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Keywords: Mitochondria
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Clin Sci (Lond) (2022) 136 (14): 1081–1110.
Published: 27 July 2022
... is associated with lower expression of OXPHOS and ribosomal genes, diminished glutathione redox, less type I muscle fibers, and decreased oxidative capacity. Figure created with BioRender.com. Figure 2 Mitochondria-specific differences observed in skeletal muscle from diet-resistant versus diet...
Clin Sci (Lond) (2022) 136 (11): 841–860.
Published: 01 June 2022
... investigated whether treatment with Mdivi-1 and M1 protects the heart against DOX-induced cardiotoxicity via mitochondria-targeted pathways. Male Wistar rats ( n =40) received DOX (3 mg/kg, six doses, n =32) or 3% dimethylsulfoxide (DMSO) in the normal saline solution (NSS) ( n =8) as a control. DOX-injected...
Clin Sci (Lond) (2022) 136 (5): 345–360.
Published: 09 March 2022
... progression towards end-stage renal disease (ESRD). Renal tubular cells are populated with a high number of mitochondria, which produce cellular energy and modulate several important cellular processes, including generation of reactive oxygen species (ROS), calcium homeostasis, proliferation, and apoptosis...
Clin Sci (Lond) (2021) 135 (4): 593–595.
Published: 18 February 2021
...Shaimaa Nasr Amin This commentary highlights the research entitled: Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db/db mice, presented by Ma et al. appearing in Clinical Science (2020) 134 (16), https://doi.org/10.1042/CS20200530...
Clin Sci (Lond) (2020) 134 (17): 2381–2398.
Published: 16 September 2020
..., the precipitates were cytoplasmic protein. The supernatants were transferred to new centrifuge tubes and then centrifuged at 12000× g for 15 min, the precipitates were mitochondria. ATP content of C2C12 cells was detected via ATP Assay Kit (Beyotime, S0026). Brifely, mitochondria was extracted from C2C12 cells...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (2): 239–259.
Published: 29 January 2020
... nephropathy mitochondria mitochondrial permeability transition pores Chronic kidney disease (CKD) is recognised as a leading cause of morbidity and mortality amongst the 425 million people estimated to have diabetes globally [ 1 ]. This represents a significant burden to healthcare systems...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (22): 2245–2264.
Published: 19 November 2019
... importance. In turn, the liver houses a very high number of mitochondria, crucial metabolic unifiers of both extrinsic and intrinsic signals that converge in apoptosis activation. The role of lifestyle options is also dissected, highlighting the management of modifiable risk factors, such as obesity...
Clin Sci (Lond) (2019) 133 (17): 1871–1881.
Published: 10 September 2019
... cardiomyopathy exosome microRNA-122 mitochondria obesity Obesity has become a global epidemic worldwide and is closely associated with an increased risk of myocardial diseases [ 1 ]. Importantly, excess saturated fatty acids composed in the western diet have irreversibly induced cardiac homeostasis...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (15): 1759–1777.
Published: 14 August 2019
... Commons Attribution License 4.0 (CC BY-NC-ND) . autophagy diabetes lysosome mitochondria macrophage polarization In the last several decades, the increased prevalence of diabetes and its associated complications have been a serious health problem worldwide [ 1 , 2 ]. Diabetic...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (23): 2509–2518.
Published: 05 December 2018
... 2018 05 11 2018 06 11 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 bioenergetics diabetes mitochondria neuroimaging Type 2 diabetes mellitus (T2DM) is one of the most common diseases in older adults [ 1...
Clin Sci (Lond) (2018) 132 (20): 2163–2167.
Published: 19 October 2018
... mitochondria resulting in excessive mitochondrial fragmentation and dysfunctional mitochondria [ 12 ]. Given that calcium is a known inducer of mitochondrial fission, the calcium overload following I/R likely contributes to the excessive mitochondrial fission via calcineurin-mediated dephosphorylation Drp1...
Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
... dynamics were investigated by confocal microscopy of HK2 cells (human proximal tubular cell lines) stained with Mitotracker red or green dye along with Western blotting of the relevant proteins that modulate mitochondrial dynamics. Filamentous morphologic characteristic of mitochondria was readily...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (16): 2063–2078.
Published: 24 July 2017
...Xiaoqiang Tang; Xiao-Feng Chen; Hou-Zao Chen; De-Pei Liu Mitochondria are heterogeneous and essentially contribute to cellular functions and tissue homeostasis. Mitochondrial dysfunction compromises overall cell functioning, tissue damage, and diseases. The advances in mitochondrion biology...
