elke Dworatzek, Frédéric Jaisser, Smail Messaoudi, Ingo Morano, Vera Regitz-Zagrosek

Clin Sci (Lond) (2016) 130 (5): 365–376.

https://doi.org/10.1042/CS20150609

Published: 26 January 2016

... restricted to cardiomyocytes contributes to the observed cardioprotection, we tested the effects of cardiomyocyte-specific ERβ-OE (ERβ overexpression) on survival, cardiac remodelling and function after MI (myocardial infarction) and studied the molecular pathways potentially involved. Female and male mice...

View article titled, Cardiomyocyte-specific overexpression of oestrogen receptor β improves survival and cardiac function after myocardial infarction in female and male mice

Includes: Supplementary data

Articles

Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse

Roumen Parapanov, Jérôme Lugrin, Nathalie Rosenblatt-Velin, François Feihl, Bernard Waeber, Giuseppina Milano, Catherine Vergely, Na Li, Pal Pacher, Lucas Liaudet

Clin Sci (Lond) (2015) 129 (2): 187–198.

https://doi.org/10.1042/CS20140444

Published: 30 April 2015

...-reperfusion, by enhancing cardiac oxidative stress and p38 activation. TLR5 may thus convey cardioprotective signals during myocardial infarction (MI). Echocardiographic evaluation of WT and TLR5 −/− mice did not show any significant differences ( Figure 1 A). Hearts from 10-weeks-old mice were...

View article titled, Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse

Articles

Vinexin-β exacerbates cardiac dysfunction post-myocardial infarction via mediating apoptotic and inflammatory responses

Xiaoxiong Liu, Nian Wan, Xiao-Jing Zhang, Yichao Zhao, Yan Zhang, Gangying Hu, Fengwei Wan, Rui Zhang, Xueyong Zhu, Hao Xia, Hongliang Li

Clin Sci (Lond) (2015) 128 (12): 923–936.

https://doi.org/10.1042/CS20140648

Published: 27 March 2015

..., including cardiac hypertrophy. However, the role of Vinexin-β in myocardial infarction (MI) remains unknown. In this study, dramatically up-regulated Vinexin-β expression was observed in both ischaemic human hearts and infarcted animal hearts. To explore the potential involvement of Vinexin-β in MI further...

View article titled, Vinexin-β exacerbates cardiac dysfunction post-myocardial infarction via mediating apoptotic and inflammatory responses

Articles

Role of MIF in myocardial ischaemia and infarction: insight from recent clinical and experimental findings

Nalin H. Dayawansa, Xiao-Ming Gao, David A. White, Anthony M. Dart, Xiao-Jun Du

Clin Sci (Lond) (2014) 127 (3): 149–161.

https://doi.org/10.1042/CS20130828

Published: 03 April 2014

... and atherosclerosis. Although initial studies over a decade ago reported increases in circulating MIF levels following acute MI (myocardial infarction), the dynamic changes in MIF and its pathophysiological significance following MI have been unknown until recently. In the present review, we summarize recent...

View article titled, Role of MIF in myocardial ischaemia and infarction: insight from recent clinical and experimental findings

Articles

CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation

Geena Varghese Paramel, Lasse Folkersen, Rona J. Strawbridge, Ali Ateia Elmabsout, Eva Särndahl, Pia Lundman, Jan-Håkan Jansson, Göran K. Hansson, Allan Sirsjö, Karin Fransén

Clin Sci (Lond) (2013) 125 (8): 401–407.

https://doi.org/10.1042/CS20120572

Published: 14 June 2013

... mRNA was examined in atherosclerotic vascular tissue and the impact on MI (myocardial infarction) of a polymorphism in the CARD8 gene determined. CARD8 mRNA was analysed by microarray of human atherosclerotic tissue and compared with transplant donor arterial tissue. Microarray analysis was performed...

