...) and to elucidate the potential cross-talk among AT 2 R, Mas receptor (MasR) and/or bradykinin type 2 receptor (B 2 R) in this response. Five-week-old male C57BL6J mice were fed a standard (CHOW) or a high-fat diet (HF) for 6 weeks and treated daily with C21 (1 mg/kg p.o) or vehicle, generating four groups: CHOW-C...

... by MLN4760, a potent ACE2 inhibitor, or if the Mas receptor (MasR) was blocked by A779, a MasR antagonist. Our findings suggest that in the brain, the increase in ACE2 activity resulting from APA inhibition by RB150/firibastat treatment, subsequently increasing Ang 1-7 and activating the MasR while blocking...

... of the ACE2/Ang-(1-7)/Mas receptor axis in female and male reproduction, from gametogenesis to pregnancy and postpartum. The female reproductive system expresses ACE2 quite abundantly [ 6 ] and therefore is able to generate Ang-(1-7) using precursor peptides produced locally or taken from circulation...

... tibialis anterior μCT microcomputed tomography Angiotensin 1-7 Angiotensin Converting Enzyme 2 Mas receptor Muscle weakness osteoporosis References 1. Fried L.P. , Tangen C.M. , Walston J. , Newman A.B. , Hirsch C. , Gottdiener J. et...

...-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1–7)/ angiotensin-converting enzyme 2/Mas receptors. Although the RAS exerts a pivotal role on electrolyte homeostasis and blood pressure regulation, their components are also implicated in higher brain functions...

... and muscle mass, an increase in MHC (myosin heavy chain) degradation, and an increase in the expression of atrogin-1 and MuRF-1 (muscle-specific RING-finger protein 1), two ubiquitin E3 ligases belonging to the ubiquitin–proteasome system. Ang-(1–7) [Angiotensin-(1–7)], through its Mas receptor, has...

...@health.sdu.dk ). 2 9 2013 30 7 2014 13 8 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 angiotensin type 2 receptor (AT 2 R) Mas receptor renin–angiotensin system (RAS) The renin–angiotensin system (RAS) is usually associated with cardiovascular...

...), and the depressor arm represented by Ang-(1–7) [angiotensin-(1–7)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1–7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1–7...

... pathway. We also address the molecular mechanisms behind the beneficial effects of Ang-(1–7) on AngII-mediated insulin resistance. Finally, we discuss potential therapeutic approaches leading to modulation of the ACE2 (angiotensin-converting enzyme 2)/Ang-(1–7)/Mas receptor axis as a very attractive...

... Biochemical Society 2014 angiotensin inflammation Mas receptor renin renin–angiotensin system (RAS) stroke Stroke is a leading cause of death and serious long-term disability worldwide [ 1 ]. This disease can be broadly classified into two types: ischaemic and haemorrhagic strokes...

... the coronary effects of Ang-(1–7) [angiotensin-(1–7)] in hypertrophic rat hearts. Heart hypertrophy was induced by abdominal aorta CoA (coarctation). Ang-(1–7) and AVE 0991, a non-peptide Mas-receptor agonist, at picomolar concentration, induced a significant vasodilation in hearts from sham-operated rats...

... associated with phospholipase C activation [ 50 ], has been shown to specifically bind Ang-(1–7) and is involved in many of its biological actions [ 8 , 51 ]. At the central level, a strong staining for the Mas receptor was found in the NTS, CVLM and RVLM, inferior olive, parvocellular and magnocellular...

... Ang-(1–7) signalling, it has been reported that Ang-(1–7) phosphorylates the insulin downstream effectors PI3K (phosphoinositide 3-kinase) and AKT via the Mas receptor in HAECs [ 38 , 39 ], and IRS1 (insulin receptor substrate 1) and JAK2 (Janus kinase 2) via the AT 1 R in rat hearts [ 39 ]. Moreover...

... in the present review. Dedicated studies have now provided clear evidence that ACE, AngII/AT 1 receptor and Ang-(1–7)/Mas receptor activity are involved in haematopoiesis, as well as in the formation of cardiovascular cells and other somatic cell types from progenitor cells [ 27 ]. In the present article...

... enzyme) and the AT 1 receptor (AngII type 1 receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia/reperfusion). However, Ang-(1–7) [angiotensin-(1–7)], ACE2 (angiotensin I-converting enzyme 2) and the Mas receptor...

... induced by STNx (subtotal nephrectomy). STNx and Control rats received vehicle or ramipril (1 mg·kg −1 of body weight·day −1 ), and renal ACE, ACE2 and mas receptor gene and protein expression were measured 10 days later. STNx rats were characterized by polyuria, proteinuria, hypertension and elevated...