Clin Sci (Lond) (2017) 131 (15): 1919–1922.
Published: 07 July 2017
...Gareth A. Nye; Giorgos K. Sakellariou; Hans Degens; Adam P. Lightfoot Mitochondria are no longer solely regarded as the cellular powerhouse; instead, they are now implicated in mediating a wide-range of cellular processes, in the context of health and disease. A recent article in Clinical Science...
Clin Sci (Lond) (2017) 131 (9): 803–822.
Published: 19 April 2017
...Renée Ventura-Clapier; Maryline Moulin; Jérôme Piquereau; Christophe Lemaire; Mathias Mericskay; Vladimir Veksler; Anne Garnier It is increasingly acknowledged that a sex and gender specificity affects the occurrence, development, and consequence of a plethora of pathologies. Mitochondria...
Clin Sci (Lond) (2017) 131 (8): 747–758.
Published: 06 April 2017
... preceded clinical improvement in a murine model of sepsis [ 20 ], whereas inadequate biogenesis prognosticated for non-survival in patients [ 21 ]. mitochondria organ dysfunction plasma simvastatin acid sepsis statins ubiquinone • Statins have pleiotropic actions that may...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (1): 1–2.
Published: 21 November 2016
... cellular organelles ER exosomes microparticles mitochondria Cellular organelles have their own critical functions. For example, mitochondria are a power source to maintain cellular and tissue energy demand. However, recent expansion of pharmacological, molecular and genetic tools have allowed us...
Clin Sci (Lond) (2016) 130 (23): 2217–2237.
Published: 31 October 2016
...). published by Portland Press Limited on behalf of the Biochemical Society 2016 inflammation mitochondria peroxidation polyphenol • Apple peel polyphenols represent an efficient functional food for the prevention and treatment of inflammatory bowel diseases. • Apple peel polyphenols...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (19): 1741–1751.
Published: 31 August 2016
... 13 7 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 In this study, we describe the role of mitochondria in sIBM, demonstrating that deregulated mitochondrial dynamics correlates with altered mtDNA stability and that the OXPHOS...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (14): 1179–1184.
Published: 01 June 2016
...Cathal Michael McCarthy; Louise Clare Kenny Mitochondria are extensively identified for their bioenergetic capacities; however, recently these metabolic hubs are increasingly being appreciated as critical regulators of numerous cellular signalling systems. Mitochondrial reactive oxygen species have...
Clin Sci (Lond) (2016) 130 (11): 843–852.
Published: 22 April 2016
...Dennis Dahlmans; Alexandre Houzelle; Patrick Schrauwen; Joris Hoeks The western dietary habits and sedentary lifestyle largely contributes to the growing epidemic of obesity. Mitochondria are at the front line of cellular energy homoeostasis and are implicated in the pathophysiology of obesity...
Clin Sci (Lond) (2016) 130 (9): 711–720.
Published: 18 March 2016
... by mitochondria, which are dynamic organelles, constantly fusing and dividing to maintain kidney homoeostasis. In diabetic kidney disease (DKD), mitochondria appear dysfunctional, but the temporal development of diabetes-induced adaptations in mitochondrial structure and bioenergetics have not been previously...
Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
... was measured using a luciferase luminescence assay (ATPlite, PerkinElmer), corrected to total protein (BCA protein assay, Pierce Biotechnology). ATP was then calculated as nanomoles per milligram of protein. apoptosis inflammasome lymphocyte metabolism mitochondria sepsis...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (9): 567–578.
Published: 11 February 2015
...Yi Zhao; Ulf Lützen; Jürgen Fritsch; Maaz Zuhayra; Stefan Schütze; Ulrike M. Steckelings; Chiara Recanti; Pawel Namsoleck; Thomas Unger; Juraj Culman The presence of angiotensin type 2 (AT 2 ) receptors in mitochondria and their role in NO generation and cell aging were recently demonstrated...
Clin Sci (Lond) (2015) 128 (3): 197–212.
Published: 03 October 2014
.... antioxidant cyclo-oxygenase inflammation mitochondria peroxidation polyphenol transcription factor • Inflammation is the central component in inflammatory bowel diseases but it is accompanied by a persistent oxidative stress. The aim of our study consists in testing functional nutrients...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (2): 111–121.
Published: 13 September 2013
... between NADPH oxidase and mitochondria, the main ROS sources in hypertension, which may represent a vicious feed-forward cycle of ROS production. In recent years, there is experimental evidence showing a relationship between ROS and COX-derived products. Thus ROS can activate COX and the COX/PG...
Clin Sci (Lond) (2008) 114 (1): 27–35.
