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Keywords: JNK
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Clin Sci (Lond) (2020) 134 (7): 677–694.
Published: 30 March 2020
.... Mechanistically, under HG conditions, knockdown DsbA-L expression accentuated JNK phosphorylation in HK-2 cells. Furthermore, administration of a JNK inhibitor (SP600125) or the mtROS scavenger MitoQ significantly attenuated JNK activation and subsequent mitochondrial fragmentation in DsbA-L-knockdown HK-2 cells...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (22): 2087–2100.
Published: 11 October 2016
..., the molecular mechanism underlying the accelerated atherosclerosis in obesity remains unclear. In obesity, activation of c-Jun N-terminal kinase (JNK) contributes to adipose tissue inflammation. The present study investigated whether the suppression of fat inflammation through adipose-specific JNK inactivation...
Includes: Supplementary data