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Keywords: Liver fibrosis
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Clin Sci (Lond) (2022) 136 (9): 643–656.
Published: 04 May 2022
... liver transcripts for procollagen-1α and transforming growth factor 1β (TGF-1β) ( Figure 2 A–C) and the onset of liver fibrosis, as evidenced by intrahepatic collagen staining with Sirius Red ( Figure 2 D). Interestingly, mice treated with hrAnxA1 showed significant decrease in the transcripts...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (7): 925–941.
Published: 14 April 2021
..., accompanied with reduced liver fibrosis. The anti-fibrotic mechanism involved inhibition of profibrotic genes and blocking of hepatic stellate cell (HSC) activation. Our data show that roscovitine administration protects against liver diseases through inhibition of macrophage inflammatory actions and HSC...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (24): 2565–2582.
Published: 13 December 2018
... in liver fibrosis. By flow cytometry, we documented increased frequencies of peripheral ILC3 (Lin − CD127 + CD117 + CD294 − lymphocytes) in patients, especially at the advanced stage of hepatitis B virus (HBV)-related chronic liver diseases, and demonstrated their correlations with disease progression...
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Clin Sci (Lond) (2017) 131 (15): 2059–2062.
Published: 20 July 2017
... A. , Ramachandran P. , Iredale J.P. and Fallowfield J.A. ( 2014 ) Liver fibrosis and repair: immune regulation of wound healing in a solid organ . Nat. Rev. Immunol. 14 , 181 – 194 10 Setiawan V.W. , Stram D.O. , Porcel J. , Lu S.C. , Le Marchand L...
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Clin Sci (Lond) (2017) 131 (15): 1971–1987.
Published: 13 July 2017
... in these models. Results: miR-223 expression was significantly dysregulated in livers from mice after induction of acute liver injury and liver fibrosis as well as in liver samples from patients with ALF or liver cirrhosis. In acute and chronic models, hepatic miR-223 up-regulation was restricted to hepatocytes...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (1): 69–86.
Published: 09 December 2016
.... In conclusion, homocysteine is harmful to vascular derangements and liver fibrosis in cirrhosis. Rats received either vehicle ( n =6) or DL -homocysteine thiolactone (1 g/kg per day, oral gavage, n =6) from the 14th to 28th day after sham operation. On the 29th day, two series of experiments were...
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Clin Sci (Lond) (2015) 129 (9): 797–808.
Published: 07 August 2015
.... We found that moDCs (monocyte-derived dendritic cells) sustain hepatic inflammation during the progression of experimental NASH (non-alcoholic steatohepatitis). chronic inflammation CX 3 CR1 dendritic cells liver fibrosis macrophages non-alcoholic fatty liver disease Statistical...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 123 (4): 225–239.
Published: 24 April 2012
...Josephine A. Grace; Chandana B. Herath; Kai Yan Mak; Louise M. Burrell; Peter W. Angus The RAS (renin–angiotensin system) is now recognized as an important regulator of liver fibrosis and portal pressure. Liver injury stimulates the hepatic expression of components of the RAS, such as ACE...
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Clin Sci (Lond) (2011) 121 (4): 159–168.
Published: 28 April 2011
... panel, monoclonal antibodies used to stain α3, β3 and α-SMA are shown. cell motility extracellular matrix protein laminin liver fibrosis tumour–host interaction In Western industrialized countries, HCC (hepatocellular carcinoma) commonly develops on cirrhotic livers, so liver...
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Clin Sci (Lond) (1997) 92 (2): 103–112.
Published: 01 February 1997
...R. Alcolado; M. J. P. Arthur; J. P. Iredale 1. Liver fibrosis is a common sequel to diverse liver injuries. It is characterized by an accumulation of interstitial collagens and other matrix components. The hepatic stellate cell is pivotal to the pathogenic process. Fibrotic liver injury results...
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