View article titled, CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation

Articles

Protective role of AT 2 and B 1 receptors in kinin B 2 -receptor-knockout mice with myocardial infarction

Jiang Xu, Oscar A. Carretero, Liping Zhu, Edward G. Shesely, Nour-Eddine Rhaleb, Xiangguo Dai, Luchen Wang, James J. Yang, Xiao-Ping Yang

Clin Sci (Lond) (2013) 124 (2): 87–96.

https://doi.org/10.1042/CS20120341

Published: 26 September 2012

... of AT 2 R and/or B 1 R worsens cardiac remodelling and dysfunction following MI (myocardial infarction) in B 2 R −/− (B 2 -receptor-knockout mice). B 2 R −/− mice and WT (wild-type) controls were subjected to sham MI or MI and treated for 4 weeks with (i) vehicle, (ii) a B 1 R-ant (B 1 R antagonist; 300...

View article titled, Protective role of AT 2 and B 1 receptors in kinin B 2 -receptor-knockout mice with myocardial infarction

Articles

The ACE2 gene: its potential as a functional candidate for cardiovascular disease

Louise M. Burrell, Stephen B. Harrap, Elena Velkoska, Sheila K. Patel

Clin Sci (Lond) (2013) 124 (2): 65–76.

https://doi.org/10.1042/CS20120269

Published: 12 September 2012

... 2013 angiotensin-converting enzyme 2 (ACE2) coronary artery disease hypertension left ventricular hypertrophy myocardial infarction renin–angiotensin system (RAS) The RAS (renin–angiotensin system) plays a major role in the pathophysiology of CVD (cardiovascular disease) [ 1 , 2...

View article titled, The ACE2 gene: its potential as a functional candidate for cardiovascular disease

Articles

Combination renin–angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions

Luke J. Burchill, Elena Velkoska, Rachael G. Dean, Karen Griggs, Sheila K. Patel, Louise M. Burrell

Clin Sci (Lond) (2012) 123 (11): 649–658.

https://doi.org/10.1042/CS20120162

Published: 01 August 2012

...Luke J. Burchill; Elena Velkoska; Rachael G. Dean; Karen Griggs; Sheila K. Patel; Louise M. Burrell The RAS (renin–angiotensin system) is activated after MI (myocardial infarction), and RAS blockade with ACEis [ACE (angiotensin-converting enzyme) inhibitors] or ARBs (angiotensin receptor blockers...

View article titled, Combination renin–angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions

Articles

Role of Toll-like receptors in cardiovascular diseases

Jesus G. Vallejo

Clin Sci (Lond) (2011) 121 (1): 1–10.

https://doi.org/10.1042/CS20100539

Published: 18 March 2011

... are expressed in other tissues such as those of the cardiovascular system. In the present review, the role of TLRs in septic cardiomyopathy, viral myocarditis, atherosclerosis, ischaemia/reperfusion injury and cardiac remodelling after myocardial infarction are outlined, with attention paid to genetically...

View article titled, Role of Toll-like receptors in cardiovascular diseases

Articles

Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin

Jing Li, Wanli Xuan, Ran Yan, Michael B. Tropak, Emilie Jean-St-Michel, Wenbin Liang, Rachel Gladstone, Peter H. Backx, Rajesh K. Kharbanda, Andrew N. Redington

Clin Sci (Lond) (2011) 120 (10): 451–462.

https://doi.org/10.1042/CS20100466

Published: 28 January 2011

... andrew.redington@sickkids.ca ). 17 9 2010 17 11 2010 8 12 2010 8 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 β-catenin limb ischaemia myocardial infarction signal transduction remote ischaemic preconditioning The phenomenon of local IPC...

View article titled, Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin

Articles

IGF-1 and atherothrombosis: relevance to pathophysiology and therapy

Elena Conti, Maria Beatrice Musumeci, Marco De Giusti, Eleonora Dito, Vittoria Mastromarino, Camillo Autore, Massimo Volpe

Clin Sci (Lond) (2011) 120 (9): 377–402.

https://doi.org/10.1042/CS20100400

Published: 18 January 2011

... hypoxia, ischaemia and oxidative stress, thus mediating functional homoeostatic adjustments. In contrast, its deprivation results in apoptosis and dysfunction. Many prospective epidemiological surveys have associated low IGF-1 levels with late mortality, MI (myocardial infarction), HF (heart failure...

