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Keywords: Macrophages
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Articles
Clin Sci (Lond) (2023) 137 (19): 1513–1531.
Published: 28 September 2023
...Ama D. Okyere; Tapas K. Nayak; Viren Patwa; David Teplitsky; Erin McEachern; Rhonda L. Carter; Heli Xu; Erhe Gao; Yan Zhou; Douglas G. Tilley Myeloid cells, including macrophages, play important roles as first responders to cardiac injury and stress. Epidermal growth factor receptor (EGFR) has been...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (15): 1067–1093.
Published: 02 August 2023
...Zuzana Strizova; Iva Benesova; Robin Bartolini; Rene Novysedlak; Eva Cecrdlova; Lily Koumbas Foley; Ilja Striz Macrophages represent heterogeneous cell population with important roles in defence mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations adopt distinct...
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Clin Sci (Lond) (2023) 137 (5): 355–366.
Published: 09 March 2023
... of macrophages in removal of TTR deposits in ATTRv patients. The mechanisms underlying this impairment of inflammatory responses in ATTRv patients are poorly understood. Here, we show a significant down-regulation in the expression of several chemokines by bone marrow-derived macrophages (BMDM) generated from...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (15): 1111–1115.
Published: 01 August 2022
... to be achieved through the modulation of the macrophage populations present in the liver. Here, we discuss the main findings of this work and raise some outstanding questions regarding the possible mechanisms involved and the functions of distinct macrophage populations in NASH. Correspondence: Charlotte L...
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Clin Sci (Lond) (2022) 136 (11): 879–894.
Published: 06 June 2022
... (M2) macrophage ratio, increased inflammation, and inflammation-associated lymphangiogenesis have been observed in animals with HTN. However, the impact of HTN on gonadal macrophages, inflammation, and lymphatics remains obscure. We hypothesized that salt-sensitive HTN (SSHTN) and HTN alters gonadal...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (9): 643–656.
Published: 04 May 2022
... attenuated the hepatic expression of α1-procollagen and TGF-β1 and reduced collagen deposition, as evaluated by collagen Sirius Red staining. Flow cytometry and immunohistochemistry showed that hrAnxA1 did not affect the liver recruitment of macrophages, but strongly interfered with the formation of crown...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (6): 435–454.
Published: 29 March 2022
... characterised in innate and adaptive immune cells, and discuss how macrophages’ and T cells’ metabolism may influence phenotypic changes in the plaque. Moreover, we discuss the potential of targeting immunometabolism to prevent and treat cardiovascular diseases (CVDs). Correspondence: Maria J. Forteza...
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Clin Sci (Lond) (2021) 135 (17): 2067–2083.
Published: 01 September 2021
... with inflammation in various organs, including LPS-induced acute lung inflammation. Since non-typeable Haemophilus influenzae (NTHi) causes acute exacerbations in COPD patients, we examined the contribution of DPP4 in NTHi-induced lung inflammation in COPD. Pulmonary macrophages isolated from COPD patients showed...
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Clin Sci (Lond) (2021) 135 (15): 1859–1871.
Published: 04 August 2021
... inflammation has additive and deleterious effects on atherosclerosis in ApoE −/− mice. Here, we aimed to investigate whether innate immune training is a contributory inflammatory mechanism in this murine model of atherosclerosis. Methods: Bone marrow-derived macrophages and peritoneal macrophages were isolated...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (13): 1631–1635.
Published: 01 July 2020
...Stephan F. van Eeden; Kentaro Akata Lung macrophages (LMs) are key immune effector cells that protect the lung from inhaled particulate matter, noxious gases and pathogens. In Chronic Obstructive Pulmonary Disease (COPD), there is an abundance of macrophages in airspaces and lung tissues suggesting...
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Clin Sci (Lond) (2019) 133 (14): 1581–1585.
Published: 22 July 2019
... wall, monocyte differentiation to macrophages and uptake of oxidized low density lipoprotein. Macrophage activation and inflammatory cytokine production are major factors which drive ongoing inflammation and plaque development. Identification of novel pathways driving this on-going inflammatory process...
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Clin Sci (Lond) (2019) 133 (11): 1215–1228.
Published: 03 June 2019
... in macrophages. Enhanced expression of JAML in cultured macrophages was observed following exposure of the cells to oxLDL. The functional role of JAML in atherosclerosis and macrophages function was assessed by interference of JAML with shRNA in vivo and siRNA in vitro . Silencing of JAML in mice significantly...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (8): 983–996.
Published: 29 April 2019
... (COPD), but the underlying mechanisms are not well-known. Recently, we demonstrated that RV causes persistent lung inflammation with accumulation of a subset of macrophages (CD11b + /CD11c + ), and CD8 + T cells, and progression of emphysema. In the present study, we examined the mechanisms underlying...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (12): 1253–1256.
Published: 21 June 2018
... in Clinical Science (2018) 132 (6), 655–668), Liu et al . explore the mechanism through which aortic vascular smooth cells and macrophages participate in TAAD using a mouse model. The authors propose that interleukin-3 (IL-3) released from aortic vascular smooth cells is central to the disease process. IL-3...