Published: 30 November 2007
... metabolism magnesium transport mitochondria Mg (magnesium; referring to both bound and free forms) is referred to as the intracellular divalent cation par excellence . Its biological role is extremely versatile as it can serve structural functions (e.g. fluidity and stability of phospholipid...
Clin Sci (Lond) (2006) 110 (2): 205–206.
Published: 17 January 2006
... mitochondria to generate reactive oxygen species in the vascular wall during mineralocorticoid-induced hypertension in the rat. These studies open a new line of investigation that could be important for the development of therapeutic strategies; however, there still remains a great deal of uncertainty about...
Clin Sci (Lond) (2005) 108 (3): 185–194.
Published: 18 February 2005
... identify novel targets for future diabetes therapies. Mitochondrial metabolism is crucial for the coupling of amino acid and glucose recognition to the exocytosis of the insulin granules. This is illustrated by in vitro and in vivo observations discussed in the present review. Mitochondria generate ATP...
Clin Sci (Lond) (2001) 101 (5): 493–498.
Published: 25 September 2001
... and energy charge were less conclusive. These findings suggest that indomethacin affects mitochondria and thereby impairs energy metabolism in jejunal tissue. Correspondence: Dr R. J. Simpson, Department of Endocrinology, Diabetes and Internal Medicine, King's College Denmark Hill Campus, Bessemer Rd...
Clin Sci (Lond) (1998) 95 (3): 385–388.
Published: 01 September 1998
... form of the drug with protons in the intermembrane space of mitochondria to disrupt the potential across the inner mitochondrial membrane and thereby initiate apoptosis. Normal cells are not affected. Present address: P.O. Box 289, Silver City, NM 88062, U.S.A. 13 10 1997 20 1 1998...
Clin Sci (Lond) (1997) 92 (3): 225–235.
Published: 01 March 1997
... and nerve deafness. 6. Nuclear gene defects may result in mitochondrial disorders by predisposing to multiple mitochondrial DNA deletions or quantitative depletions of mitochondrial DNA content. © 1997 The Biochemical Society and the Medical Research Society 1997 diabetes genetics mitochondria...
Clin Sci (Lond) (1996) 91 (1): 51–58.
Published: 01 July 1996
... 3 haemodynamics ischaemia mitochondria spectrophotometry Clinical Science (1996) 91, 51-58 (Printed in Great Britain) 51 Non-invasive measurement of cardiac oxygenation and haemodynamics during transient episodes of coronary artery occlusion and reperfusion in the pig M. S. THORNILEY...
Clin Sci (Lond) (1996) 90 (4): 295–300.
Published: 01 April 1996
... by reverse transcriptase-polymerase chain reaction techniques in relation to functional studies of muscle mitochondria and the muscle RNA/DNA ratio. 3. Fifty-eight percent of patients reported an uncharacterized ‘viral infection’ before the onset of their illness, but none of the muscle samples from 34...
Clin Sci (Lond) (1995) 89 (6): 581–590.
Published: 01 December 1995
... consequence of reduced blood flow, and may be related to change in muscle fibre type. 4 7 1995 1 9 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 arterial disease ATP synthesis bioenergetics glycogenolysis mitochondria occlusive oxidative metabolism 31...
Clin Sci (Lond) (1994) 87 (5): 499–503.
Published: 01 November 1994
... and salicylate on ADP-induced O 2 consumption by mitochondria (State 3 rate) respiring on pyruvate, and oxidation of [1- 14 C]- and [2- 14 C]-pyruvate to 14 CO 2 . 2. The rate of State 3 respiration was inhibited and plateaued at 45% with 10 mmol/l NH 4 Cl. 3. Oxidation of [1- 14 C]pyruvate was not significantly...
Clin Sci (Lond) (1993) 84 (3): 339–348.
Published: 01 March 1993
... The Biochemical Society and the Medical Research Society 1993 alcohol free radical iron liver mitochondria peroxisome electron paramagnetic resonance spectroscopy subcellular fractionation Clinical Science (1993) 84, 339-348 (Printed in Great Britain) 339 Electron paramagnetic resonance...
Clin Sci (Lond) (1991) 81 (5): 645–653.
Published: 01 November 1991
...Peter Bárány; Rolf Wibom; Eric Hultman; Jonas Bergström 1. The ATP production rate in isolated skeletal muscle mitochondria was measured with a bioluminescence method, before and during erythropoietin treatment, in 21 anaemic haemodialysis patients. In addition, the concentrations of ATP...
Clin Sci (Lond) (1988) 74 (5): 485–489.