View article titled, IGF-1 and atherothrombosis: relevance to pathophysiology and therapy

Articles

Proteinase 3 and prognosis of patients with acute myocardial infarction

Leong L. Ng, Sohail Q. Khan, Hafid Narayan, Paulene Quinn, Iain B. Squire, Joan E. Davies

Clin Sci (Lond) (2011) 120 (6): 231–238.

https://doi.org/10.1042/CS20100366

Published: 03 December 2010

...Leong L. Ng; Sohail Q. Khan; Hafid Narayan; Paulene Quinn; Iain B. Squire; Joan E. Davies A multimarker approach may be useful for risk stratification in AMI (acute myocardial infarction) patients, particularly utilizing pathways that are pathophysiologically distinct. Our aim was to assess...

View article titled, Proteinase 3 and prognosis of patients with acute myocardial infarction

Articles

Association of putative functional variants in the PLAU gene and the PLAUR gene with myocardial infarction

Jing Xu, Wenlong Li, Xunna Bao, Hu Ding, Jingzhou Chen, Weili Zhang, Kai Sun, Jizheng Wang, Xiaojian Wang, Hu Wang, Hui Yu, Weihua Song, Weiwei Ma, Lin Zhang, Changxin Wang, Daowen Wang, Rutai Hui

Clin Sci (Lond) (2010) 119 (8): 353–359.

https://doi.org/10.1042/CS20100151

Published: 06 July 2010

... of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction). We hypothesized that putative functional genetic variation in the two genes encoding uPA and uPAR ( PLAU and PLAUR...

View article titled, Association of putative functional variants in the PLAU gene and the PLAUR gene with myocardial infarction

Articles

Activation of peripheral blood mononuclear cells and extracellular matrix and inflammatory gene profile in acute myocardial infarction

Lu Fang, Xiao-Jun Du, Xiao-Ming Gao, Anthony M. Dart

Clin Sci (Lond) (2010) 119 (4): 175–183.

https://doi.org/10.1042/CS20100011

Published: 18 May 2010

...Lu Fang; Xiao-Jun Du; Xiao-Ming Gao; Anthony M. Dart Inflammation and ECM (extracellular matrix) remodelling play important roles in LV (left ventricular) remodelling following acute MI (myocardial infarction). Previous studies show elevated plasma MMP (matrix metalloproteinase) levels in patients...

View article titled, Activation of peripheral blood mononuclear cells and extracellular matrix and inflammatory gene profile in acute myocardial infarction

Includes: Supplementary data

Articles

Role of nuclear factor κB in cardiovascular health and disease

Kim van der Heiden, Simon Cuhlmann, Le A. Luong, Mustafa Zakkar, Paul C. Evans

Clin Sci (Lond) (2010) 118 (10): 593–605.

https://doi.org/10.1042/CS20090557

Published: 23 February 2010

... atherosclerosis heart failure myocardial infarction nuclear factor-κB (NF-κB) percutaneous coronary intervention (PCI) vein grafting The NF-κB family ( Figure 1 ) consists of five members: p65 ( RelA ), RelB ( RelB ), c-Rel ( Rel ), p105/p50 ( NFKB1 ) and p100/p52 ( NFKB2 ). All members share an N...

View article titled, Role of nuclear factor κB in cardiovascular health and disease

Articles

Prognostic value of admission blood glucose concentration and diabetes diagnosis on survival after acute myocardial infarction: results from 4702 index cases in routine practice

Iain B. Squire, Christopher P. Nelson, Leong L. Ng, David R. Jones, Kent L. Woods, Paul C. Lambert

Clin Sci (Lond) (2010) 118 (8): 527–535.

https://doi.org/10.1042/CS20090322

Published: 02 February 2010

... elevation AMI (acute myocardial infarction) of admission blood glucose concentration and of diabetes diagnosis. We carried out a retrospective cohort study in 4702 consecutive patients with STEMI (ST elevation AMI) occurring from 1 April 1993 to 31 December 2005, assessed for mortality at 30 days and 1 year...

