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Keywords: GMP-AMP synthase (cGAS)
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Articles
Michael Schuliga, Jane Read, Kaj E.C. Blokland, David W. Waters, Janette Burgess, Cecilia Prêle, Steven E. Mutsaers, Jade Jaffar, Glen Westall, Andrew Reid, Allen James, Christopher Grainge, Darryl A. Knight
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (7): 889–905.
Published: 17 April 2020
... that contribute to idiopathic pulmonary fibrosis (IPF); a lethal disease that manifests primarily in the elderly. Whilst evidence is accumulating that GMP-AMP synthase (cGAS) is crucial in perpetuating senescence by binding damaged DNA released into the cytosol, its role in IPF is not known. The present study...
Includes: Supplementary data
