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Keywords: Insulin resistance
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Clin Sci (Lond) (2023) 137 (17): 1391–1407.
Published: 07 September 2023
...Yu Tao; Wenbin Luo; Yue Chen; Caiyu Chen; Shengnan Chen; Xiaoping Li; Ken Chen; Chunyu Zeng Exercise has been recommended as a nonpharmaceutical therapy to treat insulin resistance (IR). Previous studies showed that dopamine D 1 -like receptor agonists, such as fenoldopam, could improve peripheral...
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Clin Sci (Lond) (2023) 137 (16): 1311–1332.
Published: 31 August 2023
...-mediated EV cross-talk serving as central components in GDM pathophysiology. This review focuses on the role of the placenta in the pathophysiology of GDM and explores the possibilities and prospects of targeting the placenta to address insulin resistance and placental dysfunction in GDM. Additionally, we...
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Clin Sci (Lond) (2023) 137 (10): 847–862.
Published: 31 May 2023
.... In addition, reduced insulin pathway signaling proteins in NPFFR2 KO mice fed a HFD resulted in the development of hypothalamic insulin resistance. HFD feeding did not cause liver steatosis in NPFFR2 KO mice of either sex, but NPFFR2 KO male mice fed a HFD had lower body weights, white adipose tissues...
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Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
..., inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high-fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ET A receptor antagonist, 10 mg/kg/day) or bosentan...
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Clin Sci (Lond) (2020) 134 (22): 3047–3062.
Published: 24 November 2020
... leading to protection from pathological muscle remodelling and muscle insulin resistance. In contrast, there is relatively little evidence to support the protective role of ACE2 in skeletal muscle. The potential contribution of endogenous ACE2 to the regulation of Ang 1-7-mediated protection...
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Clin Sci (Lond) (2018) 132 (15): 1685–1698.
Published: 14 August 2018
... sensitive (IS) ( n =10), obese IS ( n =10), and obese insulin resistant (IR) ( n =10) men. Obese men participated in a 12-week exercise training intervention to determine the effects on SCAT lipolysis. Abdominal SCAT extracellular glycerol concentration and blood flow (ATBF) were investigated using...
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Clin Sci (Lond) (2018) 132 (11): 1085–1095.
Published: 05 June 2018
... the insulin resistance (IR) are available as research tool but are very difficult to implement in the clinical practice. Therefore, a better understanding of the key players contributing to IR may lead to the development of new non-invasive tools to assess organ-specific insulin sensitivity (IS). We...
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Clin Sci (Lond) (2018) 132 (10): 1039–1054.
Published: 25 May 2018
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 brown adipose tissue beige adipose tissue insulin resistance obesity type 2 diabetes Since the re-discovery and definitive identification of functional brown adipose tissue (BAT) in adult humans...
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Clin Sci (Lond) (2017) 131 (22): 2701–2704.
Published: 06 November 2017
...Amalia Gastaldelli Whether non-alcoholic fatty liver disease (NAFLD) precedes insulin resistance (IR) or IR preludes/causes NAFLD has been long debated. Recent studies have shown that there are two phenotypes of NAFLD, ‘genetic’ vs ‘metabolic’ NAFLD. The former patients are more at risk...
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Clin Sci (Lond) (2017) 131 (15): 1905–1917.
Published: 07 July 2017
...), hepatic insulin resistance index (HIR i ) ( r =0.576, P =0.001), and Δ R d ( r =−0.653, P <0.001) correlated with IHL content. Individuals with NAFL suffer from metabolic perturbations to a similar degree as T2DM patients. NAFL is an important feature leading to severe insulin resistance and should...
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Clin Sci (Lond) (2017) 131 (1): 37–47.
Published: 09 December 2016
...Rikke Kruse; Andreas J.T. Pedersen; Jonas M. Kristensen; Stine J. Petersson; Jørgen F.P. Wojtaszewski; Kurt Højlund Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy...
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Clin Sci (Lond) (2016) 130 (18): 1603–1614.
Published: 08 August 2016
...Matthias Blüher The worldwide obesity epidemic has become a major health concern, because it contributes to higher mortality due to an increased risk for noncommunicable diseases including cardiovascular diseases, type 2 diabetes, musculoskeletal disorders and some cancers. Insulin resistance may...
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Clin Sci (Lond) (2016) 130 (14): 1257–1268.
Published: 13 June 2016
... demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet (HFD)-induced insulin resistance and chronic inflammation, characterized by the elevation of proinflammatory cytokines in the blood, liver and white adipose tissue, as well as a proinflammatory profile of immune cells in visceral...
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Clin Sci (Lond) (2015) 129 (12): 1083–1096.