View article titled, Prognostic value of admission blood glucose concentration and diabetes diagnosis on survival after acute myocardial infarction: results from 4702 index cases in routine practice

Articles

Reliability of heart rate variability measurements in patients with a history of myocardial infarction

Roberto Maestri, Grzegorz Raczak, Ludmila Danilowicz-Szymanowicz, Antoni Torunski, Adam Sukiennik, Jacek Kubica, Maria Teresa La Rovere, Gian Domenico Pinna

Clin Sci (Lond) (2010) 118 (3): 195–201.

https://doi.org/10.1042/CS20090183

Published: 01 February 2010

... setting. Poor reliability of the measurements might be a possible explanation for this. In the present study, we assessed the reliability of short-term HRV indexes in post-MI (myocardial infarction) patients. We studied 61 MI patients [50 males; age, 59±8 years; and LVEF (left ventricular ejection...

View article titled, Reliability of heart rate variability measurements in patients with a history of myocardial infarction

Articles

Matrix metalloproteinase-2 predicts mortality in patients with acute coronary syndrome

Onkar S. Dhillon, Sohail Q. Khan, Hafid K. Narayan, Kelvin H. Ng, Noor Mohammed, Paulene A. Quinn, Iain B. Squire, Joan E. Davies, Leong L. Ng

Clin Sci (Lond) (2010) 118 (4): 249–257.

https://doi.org/10.1042/CS20090226

Published: 09 November 2009

... coronary syndrome for death, readmission with HF (heart failure) or recurrent MI (myocardial infarction) and to compare them with established markers, NT-proBNP (N-terminal pro-B-type natriuretic peptide) and the GRACE (Global Registry of Acute Coronary Events) score. A single blood test was taken 4 days...

View article titled, Matrix metalloproteinase-2 predicts mortality in patients with acute coronary syndrome

Articles

New statistical methods for the evaluation of cardiovascular risk markers: what the clinician should know

Helge Røsjø, Torbjørn Omland

Clin Sci (Lond) (2009) 117 (1): 13–15.

https://doi.org/10.1042/CS20090185

Published: 02 June 2009

..., for the prediction of mortality after acute myocardial infarction, using a combination of statistical methods. Correspondence: Professor Torbjørn Omland (email torbjorn.omland@medisin.uio.no ). 26 3 2009 7 4 2009 7 4 2009 © The Authors Journal compilation © 2009 Biochemical Society...

View article titled, New statistical methods for the evaluation of cardiovascular risk markers: what the clinician should know

Articles

N-terminal pro-B-type natriuretic peptide complements the GRACE risk score in predicting early and late mortality following acute coronary syndrome

Sohail Q. Khan, Hafid Narayan, Kelvin H. Ng, Onkar S. Dhillon, Dominic Kelly, Paulene Quinn, Iain B. Squire, Joan E. Davies, Leong L. Ng

Clin Sci (Lond) (2009) 117 (1): 31–39.

https://doi.org/10.1042/CS20080419

Published: 02 June 2009

...Sohail Q. Khan; Hafid Narayan; Kelvin H. Ng; Onkar S. Dhillon; Dominic Kelly; Paulene Quinn; Iain B. Squire; Joan E. Davies; Leong L. Ng The GRACE (Global Registry of Acute Coronary Events) risk score has been shown to offer predictive power with regard to death and AMI (acute myocardial infarction...