Published: 01 May 1988
..., the cytochrome oxidase activity of mitochondria and the hepatic adenylate energy charge level ( in situ ) were studied in cirrhotic rat liver induced by carbon tetrachloride (CCl 4 ). 2. In the cirrhotic liver mitochondria, concentrations of cytochrome a (+ a 3 ), cytochrome b , coenzyme Q 9 and coenzyme Q 10...
Clin Sci (Lond) (1985) 69 (2): 153–163.
Published: 01 August 1985
... individuals. 2. The subsarcolemmal mitochondria were released by gentle homogenization, with a recovery of 32-37%, and the intermyofibrillar by enzymic digestion and further mechanical disintegration, recovery 18-21%. The subsarcolemmal mitochondria were morphologically defined as those located within 2 μm...
Clin Sci (Lond) (1984) 66 (2): 173–178.
Published: 01 February 1984
...K. Gohil; D. A. Jones; R. H. T. Edwards 1. Activities for the oxidation of palmitoyl-carnitine, of palmitoyl-CoA and of carnitine palmitoyltransferase were measured in mitochondria prepared from needle biopsy samples of human skeletal muscle. Results are presented for nine normal subjects and 18...
Clin Sci (Lond) (1980) 59 (6): 457–462.
Published: 01 December 1980
... a major peak (modal density, 1.17) with a small subsidiary peak (modal density 1.24). 3. The following organelles, characterized by their marker enzymes, were located in the density gradients; plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes (β- N...
Clin Sci (Lond) (1980) 59 (1): 7–12.
Published: 01 July 1980
... lysosomes mitochondria plasma membrane Pompe's disease subcellular fractionation © 1980 The Biochemical Society and the Medical Research Society 1980 6 11 1979 13 2 1980 Clinical Science (1 980) 59,7- 12 7 Subcellular fractionation studies on hepatic tissue from a patient...
Clin Sci (Lond) (1980) 59 (1): 1–6.
Published: 01 July 1980
... density 1.18) and a substantial shoulder extending into the denser regions of the gradient. 3. The following organelles, characterized by their marker enzymes, were located in the density gradients: plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes...
Clin Sci (Lond) (1979) 56 (5): 479–486.
Published: 01 May 1979
... 8 1978 15 12 1978 © 1979 The Biochemical Society and the Medical Research Society 1979 basal—lateral membrane brush borders cytosol endoplasmic reticulum enzymes giardiasis lysosomes mitochondria subcellular fractionation tropical malabsorption Clinical Science (1979...
Clin Sci (Lond) (1979) 56 (2): 179–188.
Published: 01 February 1979
... and after 5 min 45% of the radioactivity sedimented in the mitochondrial fraction. 4. Density gradient centrifugation indicated that approximately 80% of this radioactivity was associated with the mitochondria themselves; the remainder was in brush-border fragments. 5. Selective disruption...
Clin Sci Mol Med (1978) 55 (4): 383–389.
Published: 01 October 1978
... Society 1978 alcoholic liver disease enzymes ethanol lysosomes microsomes mitochondria subcellular fractionation plasma membrane Clinical Science and Molecular Medicine (1978) 55, 383-389 Changes in hepatic enzymes and organelles in alcoholic liver disease C A R O L A. S E Y M O U R * A N...
Clin Sci Mol Med (1978) 54 (5): 549–553.
Published: 01 May 1978
... hyperbilirubinaemia liver disease lysosomes melanin mitochondria superoxide dismutase Clinical Science and Molecular Medicine (1978) 54,549-553 The organelle pathology and demonstration of mitochondrial Superoxide dismutase deficiency in two patients with Dubin-Johnson-Sprinz syndrome T. J. PETERS AND CAROL...
Clin Sci Mol Med (1977) 53 (6): 551–562.
Published: 01 December 1977
... in the duodenal mucosa. brush borders cytosol duodenum enterokinase lysosomes microvillous membranes mitochondria subcellular fractionation Clinical Science and Molecular Medicine (1977) 53,551-562. Subcellular localization of enterokinase in human duodenal mucosa R. W. LOBLEY, RUTH FRANKS AND R...
Clin Sci Mol Med (1977) 53 (1): 63–74.
Published: 01 July 1977
... content, were resolved by density gradient centrifugation in a small-volume zonal rotor. The equilibrium densities ( p ) of the principal organelles are (with marker enzymes in parentheses): sarcolemma, 1·12 (5′-nucleotidase); lysosomes, 1·16 ( N -acetyl-β-glucosaminidase); mitochondria, 1·17 (cytochrome...