Published: 13 October 2015
... inflammation, which also manifests within metabolic tissues such as adipose tissue and liver. This metabolic inflammation can promote insulin resistance and dysglycaemia. However, the obesity and metabolic disease-related immune responses that are compartmentalized in the intestinal environment do...
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Clin Sci (Lond) (2015) 129 (10): 839–850.
Published: 19 August 2015
..., induces the browning of white adipose tissue, but its effects on gluconeogenesis and glycogenesis are unknown. In the present study, we investigated the effects and underlying mechanisms of irisin on gluconeogenesis and glycogenesis in hepatocytes with insulin resistance, and its therapeutic role in type...
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Clin Sci (Lond) (2015) 129 (5): 405–414.
Published: 11 June 2015
...Camilla Kappe; Liselotte Fransson; Petra Wolbert; Henrik Ortsäter Evidence indicates that subtle abnormalities in GC (glucocorticoid) plasma concentrations and/or in tissue sensitivity to GCs are important in the metabolic syndrome, and it is generally agreed that GCs induce insulin resistance...
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Clin Sci (Lond) (2015) 128 (8): 493–506.
Published: 23 January 2015
... with a FOXO1 inhibitor, an antioxidant that inhibits FOXO1 or IL-1 receptor antagonist alleviates chronic inflammation and insulin resistance in high-fat diet (HFD)-fed mice. Collectively, our data suggest that obesity-associated factors such as NEFA and lipopolysaccharide (LPS) probably adopt this vicious...
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Clin Sci (Lond) (2014) 127 (2): 91–100.
Published: 17 March 2014
...; for example, its chloride form (GdCl 3 ) is a commonly used specific inhibitor of macrophages in vivo and its chelate is an MRI contrast agent in medical practice [ 15 – 17 ]. GdCl 3 has been shown to be able to activate the Akt pathway in NIH 3T3 cells [ 18 ] and to improve insulin resistance in Type 2...
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Clin Sci (Lond) (2013) 125 (11): 501–511.
Published: 25 July 2013
... (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression. In NAFLD, steatosis, lipotoxicity and liver inflammation participate to hepatic insulin resistance. The aim of the present study was to verify...
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Clin Sci (Lond) (2012) 123 (9): 545–546.
Published: 13 July 2012
.... These results suggest that TRAIL could be an exciting new therapeutic for treating obesity, but further studies are required to determine its major mechanisms of action. References 1 Hardy O. T. Czech M. P. Corvera S. What causes the insulin resistance underlying obesity? Curr. Opin...
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Clin Sci (Lond) (2012) 122 (5): 203–214.
Published: 28 October 2011
.... 12 7 2011 1 9 2011 8 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 hyperglycaemia inflammation insulin resistance oxidative stress Toll-like receptor Type 2 diabetes Diabetes affects more than 348 million people worldwide and around 36...
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Clin Sci (Lond) (2011) 121 (4): 179–189.
Published: 04 May 2011
... with estimates of whole body rate of protein turnover and urea synthesis in clinically stable biopsy-confirmed subjects with NASH (non-alcoholic steatohepatitis). Subjects with NASH were more insulin-resistant and had significantly higher plasma concentrations of usCRP (ultrasensitive C-reactive protein), TNFα...
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Clin Sci (Lond) (2011) 120 (7): 297–305.
Published: 13 December 2010
... syndrome represents a cluster of cardiometabolic risk determinants, including central adiposity, insulin resistance, glucose intolerance, dyslipidaemia and hypertension. The metabolic syndrome is rapidly increasing in prevalence worldwide as a consequence of changes in human behaviour and lifestyle...
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Clin Sci (Lond) (2010) 119 (8): 313–322.
Published: 06 July 2010
... ]. As noted above, ATBF responsiveness to nutrients is impaired in obesity or insulin resistance, but it is not known whether it is also associated with direct markers of atherosclerotic risk. Subjects were semi-supine in a quiet room. Respiration was controlled using an electronic metronome at a rate...
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Clin Sci (Lond) (2009) 117 (5): 173–190.
Published: 03 August 2009
...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...
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Clin Sci (Lond) (2009) 116 (10): 761–770.
Published: 15 April 2009
...Lisa J. Moran; Samantha K. Hutchison; Caroline Meyer; Sophia Zoungas; Helena J. Teede PCOS (polycystic ovary syndrome) is associated with reproductive abnormalities, IR (insulin resistance) and elevated risk factors for CVD (cardiovascular disease) and Type 2 diabetes, including endothelial...
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Clin Sci (Lond) (2009) 116 (8): 607–620.
Published: 16 March 2009
...-4-imidazolecarboxamide riboside-1-β- D -ribofuranoside (AICAR) AMP-activated protein kinase (AMPK) cardiovascular disease insulin resistance metformin obesity The prevalence of cardiometabolic diseases is reaching epidemic proportions in industrialized nations and in developing...