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Keywords: Inflammation
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Clin Sci (Lond) (2023) 137 (21): 1665–1681.
Published: 15 November 2023
... day. Data in (A,B) were analyzed by one-way ANOVA with Bonferroni’s multiple comparisons test. cardiac arrhythmia inflammation myocardial remodeling Sudden cardiac death (SCD) is a major life-threatening health problem worldwide, and approximately 80% of SCDs are caused...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (19): 1533–1545.
Published: 03 October 2023
... the phenotypic switching of vascular smooth muscle cells from a contractile to synthetic state during AAA. In addition, it was demonstrated that colchicine was able to reduce vascular inflammation, oxidative stress, cell pyroptosis and immune cells infiltration to the aortic wall in the AAA mice model. Finally...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (17): 1409–1429.
Published: 13 September 2023
... a kidney transplant, (3) having a life expectancy lower than 1 year, (4) to have chronic inflammation or active infections or (5) to have undergone previous carotid artery surgery. The classification of patients in the different CKD stages due to their estimated GFR was based on the equations used...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (16): 1225–1247.
Published: 22 August 2023
... therapies. Inflammation has emerged as a potential contributor to the pathogenesis of HFpEF. Many of the risk factors for HFpEF are also associated with chronic inflammation, such as obesity, hypertension, aging, and renal dysfunction. A large amount of preclinical evidence suggests that immune cells...
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Clin Sci (Lond) (2023) 137 (12): 979–993.
Published: 28 June 2023
...Huahui Yu; Xiaolu Jiao; Yunyun Yang; Qianwen Lv; Zhiyong Du; Linyi Li; Chaowei Hu; Yunhui Du; Jing Zhang; Fan Li; Qiuju Sun; Yu Wang; Dong Chen; Xiaoping Zhang; Yanwen Qin Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism, glucose metabolism, inflammation, and cell...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (8): 617–631.
Published: 21 April 2023
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Open access for this article was enabled through a transformative open access agreement between Portland Press and the University of California. Fibrosis Inflammation Pulmonary...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (6): 469–494.
Published: 24 March 2023
... of social determinants of health (SDoH). The main topics covered include biomarkers of sympathetic nervous system and hypothalamic–pituitary–adrenal axis activation, and the role of inflammation in the biology of adversity focusing on glucocorticoid resistance and key inflammatory cytokines linked...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (24): 1877–1891.
Published: 22 December 2022
... with wild-type (WT) mice, Park7 -deficient mice experienced aggravated kidney tissue damage and dysfunction, and enhanced tubular apoptosis and inflammation following LPS treatment. Consistently, LPS-induced apoptosis and inflammation in renal tubular cells in vitro were exacerbated by Park7 knockdown...
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Clin Sci (Lond) (2022) 136 (24): 1809–1829.
Published: 16 December 2022
... mechanisms that cause inflammation-driven haemostatic dysregulation, including aberrant contact pathway activation, increased tissue factor activity and release, innate immune cell activation and programmed cell death, and T cell-mediated changes in thrombus resolution. In addition, we consider how lifestyle...
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Clin Sci (Lond) (2022) 136 (23): 1759–1772.
Published: 02 December 2022
... on behalf of the Biochemical Society 2022 hypertension immunity inflammation kidney lymphatics Hypertension (HTN), defined by the American Heart Association as having a blood pressure of 130/80 mmHg or above, afflicts nearly half of adults [ 1 ]. The condition is a major risk factor...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (20): 1433–1437.
Published: 18 October 2022
... of adhesion molecules in the injured kidney. This, the authors speculate, may prevent inflammation from driving the functional decline of the kidney. Identifying these novel pathways represents an important step forward harnessing the potential benefits of alkali therapy in CKD. References 1. Hill...
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Clin Sci (Lond) (2022) 136 (12): 935–952.
Published: 22 June 2022
...Tom Macleod; Charles Bridgewood; Isabel Hyde; Megan Heague; Philip Helliwell; Martin Stacey; Miriam Wittmann This review highlights the molecular and cellular mechanisms underlying psoriatic inflammation with an emphasis on recent developments which may impact on treatment approaches...
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Clin Sci (Lond) (2022) 136 (10): 733–746.
Published: 24 May 2022
... to the pathogenesis of many chronic diseases, including asthma and chronic obstructive pulmonary disease (COPD). In asthma, increased autophagy plays a role in promoting type 2 immune responses and eosinophilic inflammation, whereas decreased autophagy may be important in neutrophilic asthma. Acute exposure...
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Clin Sci (Lond) (2022) 136 (3): 239–256.
Published: 07 February 2022
..., leading to extensive investigation to unravel key pathophysiological mechanisms underlying irreversible functional loss and structural damage in the chronically ischemic kidney. Research studies identified complex interactions among various players, including inflammation, fibrosis, mitochondrial injury...