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Clin Sci (Lond) (2018) 132 (12): 1243–1252.
Published: 21 June 2018
...). atherosclerosis atherogenesis inflammation lipids macrophages statins Numerous data support the key role of the inflammatory mechanisms to atheroma formation [ 1–4 ]. Leukocyte recruitment and proinflammatory cytokines participate pivotally in the early phase of atherogenesis [ 1 , 2...
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Clin Sci (Lond) (2018) 132 (5): 609–613.
Published: 15 March 2018
... following DILI. androgen receptor drug-induced liver injury immunity monocytes macrophages Drug-induced liver injury (DILI) is a major hurdle in drug discovering and manufacturing, since it represents one of the most frequent reasons of failures in terms of marketing innovative therapeutic...
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Clin Sci (Lond) (2017) 131 (16): 2161–2182.
Published: 31 July 2017
...Rocio Rojo; Clare Pridans; David Langlais; David A. Hume The proliferation, differentiation, and survival of cells of the macrophage lineage depends upon signals from the macrophage colony-stimulating factor (CSF) receptor (CSF1R). CSF1R is expressed by embryonic macrophages and induced early...
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Clin Sci (Lond) (2017) 131 (12): 1329–1342.
Published: 07 June 2017
...Rui Curi; Renata de Siqueira Mendes; Luiz Aurélio de Campos Crispin; Giuseppe Danilo Norata; Sandra Coccuzzo Sampaio; Philip Newsholme In 1986 and 1987, Philip Newsholme et al. reported macrophages utilize glutamine, as well as glucose, at high rates. These authors measured key enzyme activities...
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Clin Sci (Lond) (2017) 131 (11): 1107–1121.
Published: 17 May 2017
... transport and corrects mislocalization of the most common CF mutation, F508del-CFTR. It also reduces lung pro-inflammatory responses in mice and in patients with CF. To test the hypothesis that macrophages are target effector cells of the immunomo-dulatory effect of vardenafil, we isolated lung macrophages...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (20): 1793–1806.
Published: 09 September 2016
... of action are poorly understood. In the present study, we tested BRB in steatohepatitis induced by a methionine- and choline-deficient (MCD) diet, in acute acetaminophen intoxication and in cultured murine macrophages. BRB markedly improved parameters of liver injury and necroinflammation induced by the MCD...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (14): 1257–1268.
Published: 13 June 2016
... demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet (HFD)-induced insulin resistance and chronic inflammation, characterized by the elevation of proinflammatory cytokines in the blood, liver and white adipose tissue, as well as a proinflammatory profile of immune cells in visceral...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 129 (9): 797–808.
Published: 07 August 2015
...Salvatore Sutti; Irene Locatelli; Stefania Bruzzì; Aastha Jindal; Marco Vacchiano; Cristina Bozzola; Emanuele Albano Liver monocytes play a major role in the development of NASH (non-alcoholic steatohepatitis). In inflamed tissues, monocytes can differentiate in both macrophages and dendritic cells...
Includes: Supplementary data
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Clin Sci (Lond) (2000) 98 (2): 183–192.
Published: 11 January 2000
...Kenneth C.-W. YU; John C. L. MAMO The effects of chylomicron remnants on cytoplasmic lipid loading and cell viability were assessed in cultures of human monocyte-derived macrophages and rabbit arterial smooth muscle cells. At a cholesterol concentration of 150 μ g/ml, chylomicron remnants induced...
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Clin Sci (Lond) (1999) 97 (1): 59–65.
Published: 21 May 1999
...), a precursor of both glutamine and arginine] on phagocyte functions [i.e. H 2 O 2 production by leucocytes and secretion of tumour necrosis factor α (TNFα) by stimulated macrophages] of stressed rats were studied. The relationship between the immunological effects of these amino acids and their plasma...
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Clin Sci (Lond) (1998) 96 (1): 89–97.
Published: 01 January 1999
...Colin MURPHY; Philip NEWSHOLME Macrophages and monocytes are cells with a large capacity for cytokine production. Cytokines produced by these cells are not preformed and released upon stimulation, but must be transcribed and translated. Although much is known concerning the regulation of the latter...
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Clin Sci (Lond) (1997) 92 (3): 277–284.
Published: 01 March 1997
... and S -nitroso- N -acetyl-penicillamine which corresponded with an increased concentration of nitrite accumulation in the culture medium. 5. High concentrations of nitrites were measured in the medium of granulosa/lutein cells co-cultured with peritoneal macrophages and progesterone synthesis...
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Clin Sci (Lond) (1994) 87 (2): 179–186.
Published: 01 August 1994
... to localize inducible NO synthase in rats given lipopolysaccharide or Corynebacterium parvum and lipopolysaccharide. Immunohistochemistry was carried out with an antibody raised against a synthetic peptide of mouse macrophage NO synthase. In situ hybridization was performed with 35 S-labelled oligonucleotide...