View article titled, N-terminal pro-B-type natriuretic peptide complements the GRACE risk score in predicting early and late mortality following acute coronary syndrome

Articles

Total leucocyte count, but not C-reactive protein, predicts 1-year mortality in patients with acute coronary syndromes treated with percutaneous coronary intervention

Gjin Ndrepepa, Siegmund Braun, Raisuke Iijima, Dritan Keta, Robert A. Byrne, Stefanie Schulz, Julinda Mehilli, Albert Schömig, Adnan Kastrati

Clin Sci (Lond) (2009) 116 (8): 651–658.

https://doi.org/10.1042/CS20080298

Published: 16 March 2009

... of this association from coronary risk factors and C-reactive protein has been inadequately studied. In the present study, this prospective registry included 4329 patients with ACS treated with PCI (percutaneous coronary intervention): 1059 patients with STEMI [ST-segment elevation MI (myocardial infarction)], 1753...

View article titled, Total leucocyte count, but not C-reactive protein, predicts 1-year mortality in patients with acute coronary syndromes treated with percutaneous coronary intervention

Articles

Statins for heart failure: still caught in no man's land?

Stephan von Haehling

Clin Sci (Lond) (2009) 116 (1): 37–39.

https://doi.org/10.1042/CS20080530

Published: 28 November 2008

...@web.de ). 13 10 2008 29 10 2008 29 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 atorvastatin heart failure inflammation interleukin-10 myocardial infarction Statins can lower serum cholesterol levels. That fact is beyond doubt. Patients...

View article titled, Statins for heart failure: still caught in no man's land?

Articles

Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction

Christian Stumpf, Sebastian Petzi, Katrin Seybold, Gerald Wasmeier, Martin Arnold, Dorette Raaz, Atilla Yilmaz, Werner G. Daniel, Christoph D. Garlichs

Clin Sci (Lond) (2009) 116 (1): 45–52.

https://doi.org/10.1042/CS20080042

Published: 28 November 2008

...Christian Stumpf; Sebastian Petzi; Katrin Seybold; Gerald Wasmeier; Martin Arnold; Dorette Raaz; Atilla Yilmaz; Werner G. Daniel; Christoph D. Garlichs LV (left ventricular) remodelling is the basic mechanism of HF (heart failure) following MI (myocardial infarction). Although there is evidence...

View article titled, Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction

Articles

Genetic variation in the arachidonate 5-lipoxygenase-activating protein ( ALOX5AP ) is associated with myocardial infarction in the German population

Patrick Linsel-Nitschke, Anika Götz, Anja Medack, Inke R. König, Petra Bruse, Wolfgang Lieb, Björn Mayer, Klaus Stark, Christian Hengstenberg, Marcus Fischer, Andrea Baessler, Andreas Ziegler, Heribert Schunkert, Jeanette Erdmann

Clin Sci (Lond) (2008) 115 (10): 309–315.

https://doi.org/10.1042/CS20070468

Published: 15 October 2008

...-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) and stroke in Icelandic and Scottish populations. Both genes encode proteins playing a role in the synthesis of the pro-inflammatory leukotriene B mediators, possibly...

View article titled, Genetic variation in the arachidonate 5-lipoxygenase-activating protein ( ALOX5AP ) is associated with myocardial infarction in the German population

Articles

Association between PPAR α gene polymorphisms and myocardial infarction

Wibke Reinhard, Klaus Stark, Kamil Sedlacek, Marcus Fischer, Andrea Baessler, Katharina Neureuther, Stefan Weber, Bernhard Kaess, Silke Wiedmann, Stefan Mitsching, Wolfgang Lieb, Jeanette Erdmann, Christa Meisinger, Angela Doering, Ralf Tolle, Andreas Jeron, Guenter Riegger, Christian Hengstenberg

Clin Sci (Lond) (2008) 115 (10): 301–308.

https://doi.org/10.1042/CS20070391

Published: 15 October 2008

... (Human Genome Organisation) gene nomenclature] as a candidate gene for coronary artery disease. In the present study, we comprehensively evaluated common genetic variations within the PPAR α gene and assessed their association with myocardial infarction. First, we characterized the linkage disequilibrium...