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Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... the impact of NLRP3 inhibition on renal inflammation and associated pathology in DKD. We identified an adverse effect of MCC950 on renal pathology in diabetic animals. Indeed, MCC950-treated diabetic animals showed increased renal inflammation and macrophage infiltration in association with enhanced...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (1): 29–44.
Published: 05 January 2022
...Bo Wang; Chenguang Ding; Xiaoming Ding; Greg Tesch; Jin Zheng; PuYun Tian; Yang Li; Sharon Ricardo; Hsin-Hui Shen; Wujun Xue Inflammation is a pathological feature of kidney injury and its progression correlates with the development of kidney fibrosis which can lead to kidney function impairment...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (1): 61–80.
Published: 05 January 2022
...Manon Chauvin; Delphine Sauce Massive CD4 + T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many...
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Clin Sci (Lond) (2021) 135 (17): 2035–2048.
Published: 31 August 2021
...Koji Akita; Kikuo Isoda; Fumie Ohtomo; Sarasa Isobe; Tomiharu Niida; Yayoi Sato-Okabayashi; Motoaki Sano; Kazunori Shimada; Yoichiro Iwakura; Tohru Minamino Clinical hypertension (HT) is associated with renal inflammation and elevated circulating levels of proinflammatory cytokines. Interleukin (IL...
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Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
..., inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high-fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ET A receptor antagonist, 10 mg/kg/day) or bosentan...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
... inflammation in obese adipose tissue may contribute to the risk of developing insulin resistance and type 2 diabetes. Furthermore, increased vascular pro-inflammatory signalling is a key event in the development of cardiovascular diseases. Overnutrition exacerbates pro-inflammatory signalling in vascular...
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Clin Sci (Lond) (2021) 135 (11): 1389–1408.
Published: 04 June 2021
...Diana Cardoso; Esperanza Perucha The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the danger signal. This process relies on the metabolic reprogramming...
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Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... Biomimetics chronic kidney disease Inflammation life style diseases oxidative stress Human life expectancy has achieved an unprecedented rise, at a rate of 5 years per decade, since the beginning of the millennium. The population aged 65 years or over is projected to reaching 1.5 billion in 2050...
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Clin Sci (Lond) (2021) 135 (6): 731–752.
Published: 17 March 2021
... change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge...
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Clin Sci (Lond) (2021) 135 (1): 229.
Published: 11 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...
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Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... indicates a link between disturbances in phosphate homeostasis and inflammation. The present review focuses on critical interactions of phosphate homeostasis, inflammation, vascular calcification and CVD. Especially, pro-inflammatory responses mediating hyperphosphatemia-related development of vascular...
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Clin Sci (Lond) (2020) 134 (23): 3175–3193.
Published: 09 December 2020
...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (22): 2987–3006.
Published: 19 November 2020
... The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . angiotensin converting enzyme 2 AT2 receptor COVID-19 inflammation The discovery...
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Clin Sci (Lond) (2020) 134 (18): 2447–2451.
Published: 25 September 2020
... volume. Correspondence: Gavin Y. Oudit ( gavin.oudit@ualberta.ca ) 02 09 2020 15 09 2020 17 09 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 adipose tissue inflammation Maternal programming obesity...
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Clin Sci (Lond) (2020) 134 (15): 2053.
Published: 10 August 2020
... The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. aldosterone cardiac remodeling inflammation microRNA-34a TRIF ©...
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Clin Sci (Lond) (2020) 134 (13): 1751–1762.
Published: 10 July 2020
.... Neutralization of HMGB1 attenuated IR-induced increases in plasma creatinine, blood urea nitrogen (BUN), inflammation, tubular damage and tubular cell death only in male SHR. In conclusion, our data demonstrate that there is a sex difference in the contribution of HMGB1 to IR-induced injury, where males exhibit...
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Clin Sci (Lond) (2020) 134 (13): 1613–1629.
Published: 30 June 2020
... The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . angiogenesis c-reactive protein diabetic retinopathy inflammation oxidative stress...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (12): 1433–1448.
Published: 18 June 2020
...Simeng Liu; Zhimin Huang; Anna Tang; Xiaoqing Wu; Jeffrey Aube; Liang Xu; Changying Xing; Yufeng Huang Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation...
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Clin Sci (Lond) (2020) 134 (12): 1357–1376.
Published: 18 June 2020
... Society 2020 inflammation KD025 metabolism ROCK2 tubulointerstitial fibrosis Epidemiological studies have demonstrated that the prevalence of chronic kidney disease (CKD) is approximately 8–16% worldwide [ 1 , 2 ]. Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable...
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Clin Sci (Lond) (2020) 134 (12): 1319–1331.
Published: 16 June 2020
... License 4.0 (CC BY-NC-ND) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF Cardiac pathophysiological remodeling is one of the major characteristics in the development of heart failure. There has been a sustained effort to develop novel strategies to protect against...
Includes: Supplementary data
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