..., in part, to increased JNK activation and mitochondrial dysfunction. The PO model was generated by TAC as described previously [ 20 , 21 ]. Briefly, 8–10-week-old male NRK2 KO and littermate control mice ( n =16–17) were anesthetized through intraperitoneal injection of ketamine (50 mg/kg...

... G. et al . ( 2014 ) Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice . Nat. Commun. 5 , 3837 24815183 10.1038/ncomms4837 38. Wang Y. and Hekimi S. ( 2015 ) Mitochondrial dysfunction and longevity in animals: untangling the knot...

... Ritter; Felipe Dal-Pizzol Background: Several different mechanisms have been proposed to explain long-term cognitive impairment in sepsis survivors. The role of persisting mitochondrial dysfunction is not known. We thus sought to determine whether stimulation of mitochondrial dynamics improves...

... design of effective strategies to delay or treat DCM. Mitochondrial dysfunction is recognized as the driving force for the pathogenesis of DCM; therefore, maintaining cardiac mitochondrial quality is crucial for DCM prevention. Mitophagy is the process by which cells degrade abnormal or superfluous...

... stress heart failure iron deficiency iron overload lipocalin 2 (Lcn2) mitochondrial dysfunction NGAL oxidative stress IOC is defined as the presence of systolic or diastolic cardiac dysfunction secondary to increased deposition of iron in the heart independent of other concomitant...

...José Magalhães; Rita Ferreira; Maria J. Neuparth; Paulo J. Oliveira; Franklim Marques; António Ascensão In the present study, the effect of vitamin E (α-tocopherol) on mice skeletal muscle mitochondrial dysfunction and oxidative damage induced by an in vivo acute and severe hypobaric hypoxic insult...