View article titled, Association between PPAR α gene polymorphisms and myocardial infarction

Articles

MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets

Anthony J. Muslin

Clin Sci (Lond) (2008) 115 (7): 203–218.

https://doi.org/10.1042/CS20070430

Published: 03 September 2008

... myocardial infarction, atherosclerosis and vascular restenosis will be examined, with attention paid to genetically modified murine model systems and to the use of pharmacological inhibitors of protein kinases. Despite the complexities of this field of research, attractive targets for pharmacological therapy...

View article titled, MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets

Articles

Immune regulatory cells: circulating biomarker factories in cardiovascular disease

Gerard Pasterkamp, Dik Versteeg, Dominique P. V. de Kleijn

Clin Sci (Lond) (2008) 115 (4): 129–131.

https://doi.org/10.1042/CS20080089

Published: 15 July 2008

... in coronary artery disease. HSP heat-shock protein LPS lipopolysaccharide MI myocardial infarction AMI acute MI SA stable angina TLR Toll-like receptor References 1 Ishikawa Y. Satoh M. Itoh T. Minami Y. Takahashi Y. Nakamura M. Local...

View article titled, Immune regulatory cells: circulating biomarker factories in cardiovascular disease

Articles

Local expression of Toll-like receptor 4 at the site of ruptured plaques in patients with acute myocardial infarction

Yuh Ishikawa, Mamoru Satoh, Tomonori Itoh, Yoshitaka Minami, Yuji Takahashi, Motoyuki Akamura

Clin Sci (Lond) (2008) 115 (4): 133–140.

https://doi.org/10.1042/CS20070379

Published: 15 July 2008

... receptor 4) mediates the synthesis of cytokines in circulating monocytes of patients with AMI (acute myocardial infarction); however, it remains unclear whether TLRs are expressed at the site of the ruptured plaque in these patients. The aim of the present study was to determine whether TLR2 and TLR4...

View article titled, Local expression of Toll-like receptor 4 at the site of ruptured plaques in patients with acute myocardial infarction

Articles

Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarction

Lu Fang, Xiao-Ming Gao, Chrishan S. Samuel, Yidan Su, Yean Leng Lim, Anthony M. Dart, Xiao-Jun Du

Clin Sci (Lond) (2008) 115 (3): 99–106.

https://doi.org/10.1042/CS20070365

Published: 02 July 2008

...Lu Fang; Xiao-Ming Gao; Chrishan S. Samuel; Yidan Su; Yean Leng Lim; Anthony M. Dart; Xiao-Jun Du The mechanism of cardiac rupture after MI (myocardial infarction) is not fully understood. Rupture has not been reported in most laboratory species, including the rat, but does occur in mice. We have...

View article titled, Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarction

Articles

Global longitudinal strain by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease

Ze-Zhou Song

Clin Sci (Lond) (2007) 113 (9): 393.

https://doi.org/10.1042/CS20070171

Published: 01 October 2007

...Ze-Zhou Song 22 5 2007 4 6 2007 4 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 ischaemic heart disease longitudinal strain myocardial infarction two-dimensional speckle tracking echocardiography Correspondence: Mr Ze-Zhou Song...

View article titled, Global longitudinal strain by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease

Articles

The RANTES −403G>A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease

Yangsoo Jang, Jey Sook Chae, Yae Jung Hyun, Soo Jeong Koh, Ji Young Kim, Min Ji Ko, Se-Joong Rim, Hyun-Joon Shin, Jose M. Ordovas, Jong Ho Lee

Clin Sci (Lond) (2007) 113 (8): 349–356.

https://doi.org/10.1042/CS20070014

Published: 12 September 2007

...>A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with ( n =176) or without ( n =377) Type 2 diabetes, aged 40–65 years with previous myocardial infarction (∼50%) or angiographically confirmed CAD (∼50%), and 416...

View article titled, The RANTES −403G>A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only